O94901 (SUN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SUN domain-containing protein 1

Alternative name(s):
Protein unc-84 homolog A
Sad1/unc-84 protein-like 1

Gene names

Name:	SUN1
Synonyms:	KIAA0810, UNC84A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	812 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs) By similarity. Ref.9 Ref.14
Subunit structure	Dimers and tetramers By similarity. Component of LINC complexes composed of SUN domain-containing proteins SUN1 or SUN2 coupled to KASH domain-containing proteins (SYNE1, SYNE2 or SYNE3), also called nesprins. Interacts with TSNAX By similarity. Interacts with EMD, LMNA, NAT10, SYNE1, SYNE2 and SYNE3. Associates with the nuclear pore complex (NPC) By similarity. Interacts with CCDC155 (via the last 22 AA); this interaction mediates CCDC155 telomere localization By similarity. Ref.9 Ref.10 Ref.12 Ref.13 Ref.14 Ref.16
Subcellular location	Nucleus inner membrane; Single-pass type II membrane protein Ref.7 Ref.10 Ref.11 Ref.13 Ref.16.
Domain	The SUN domain may play a role in the nuclear anchoring and/or migration. Ref.16
Sequence similarities	Contains 1 SUN domain.
Sequence caution	The sequence BAA34530.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Signal-anchor Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytoskeletal anchoring at nuclear membrane Inferred from direct assay Ref.14. Source: UniProtKB nuclear envelope organization Inferred from genetic interaction PubMed 16380439. Source: MGI nuclear matrix anchoring at nuclear membrane Inferred from direct assay Ref.14. Source: UniProtKB
Cellular_component	SUN-KASH complex Inferred from direct assay Ref.14. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear membrane Inferred from direct assay. Source: HPA
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SYNE1	Q8NF91-1	2	EBI-2796904,EBI-6170938
SYNE2	Q8WXH0-1	2	EBI-2796904,EBI-6170976

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O94901-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O94901-2)

The sequence of this isoform differs from the canonical sequence as follows:
     221-257: DDCKGKRHLDAHPGRAGTLWHIWACAGYFLLQILRRI → KSQSFKTQKKVCFPNLIFPFCKSQCLHYLSWRLKIIP
     258-812: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: O94901-3)

The sequence of this isoform differs from the canonical sequence as follows:
     221-341: DDCKGKRHLD...GLSLRGQGNF → GASFYVNRIL...AVMLGTSSRE
     342-812: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: O94901-4)

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: R → V
     110-812: Missing.

Isoform 5 (identifier: O94901-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.
     220-280: CDDCKGKRHLDAHPGRAGTLWHIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPG → W

Isoform 6 (identifier: O94901-6)

The sequence of this isoform differs from the canonical sequence as follows:
     151-279: Missing.
     331-331: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: O94901-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRISPGSPGLPRTVWFEVVNM
     221-257: DDCKGKRHLDAHPGRAGTLWHIWACAGYFLLQILRRI → KSQSFKTQKKVCFPNLIFPFCKSQCLHYLSWRLKIIP
     258-812: Missing.

Note: No experimental confirmation available.

Isoform 8 (identifier: O94901-8)

