Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O94900 (TOX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymocyte selection-associated high mobility group box protein TOX
Alternative name(s):
Thymus high mobility group box protein TOX
Gene names
Name:TOX
Synonyms:KIAA0808
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in regulating T-cell development By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Sequence caution

The sequence BAA34528.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 526526Thymocyte selection-associated high mobility group box protein TOX
PRO_0000244569

Regions

DNA binding261 – 32969HMG box
Motif237 – 25620Nuclear localization signal Potential
Compositional bias417 – 4204Poly-Pro

Natural variations

Natural variant2671A → T Found in a renal cell carcinoma sample; somatic mutation. Ref.4
VAR_064759

Experimental info

Sequence conflict91P → V in AAH16665. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O94900 [UniParc].

Last modified June 27, 2006. Version 3.
Checksum: 5AE4C5B07F2EB8FF

FASTA52657,513
        10         20         30         40         50         60 
MDVRFYPPPA QPAAAPDAPC LGPSPCLDPY YCNKFDGENM YMSMTEPSQD YVPASQSYPG 

        70         80         90        100        110        120 
PSLESEDFNI PPITPPSLPD HSLVHLNEVE SGYHSLCHPM NHNGLLPFHP QNMDLPEITV 

       130        140        150        160        170        180 
SNMLGQDGTL LSNSISVMPD IRNPEGTQYS SHPQMAAMRP RGQPADIRQQ PGMMPHGQLT 

       190        200        210        220        230        240 
TINQSQLSAQ LGLNMGGSNV PHNSPSPPGS KSATPSPSSS VHEDEGDDTS KINGGEKRPA 

       250        260        270        280        290        300 
SDMGKKPKTP KKKKKKDPNE PQKPVSAYAL FFRDTQAAIK GQNPNATFGE VSKIVASMWD 

       310        320        330        340        350        360 
GLGEEQKQVY KKKTEAAKKE YLKQLAAYRA SLVSKSYSEP VDVKTSQPPQ LINSKPSVFH 

       370        380        390        400        410        420 
GPSQAHSALY LSSHYHQQPG MNPHLTAMHP SLPRNIAPKP NNQMPVTVSI ANMAVSPPPP 

       430        440        450        460        470        480 
LQISPPLHQH LNMQQHQPLT MQQPLGNQLP MQVQSALHSP TMQQGFTLQP DYQTIINPTS 

       490        500        510        520 
TAAQVVTQAM EYVRSGCRNP PPQPVDWNND YCSSGGMQRD KALYLT 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymph.
[4]"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. expand/collapse author list , Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.
Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT THR-267.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB018351 mRNA. Translation: BAA34528.2. Different initiation.
BC016665 mRNA. Translation: AAH16665.1.
CCDSCCDS34897.1.
RefSeqNP_055544.1. NM_014729.2.
UniGeneHs.491805.
Hs.634856.

3D structure databases

ProteinModelPortalO94900.
SMRO94900. Positions 257-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO94900. 1 interaction.
STRING9606.ENSP00000354842.

PTM databases

PhosphoSiteO94900.

Proteomic databases

MaxQBO94900.
PaxDbO94900.
PRIDEO94900.

Protocols and materials databases

DNASU9760.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361421; ENSP00000354842; ENSG00000198846.
GeneID9760.
KEGGhsa:9760.
UCSCuc003xtw.1. human.

Organism-specific databases

CTD9760.
GeneCardsGC08M059717.
HGNCHGNC:18988. TOX.
HPAHPA018322.
MIM606863. gene.
neXtProtNX_O94900.
PharmGKBPA162406704.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284736.
HOGENOMHOG000230949.
HOVERGENHBG051183.
InParanoidO94900.
OMACRNPPAQ.
OrthoDBEOG7R834J.
PhylomeDBO94900.
TreeFamTF106481.

Gene expression databases

ArrayExpressO94900.
BgeeO94900.
CleanExHS_TOX.
GenevestigatorO94900.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTOX.
GenomeRNAi9760.
NextBio36737.
PROO94900.
SOURCESearch...

Entry information

Entry nameTOX_HUMAN
AccessionPrimary (citable) accession number: O94900
Secondary accession number(s): Q96AV5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM