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O94898

- LRIG2_HUMAN

UniProt

O94898 - LRIG2_HUMAN

Protein

Leucine-rich repeats and immunoglobulin-like domains protein 2

Gene

LRIG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 3 (11 Oct 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich repeats and immunoglobulin-like domains protein 2
    Short name:
    LIG-2
    Gene namesi
    Name:LRIG2
    Synonyms:KIAA0806, LIG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:20889. LRIG2.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Urofacial syndrome 2 (UFS2) [MIM:615112]: A rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi615112. phenotype.
    Orphaneti2704. Ochoa syndrome.
    PharmGKBiPA134905053.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4040Sequence AnalysisAdd
    BLAST
    Chaini41 – 10651025Leucine-rich repeats and immunoglobulin-like domains protein 2PRO_0000014829Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi519 ↔ 580PROSITE-ProRule annotation
    Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi589 – 5891N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi623 ↔ 675PROSITE-ProRule annotation
    Glycosylationi687 – 6871N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi717 ↔ 766PROSITE-ProRule annotation
    Glycosylationi728 – 7281N-linked (GlcNAc...)Sequence Analysis
    Modified residuei906 – 9061PhosphotyrosineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO94898.
    PaxDbiO94898.
    PRIDEiO94898.

    PTM databases

    PhosphoSiteiO94898.

    Expressioni

    Tissue specificityi

    Detected in all tissues analyzed.1 Publication

    Gene expression databases

    BgeeiO94898.
    CleanExiHS_LRIG2.
    GenevestigatoriO94898.

    Organism-specific databases

    HPAiHPA015538.

    Interactioni

    Protein-protein interaction databases

    BioGridi115194. 1 interaction.
    IntActiO94898. 1 interaction.
    STRINGi9606.ENSP00000355396.

    Structurei

    3D structure databases

    ProteinModelPortaliO94898.
    SMRiO94898. Positions 34-883.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini41 – 807767ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini829 – 1065237CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei808 – 82821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 7535LRRNTAdd
    BLAST
    Repeati76 – 9722LRR 1Add
    BLAST
    Repeati98 – 11922LRR 2Add
    BLAST
    Repeati121 – 14222LRR 3Add
    BLAST
    Repeati145 – 16622LRR 4Add
    BLAST
    Repeati168 – 18922LRR 5Add
    BLAST
    Repeati193 – 21422LRR 6Add
    BLAST
    Repeati216 – 23722LRR 7Add
    BLAST
    Repeati240 – 26122LRR 8Add
    BLAST
    Repeati264 – 28522LRR 9Add
    BLAST
    Repeati288 – 30922LRR 10Add
    BLAST
    Repeati312 – 33322LRR 11Add
    BLAST
    Repeati336 – 35722LRR 12Add
    BLAST
    Repeati360 – 38223LRR 13Add
    BLAST
    Repeati387 – 40822LRR 14Add
    BLAST
    Repeati411 – 43222LRR 15Add
    BLAST
    Domaini443 – 49452LRRCTAdd
    BLAST
    Domaini498 – 597100Ig-like C2-type 1Add
    BLAST
    Domaini602 – 69190Ig-like C2-type 2Add
    BLAST
    Domaini696 – 78590Ig-like C2-type 3Add
    BLAST

    Sequence similaritiesi

    Contains 15 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000113380.
    HOVERGENiHBG052353.
    InParanoidiO94898.
    OMAiFPTNHER.
    OrthoDBiEOG7DNNTD.
    PhylomeDBiO94898.
    TreeFamiTF325380.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    [Graphical view]
    PfamiPF07679. I-set. 2 hits.
    PF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 3 hits.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00408. IGc2. 2 hits.
    SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS51450. LRR. 14 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O94898-1 [UniParc]FASTAAdd to Basket

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    MAPAPLGVPE EQLLGCRSRV LSRLLFIAQT ALLLLPAAGA GLCPAPCSCR     50
    IPLLDCSRRK LPAPSWRALS GLLPPDTAIL DFSHNRLSNW NISLESQTLQ 100
    EVKMNYNELT EIPYFGEPTS NITLLSLVHN IIPEINAQAL QFYPALESLD 150
    LSSNIISEIK TSSFPRMQLK YLNLSNNRIT TLEAGCFDNL SSSLLVVKLN 200
    RNRMSMIPPK IFKLPHLQFL ELKRNRIKIV EGLTFQGLDS LRSLKMQRNG 250
    ISKLKDGAFF GLNNMEELEL EHNNLTRVNK GWLYGLRMLQ QLYVSQNAIE 300
    RISPDAWEFC QRLSELDLSY NQLTRLDESA FVGLSLLERL NLGDNRVTHI 350
    ADGVFRFLSN LQTLDLRNNE ISWAIEDASE AFAGLTSLTK LILQGNQIKS 400
    ITKKAFIGLE SLEHLDLNNN AIMSIQENAF SQTHLKELIL NTSSLLCDCH 450
    LKWLLQWLVD NNFQHSVNVS CAHPEWLAGQ SILNVDLKDF VCDDFLKPQI 500
    RTHPETIIAL RGMNVTLTCT AVSSSDSPMS TVWRKDSEIL YDVDTENFVR 550
    YWQQAGEALE YTSILHLFNV NFTDEGKYQC IVTNHFGSNY SQKAKLTVNE 600
    MPSFLKTPMD LTIRTGAMAR LECAAEGHPA PQISWQKDGG TDFPAARERR 650
    MHVMPEDDVF FIANVKIEDM GIYSCMAQNT AGGLSANASL TVLETPSFIR 700
    PLEDKTVTRG ETAVLQCIAG GSPAPRLNWT KDDGPLLVTE RHFFAAANQL 750
    LIIVDAGLED AGKYTCIMSN TLGTERGHIY LNVISSPNCD SSQSSIGHED 800
    DGWTTVGIVI IVVVCCVVGT SLIWVIVIYH MRRKNEDYSI TNTEELNLPA 850
    DIPSYLSSQG TLSEPQEGYS NSEAGSHQQL MPPANGYIHK GTDGGTGTRV 900
    ICSDCYDNAN IYSRTREYCP YTYIAEEDVL DQTLSSLMVQ MPKETYLVHP 950
    PQDTTALESL IPSANREPSA FPTNHERISE KKLPSTQMSG ETLQRPVWNI 1000
    NRELGLPHPP FSQQPVHESP QLHQNEGLAG REPDCSASSM SCHRLQDHAF 1050
    DFSRTRNIQD GSEGT 1065
    Length:1,065
    Mass (Da):118,965
    Last modified:October 11, 2004 - v3
    Checksum:iCD2903A861DC4887
    GO

    Sequence cautioni

    The sequence BAA34526.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018349 mRNA. Translation: BAA34526.2. Different initiation.
    AL161998 mRNA. Translation: CAB82328.2.
    CCDSiCCDS30808.1.
    PIRiT47152.
    RefSeqiNP_055628.1. NM_014813.1.
    UniGeneiHs.448972.
    Hs.729143.

    Genome annotation databases

    EnsembliENST00000361127; ENSP00000355396; ENSG00000198799.
    GeneIDi9860.
    KEGGihsa:9860.
    UCSCiuc001edf.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018349 mRNA. Translation: BAA34526.2 . Different initiation.
    AL161998 mRNA. Translation: CAB82328.2 .
    CCDSi CCDS30808.1.
    PIRi T47152.
    RefSeqi NP_055628.1. NM_014813.1.
    UniGenei Hs.448972.
    Hs.729143.

    3D structure databases

    ProteinModelPortali O94898.
    SMRi O94898. Positions 34-883.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115194. 1 interaction.
    IntActi O94898. 1 interaction.
    STRINGi 9606.ENSP00000355396.

    PTM databases

    PhosphoSitei O94898.

    Proteomic databases

    MaxQBi O94898.
    PaxDbi O94898.
    PRIDEi O94898.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361127 ; ENSP00000355396 ; ENSG00000198799 .
    GeneIDi 9860.
    KEGGi hsa:9860.
    UCSCi uc001edf.1. human.

    Organism-specific databases

    CTDi 9860.
    GeneCardsi GC01P113615.
    GeneReviewsi LRIG2.
    HGNCi HGNC:20889. LRIG2.
    HPAi HPA015538.
    MIMi 608869. gene.
    615112. phenotype.
    neXtProti NX_O94898.
    Orphaneti 2704. Ochoa syndrome.
    PharmGKBi PA134905053.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000113380.
    HOVERGENi HBG052353.
    InParanoidi O94898.
    OMAi FPTNHER.
    OrthoDBi EOG7DNNTD.
    PhylomeDBi O94898.
    TreeFami TF325380.

    Miscellaneous databases

    GenomeRNAii 9860.
    NextBioi 37168.
    PROi O94898.
    SOURCEi Search...

    Gene expression databases

    Bgeei O94898.
    CleanExi HS_LRIG2.
    Genevestigatori O94898.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    [Graphical view ]
    Pfami PF07679. I-set. 2 hits.
    PF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 3 hits.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00408. IGc2. 2 hits.
    SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS51450. LRR. 14 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-133.
      Tissue: Brain.
    3. "Characterization and tissue-specific expression of human LRIG2."
      Holmlund C., Nilsson J., Guo D., Starefeldt A., Golovleva I., Henriksson R., Hedman H.
      Gene 332:35-43(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    4. Cited for: INVOLVEMENT IN UFS2.

    Entry informationi

    Entry nameiLRIG2_HUMAN
    AccessioniPrimary (citable) accession number: O94898
    Secondary accession number(s): Q9NSN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3