The sequence of this isoform differs from the canonical sequence as follows:
     221-247: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 812	812	SUN domain-containing protein 1		PRO_0000218911
Regions
	Topological domain	1 – 315	315	Nuclear Ref.13
	Transmembrane	316 – 335	20	Helical
	Topological domain	336 – 812	477	Perinuclear space Ref.13
	Domain	649 – 811	163	SUN
	Region	1 – 138	138	LMNA-binding
	Region	209 – 302	94	SYNE2-binding
	Region	223 – 302	80	EMD-binding
	Coiled coil	393 – 430	38	Potential
	Coiled coil	455 – 493	39	Potential
	Coiled coil	501 – 523	23	Potential
Amino acid modifications
	Modified residue	48	1	Phosphoserine By similarity
	Modified residue	52	1	Phosphoserine By similarity
	Modified residue	100	1	Phosphoserine Ref.17
	Modified residue	138	1	Phosphoserine Ref.8 Ref.17
Natural variations
	Alternative sequence	1 – 50	50	Missing in isoform 5.		VSP_037867
	Alternative sequence	1	1	M → MGRISPGSPGLPRTVWFEVV NM in isoform 7.		VSP_046108
	Alternative sequence	109	1	R → V in isoform 4.		VSP_007741
	Alternative sequence	110 – 812	703	Missing in isoform 4.		VSP_007742
	Alternative sequence	151 – 279	129	Missing in isoform 6.		VSP_045815
	Alternative sequence	220 – 280	61	CDDCK…VVAPG → W in isoform 5.		VSP_037868
	Alternative sequence	221 – 341	121	DDCKG…GQGNF → GASFYVNRILWLARYTASSF SSFLVQLFQVVLMKLSYESE NYKLKTHESKDCESESYKSK SHESKAHASYYGRMNVREVL REDGHLSVNGEALCKYGFVF LWASVVELVPHAVMLGTSSR E in isoform 3.		VSP_007745
	Alternative sequence	221 – 257	37	DDCKG…ILRRI → KSQSFKTQKKVCFPNLIFPF CKSQCLHYLSWRLKIIP in isoform 2 and isoform 7.		VSP_007743
	Alternative sequence	221 – 247	27	Missing in isoform 8.		VSP_046269
	Alternative sequence	258 – 812	555	Missing in isoform 2 and isoform 7.		VSP_007744
	Alternative sequence	331	1	Missing in isoform 6.		VSP_045816
	Alternative sequence	342 – 812	471	Missing in isoform 3.		VSP_007746
	Natural variant	118	1	H → Y. Ref.1 Ref.2 Ref.5 Corresponds to variant rs6461378 [ dbSNP | Ensembl ].		VAR_059828
Experimental info
	Sequence conflict	15	1	V → A in CAD98070. Ref.3
	Sequence conflict	78	1	S → G in CAD98070. Ref.3
	Sequence conflict	174	1	A → V in BAA34530. Ref.1
	Sequence conflict	204	1	A → P in AAH13613. Ref.5
	Sequence conflict	445	1	P → L in BAG51119. Ref.2
	Sequence conflict	503	1	E → K in BAG64069. Ref.2
	Sequence conflict	520	1	R → Q in BAG51119. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 11, 2003. Version 3. Checksum: B958E95510B6F15F	FASTA	812	90,064
