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Protein

Zinc finger protein 432

Gene

ZNF432

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri205 – 227C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri567 – 591C2H2-type 14PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri597 – 619C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri625 – 647C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 432
Gene namesi
Name:ZNF432
Synonyms:KIAA0798
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000256087.6
HGNCiHGNC:20810 ZNF432
neXtProtiNX_O94892

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9668
OpenTargetsiENSG00000256087
PharmGKBiPA134935907

Polymorphism and mutation databases

BioMutaiZNF432

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475801 – 652Zinc finger protein 432Add BLAST652

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41Nitrated tyrosineCombined sources1

Keywords - PTMi

Nitration

Proteomic databases

EPDiO94892
MaxQBiO94892
PaxDbiO94892
PeptideAtlasiO94892
PRIDEiO94892

PTM databases

iPTMnetiO94892
PhosphoSitePlusiO94892

Expressioni

Gene expression databases

BgeeiENSG00000256087
ExpressionAtlasiO94892 baseline and differential
GenevisibleiO94892 HS

Organism-specific databases

HPAiHPA052082
HPA060274
HPA065606

Interactioni

Protein-protein interaction databases

BioGridi115023, 3 interactors
IntActiO94892, 1 interactor
STRINGi9606.ENSP00000221315

Structurei

3D structure databases

ProteinModelPortaliO94892
SMRiO94892
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri205 – 227C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri567 – 591C2H2-type 14PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri597 – 619C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri625 – 647C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140826
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiO94892
KOiK09228
OMAiFTVKSML
OrthoDBiEOG091G02KC
PhylomeDBiO94892
TreeFamiTF350804

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

Sequencei

Sequence statusi: Complete.

O94892-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINAQELLTL EDVTVEFTWE EWQLLGPFQK DLYRDVMLEI YSNLLSMGYQ
60 70 80 90 100
VSKPDALSKL ERGEEPWTME DERHSRICPE NNEVDDHLQD HLENQRMLKS
110 120 130 140 150
VEQYHEHNAF GNTASQTKSL CLFRENHDTF ELYIKTLKSN LSLVNQNKSC
160 170 180 190 200
EINNSTKFSG DGKSFLHGNY EELYSAAKFS VSTKANSTKS QVSKHQRTHE
210 220 230 240 250
IEKNHVCSEC GKAFVKKSQL TDHERVHTGE KPYGCTLCAK VFSRKSRLNE
260 270 280 290 300
HQRIHKREKS FICSECGKVF TMKSRLIEHQ RTHTGEKPYI CNECGKGFPG
310 320 330 340 350
KRNLIVHQRN HTGEKSYICS ECGKGFTGKS MLIIHQRTHT GEKPYICSEC
360 370 380 390 400
GKGFTTKHYV IIHQRNHTGE KPYICNECGK GFTMKSRMIE HQRTHTGEKP
410 420 430 440 450
YICSECGKGF PRKSNLIVHQ RNHTVEKSYL CSECGKGFTV KSMLIIHQRT
460 470 480 490 500
HTGEKPYTCS ECGKGFPLKS RLIVHQRTHT GEKPYRCSEC GKGFIVNSGL
510 520 530 540 550
MLHQRTHTGE KPYICNECGK GFAFKSNLVV HQRTHTGEKP FMCSECGKGF
560 570 580 590 600
TMKRYLIVHQ QIHTEEKSCI CSECGRGFAK ETELALHKQV HTGEKPYGCN
610 620 630 640 650
ECGKGFTMKS RLIVHQRTHT GEKPFVCSEC RKAFSSKRNL IVHQRTHNGN

KP
Length:652
Mass (Da):74,836
Last modified:May 1, 1999 - v1
Checksum:i14B61461EE54A6EB
GO

Sequence cautioni

The sequence BAA34518 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035577416L → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035578490C → Y in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs755035378Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018341 mRNA Translation: BAA34518.2 Different initiation.
BC002858 mRNA Translation: AAH02858.1
CCDSiCCDS12848.1
RefSeqiNP_001309213.1, NM_001322284.1
NP_001309214.1, NM_001322285.1
NP_055465.1, NM_014650.3
UniGeneiHs.655934
Hs.665751

Genome annotation databases

EnsembliENST00000221315; ENSP00000221315; ENSG00000256087
ENST00000594154; ENSP00000470488; ENSG00000256087
GeneIDi9668
KEGGihsa:9668
UCSCiuc002pyk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN432_HUMAN
AccessioniPrimary (citable) accession number: O94892
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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