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Protein

Thymocyte selection-associated high mobility group box protein TOX

Gene

TOX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in regulating T-cell development.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi261 – 32969HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: GO_Central
  2. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. chromatin remodeling Source: GO_Central
  2. regulation of transcription, DNA-templated Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymocyte selection-associated high mobility group box protein TOX
Alternative name(s):
Thymus high mobility group box protein TOX
Gene namesi
Name:TOX
Synonyms:KIAA0808
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:18988. TOX.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406704.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Thymocyte selection-associated high mobility group box protein TOXPRO_0000244569Add
BLAST

Proteomic databases

MaxQBiO94900.
PaxDbiO94900.
PRIDEiO94900.

PTM databases

PhosphoSiteiO94900.

Expressioni

Gene expression databases

BgeeiO94900.
CleanExiHS_TOX.
ExpressionAtlasiO94900. baseline and differential.
GenevestigatoriO94900.

Organism-specific databases

HPAiHPA018322.

Interactioni

Protein-protein interaction databases

IntActiO94900. 1 interaction.
STRINGi9606.ENSP00000354842.

Structurei

3D structure databases

ProteinModelPortaliO94900.
SMRiO94900. Positions 257-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi237 – 25620Nuclear localization signalSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi417 – 4204Poly-Pro

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG284736.
GeneTreeiENSGT00560000076898.
HOGENOMiHOG000230949.
HOVERGENiHBG051183.
InParanoidiO94900.
OMAiCRNPPAQ.
OrthoDBiEOG7R834J.
PhylomeDBiO94900.
TreeFamiTF106481.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94900-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVRFYPPPA QPAAAPDAPC LGPSPCLDPY YCNKFDGENM YMSMTEPSQD
60 70 80 90 100
YVPASQSYPG PSLESEDFNI PPITPPSLPD HSLVHLNEVE SGYHSLCHPM
110 120 130 140 150
NHNGLLPFHP QNMDLPEITV SNMLGQDGTL LSNSISVMPD IRNPEGTQYS
160 170 180 190 200
SHPQMAAMRP RGQPADIRQQ PGMMPHGQLT TINQSQLSAQ LGLNMGGSNV
210 220 230 240 250
PHNSPSPPGS KSATPSPSSS VHEDEGDDTS KINGGEKRPA SDMGKKPKTP
260 270 280 290 300
KKKKKKDPNE PQKPVSAYAL FFRDTQAAIK GQNPNATFGE VSKIVASMWD
310 320 330 340 350
GLGEEQKQVY KKKTEAAKKE YLKQLAAYRA SLVSKSYSEP VDVKTSQPPQ
360 370 380 390 400
LINSKPSVFH GPSQAHSALY LSSHYHQQPG MNPHLTAMHP SLPRNIAPKP
410 420 430 440 450
NNQMPVTVSI ANMAVSPPPP LQISPPLHQH LNMQQHQPLT MQQPLGNQLP
460 470 480 490 500
MQVQSALHSP TMQQGFTLQP DYQTIINPTS TAAQVVTQAM EYVRSGCRNP
510 520
PPQPVDWNND YCSSGGMQRD KALYLT
Length:526
Mass (Da):57,513
Last modified:June 27, 2006 - v3
Checksum:i5AE4C5B07F2EB8FF
GO

Sequence cautioni

The sequence BAA34528.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91P → V in AAH16665. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti267 – 2671A → T Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064759

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018351 mRNA. Translation: BAA34528.2. Different initiation.
BC016665 mRNA. Translation: AAH16665.1.
CCDSiCCDS34897.1.
RefSeqiNP_055544.1. NM_014729.2.
UniGeneiHs.491805.
Hs.634856.

Genome annotation databases

EnsembliENST00000361421; ENSP00000354842; ENSG00000198846.
GeneIDi9760.
KEGGihsa:9760.
UCSCiuc003xtw.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018351 mRNA. Translation: BAA34528.2. Different initiation.
BC016665 mRNA. Translation: AAH16665.1.
CCDSiCCDS34897.1.
RefSeqiNP_055544.1. NM_014729.2.
UniGeneiHs.491805.
Hs.634856.

3D structure databases

ProteinModelPortaliO94900.
SMRiO94900. Positions 257-339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO94900. 1 interaction.
STRINGi9606.ENSP00000354842.

PTM databases

PhosphoSiteiO94900.

Proteomic databases

MaxQBiO94900.
PaxDbiO94900.
PRIDEiO94900.

Protocols and materials databases

DNASUi9760.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361421; ENSP00000354842; ENSG00000198846.
GeneIDi9760.
KEGGihsa:9760.
UCSCiuc003xtw.1. human.

Organism-specific databases

CTDi9760.
GeneCardsiGC08M059717.
HGNCiHGNC:18988. TOX.
HPAiHPA018322.
MIMi606863. gene.
neXtProtiNX_O94900.
PharmGKBiPA162406704.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG284736.
GeneTreeiENSGT00560000076898.
HOGENOMiHOG000230949.
HOVERGENiHBG051183.
InParanoidiO94900.
OMAiCRNPPAQ.
OrthoDBiEOG7R834J.
PhylomeDBiO94900.
TreeFamiTF106481.

Miscellaneous databases

ChiTaRSiTOX. human.
GeneWikiiTOX.
GenomeRNAii9760.
NextBioi36737.
PROiO94900.
SOURCEiSearch...

Gene expression databases

BgeeiO94900.
CleanExiHS_TOX.
ExpressionAtlasiO94900. baseline and differential.
GenevestigatoriO94900.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  4. Cited for: VARIANT THR-267.

Entry informationi

Entry nameiTOX_HUMAN
AccessioniPrimary (citable) accession number: O94900
Secondary accession number(s): Q96AV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: February 4, 2015
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.