	10 20 30 40 50 60 MDFSRLHMYS PPQCVPENTG YTYALSSSYS SDALDFETEH KLDPVFDSPR MSRRSLRLAT 70 80 90 100 110 120 TACTLGDGEA VGADSGTSSA VSLKNRAART TKQRRSTNKS AFSINHVSRQ VTSSGVSHGG 130 140 150 160 170 180 TVSLQDAVTR RPPVLDESWI REQTTVDHFW GLDDDGDLKG GNKAAIQGNG DVGAAAATAH 190 200 210 220 230 240 NGFSCSNCSM LSERKDVLTA HPAAPGPVSR VYSRDRNQKC DDCKGKRHLD AHPGRAGTLW 250 260 270 280 290 300 HIWACAGYFL LQILRRIGAV GQAVSRTAWS ALWLAVVAPG KAASGVFWWL GIGWYQFVTL 310 320 330 340 350 360 ISWLNVFLLT RCLRNICKFL VLLIPLFLLL AGLSLRGQGN FFSFLPVLNW ASMHRTQRVD 370 380 390 400 410 420 DPQDVFKPTT SRLKQPLQGD SEAFPWHWMS GVEQQVASLS GQCHHHGENL RELTTLLQKL 430 440 450 460 470 480 QARVDQMEGG AAGPSASVRD AVGQPPRETD FMAFHQEHEV RMSHLEDILG KLREKSEAIQ 490 500 510 520 530 540 KELEQTKQKT ISAVGEQLLP TVEHLQLELD QLKSELSSWR HVKTGCETVD AVQERVDVQV 550 560 570 580 590 600 REMVKLLFSE DQQGGSLEQL LQRFSSQFVS KGDLQTMLRD LQLQILRNVT HHVSVTKQLP 610 620 630 640 650 660 TSEAVVSAVS EAGASGITEA QARAIVNSAL KLYSQDKTGM VDFALESGGG SILSTRCSET 670 680 690 700 710 720 YETKTALMSL FGIPLWYFSQ SPRVVIQPDI YPGNCWAFKG SQGYLVVRLS MMIHPAAFTL 730 740 750 760 770 780 EHIPKTLSPT GNISSAPKDF AVYGLENEYQ EEGQLLGQFT YDQDGESLQM FQALKRPDDT 790 800 810 AFQIVELRIF SNWGHPEYTC LYRFRVHGEP VK
	Isoform 2 [UniParc]. Checksum: 5E674FAF6714115C	FASTA	257	28,083
	10 20 30 40 50 60 MDFSRLHMYS PPQCVPENTG YTYALSSSYS SDALDFETEH KLDPVFDSPR MSRRSLRLAT 70 80 90 100 110 120 TACTLGDGEA VGADSGTSSA VSLKNRAART TKQRRSTNKS AFSINHVSRQ VTSSGVSHGG 130 140 150 160 170 180 TVSLQDAVTR RPPVLDESWI REQTTVDHFW GLDDDGDLKG GNKAAIQGNG DVGAAAATAH 190 200 210 220 230 240 NGFSCSNCSM LSERKDVLTA HPAAPGPVSR VYSRDRNQKC KSQSFKTQKK VCFPNLIFPF 250 CKSQCLHYLS WRLKIIP
	Isoform 3 [UniParc]. Checksum: 144E6797A593A612	FASTA	341	37,468
	10 20 30 40 50 60 MDFSRLHMYS PPQCVPENTG YTYALSSSYS SDALDFETEH KLDPVFDSPR MSRRSLRLAT 70 80 90 100 110 120 TACTLGDGEA VGADSGTSSA VSLKNRAART TKQRRSTNKS AFSINHVSRQ VTSSGVSHGG 130 140 150 160 170 180 TVSLQDAVTR RPPVLDESWI REQTTVDHFW GLDDDGDLKG GNKAAIQGNG DVGAAAATAH 190 200 210 220 230 240 NGFSCSNCSM LSERKDVLTA HPAAPGPVSR VYSRDRNQKC GASFYVNRIL WLARYTASSF 250 260 270 280 290 300 SSFLVQLFQV VLMKLSYESE NYKLKTHESK DCESESYKSK SHESKAHASY YGRMNVREVL 310 320 330 340 REDGHLSVNG EALCKYGFVF LWASVVELVP HAVMLGTSSR E
	Isoform 4 [UniParc]. Checksum: ED8ECECB9657080A	FASTA	109	11,897
	10 20 30 40 50 60 MDFSRLHMYS PPQCVPENTG YTYALSSSYS SDALDFETEH KLDPVFDSPR MSRRSLRLAT 70 80 90 100 TACTLGDGEA VGADSGTSSA VSLKNRAART TKQRRSTNKS AFSINHVSV
	Isoform 5 [UniParc]. Checksum: 630DD5C326645BCE	FASTA	702	77,911
	10 20 30 40 50 60 MSRRSLRLAT TACTLGDGEA VGADSGTSSA VSLKNRAART TKQRRSTNKS AFSINHVSRQ 70 80 90 100 110 120 VTSSGVSHGG TVSLQDAVTR RPPVLDESWI REQTTVDHFW GLDDDGDLKG GNKAAIQGNG 130 140 150 160 170 180 DVGAAAATAH NGFSCSNCSM LSERKDVLTA HPAAPGPVSR VYSRDRNQKW KAASGVFWWL 190 200 210 220 230 240 GIGWYQFVTL ISWLNVFLLT RCLRNICKFL VLLIPLFLLL AGLSLRGQGN FFSFLPVLNW 250 260 270 280 290 300 ASMHRTQRVD DPQDVFKPTT SRLKQPLQGD SEAFPWHWMS GVEQQVASLS GQCHHHGENL 310 320 330 340 350 360 RELTTLLQKL QARVDQMEGG AAGPSASVRD AVGQPPRETD FMAFHQEHEV RMSHLEDILG 370 380 390 400 410 420 KLREKSEAIQ KELEQTKQKT ISAVGEQLLP TVEHLQLELD QLKSELSSWR HVKTGCETVD 430 440 450 460 470 480 AVQERVDVQV REMVKLLFSE DQQGGSLEQL LQRFSSQFVS KGDLQTMLRD LQLQILRNVT 490 500 510 520 530 540 HHVSVTKQLP TSEAVVSAVS EAGASGITEA QARAIVNSAL KLYSQDKTGM VDFALESGGG 550 560 570 580 590 600 SILSTRCSET YETKTALMSL FGIPLWYFSQ SPRVVIQPDI YPGNCWAFKG SQGYLVVRLS 610 620 630 640 650 660 MMIHPAAFTL EHIPKTLSPT GNISSAPKDF AVYGLENEYQ EEGQLLGQFT YDQDGESLQM 670 680 690 700 FQALKRPDDT AFQIVELRIF SNWGHPEYTC LYRFRVHGEP VK
