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Protein

Proline synthase co-transcribed bacterial homolog protein

Gene

PROSC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciZFISH:G66-31923-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline synthase co-transcribed bacterial homolog protein
Gene namesi
Name:PROSC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:9457. PROSC.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • intracellular Source: LIFEdb
  • mitochondrion Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147471.
PharmGKBiPA33810.

Chemistry databases

DrugBankiDB00172. L-Proline.

Polymorphism and mutation databases

BioMutaiPROSC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001632101 – 275Proline synthase co-transcribed bacterial homolog proteinAdd BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei47N6-(pyridoxal phosphate)lysineBy similarity1
Modified residuei69PhosphotyrosineBy similarity1
Modified residuei125N6-succinyllysineBy similarity1
Modified residuei226PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO94903.
MaxQBiO94903.
PaxDbiO94903.
PeptideAtlasiO94903.
PRIDEiO94903.

2D gel databases

UCD-2DPAGEO94903.

PTM databases

iPTMnetiO94903.
PhosphoSitePlusiO94903.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000147471.
CleanExiHS_PROSC.
ExpressionAtlasiO94903. baseline and differential.
GenevisibleiO94903. HS.

Organism-specific databases

HPAiCAB017033.
HPA023646.
HPA023733.

Interactioni

Protein-protein interaction databases

BioGridi116381. 66 interactors.
IntActiO94903. 13 interactors.
MINTiMINT-3002521.
STRINGi9606.ENSP00000333551.

Structurei

3D structure databases

ProteinModelPortaliO94903.
SMRiO94903.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0001 family.Curated

Phylogenomic databases

eggNOGiKOG3157. Eukaryota.
COG0325. LUCA.
GeneTreeiENSGT00390000004928.
HOVERGENiHBG053692.
InParanoidiO94903.
KOiK06997.
OMAiHGSTMVR.
OrthoDBiEOG091G0IMD.
PhylomeDBiO94903.
TreeFamiTF314637.

Family and domain databases

Gene3Di3.20.20.10. 1 hit.
InterProiIPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
IPR011078. UPF0001.
[Graphical view]
PANTHERiPTHR10146. PTHR10146. 1 hit.
PfamiPF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004848. YBL036c_PLPDEIII. 1 hit.
SUPFAMiSSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00044. TIGR00044. 1 hit.
PROSITEiPS01211. UPF0001. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94903-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRAGSMSAE LGVGCALRAV NERVQQAVAR RPRDLPAIQP RLVAVSKTKP
60 70 80 90 100
ADMVIEAYGH GQRTFGENYV QELLEKASNP KILSLCPEIK WHFIGHLQKQ
110 120 130 140 150
NVNKLMAVPN LFMLETVDSV KLADKVNSSW QRKGSPERLK VMVQINTSGE
160 170 180 190 200
ESKHGLPPSE TIAIVEHINA KCPNLEFVGL MTIGSFGHDL SQGPNPDFQL
210 220 230 240 250
LLSLREELCK KLNIPADQVE LSMGMSADFQ HAVEVGSTNV RIGSTIFGER
260 270
DYSKKPTPDK CAADVKAPLE VAQEH
Length:275
Mass (Da):30,344
Last modified:May 1, 1999 - v1
Checksum:iA81049432B1A8732
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05247624V → M.Corresponds to variant rs35423325dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018566 Genomic DNA. Translation: BAA36842.1.
AL136616 mRNA. Translation: CAB66551.1.
CR533532 mRNA. Translation: CAG38563.1.
BC012334 mRNA. Translation: AAH12334.1.
CCDSiCCDS6096.1.
RefSeqiNP_009129.1. NM_007198.3.
UniGeneiHs.304792.
Hs.608177.

Genome annotation databases

EnsembliENST00000328195; ENSP00000333551; ENSG00000147471.
GeneIDi11212.
KEGGihsa:11212.
UCSCiuc003xkh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018566 Genomic DNA. Translation: BAA36842.1.
AL136616 mRNA. Translation: CAB66551.1.
CR533532 mRNA. Translation: CAG38563.1.
BC012334 mRNA. Translation: AAH12334.1.
CCDSiCCDS6096.1.
RefSeqiNP_009129.1. NM_007198.3.
UniGeneiHs.304792.
Hs.608177.

3D structure databases

ProteinModelPortaliO94903.
SMRiO94903.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116381. 66 interactors.
IntActiO94903. 13 interactors.
MINTiMINT-3002521.
STRINGi9606.ENSP00000333551.

Chemistry databases

DrugBankiDB00172. L-Proline.

PTM databases

iPTMnetiO94903.
PhosphoSitePlusiO94903.

Polymorphism and mutation databases

BioMutaiPROSC.

2D gel databases

UCD-2DPAGEO94903.

Proteomic databases

EPDiO94903.
MaxQBiO94903.
PaxDbiO94903.
PeptideAtlasiO94903.
PRIDEiO94903.

Protocols and materials databases

DNASUi11212.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328195; ENSP00000333551; ENSG00000147471.
GeneIDi11212.
KEGGihsa:11212.
UCSCiuc003xkh.4. human.

Organism-specific databases

CTDi11212.
GeneCardsiPROSC.
HGNCiHGNC:9457. PROSC.
HPAiCAB017033.
HPA023646.
HPA023733.
MIMi604436. gene.
neXtProtiNX_O94903.
OpenTargetsiENSG00000147471.
PharmGKBiPA33810.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3157. Eukaryota.
COG0325. LUCA.
GeneTreeiENSGT00390000004928.
HOVERGENiHBG053692.
InParanoidiO94903.
KOiK06997.
OMAiHGSTMVR.
OrthoDBiEOG091G0IMD.
PhylomeDBiO94903.
TreeFamiTF314637.

Enzyme and pathway databases

BioCyciZFISH:G66-31923-MONOMER.

Miscellaneous databases

ChiTaRSiPROSC. human.
GeneWikiiPROSC.
GenomeRNAii11212.
PROiO94903.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147471.
CleanExiHS_PROSC.
ExpressionAtlasiO94903. baseline and differential.
GenevisibleiO94903. HS.

Family and domain databases

Gene3Di3.20.20.10. 1 hit.
InterProiIPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
IPR011078. UPF0001.
[Graphical view]
PANTHERiPTHR10146. PTHR10146. 1 hit.
PfamiPF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004848. YBL036c_PLPDEIII. 1 hit.
SUPFAMiSSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00044. TIGR00044. 1 hit.
PROSITEiPS01211. UPF0001. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPROSC_HUMAN
AccessioniPrimary (citable) accession number: O94903
Secondary accession number(s): Q6FI94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.