O94903 (PROSC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proline synthase co-transcribed bacterial homolog protein

Gene names

Name:

PROSC

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Cofactor	Pyridoxal phosphate By similarity.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the UPF0001 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	Pyridoxal phosphate
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	pyridoxal phosphate binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Proline synthase co-transcribed bacterial homolog protein		PRO_0000163210
Amino acid modifications
	Modified residue	47	1	N6-(pyridoxal phosphate)lysine By similarity
	Modified residue	69	1	Phosphotyrosine By similarity
	Modified residue	244	1	Phosphoserine Ref.5
Natural variations
	Natural variant	24	1	V → M. Corresponds to variant rs35423325 [ dbSNP | Ensembl ].		VAR_052476

Sequences

	Sequence		Length	Mass (Da)
	O94903 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: A81049432B1A8732	FASTA	275	30,344
	10 20 30 40 50 60 MWRAGSMSAE LGVGCALRAV NERVQQAVAR RPRDLPAIQP RLVAVSKTKP ADMVIEAYGH 70 80 90 100 110 120 GQRTFGENYV QELLEKASNP KILSLCPEIK WHFIGHLQKQ NVNKLMAVPN LFMLETVDSV 130 140 150 160 170 180 KLADKVNSSW QRKGSPERLK VMVQINTSGE ESKHGLPPSE TIAIVEHINA KCPNLEFVGL 190 200 210 220 230 240 MTIGSFGHDL SQGPNPDFQL LLSLREELCK KLNIPADQVE LSMGMSADFQ HAVEVGSTNV 250 260 270 RIGSTIFGER DYSKKPTPDK CAADVKAPLE VAQEH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes." Ikegawa S., Isomura M., Koshizuka Y., Nakamura Y. J. Hum. Genet. 44:337-342(1999) [PubMed: 10496079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB018566 Genomic DNA. Translation: BAA36842.1. AL136616 mRNA. Translation: CAB66551.1. CR533532 mRNA. Translation: CAG38563.1. BC012334 mRNA. Translation: AAH12334.1.
IPI	IPI00016346.
RefSeq	NP_009129.1. NM_007198.3.
UniGene	Hs.304792. Hs.608177.
3D structure databases
ProteinModelPortal	O94903.
SMR	O94903. Positions 11-248.
ModBase	Search...
Protein-protein interaction databases
IntAct	O94903. 1 interaction.
STRING	O94903.
PTM databases
PhosphoSite	O94903.
2D gel databases
UCD-2DPAGE	O94903.
Proteomic databases
PeptideAtlas	O94903.
PRIDE	O94903.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328195; ENSP00000333551; ENSG00000147471.
GeneID	11212.
KEGG	hsa:11212.
UCSC	uc003xkh.1. human.
Organism-specific databases
CTD	11212.
GeneCards	GC08P037676.
H-InvDB	HIX0201282.
HGNC	HGNC:9457. PROSC.
HPA	CAB017033. HPA023646. HPA023733.
MIM	604436. gene.
neXtProt	NX_O94903.
PharmGKB	PA33810.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12348.
GeneTree	ENSGT00390000004928.
HOGENOM	HBG289671.
HOVERGEN	HBG053692.
InParanoid	O94903.
OMA	AVSKTFE.
OrthoDB	EOG40CHHN.
PhylomeDB	O94903.
Gene expression databases
ArrayExpress	O94903.
Bgee	O94903.
CleanEx	HS_PROSC.
Genevestigator	O94903.
GermOnline	ENSG00000147471. Homo sapiens.
Family and domain databases
InterPro	IPR001608. Ala_racemase_N. IPR011078. UPF0001. [Graphical view]
KO	K06997.
PANTHER	PTHR10146. PP_YBL036C. 1 hit.
Pfam	PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PIRSF	PIRSF004848. YBL036c_PLPDEIII. 1 hit.
TIGRFAMs	TIGR00044. TIGR00044. 1 hit.
PROSITE	PS01211. UPF0001. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00172. L-Proline. DB00114. Pyridoxal Phosphate.
NextBio	42671.
SOURCE	Search...

Entry information

Entry name

PROSC_HUMAN

Accession

Primary (citable) accession number: O94903
Secondary accession number(s): Q6FI94

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.