O94900 (TOX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymocyte selection-associated high mobility group box protein TOX

Alternative name(s):
Thymus high mobility group box protein TOX

Gene names

Name:	TOX
Synonyms:	KIAA0808

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in regulating T-cell development By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 HMG box DNA-binding domain.
Sequence caution	The sequence BAA34528.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 526	526	Thymocyte selection-associated high mobility group box protein TOX		PRO_0000244569
Regions
	DNA binding	261 – 329	69	HMG box
	Motif	237 – 256	20	Nuclear localization signal Potential
	Compositional bias	417 – 420	4	Poly-Pro
Natural variations
	Natural variant	267	1	A → T Found in a renal cell carcinoma sample; somatic mutation. Ref.4		VAR_064759
Experimental info
	Sequence conflict	9	1	P → V in AAH16665. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O94900 [UniParc]. Last modified June 27, 2006. Version 3. Checksum: 5AE4C5B07F2EB8FF	FASTA	526	57,513
	10 20 30 40 50 60 MDVRFYPPPA QPAAAPDAPC LGPSPCLDPY YCNKFDGENM YMSMTEPSQD YVPASQSYPG 70 80 90 100 110 120 PSLESEDFNI PPITPPSLPD HSLVHLNEVE SGYHSLCHPM NHNGLLPFHP QNMDLPEITV 130 140 150 160 170 180 SNMLGQDGTL LSNSISVMPD IRNPEGTQYS SHPQMAAMRP RGQPADIRQQ PGMMPHGQLT 190 200 210 220 230 240 TINQSQLSAQ LGLNMGGSNV PHNSPSPPGS KSATPSPSSS VHEDEGDDTS KINGGEKRPA 250 260 270 280 290 300 SDMGKKPKTP KKKKKKDPNE PQKPVSAYAL FFRDTQAAIK GQNPNATFGE VSKIVASMWD 310 320 330 340 350 360 GLGEEQKQVY KKKTEAAKKE YLKQLAAYRA SLVSKSYSEP VDVKTSQPPQ LINSKPSVFH 370 380 390 400 410 420 GPSQAHSALY LSSHYHQQPG MNPHLTAMHP SLPRNIAPKP NNQMPVTVSI ANMAVSPPPP 430 440 450 460 470 480 LQISPPLHQH LNMQQHQPLT MQQPLGNQLP MQVQSALHSP TMQQGFTLQP DYQTIINPTS 490 500 510 520 TAAQVVTQAM EYVRSGCRNP PPQPVDWNND YCSSGGMQRD KALYLT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
[4]	"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. , Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A. Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT THR-267.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB018351 mRNA. Translation: BAA34528.2. Different initiation. BC016665 mRNA. Translation: AAH16665.1.
IPI	IPI00006065.
RefSeq	NP_055544.1. NM_014729.2.
UniGene	Hs.491805. Hs.634856.
3D structure databases
ProteinModelPortal	O94900.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000354842.
PTM databases
PhosphoSite	O94900.
Proteomic databases
PaxDb	O94900.
PRIDE	O94900.
Protocols and materials databases
DNASU	9760.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361421; ENSP00000354842; ENSG00000198846.
GeneID	9760.
KEGG	hsa:9760.
UCSC	uc003xtw.1. human.
Organism-specific databases
CTD	9760.
GeneCards	GC08M059717.
HGNC	HGNC:18988. TOX.
HPA	HPA018322.
MIM	606863. gene.
neXtProt	NX_O94900.
PharmGKB	PA162406704.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG284736.
HOGENOM	HOG000230949.
HOVERGEN	HBG051183.
InParanoid	O94900.
OMA	CRNPPAQ.
OrthoDB	EOG44XJGQ.
Gene expression databases
ArrayExpress	O94900.
Bgee	O94900.
CleanEx	HS_TOX.
Genevestigator	O94900.
GermOnline	ENSG00000198846. Homo sapiens.
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR009071. HMG_box_dom. [Graphical view]
Pfam	PF00505. HMG_box. 1 hit. [Graphical view]
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS00353. HMG_BOX_1. False negative. PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9760.
NextBio	36737.
SOURCE	Search...

Entry information

Entry name

TOX_HUMAN

Accession

Primary (citable) accession number: O94900
Secondary accession number(s): Q96AV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	May 1, 2013
This is version 90 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.