	Isoform 6 [UniParc]. Checksum: CEEE24E27B0B6069	FASTA	682	76,403
	10 20 30 40 50 60 MDFSRLHMYS PPQCVPENTG YTYALSSSYS SDALDFETEH KLDPVFDSPR MSRRSLRLAT 70 80 90 100 110 120 TACTLGDGEA VGADSGTSSA VSLKNRAART TKQRRSTNKS AFSINHVSRQ VTSSGVSHGG 130 140 150 160 170 180 TVSLQDAVTR RPPVLDESWI REQTTVDHFW GKAASGVFWW LGIGWYQFVT LISWLNVFLL 190 200 210 220 230 240 TRCLRNICKF LVLLIPLFLL LGLSLRGQGN FFSFLPVLNW ASMHRTQRVD DPQDVFKPTT 250 260 270 280 290 300 SRLKQPLQGD SEAFPWHWMS GVEQQVASLS GQCHHHGENL RELTTLLQKL QARVDQMEGG 310 320 330 340 350 360 AAGPSASVRD AVGQPPRETD FMAFHQEHEV RMSHLEDILG KLREKSEAIQ KELEQTKQKT 370 380 390 400 410 420 ISAVGEQLLP TVEHLQLELD QLKSELSSWR HVKTGCETVD AVQERVDVQV REMVKLLFSE 430 440 450 460 470 480 DQQGGSLEQL LQRFSSQFVS KGDLQTMLRD LQLQILRNVT HHVSVTKQLP TSEAVVSAVS 490 500 510 520 530 540 EAGASGITEA QARAIVNSAL KLYSQDKTGM VDFALESGGG SILSTRCSET YETKTALMSL 550 560 570 580 590 600 FGIPLWYFSQ SPRVVIQPDI YPGNCWAFKG SQGYLVVRLS MMIHPAAFTL EHIPKTLSPT 610 620 630 640 650 660 GNISSAPKDF AVYGLENEYQ EEGQLLGQFT YDQDGESLQM FQALKRPDDT AFQIVELRIF 670 680 SNWGHPEYTC LYRFRVHGEP VK
	Isoform 7 [UniParc]. Checksum: C4E91043C5F2C0BD	FASTA	278	30,365
	10 20 30 40 50 60 MGRISPGSPG LPRTVWFEVV NMDFSRLHMY SPPQCVPENT GYTYALSSSY SSDALDFETE 70 80 90 100 110 120 HKLDPVFDSP RMSRRSLRLA TTACTLGDGE AVGADSGTSS AVSLKNRAAR TTKQRRSTNK 130 140 150 160 170 180 SAFSINHVSR QVTSSGVSHG GTVSLQDAVT RRPPVLDESW IREQTTVDHF WGLDDDGDLK 190 200 210 220 230 240 GGNKAAIQGN GDVGAAAATA HNGFSCSNCS MLSERKDVLT AHPAAPGPVS RVYSRDRNQK 250 260 270 CKSQSFKTQK KVCFPNLIFP FCKSQCLHYL SWRLKIIP
	Isoform 8 [UniParc]. Checksum: 1099A50C9540ECF5	FASTA	785	87,110
	10 20 30 40 50 60 MDFSRLHMYS PPQCVPENTG YTYALSSSYS SDALDFETEH KLDPVFDSPR MSRRSLRLAT 70 80 90 100 110 120 TACTLGDGEA VGADSGTSSA VSLKNRAART TKQRRSTNKS AFSINHVSRQ VTSSGVSHGG 130 140 150 160 170 180 TVSLQDAVTR RPPVLDESWI REQTTVDHFW GLDDDGDLKG GNKAAIQGNG DVGAAAATAH 190 200 210 220 230 240 NGFSCSNCSM LSERKDVLTA HPAAPGPVSR VYSRDRNQKC YFLLQILRRI GAVGQAVSRT 250 260 270 280 290 300 AWSALWLAVV APGKAASGVF WWLGIGWYQF VTLISWLNVF LLTRCLRNIC KFLVLLIPLF 310 320 330 340 350 360 LLLAGLSLRG QGNFFSFLPV LNWASMHRTQ RVDDPQDVFK PTTSRLKQPL QGDSEAFPWH 370 380 390 400 410 420 WMSGVEQQVA SLSGQCHHHG ENLRELTTLL QKLQARVDQM EGGAAGPSAS VRDAVGQPPR 430 440 450 460 470 480 ETDFMAFHQE HEVRMSHLED ILGKLREKSE AIQKELEQTK QKTISAVGEQ LLPTVEHLQL 490 500 510 520 530 540 ELDQLKSELS SWRHVKTGCE TVDAVQERVD VQVREMVKLL FSEDQQGGSL EQLLQRFSSQ 550 560 570 580 590 600 FVSKGDLQTM LRDLQLQILR NVTHHVSVTK QLPTSEAVVS AVSEAGASGI TEAQARAIVN 610 620 630 640 650 660 SALKLYSQDK TGMVDFALES GGGSILSTRC SETYETKTAL MSLFGIPLWY FSQSPRVVIQ 670 680 690 700 710 720 PDIYPGNCWA FKGSQGYLVV RLSMMIHPAA FTLEHIPKTL SPTGNISSAP KDFAVYGLEN 730 740 750 760 770 780 EYQEEGQLLG QFTYDQDGES LQMFQALKRP DDTAFQIVEL RIFSNWGHPE YTCLYRFRVH GEPVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TYR-118. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 5; 6 AND 7), VARIANT TYR-118. Tissue: Mammary gland, Substantia nigra and Testis.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Cerebellum.
