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O94903

- PROSC_HUMAN

UniProt

O94903 - PROSC_HUMAN

Protein

Proline synthase co-transcribed bacterial homolog protein

Gene

PROSC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Cofactori

    Pyridoxal phosphate.By similarity

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: RefGenome

    GO - Biological processi

    1. alpha-amino acid metabolic process Source: RefGenome

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline synthase co-transcribed bacterial homolog protein
    Gene namesi
    Name:PROSC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:9457. PROSC.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt
    3. intracellular Source: LIFEdb
    4. mitochondrion Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33810.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Proline synthase co-transcribed bacterial homolog proteinPRO_0000163210Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei47 – 471N6-(pyridoxal phosphate)lysineBy similarity
    Modified residuei69 – 691PhosphotyrosineBy similarity
    Modified residuei125 – 1251N6-succinyllysineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO94903.
    PaxDbiO94903.
    PeptideAtlasiO94903.
    PRIDEiO94903.

    2D gel databases

    UCD-2DPAGEO94903.

    PTM databases

    PhosphoSiteiO94903.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiO94903.
    BgeeiO94903.
    CleanExiHS_PROSC.
    GenevestigatoriO94903.

    Organism-specific databases

    HPAiCAB017033.
    HPA023646.
    HPA023733.

    Interactioni

    Protein-protein interaction databases

    BioGridi116381. 31 interactions.
    IntActiO94903. 1 interaction.
    MINTiMINT-3002521.
    STRINGi9606.ENSP00000333551.

    Structurei

    3D structure databases

    ProteinModelPortaliO94903.
    SMRiO94903. Positions 42-248.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0001 family.Curated

    Phylogenomic databases

    eggNOGiCOG0325.
    HOVERGENiHBG053692.
    InParanoidiO94903.
    KOiK06997.
    OMAiQEVIPFV.
    OrthoDBiEOG712TX0.
    PhylomeDBiO94903.
    TreeFamiTF314637.

    Family and domain databases

    Gene3Di3.20.20.10. 1 hit.
    InterProiIPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    IPR011078. UPF0001.
    [Graphical view]
    PANTHERiPTHR10146. PTHR10146. 1 hit.
    PfamiPF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004848. YBL036c_PLPDEIII. 1 hit.
    SUPFAMiSSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00044. TIGR00044. 1 hit.
    PROSITEiPS01211. UPF0001. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O94903-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWRAGSMSAE LGVGCALRAV NERVQQAVAR RPRDLPAIQP RLVAVSKTKP    50
    ADMVIEAYGH GQRTFGENYV QELLEKASNP KILSLCPEIK WHFIGHLQKQ 100
    NVNKLMAVPN LFMLETVDSV KLADKVNSSW QRKGSPERLK VMVQINTSGE 150
    ESKHGLPPSE TIAIVEHINA KCPNLEFVGL MTIGSFGHDL SQGPNPDFQL 200
    LLSLREELCK KLNIPADQVE LSMGMSADFQ HAVEVGSTNV RIGSTIFGER 250
    DYSKKPTPDK CAADVKAPLE VAQEH 275
    Length:275
    Mass (Da):30,344
    Last modified:May 1, 1999 - v1
    Checksum:iA81049432B1A8732
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241V → M.
    Corresponds to variant rs35423325 [ dbSNP | Ensembl ].
    VAR_052476

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018566 Genomic DNA. Translation: BAA36842.1.
    AL136616 mRNA. Translation: CAB66551.1.
    CR533532 mRNA. Translation: CAG38563.1.
    BC012334 mRNA. Translation: AAH12334.1.
    CCDSiCCDS6096.1.
    RefSeqiNP_009129.1. NM_007198.3.
    UniGeneiHs.304792.
    Hs.608177.

    Genome annotation databases

    EnsembliENST00000328195; ENSP00000333551; ENSG00000147471.
    GeneIDi11212.
    KEGGihsa:11212.
    UCSCiuc003xkh.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018566 Genomic DNA. Translation: BAA36842.1 .
    AL136616 mRNA. Translation: CAB66551.1 .
    CR533532 mRNA. Translation: CAG38563.1 .
    BC012334 mRNA. Translation: AAH12334.1 .
    CCDSi CCDS6096.1.
    RefSeqi NP_009129.1. NM_007198.3.
    UniGenei Hs.304792.
    Hs.608177.

    3D structure databases

    ProteinModelPortali O94903.
    SMRi O94903. Positions 42-248.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116381. 31 interactions.
    IntActi O94903. 1 interaction.
    MINTi MINT-3002521.
    STRINGi 9606.ENSP00000333551.

    Chemistry

    DrugBanki DB00172. L-Proline.
    DB00114. Pyridoxal Phosphate.

    PTM databases

    PhosphoSitei O94903.

    2D gel databases

    UCD-2DPAGE O94903.

    Proteomic databases

    MaxQBi O94903.
    PaxDbi O94903.
    PeptideAtlasi O94903.
    PRIDEi O94903.

    Protocols and materials databases

    DNASUi 11212.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328195 ; ENSP00000333551 ; ENSG00000147471 .
    GeneIDi 11212.
    KEGGi hsa:11212.
    UCSCi uc003xkh.3. human.

    Organism-specific databases

    CTDi 11212.
    GeneCardsi GC08P037620.
    HGNCi HGNC:9457. PROSC.
    HPAi CAB017033.
    HPA023646.
    HPA023733.
    MIMi 604436. gene.
    neXtProti NX_O94903.
    PharmGKBi PA33810.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0325.
    HOVERGENi HBG053692.
    InParanoidi O94903.
    KOi K06997.
    OMAi QEVIPFV.
    OrthoDBi EOG712TX0.
    PhylomeDBi O94903.
    TreeFami TF314637.

    Miscellaneous databases

    ChiTaRSi PROSC. human.
    GeneWikii PROSC.
    GenomeRNAii 11212.
    NextBioi 42671.
    PROi O94903.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O94903.
    Bgeei O94903.
    CleanExi HS_PROSC.
    Genevestigatori O94903.

    Family and domain databases

    Gene3Di 3.20.20.10. 1 hit.
    InterProi IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    IPR011078. UPF0001.
    [Graphical view ]
    PANTHERi PTHR10146. PTHR10146. 1 hit.
    Pfami PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004848. YBL036c_PLPDEIII. 1 hit.
    SUPFAMi SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00044. TIGR00044. 1 hit.
    PROSITEi PS01211. UPF0001. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes."
      Ikegawa S., Isomura M., Koshizuka Y., Nakamura Y.
      J. Hum. Genet. 44:337-342(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPROSC_HUMAN
    AccessioniPrimary (citable) accession number: O94903
    Secondary accession number(s): Q6FI94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families
    6. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3