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Protein

Zinc finger protein 432

Gene

ZNF432

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri205 – 22723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri513 – 53523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri541 – 56323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri567 – 59125C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri597 – 61923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri625 – 64723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 432
Gene namesi
Name:ZNF432
Synonyms:KIAA0798
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20810. ZNF432.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134935907.

Polymorphism and mutation databases

BioMutaiZNF432.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 652652Zinc finger protein 432PRO_0000047580Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411Nitrated tyrosineCombined sources

Keywords - PTMi

Nitration

Proteomic databases

MaxQBiO94892.
PaxDbiO94892.
PeptideAtlasiO94892.
PRIDEiO94892.

PTM databases

iPTMnetiO94892.
PhosphoSiteiO94892.

Expressioni

Gene expression databases

BgeeiENSG00000256087.
ExpressionAtlasiO94892. baseline and differential.
GenevisibleiO94892. HS.

Organism-specific databases

HPAiHPA060274.

Interactioni

Protein-protein interaction databases

BioGridi115023. 1 interaction.
STRINGi9606.ENSP00000221315.

Structurei

3D structure databases

ProteinModelPortaliO94892.
SMRiO94892. Positions 8-49, 187-652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri205 – 22723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri513 – 53523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri541 – 56323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri567 – 59125C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri597 – 61923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri625 – 64723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129783.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO94892.
KOiK09228.
OMAiQRTHEIE.
OrthoDBiEOG091G02KC.
PhylomeDBiO94892.
TreeFamiTF350804.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94892-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINAQELLTL EDVTVEFTWE EWQLLGPFQK DLYRDVMLEI YSNLLSMGYQ
60 70 80 90 100
VSKPDALSKL ERGEEPWTME DERHSRICPE NNEVDDHLQD HLENQRMLKS
110 120 130 140 150
VEQYHEHNAF GNTASQTKSL CLFRENHDTF ELYIKTLKSN LSLVNQNKSC
160 170 180 190 200
EINNSTKFSG DGKSFLHGNY EELYSAAKFS VSTKANSTKS QVSKHQRTHE
210 220 230 240 250
IEKNHVCSEC GKAFVKKSQL TDHERVHTGE KPYGCTLCAK VFSRKSRLNE
260 270 280 290 300
HQRIHKREKS FICSECGKVF TMKSRLIEHQ RTHTGEKPYI CNECGKGFPG
310 320 330 340 350
KRNLIVHQRN HTGEKSYICS ECGKGFTGKS MLIIHQRTHT GEKPYICSEC
360 370 380 390 400
GKGFTTKHYV IIHQRNHTGE KPYICNECGK GFTMKSRMIE HQRTHTGEKP
410 420 430 440 450
YICSECGKGF PRKSNLIVHQ RNHTVEKSYL CSECGKGFTV KSMLIIHQRT
460 470 480 490 500
HTGEKPYTCS ECGKGFPLKS RLIVHQRTHT GEKPYRCSEC GKGFIVNSGL
510 520 530 540 550
MLHQRTHTGE KPYICNECGK GFAFKSNLVV HQRTHTGEKP FMCSECGKGF
560 570 580 590 600
TMKRYLIVHQ QIHTEEKSCI CSECGRGFAK ETELALHKQV HTGEKPYGCN
610 620 630 640 650
ECGKGFTMKS RLIVHQRTHT GEKPFVCSEC RKAFSSKRNL IVHQRTHNGN

KP
Length:652
Mass (Da):74,836
Last modified:May 1, 1999 - v1
Checksum:i14B61461EE54A6EB
GO

Sequence cautioni

The sequence BAA34518 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti416 – 4161L → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_035577
Natural varianti490 – 4901C → Y in a breast cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs755035378 [ dbSNP | Ensembl ].
VAR_035578

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018341 mRNA. Translation: BAA34518.2. Different initiation.
BC002858 mRNA. Translation: AAH02858.1.
CCDSiCCDS12848.1.
RefSeqiNP_001309213.1. NM_001322284.1.
NP_001309214.1. NM_001322285.1.
NP_055465.1. NM_014650.3.
UniGeneiHs.655934.
Hs.665751.

Genome annotation databases

EnsembliENST00000221315; ENSP00000221315; ENSG00000256087.
ENST00000594154; ENSP00000470488; ENSG00000256087.
GeneIDi9668.
KEGGihsa:9668.
UCSCiuc002pyk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018341 mRNA. Translation: BAA34518.2. Different initiation.
BC002858 mRNA. Translation: AAH02858.1.
CCDSiCCDS12848.1.
RefSeqiNP_001309213.1. NM_001322284.1.
NP_001309214.1. NM_001322285.1.
NP_055465.1. NM_014650.3.
UniGeneiHs.655934.
Hs.665751.

3D structure databases

ProteinModelPortaliO94892.
SMRiO94892. Positions 8-49, 187-652.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115023. 1 interaction.
STRINGi9606.ENSP00000221315.

PTM databases

iPTMnetiO94892.
PhosphoSiteiO94892.

Polymorphism and mutation databases

BioMutaiZNF432.

Proteomic databases

MaxQBiO94892.
PaxDbiO94892.
PeptideAtlasiO94892.
PRIDEiO94892.

Protocols and materials databases

DNASUi9668.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221315; ENSP00000221315; ENSG00000256087.
ENST00000594154; ENSP00000470488; ENSG00000256087.
GeneIDi9668.
KEGGihsa:9668.
UCSCiuc002pyk.4. human.

Organism-specific databases

CTDi9668.
GeneCardsiZNF432.
HGNCiHGNC:20810. ZNF432.
HPAiHPA060274.
neXtProtiNX_O94892.
PharmGKBiPA134935907.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129783.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO94892.
KOiK09228.
OMAiQRTHEIE.
OrthoDBiEOG091G02KC.
PhylomeDBiO94892.
TreeFamiTF350804.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii9668.
PROiO94892.

Gene expression databases

BgeeiENSG00000256087.
ExpressionAtlasiO94892. baseline and differential.
GenevisibleiO94892. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN432_HUMAN
AccessioniPrimary (citable) accession number: O94892
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.