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 8), VARIANT TYR-118. Tissue: Ovary.
[6]	"UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development." Malone C.J., Fixsen W.D., Horvitz H.R., Han M. Development 126:3171-3181(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 389-812.
[7]	"Nuclear membrane proteins with potential disease links found by subtractive proteomics." Schirmer E.C., Florens L., Guan T., Yates J.R. III, Gerace L. Science 301:1380-1382(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Telomere anchoring at the nuclear periphery requires the budding yeast Sad1-UNC-84 domain protein Mps3." Bupp J.M., Martin A.E., Stensrud E.S., Jaspersen S.L. J. Cell Biol. 179:845-854(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH MPS3.
[10]	"Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome." Wang Q., Du X., Cai Z., Greene M.I. DNA Cell Biol. 25:554-562(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, SUBUNIT, ASSOCIATION WITH THE CENTROSOME.
[11]	"Nuclear envelope localization of human UNC84A does not require nuclear lamins." Hasan S., Guttinger S., Muhlhausser P., Anderegg F., Burgler S., Kutay U. FEBS Lett. 580:1263-1268(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[12]	"Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes." Chi Y.-H., Haller K., Peloponese J.-M. Jr., Jeang K.-T. J. Biol. Chem. 282:27447-27458(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NAT10.
[13]	"Sun1 forms immobile macromolecular assemblies at the nuclear envelope." Lu W., Gotzmann J., Sironi L., Jaeger V.M., Schneider M., Luke Y., Uhlen M., Szigyarto C.A., Brachner A., Ellenberg J., Foisner R., Noegel A.A., Karakesisoglou I. Biochim. Biophys. Acta 1783:2415-2426(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TOPOLOGY, SUBUNIT, INTERACTION WITH SUN2.
[14]	"Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness." Stewart-Hutchinson P.J., Hale C.M., Wirtz D., Hodzic D. Exp. Cell Res. 314:1892-1905(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SYNE1; SYNE2 AND SYNE3, FUNCTION OF THE LINC COMPLEXES.
[15]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[16]	"Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes." Haque F., Mazzeo D., Patel J.T., Smallwood D.T., Ellis J.A., Shanahan C.M., Shackleton S. J. Biol. Chem. 285:3487-3498(2010) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH EMD; LMNA AND SYNE2, DOMAIN, ASSOCIATION WITH THE NUCLEOSKELETON.
