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Protein

Proline synthase co-transcribed bacterial homolog protein

Gene

PROSC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Proline synthase co-transcribed bacterial homolog protein
Gene namesi
Name:PROSC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:9457. PROSC.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • intracellular Source: LIFEdb
  • mitochondrion Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33810.

Chemistry

DrugBankiDB00172. L-Proline.

Polymorphism and mutation databases

BioMutaiPROSC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Proline synthase co-transcribed bacterial homolog proteinPRO_0000163210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471N6-(pyridoxal phosphate)lysineBy similarity
Modified residuei69 – 691PhosphotyrosineBy similarity
Modified residuei125 – 1251N6-succinyllysineBy similarity
Modified residuei226 – 2261Phosphoserine1 Publication
Modified residuei244 – 2441Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO94903.
PaxDbiO94903.
PeptideAtlasiO94903.
PRIDEiO94903.

2D gel databases

UCD-2DPAGEO94903.

PTM databases

PhosphoSiteiO94903.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiO94903.
CleanExiHS_PROSC.
ExpressionAtlasiO94903. baseline and differential.
GenevisibleiO94903. HS.

Organism-specific databases

HPAiCAB017033.
HPA023646.
HPA023733.

Interactioni

Protein-protein interaction databases

BioGridi116381. 33 interactions.
IntActiO94903. 1 interaction.
MINTiMINT-3002521.
STRINGi9606.ENSP00000333551.

Structurei

3D structure databases

ProteinModelPortaliO94903.
SMRiO94903. Positions 17-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0001 family.Curated

Phylogenomic databases

eggNOGiCOG0325.
GeneTreeiENSGT00390000004928.
HOVERGENiHBG053692.
InParanoidiO94903.
KOiK06997.
OMAiIGPVQSN.
OrthoDBiEOG712TX0.
PhylomeDBiO94903.
TreeFamiTF314637.

Family and domain databases

Gene3Di3.20.20.10. 1 hit.
InterProiIPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
IPR011078. UPF0001.
[Graphical view]
PANTHERiPTHR10146. PTHR10146. 1 hit.
PfamiPF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004848. YBL036c_PLPDEIII. 1 hit.
SUPFAMiSSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00044. TIGR00044. 1 hit.
PROSITEiPS01211. UPF0001. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94903-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRAGSMSAE LGVGCALRAV NERVQQAVAR RPRDLPAIQP RLVAVSKTKP
60 70 80 90 100
ADMVIEAYGH GQRTFGENYV QELLEKASNP KILSLCPEIK WHFIGHLQKQ
110 120 130 140 150
NVNKLMAVPN LFMLETVDSV KLADKVNSSW QRKGSPERLK VMVQINTSGE
160 170 180 190 200
ESKHGLPPSE TIAIVEHINA KCPNLEFVGL MTIGSFGHDL SQGPNPDFQL
210 220 230 240 250
LLSLREELCK KLNIPADQVE LSMGMSADFQ HAVEVGSTNV RIGSTIFGER
260 270
DYSKKPTPDK CAADVKAPLE VAQEH
Length:275
Mass (Da):30,344
Last modified:May 1, 1999 - v1
Checksum:iA81049432B1A8732
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241V → M.
Corresponds to variant rs35423325 [ dbSNP | Ensembl ].
VAR_052476

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018566 Genomic DNA. Translation: BAA36842.1.
AL136616 mRNA. Translation: CAB66551.1.
CR533532 mRNA. Translation: CAG38563.1.
BC012334 mRNA. Translation: AAH12334.1.
CCDSiCCDS6096.1.
RefSeqiNP_009129.1. NM_007198.3.
UniGeneiHs.304792.
Hs.608177.

Genome annotation databases

EnsembliENST00000328195; ENSP00000333551; ENSG00000147471.
GeneIDi11212.
KEGGihsa:11212.
UCSCiuc003xkh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018566 Genomic DNA. Translation: BAA36842.1.
AL136616 mRNA. Translation: CAB66551.1.
CR533532 mRNA. Translation: CAG38563.1.
BC012334 mRNA. Translation: AAH12334.1.
CCDSiCCDS6096.1.
RefSeqiNP_009129.1. NM_007198.3.
UniGeneiHs.304792.
Hs.608177.

3D structure databases

ProteinModelPortaliO94903.
SMRiO94903. Positions 17-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116381. 33 interactions.
IntActiO94903. 1 interaction.
MINTiMINT-3002521.
STRINGi9606.ENSP00000333551.

Chemistry

DrugBankiDB00172. L-Proline.

PTM databases

PhosphoSiteiO94903.

Polymorphism and mutation databases

BioMutaiPROSC.

2D gel databases

UCD-2DPAGEO94903.

Proteomic databases

MaxQBiO94903.
PaxDbiO94903.
PeptideAtlasiO94903.
PRIDEiO94903.

Protocols and materials databases

DNASUi11212.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328195; ENSP00000333551; ENSG00000147471.
GeneIDi11212.
KEGGihsa:11212.
UCSCiuc003xkh.3. human.

Organism-specific databases

CTDi11212.
GeneCardsiGC08P037620.
HGNCiHGNC:9457. PROSC.
HPAiCAB017033.
HPA023646.
HPA023733.
MIMi604436. gene.
neXtProtiNX_O94903.
PharmGKBiPA33810.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0325.
GeneTreeiENSGT00390000004928.
HOVERGENiHBG053692.
InParanoidiO94903.
KOiK06997.
OMAiIGPVQSN.
OrthoDBiEOG712TX0.
PhylomeDBiO94903.
TreeFamiTF314637.

Miscellaneous databases

ChiTaRSiPROSC. human.
GeneWikiiPROSC.
GenomeRNAii11212.
NextBioi42671.
PROiO94903.
SOURCEiSearch...

Gene expression databases

BgeeiO94903.
CleanExiHS_PROSC.
ExpressionAtlasiO94903. baseline and differential.
GenevisibleiO94903. HS.

Family and domain databases

Gene3Di3.20.20.10. 1 hit.
InterProiIPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
IPR011078. UPF0001.
[Graphical view]
PANTHERiPTHR10146. PTHR10146. 1 hit.
PfamiPF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004848. YBL036c_PLPDEIII. 1 hit.
SUPFAMiSSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00044. TIGR00044. 1 hit.
PROSITEiPS01211. UPF0001. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes."
    Ikegawa S., Isomura M., Koshizuka Y., Nakamura Y.
    J. Hum. Genet. 44:337-342(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226 AND SER-244, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPROSC_HUMAN
AccessioniPrimary (citable) accession number: O94903
Secondary accession number(s): Q6FI94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: June 24, 2015
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.