Proline synthetase co-transcribed bacterial homolog protein

Contribute

Send feedback

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot O94903 (PROSC_HUMAN)

Last modified November 24, 2009. Version 74. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein names

Recommended name:
Proline synthetase co-transcribed bacterial homolog protein

Gene names

Name:

PROSC

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Cofactor	Pyridoxal phosphate By similarity.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the UPF0001 family.

Hide | Top

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	Pyridoxal phosphate
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 275

275

Proline synthetase co-transcribed bacterial homolog protein

PRO_0000163210

Amino acid modifications

Modified residue

N6-(pyridoxal phosphate)lysine By similarity

Modified residue

Phosphotyrosine By similarity

Modified residue

244

Phosphoserine

Natural variations

Natural variant

V → M: dbSNP rs35423325.

VAR_052476

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

O94903-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: A81049432B1A8732
Show »

FASTA

275

30,344

        10         20         30         40         50         60 
MWRAGSMSAE LGVGCALRAV NERVQQAVAR RPRDLPAIQP RLVAVSKTKP ADMVIEAYGH 

        70         80         90        100        110        120 
GQRTFGENYV QELLEKASNP KILSLCPEIK WHFIGHLQKQ NVNKLMAVPN LFMLETVDSV 

       130        140        150        160        170        180 
KLADKVNSSW QRKGSPERLK VMVQINTSGE ESKHGLPPSE TIAIVEHINA KCPNLEFVGL 

       190        200        210        220        230        240 
MTIGSFGHDL SQGPNPDFQL LLSLREELCK KLNIPADQVE LSMGMSADFQ HAVEVGSTNV 

       250        260        270 
RIGSTIFGER DYSKKPTPDK CAADVKAPLE VAQEH

« Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes." Ikegawa S., Isomura M., Koshizuka Y., Nakamura Y. J. Hum. Genet. 44:337-342(1999) [PubMed: 10496079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, MASS SPECTROMETRY. Tissue: T-cell.

Hide | Top

Cross-references

Sequence databases
	AB018566 Genomic DNA. Translation: BAA36842.1. AL136616 mRNA. Translation: CAB66551.1. CR533532 mRNA. Translation: CAG38563.1. BC012334 mRNA. Translation: AAH12334.1.
IPI	IPI00016346.
RefSeq	NP_009129.1.
UniGene	Hs.304792 Hs.608177
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O94903.
PTM databases
PhosphoSite	O94903.
Proteomic databases
PeptideAtlas	O94903.
PRIDE	O94903.
Genome annotation databases
Ensembl	ENST00000328195; ENSP00000333551; ENSG00000147471; Homo sapiens. [Genome view]
GeneID	11212.
KEGG	hsa:11212.
UCSC	uc003xkh.1. human.
Organism-specific databases
CTD	11212.
GeneCards	GC08P037738.
HGNC	HGNC:9457. PROSC.
HPA	CAB017033. HPA023646. HPA023733.
MIM	604436. gene.
PharmGKB	PA33810.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O94903.
HOVERGEN	O94903.
OMA	HFALTAK
OrthoDB	EOG95MQR7
Gene expression databases
ArrayExpress	O94903.
Bgee	O94903.
CleanEx	HS_PROSC.
Genevestigator	O94903.
GermOnline	ENSG00000147471. Homo sapiens.
Family and domain databases
InterPro	IPR001608. Ala_racemase_N. IPR011078. Prd-pyrdxlP-dep_enz_YBL036C. [Graphical view]
PANTHER	PTHR10146. PP_YBL036C. 1 hit.
Pfam	PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PIRSF	PIRSF004848. YBL036c_PLPDEIII. 1 hit.
TIGRFAMs	TIGR00044. PP_YBL036C. 1 hit.
PROSITE	PS01211. UPF0001. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00172. L-Proline. DB00114. Pyridoxal Phosphate.
NextBio	42671.
SOURCE	Search...

Hide | Top

Entry information

Entry name

PROSC_HUMAN

Accession

Primary (citable) accession number: O94903
Secondary accession number(s): Q6FI94

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 1999
Last modified:	November 24, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Hide | Top