[17]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100 AND SER-138, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB018353 mRNA. Translation: BAA34530.1. Different initiation. AK022469 mRNA. Translation: BAB14046.1. AK022816 mRNA. Translation: BAG51119.1. AK302896 mRNA. Translation: BAG64069.1. AK309120 mRNA. No translation available. BX538211 mRNA. Translation: CAD98070.1. AC073957 Genomic DNA. No translation available. AC099731 Genomic DNA. No translation available. BC013613 mRNA. Translation: AAH13613.1. BC142707 mRNA. Translation: AAI42708.1. AF202724 mRNA. Translation: AAF15888.1.
IPI	IPI00306682. IPI00335367. IPI00409738. IPI00783943. IPI00873723. IPI00893282. IPI00894044. IPI00955411.
RefSeq	NP_001124437.1. NM_001130965.2. NP_001165415.1. NM_001171944.1. NP_001165416.1. NM_001171945.1. NP_001165417.1. NM_001171946.1. NP_079430.3. NM_025154.5.
UniGene	Hs.438072.
3D structure databases
ProteinModelPortal	O94901.
ModBase	Search...
Protein-protein interaction databases
IntAct	O94901. 4 interactions.
PTM databases
PhosphoSite	O94901.
Proteomic databases
PaxDb	O94901.
PRIDE	O94901.
Protocols and materials databases
DNASU	23353.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000389574; ENSP00000374225; ENSG00000164828. ENST00000401592; ENSP00000384015; ENSG00000164828. ENST00000403868; ENSP00000383947; ENSG00000164828. ENST00000425407; ENSP00000392309; ENSG00000164828. ENST00000452783; ENSP00000413439; ENSG00000164828. ENST00000457378; ENSP00000395952; ENSG00000164828.
GeneID	23353.
KEGG	hsa:23353.
UCSC	uc003sje.1. human. uc003sjf.3. human. uc003sjk.3. human. uc010ksa.1. human. uc011jvq.2. human. uc021zyl.1. human. uc021zym.1. human.
Organism-specific databases
CTD	23353.
GeneCards	GC07P000857.
H-InvDB	HIX0078880.
HGNC	HGNC:18587. SUN1.
HPA	HPA008346. HPA008461.
MIM	607723. gene.
neXtProt	NX_O94901.
PharmGKB	PA165618311.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG285464.
HOGENOM	HOG000253025.
HOVERGEN	HBG104132.
OrthoDB	EOG447FSW.
Enzyme and pathway databases
Reactome	REACT_111183. Meiosis. REACT_115566. Cell Cycle.
Gene expression databases
ArrayExpress	O94901.
Bgee	O94901.
CleanEx	HS_UNC84A.
Genevestigator	O94901.
GermOnline	ENSG00000164828. Homo sapiens.
Family and domain databases
InterPro	IPR018539. RNA-bd_mt. IPR012919. Sad1_UNC_C. [Graphical view]
Pfam	PF09387. MRP. 2 hits. PF07738. Sad1_UNC. 1 hit. [Graphical view]
PROSITE	PS51469. SUN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23353.
NextBio	27033591.
SOURCE	Search...

Entry information

Entry name

SUN1_HUMAN

Accession

Primary (citable) accession number: O94901
Secondary accession number(s): A5PL20 , B3KMV7, B4DZF7, B7WNY4, B7WP53, E9PDU4, E9PF23, F8WD13, Q96CZ7, Q9HA14, Q9UH98

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	July 11, 2003
Last modified:	May 29, 2013
This is version 120 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.