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O94903 (PROSC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proline synthase co-transcribed bacterial homolog protein
Gene names
Name:PROSC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Cofactor

Pyridoxal phosphate By similarity.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the UPF0001 family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   LigandPyridoxal phosphate
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Non-traceable author statement Ref.1. Source: UniProtKB

intracellular

Inferred from direct assay. Source: LIFEdb

mitochondrion

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionpyridoxal phosphate binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Proline synthase co-transcribed bacterial homolog protein
PRO_0000163210

Amino acid modifications

Modified residue471N6-(pyridoxal phosphate)lysine By similarity
Modified residue691Phosphotyrosine By similarity
Modified residue1251N6-succinyllysine By similarity

Natural variations

Natural variant241V → M.
Corresponds to variant rs35423325 [ dbSNP | Ensembl ].
VAR_052476

Sequences

Sequence LengthMass (Da)Tools
O94903 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: A81049432B1A8732

FASTA27530,344
        10         20         30         40         50         60 
MWRAGSMSAE LGVGCALRAV NERVQQAVAR RPRDLPAIQP RLVAVSKTKP ADMVIEAYGH 

        70         80         90        100        110        120 
GQRTFGENYV QELLEKASNP KILSLCPEIK WHFIGHLQKQ NVNKLMAVPN LFMLETVDSV 

       130        140        150        160        170        180 
KLADKVNSSW QRKGSPERLK VMVQINTSGE ESKHGLPPSE TIAIVEHINA KCPNLEFVGL 

       190        200        210        220        230        240 
MTIGSFGHDL SQGPNPDFQL LLSLREELCK KLNIPADQVE LSMGMSADFQ HAVEVGSTNV 

       250        260        270 
RIGSTIFGER DYSKKPTPDK CAADVKAPLE VAQEH 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes."
Ikegawa S., Isomura M., Koshizuka Y., Nakamura Y.
J. Hum. Genet. 44:337-342(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB018566 Genomic DNA. Translation: BAA36842.1.
AL136616 mRNA. Translation: CAB66551.1.
CR533532 mRNA. Translation: CAG38563.1.
BC012334 mRNA. Translation: AAH12334.1.
RefSeqNP_009129.1. NM_007198.3.
UniGeneHs.304792.
Hs.608177.

3D structure databases

ProteinModelPortalO94903.
SMRO94903. Positions 42-248.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116381. 31 interactions.
IntActO94903. 1 interaction.
MINTMINT-3002521.
STRING9606.ENSP00000333551.

Chemistry

DrugBankDB00172. L-Proline.
DB00114. Pyridoxal Phosphate.

PTM databases

PhosphoSiteO94903.

2D gel databases

UCD-2DPAGEO94903.

Proteomic databases

PaxDbO94903.
PeptideAtlasO94903.
PRIDEO94903.

Protocols and materials databases

DNASU11212.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328195; ENSP00000333551; ENSG00000147471.
GeneID11212.
KEGGhsa:11212.
UCSCuc003xkh.3. human.

Organism-specific databases

CTD11212.
GeneCardsGC08P037620.
HGNCHGNC:9457. PROSC.
HPACAB017033.
HPA023646.
HPA023733.
MIM604436. gene.
neXtProtNX_O94903.
PharmGKBPA33810.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0325.
HOVERGENHBG053692.
InParanoidO94903.
KOK06997.
OMANVCIQVN.
OrthoDBEOG712TX0.
PhylomeDBO94903.
TreeFamTF314637.

Gene expression databases

ArrayExpressO94903.
BgeeO94903.
CleanExHS_PROSC.
GenevestigatorO94903.

Family and domain databases

InterProIPR001608. Ala_racemase_N.
IPR011078. UPF0001.
[Graphical view]
PANTHERPTHR10146. PTHR10146. 1 hit.
PfamPF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PIRSFPIRSF004848. YBL036c_PLPDEIII. 1 hit.
TIGRFAMsTIGR00044. TIGR00044. 1 hit.
PROSITEPS01211. UPF0001. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPROSC. human.
GeneWikiPROSC.
GenomeRNAi11212.
NextBio42671.
PROO94903.
SOURCESearch...

Entry information

Entry namePROSC_HUMAN
AccessionPrimary (citable) accession number: O94903
Secondary accession number(s): Q6FI94
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM