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O94898

- LRIG2_HUMAN

UniProt

O94898 - LRIG2_HUMAN

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Protein

Leucine-rich repeats and immunoglobulin-like domains protein 2

Gene
LRIG2, KIAA0806, LIG2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 2
Short name:
LIG-2
Gene namesi
Name:LRIG2
Synonyms:KIAA0806, LIG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:20889. LRIG2.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Cytoplasm 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini41 – 807767Extracellular Reviewed predictionAdd
BLAST
Transmembranei808 – 82821Helical; Reviewed predictionAdd
BLAST
Topological domaini829 – 1065237Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Urofacial syndrome 2 (UFS2) [MIM:615112]: A rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Organism-specific databases

MIMi615112. phenotype.
Orphaneti2704. Ochoa syndrome.
PharmGKBiPA134905053.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4040 Reviewed predictionAdd
BLAST
Chaini41 – 10651025Leucine-rich repeats and immunoglobulin-like domains protein 2PRO_0000014829Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi121 – 1211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi173 – 1731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi189 – 1891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi274 – 2741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi441 – 4411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi468 – 4681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi514 – 5141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi519 ↔ 580 By similarity
Glycosylationi571 – 5711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi589 – 5891N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi623 ↔ 675 By similarity
Glycosylationi687 – 6871N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi717 ↔ 766 By similarity
Glycosylationi728 – 7281N-linked (GlcNAc...) Reviewed prediction
Modified residuei906 – 9061Phosphotyrosine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO94898.
PaxDbiO94898.
PRIDEiO94898.

PTM databases

PhosphoSiteiO94898.

Expressioni

Tissue specificityi

Detected in all tissues analyzed.1 Publication

Gene expression databases

BgeeiO94898.
CleanExiHS_LRIG2.
GenevestigatoriO94898.

Organism-specific databases

HPAiHPA015538.

Interactioni

Protein-protein interaction databases

BioGridi115194. 1 interaction.
IntActiO94898. 1 interaction.
STRINGi9606.ENSP00000355396.

Structurei

3D structure databases

ProteinModelPortaliO94898.
SMRiO94898. Positions 34-883.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 7535LRRNTAdd
BLAST
Repeati76 – 9722LRR 1Add
BLAST
Repeati98 – 11922LRR 2Add
BLAST
Repeati121 – 14222LRR 3Add
BLAST
Repeati145 – 16622LRR 4Add
BLAST
Repeati168 – 18922LRR 5Add
BLAST
Repeati193 – 21422LRR 6Add
BLAST
Repeati216 – 23722LRR 7Add
BLAST
Repeati240 – 26122LRR 8Add
BLAST
Repeati264 – 28522LRR 9Add
BLAST
Repeati288 – 30922LRR 10Add
BLAST
Repeati312 – 33322LRR 11Add
BLAST
Repeati336 – 35722LRR 12Add
BLAST
Repeati360 – 38223LRR 13Add
BLAST
Repeati387 – 40822LRR 14Add
BLAST
Repeati411 – 43222LRR 15Add
BLAST
Domaini443 – 49452LRRCTAdd
BLAST
Domaini498 – 597100Ig-like C2-type 1Add
BLAST
Domaini602 – 69190Ig-like C2-type 2Add
BLAST
Domaini696 – 78590Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000113380.
HOVERGENiHBG052353.
InParanoidiO94898.
OMAiFPTNHER.
OrthoDBiEOG7DNNTD.
PhylomeDBiO94898.
TreeFamiTF325380.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
PS51450. LRR. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94898-1 [UniParc]FASTAAdd to Basket

« Hide

MAPAPLGVPE EQLLGCRSRV LSRLLFIAQT ALLLLPAAGA GLCPAPCSCR     50
IPLLDCSRRK LPAPSWRALS GLLPPDTAIL DFSHNRLSNW NISLESQTLQ 100
EVKMNYNELT EIPYFGEPTS NITLLSLVHN IIPEINAQAL QFYPALESLD 150
LSSNIISEIK TSSFPRMQLK YLNLSNNRIT TLEAGCFDNL SSSLLVVKLN 200
RNRMSMIPPK IFKLPHLQFL ELKRNRIKIV EGLTFQGLDS LRSLKMQRNG 250
ISKLKDGAFF GLNNMEELEL EHNNLTRVNK GWLYGLRMLQ QLYVSQNAIE 300
RISPDAWEFC QRLSELDLSY NQLTRLDESA FVGLSLLERL NLGDNRVTHI 350
ADGVFRFLSN LQTLDLRNNE ISWAIEDASE AFAGLTSLTK LILQGNQIKS 400
ITKKAFIGLE SLEHLDLNNN AIMSIQENAF SQTHLKELIL NTSSLLCDCH 450
LKWLLQWLVD NNFQHSVNVS CAHPEWLAGQ SILNVDLKDF VCDDFLKPQI 500
RTHPETIIAL RGMNVTLTCT AVSSSDSPMS TVWRKDSEIL YDVDTENFVR 550
YWQQAGEALE YTSILHLFNV NFTDEGKYQC IVTNHFGSNY SQKAKLTVNE 600
MPSFLKTPMD LTIRTGAMAR LECAAEGHPA PQISWQKDGG TDFPAARERR 650
MHVMPEDDVF FIANVKIEDM GIYSCMAQNT AGGLSANASL TVLETPSFIR 700
PLEDKTVTRG ETAVLQCIAG GSPAPRLNWT KDDGPLLVTE RHFFAAANQL 750
LIIVDAGLED AGKYTCIMSN TLGTERGHIY LNVISSPNCD SSQSSIGHED 800
DGWTTVGIVI IVVVCCVVGT SLIWVIVIYH MRRKNEDYSI TNTEELNLPA 850
DIPSYLSSQG TLSEPQEGYS NSEAGSHQQL MPPANGYIHK GTDGGTGTRV 900
ICSDCYDNAN IYSRTREYCP YTYIAEEDVL DQTLSSLMVQ MPKETYLVHP 950
PQDTTALESL IPSANREPSA FPTNHERISE KKLPSTQMSG ETLQRPVWNI 1000
NRELGLPHPP FSQQPVHESP QLHQNEGLAG REPDCSASSM SCHRLQDHAF 1050
DFSRTRNIQD GSEGT 1065
Length:1,065
Mass (Da):118,965
Last modified:October 11, 2004 - v3
Checksum:iCD2903A861DC4887
GO

Sequence cautioni

The sequence BAA34526.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018349 mRNA. Translation: BAA34526.2. Different initiation.
AL161998 mRNA. Translation: CAB82328.2.
CCDSiCCDS30808.1.
PIRiT47152.
RefSeqiNP_055628.1. NM_014813.1.
UniGeneiHs.448972.
Hs.729143.

Genome annotation databases

EnsembliENST00000361127; ENSP00000355396; ENSG00000198799.
GeneIDi9860.
KEGGihsa:9860.
UCSCiuc001edf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018349 mRNA. Translation: BAA34526.2 . Different initiation.
AL161998 mRNA. Translation: CAB82328.2 .
CCDSi CCDS30808.1.
PIRi T47152.
RefSeqi NP_055628.1. NM_014813.1.
UniGenei Hs.448972.
Hs.729143.

3D structure databases

ProteinModelPortali O94898.
SMRi O94898. Positions 34-883.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115194. 1 interaction.
IntActi O94898. 1 interaction.
STRINGi 9606.ENSP00000355396.

PTM databases

PhosphoSitei O94898.

Proteomic databases

MaxQBi O94898.
PaxDbi O94898.
PRIDEi O94898.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361127 ; ENSP00000355396 ; ENSG00000198799 .
GeneIDi 9860.
KEGGi hsa:9860.
UCSCi uc001edf.1. human.

Organism-specific databases

CTDi 9860.
GeneCardsi GC01P113615.
GeneReviewsi LRIG2.
HGNCi HGNC:20889. LRIG2.
HPAi HPA015538.
MIMi 608869. gene.
615112. phenotype.
neXtProti NX_O94898.
Orphaneti 2704. Ochoa syndrome.
PharmGKBi PA134905053.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000113380.
HOVERGENi HBG052353.
InParanoidi O94898.
OMAi FPTNHER.
OrthoDBi EOG7DNNTD.
PhylomeDBi O94898.
TreeFami TF325380.

Miscellaneous databases

GenomeRNAii 9860.
NextBioi 37168.
PROi O94898.
SOURCEi Search...

Gene expression databases

Bgeei O94898.
CleanExi HS_LRIG2.
Genevestigatori O94898.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view ]
Pfami PF07679. I-set. 2 hits.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
PS51450. LRR. 14 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-133.
    Tissue: Brain.
  3. "Characterization and tissue-specific expression of human LRIG2."
    Holmlund C., Nilsson J., Guo D., Starefeldt A., Golovleva I., Henriksson R., Hedman H.
    Gene 332:35-43(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. Cited for: INVOLVEMENT IN UFS2.

Entry informationi

Entry nameiLRIG2_HUMAN
AccessioniPrimary (citable) accession number: O94898
Secondary accession number(s): Q9NSN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi