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O94898

- LRIG2_HUMAN

UniProt

O94898 - LRIG2_HUMAN

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Protein

Leucine-rich repeats and immunoglobulin-like domains protein 2

Gene

LRIG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. innervation Source: Ensembl
  2. regulation of platelet-derived growth factor receptor signaling pathway Source: Ensembl
  3. sensory perception of sound Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 2
Short name:
LIG-2
Gene namesi
Name:LRIG2
Synonyms:KIAA0806, LIG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:20889. LRIG2.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Urofacial syndrome 2 (UFS2) [MIM:615112]: A rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Organism-specific databases

MIMi615112. phenotype.
Orphaneti2704. Ochoa syndrome.
PharmGKBiPA134905053.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4040Sequence AnalysisAdd
BLAST
Chaini41 – 10651025Leucine-rich repeats and immunoglobulin-like domains protein 2PRO_0000014829Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi519 ↔ 580PROSITE-ProRule annotation
Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi589 – 5891N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi623 ↔ 675PROSITE-ProRule annotation
Glycosylationi687 – 6871N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi717 ↔ 766PROSITE-ProRule annotation
Glycosylationi728 – 7281N-linked (GlcNAc...)Sequence Analysis
Modified residuei906 – 9061PhosphotyrosineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO94898.
PaxDbiO94898.
PRIDEiO94898.

PTM databases

PhosphoSiteiO94898.

Expressioni

Tissue specificityi

Detected in all tissues analyzed.1 Publication

Gene expression databases

BgeeiO94898.
CleanExiHS_LRIG2.
GenevestigatoriO94898.

Organism-specific databases

HPAiHPA015538.

Interactioni

Protein-protein interaction databases

BioGridi115194. 2 interactions.
IntActiO94898. 1 interaction.
STRINGi9606.ENSP00000355396.

Structurei

3D structure databases

ProteinModelPortaliO94898.
SMRiO94898. Positions 34-883.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini41 – 807767ExtracellularSequence AnalysisAdd
BLAST
Topological domaini829 – 1065237CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei808 – 82821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 7535LRRNTAdd
BLAST
Repeati76 – 9722LRR 1Add
BLAST
Repeati98 – 11922LRR 2Add
BLAST
Repeati121 – 14222LRR 3Add
BLAST
Repeati145 – 16622LRR 4Add
BLAST
Repeati168 – 18922LRR 5Add
BLAST
Repeati193 – 21422LRR 6Add
BLAST
Repeati216 – 23722LRR 7Add
BLAST
Repeati240 – 26122LRR 8Add
BLAST
Repeati264 – 28522LRR 9Add
BLAST
Repeati288 – 30922LRR 10Add
BLAST
Repeati312 – 33322LRR 11Add
BLAST
Repeati336 – 35722LRR 12Add
BLAST
Repeati360 – 38223LRR 13Add
BLAST
Repeati387 – 40822LRR 14Add
BLAST
Repeati411 – 43222LRR 15Add
BLAST
Domaini443 – 49452LRRCTAdd
BLAST
Domaini498 – 597100Ig-like C2-type 1Add
BLAST
Domaini602 – 69190Ig-like C2-type 2Add
BLAST
Domaini696 – 78590Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000113380.
HOVERGENiHBG052353.
InParanoidiO94898.
OMAiFPTNHER.
OrthoDBiEOG7DNNTD.
PhylomeDBiO94898.
TreeFamiTF325380.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
PS51450. LRR. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94898-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPAPLGVPE EQLLGCRSRV LSRLLFIAQT ALLLLPAAGA GLCPAPCSCR
60 70 80 90 100
IPLLDCSRRK LPAPSWRALS GLLPPDTAIL DFSHNRLSNW NISLESQTLQ
110 120 130 140 150
EVKMNYNELT EIPYFGEPTS NITLLSLVHN IIPEINAQAL QFYPALESLD
160 170 180 190 200
LSSNIISEIK TSSFPRMQLK YLNLSNNRIT TLEAGCFDNL SSSLLVVKLN
210 220 230 240 250
RNRMSMIPPK IFKLPHLQFL ELKRNRIKIV EGLTFQGLDS LRSLKMQRNG
260 270 280 290 300
ISKLKDGAFF GLNNMEELEL EHNNLTRVNK GWLYGLRMLQ QLYVSQNAIE
310 320 330 340 350
RISPDAWEFC QRLSELDLSY NQLTRLDESA FVGLSLLERL NLGDNRVTHI
360 370 380 390 400
ADGVFRFLSN LQTLDLRNNE ISWAIEDASE AFAGLTSLTK LILQGNQIKS
410 420 430 440 450
ITKKAFIGLE SLEHLDLNNN AIMSIQENAF SQTHLKELIL NTSSLLCDCH
460 470 480 490 500
LKWLLQWLVD NNFQHSVNVS CAHPEWLAGQ SILNVDLKDF VCDDFLKPQI
510 520 530 540 550
RTHPETIIAL RGMNVTLTCT AVSSSDSPMS TVWRKDSEIL YDVDTENFVR
560 570 580 590 600
YWQQAGEALE YTSILHLFNV NFTDEGKYQC IVTNHFGSNY SQKAKLTVNE
610 620 630 640 650
MPSFLKTPMD LTIRTGAMAR LECAAEGHPA PQISWQKDGG TDFPAARERR
660 670 680 690 700
MHVMPEDDVF FIANVKIEDM GIYSCMAQNT AGGLSANASL TVLETPSFIR
710 720 730 740 750
PLEDKTVTRG ETAVLQCIAG GSPAPRLNWT KDDGPLLVTE RHFFAAANQL
760 770 780 790 800
LIIVDAGLED AGKYTCIMSN TLGTERGHIY LNVISSPNCD SSQSSIGHED
810 820 830 840 850
DGWTTVGIVI IVVVCCVVGT SLIWVIVIYH MRRKNEDYSI TNTEELNLPA
860 870 880 890 900
DIPSYLSSQG TLSEPQEGYS NSEAGSHQQL MPPANGYIHK GTDGGTGTRV
910 920 930 940 950
ICSDCYDNAN IYSRTREYCP YTYIAEEDVL DQTLSSLMVQ MPKETYLVHP
960 970 980 990 1000
PQDTTALESL IPSANREPSA FPTNHERISE KKLPSTQMSG ETLQRPVWNI
1010 1020 1030 1040 1050
NRELGLPHPP FSQQPVHESP QLHQNEGLAG REPDCSASSM SCHRLQDHAF
1060
DFSRTRNIQD GSEGT
Length:1,065
Mass (Da):118,965
Last modified:October 11, 2004 - v3
Checksum:iCD2903A861DC4887
GO

Sequence cautioni

The sequence BAA34526.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018349 mRNA. Translation: BAA34526.2. Different initiation.
AL161998 mRNA. Translation: CAB82328.2.
CCDSiCCDS30808.1.
PIRiT47152.
RefSeqiNP_055628.1. NM_014813.1.
UniGeneiHs.448972.
Hs.729143.

Genome annotation databases

EnsembliENST00000361127; ENSP00000355396; ENSG00000198799.
GeneIDi9860.
KEGGihsa:9860.
UCSCiuc001edf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018349 mRNA. Translation: BAA34526.2 . Different initiation.
AL161998 mRNA. Translation: CAB82328.2 .
CCDSi CCDS30808.1.
PIRi T47152.
RefSeqi NP_055628.1. NM_014813.1.
UniGenei Hs.448972.
Hs.729143.

3D structure databases

ProteinModelPortali O94898.
SMRi O94898. Positions 34-883.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115194. 2 interactions.
IntActi O94898. 1 interaction.
STRINGi 9606.ENSP00000355396.

PTM databases

PhosphoSitei O94898.

Proteomic databases

MaxQBi O94898.
PaxDbi O94898.
PRIDEi O94898.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361127 ; ENSP00000355396 ; ENSG00000198799 .
GeneIDi 9860.
KEGGi hsa:9860.
UCSCi uc001edf.1. human.

Organism-specific databases

CTDi 9860.
GeneCardsi GC01P113615.
GeneReviewsi LRIG2.
HGNCi HGNC:20889. LRIG2.
HPAi HPA015538.
MIMi 608869. gene.
615112. phenotype.
neXtProti NX_O94898.
Orphaneti 2704. Ochoa syndrome.
PharmGKBi PA134905053.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118777.
HOGENOMi HOG000113380.
HOVERGENi HBG052353.
InParanoidi O94898.
OMAi FPTNHER.
OrthoDBi EOG7DNNTD.
PhylomeDBi O94898.
TreeFami TF325380.

Miscellaneous databases

GenomeRNAii 9860.
NextBioi 37168.
PROi O94898.
SOURCEi Search...

Gene expression databases

Bgeei O94898.
CleanExi HS_LRIG2.
Genevestigatori O94898.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view ]
Pfami PF07679. I-set. 2 hits.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
PS51450. LRR. 14 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-133.
    Tissue: Brain.
  3. "Characterization and tissue-specific expression of human LRIG2."
    Holmlund C., Nilsson J., Guo D., Starefeldt A., Golovleva I., Henriksson R., Hedman H.
    Gene 332:35-43(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. Cited for: INVOLVEMENT IN UFS2.

Entry informationi

Entry nameiLRIG2_HUMAN
AccessioniPrimary (citable) accession number: O94898
Secondary accession number(s): Q9NSN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3