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Protein

Leucine-rich repeats and immunoglobulin-like domains protein 2

Gene

LRIG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32907-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 2
Short name:
LIG-2
Gene namesi
Name:LRIG2
Synonyms:KIAA0806, LIG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20889. LRIG2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini41 – 807ExtracellularSequence analysisAdd BLAST767
Transmembranei808 – 828HelicalSequence analysisAdd BLAST21
Topological domaini829 – 1065CytoplasmicSequence analysisAdd BLAST237

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Urofacial syndrome 2 (UFS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure.
See also OMIM:615112

Organism-specific databases

DisGeNETi9860.
MalaCardsiLRIG2.
MIMi615112. phenotype.
OpenTargetsiENSG00000198799.
Orphaneti2704. Ochoa syndrome.
PharmGKBiPA134905053.

Polymorphism and mutation databases

BioMutaiLRIG2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 40Sequence analysisAdd BLAST40
ChainiPRO_000001482941 – 1065Leucine-rich repeats and immunoglobulin-like domains protein 2Add BLAST1025

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...)Sequence analysis1
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Glycosylationi189N-linked (GlcNAc...)Sequence analysis1
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Glycosylationi468N-linked (GlcNAc...)Sequence analysis1
Glycosylationi514N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi519 ↔ 580PROSITE-ProRule annotation
Glycosylationi571N-linked (GlcNAc...)Sequence analysis1
Glycosylationi589N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi623 ↔ 675PROSITE-ProRule annotation
Glycosylationi687N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi717 ↔ 766PROSITE-ProRule annotation
Glycosylationi728N-linked (GlcNAc...)Sequence analysis1
Modified residuei906PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO94898.
MaxQBiO94898.
PaxDbiO94898.
PeptideAtlasiO94898.
PRIDEiO94898.

PTM databases

iPTMnetiO94898.
PhosphoSitePlusiO94898.

Expressioni

Tissue specificityi

Detected in all tissues analyzed.1 Publication

Gene expression databases

BgeeiENSG00000198799.
CleanExiHS_LRIG2.
GenevisibleiO94898. HS.

Organism-specific databases

HPAiHPA015538.

Interactioni

Protein-protein interaction databases

BioGridi115194. 3 interactors.
IntActiO94898. 1 interactor.
STRINGi9606.ENSP00000355396.

Structurei

3D structure databases

ProteinModelPortaliO94898.
SMRiO94898.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 75LRRNTAdd BLAST35
Repeati76 – 97LRR 1Add BLAST22
Repeati98 – 119LRR 2Add BLAST22
Repeati121 – 142LRR 3Add BLAST22
Repeati145 – 166LRR 4Add BLAST22
Repeati168 – 189LRR 5Add BLAST22
Repeati193 – 214LRR 6Add BLAST22
Repeati216 – 237LRR 7Add BLAST22
Repeati240 – 261LRR 8Add BLAST22
Repeati264 – 285LRR 9Add BLAST22
Repeati288 – 309LRR 10Add BLAST22
Repeati312 – 333LRR 11Add BLAST22
Repeati336 – 357LRR 12Add BLAST22
Repeati360 – 382LRR 13Add BLAST23
Repeati387 – 408LRR 14Add BLAST22
Repeati411 – 432LRR 15Add BLAST22
Domaini443 – 494LRRCTAdd BLAST52
Domaini498 – 597Ig-like C2-type 1Add BLAST100
Domaini602 – 691Ig-like C2-type 2Add BLAST90
Domaini696 – 785Ig-like C2-type 3Add BLAST90

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4194. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000113380.
HOVERGENiHBG052353.
InParanoidiO94898.
OMAiHNRLSNW.
OrthoDBiEOG091G04H0.
PhylomeDBiO94898.
TreeFamiTF325380.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
PF13855. LRR_8. 4 hits.
PF01463. LRRCT. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00369. LRR_TYP. 11 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS51450. LRR. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAPLGVPE EQLLGCRSRV LSRLLFIAQT ALLLLPAAGA GLCPAPCSCR
60 70 80 90 100
IPLLDCSRRK LPAPSWRALS GLLPPDTAIL DFSHNRLSNW NISLESQTLQ
110 120 130 140 150
EVKMNYNELT EIPYFGEPTS NITLLSLVHN IIPEINAQAL QFYPALESLD
160 170 180 190 200
LSSNIISEIK TSSFPRMQLK YLNLSNNRIT TLEAGCFDNL SSSLLVVKLN
210 220 230 240 250
RNRMSMIPPK IFKLPHLQFL ELKRNRIKIV EGLTFQGLDS LRSLKMQRNG
260 270 280 290 300
ISKLKDGAFF GLNNMEELEL EHNNLTRVNK GWLYGLRMLQ QLYVSQNAIE
310 320 330 340 350
RISPDAWEFC QRLSELDLSY NQLTRLDESA FVGLSLLERL NLGDNRVTHI
360 370 380 390 400
ADGVFRFLSN LQTLDLRNNE ISWAIEDASE AFAGLTSLTK LILQGNQIKS
410 420 430 440 450
ITKKAFIGLE SLEHLDLNNN AIMSIQENAF SQTHLKELIL NTSSLLCDCH
460 470 480 490 500
LKWLLQWLVD NNFQHSVNVS CAHPEWLAGQ SILNVDLKDF VCDDFLKPQI
510 520 530 540 550
RTHPETIIAL RGMNVTLTCT AVSSSDSPMS TVWRKDSEIL YDVDTENFVR
560 570 580 590 600
YWQQAGEALE YTSILHLFNV NFTDEGKYQC IVTNHFGSNY SQKAKLTVNE
610 620 630 640 650
MPSFLKTPMD LTIRTGAMAR LECAAEGHPA PQISWQKDGG TDFPAARERR
660 670 680 690 700
MHVMPEDDVF FIANVKIEDM GIYSCMAQNT AGGLSANASL TVLETPSFIR
710 720 730 740 750
PLEDKTVTRG ETAVLQCIAG GSPAPRLNWT KDDGPLLVTE RHFFAAANQL
760 770 780 790 800
LIIVDAGLED AGKYTCIMSN TLGTERGHIY LNVISSPNCD SSQSSIGHED
810 820 830 840 850
DGWTTVGIVI IVVVCCVVGT SLIWVIVIYH MRRKNEDYSI TNTEELNLPA
860 870 880 890 900
DIPSYLSSQG TLSEPQEGYS NSEAGSHQQL MPPANGYIHK GTDGGTGTRV
910 920 930 940 950
ICSDCYDNAN IYSRTREYCP YTYIAEEDVL DQTLSSLMVQ MPKETYLVHP
960 970 980 990 1000
PQDTTALESL IPSANREPSA FPTNHERISE KKLPSTQMSG ETLQRPVWNI
1010 1020 1030 1040 1050
NRELGLPHPP FSQQPVHESP QLHQNEGLAG REPDCSASSM SCHRLQDHAF
1060
DFSRTRNIQD GSEGT
Length:1,065
Mass (Da):118,965
Last modified:October 11, 2004 - v3
Checksum:iCD2903A861DC4887
GO

Sequence cautioni

The sequence BAA34526 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018349 mRNA. Translation: BAA34526.2. Different initiation.
AL161998 mRNA. Translation: CAB82328.2.
CCDSiCCDS30808.1.
PIRiT47152.
RefSeqiNP_001299615.1. NM_001312686.1.
NP_055628.1. NM_014813.2.
UniGeneiHs.448972.

Genome annotation databases

EnsembliENST00000361127; ENSP00000355396; ENSG00000198799.
GeneIDi9860.
KEGGihsa:9860.
UCSCiuc001edf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018349 mRNA. Translation: BAA34526.2. Different initiation.
AL161998 mRNA. Translation: CAB82328.2.
CCDSiCCDS30808.1.
PIRiT47152.
RefSeqiNP_001299615.1. NM_001312686.1.
NP_055628.1. NM_014813.2.
UniGeneiHs.448972.

3D structure databases

ProteinModelPortaliO94898.
SMRiO94898.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115194. 3 interactors.
IntActiO94898. 1 interactor.
STRINGi9606.ENSP00000355396.

PTM databases

iPTMnetiO94898.
PhosphoSitePlusiO94898.

Polymorphism and mutation databases

BioMutaiLRIG2.

Proteomic databases

EPDiO94898.
MaxQBiO94898.
PaxDbiO94898.
PeptideAtlasiO94898.
PRIDEiO94898.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361127; ENSP00000355396; ENSG00000198799.
GeneIDi9860.
KEGGihsa:9860.
UCSCiuc001edf.2. human.

Organism-specific databases

CTDi9860.
DisGeNETi9860.
GeneCardsiLRIG2.
GeneReviewsiLRIG2.
HGNCiHGNC:20889. LRIG2.
HPAiHPA015538.
MalaCardsiLRIG2.
MIMi608869. gene.
615112. phenotype.
neXtProtiNX_O94898.
OpenTargetsiENSG00000198799.
Orphaneti2704. Ochoa syndrome.
PharmGKBiPA134905053.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4194. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000113380.
HOVERGENiHBG052353.
InParanoidiO94898.
OMAiHNRLSNW.
OrthoDBiEOG091G04H0.
PhylomeDBiO94898.
TreeFamiTF325380.

Enzyme and pathway databases

BioCyciZFISH:G66-32907-MONOMER.

Miscellaneous databases

GenomeRNAii9860.
PROiO94898.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198799.
CleanExiHS_LRIG2.
GenevisibleiO94898. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
PF13855. LRR_8. 4 hits.
PF01463. LRRCT. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00369. LRR_TYP. 11 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS51450. LRR. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRIG2_HUMAN
AccessioniPrimary (citable) accession number: O94898
Secondary accession number(s): Q9NSN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.