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O94900

- TOX_HUMAN

UniProt

O94900 - TOX_HUMAN

Protein

Thymocyte selection-associated high mobility group box protein TOX

Gene

TOX

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 3 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    May play a role in regulating T-cell development.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi261 – 32969HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymocyte selection-associated high mobility group box protein TOX
    Alternative name(s):
    Thymus high mobility group box protein TOX
    Gene namesi
    Name:TOX
    Synonyms:KIAA0808
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:18988. TOX.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162406704.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 526526Thymocyte selection-associated high mobility group box protein TOXPRO_0000244569Add
    BLAST

    Proteomic databases

    MaxQBiO94900.
    PaxDbiO94900.
    PRIDEiO94900.

    PTM databases

    PhosphoSiteiO94900.

    Expressioni

    Gene expression databases

    ArrayExpressiO94900.
    BgeeiO94900.
    CleanExiHS_TOX.
    GenevestigatoriO94900.

    Organism-specific databases

    HPAiHPA018322.

    Interactioni

    Protein-protein interaction databases

    IntActiO94900. 1 interaction.
    STRINGi9606.ENSP00000354842.

    Structurei

    3D structure databases

    ProteinModelPortaliO94900.
    SMRiO94900. Positions 257-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi237 – 25620Nuclear localization signalSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi417 – 4204Poly-Pro

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG284736.
    HOGENOMiHOG000230949.
    HOVERGENiHBG051183.
    InParanoidiO94900.
    OMAiCRNPPAQ.
    OrthoDBiEOG7R834J.
    PhylomeDBiO94900.
    TreeFamiTF106481.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O94900-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVRFYPPPA QPAAAPDAPC LGPSPCLDPY YCNKFDGENM YMSMTEPSQD    50
    YVPASQSYPG PSLESEDFNI PPITPPSLPD HSLVHLNEVE SGYHSLCHPM 100
    NHNGLLPFHP QNMDLPEITV SNMLGQDGTL LSNSISVMPD IRNPEGTQYS 150
    SHPQMAAMRP RGQPADIRQQ PGMMPHGQLT TINQSQLSAQ LGLNMGGSNV 200
    PHNSPSPPGS KSATPSPSSS VHEDEGDDTS KINGGEKRPA SDMGKKPKTP 250
    KKKKKKDPNE PQKPVSAYAL FFRDTQAAIK GQNPNATFGE VSKIVASMWD 300
    GLGEEQKQVY KKKTEAAKKE YLKQLAAYRA SLVSKSYSEP VDVKTSQPPQ 350
    LINSKPSVFH GPSQAHSALY LSSHYHQQPG MNPHLTAMHP SLPRNIAPKP 400
    NNQMPVTVSI ANMAVSPPPP LQISPPLHQH LNMQQHQPLT MQQPLGNQLP 450
    MQVQSALHSP TMQQGFTLQP DYQTIINPTS TAAQVVTQAM EYVRSGCRNP 500
    PPQPVDWNND YCSSGGMQRD KALYLT 526
    Length:526
    Mass (Da):57,513
    Last modified:June 27, 2006 - v3
    Checksum:i5AE4C5B07F2EB8FF
    GO

    Sequence cautioni

    The sequence BAA34528.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91P → V in AAH16665. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti267 – 2671A → T Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
    VAR_064759

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018351 mRNA. Translation: BAA34528.2. Different initiation.
    BC016665 mRNA. Translation: AAH16665.1.
    CCDSiCCDS34897.1.
    RefSeqiNP_055544.1. NM_014729.2.
    UniGeneiHs.491805.
    Hs.634856.

    Genome annotation databases

    EnsembliENST00000361421; ENSP00000354842; ENSG00000198846.
    GeneIDi9760.
    KEGGihsa:9760.
    UCSCiuc003xtw.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018351 mRNA. Translation: BAA34528.2 . Different initiation.
    BC016665 mRNA. Translation: AAH16665.1 .
    CCDSi CCDS34897.1.
    RefSeqi NP_055544.1. NM_014729.2.
    UniGenei Hs.491805.
    Hs.634856.

    3D structure databases

    ProteinModelPortali O94900.
    SMRi O94900. Positions 257-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O94900. 1 interaction.
    STRINGi 9606.ENSP00000354842.

    PTM databases

    PhosphoSitei O94900.

    Proteomic databases

    MaxQBi O94900.
    PaxDbi O94900.
    PRIDEi O94900.

    Protocols and materials databases

    DNASUi 9760.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361421 ; ENSP00000354842 ; ENSG00000198846 .
    GeneIDi 9760.
    KEGGi hsa:9760.
    UCSCi uc003xtw.1. human.

    Organism-specific databases

    CTDi 9760.
    GeneCardsi GC08M059717.
    HGNCi HGNC:18988. TOX.
    HPAi HPA018322.
    MIMi 606863. gene.
    neXtProti NX_O94900.
    PharmGKBi PA162406704.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284736.
    HOGENOMi HOG000230949.
    HOVERGENi HBG051183.
    InParanoidi O94900.
    OMAi CRNPPAQ.
    OrthoDBi EOG7R834J.
    PhylomeDBi O94900.
    TreeFami TF106481.

    Miscellaneous databases

    GeneWikii TOX.
    GenomeRNAii 9760.
    NextBioi 36737.
    PROi O94900.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O94900.
    Bgeei O94900.
    CleanExi HS_TOX.
    Genevestigatori O94900.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph.
    4. Cited for: VARIANT THR-267.

    Entry informationi

    Entry nameiTOX_HUMAN
    AccessioniPrimary (citable) accession number: O94900
    Secondary accession number(s): Q96AV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3