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O94889

- KLH18_HUMAN

UniProt

O94889 - KLH18_HUMAN

Protein

Kelch-like protein 18

Gene

KLHL18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 3 (16 Dec 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kelch-like protein 18
    Gene namesi
    Name:KLHL18
    Synonyms:KIAA0795
    ORF Names:OK/SW-cl.74
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:29120. KLHL18.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134920201.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 574574Kelch-like protein 18PRO_0000119122Add
    BLAST

    Proteomic databases

    MaxQBiO94889.
    PaxDbiO94889.
    PRIDEiO94889.

    PTM databases

    PhosphoSiteiO94889.

    Expressioni

    Gene expression databases

    ArrayExpressiO94889.
    BgeeiO94889.
    CleanExiHS_KLHL18.
    GenevestigatoriO94889.

    Organism-specific databases

    HPAiHPA035027.
    HPA035028.

    Interactioni

    Protein-protein interaction databases

    BioGridi116877. 7 interactions.
    IntActiO94889. 2 interactions.
    MINTiMINT-3002468.
    STRINGi9606.ENSP00000232766.

    Structurei

    3D structure databases

    ProteinModelPortaliO94889.
    SMRiO94889. Positions 6-566.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini66 – 10540BTBPROSITE-ProRule annotationAdd
    BLAST
    Domaini140 – 242103BACKAdd
    BLAST
    Repeati289 – 33648Kelch 1Add
    BLAST
    Repeati337 – 38347Kelch 2Add
    BLAST
    Repeati384 – 43047Kelch 3Add
    BLAST
    Repeati432 – 47746Kelch 4Add
    BLAST
    Repeati479 – 52446Kelch 5Add
    BLAST
    Repeati525 – 57147Kelch 6Add
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 6 Kelch repeats.Curated

    Keywords - Domaini

    Kelch repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG73120.
    HOGENOMiHOG000230814.
    HOVERGENiHBG014286.
    InParanoidiO94889.
    KOiK10455.
    OMAiNRWEKCH.
    OrthoDBiEOG74BJRJ.
    PhylomeDBiO94889.
    TreeFamiTF329218.

    Family and domain databases

    Gene3Di2.130.10.80. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015916. Gal_Oxidase_b-propeller.
    IPR017096. Kelch-like_gigaxonin-typ.
    IPR006652. Kelch_1.
    [Graphical view]
    PfamiPF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 6 hits.
    [Graphical view]
    PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
    SMARTiSM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    SM00612. Kelch. 6 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O94889-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVEDGAEELE DLVHFSVSEL PSRGYGVMEE IRRQGKLCDV TLKIGDHKFS    50
    AHRIVLAASI PYFHAMFTND MMECKQDEIV MQGMDPSALE ALINFAYNGN 100
    LAIDQQNVQS LLMGASFLQL QSIKDACCTF LRERLHPKNC LGVRQFAETM 150
    MCAVLYDAAN SFIHQHFVEV SMSEEFLALP LEDVLELVSR DELNVKSEEQ 200
    VFEAALAWVR YDREQRGPYL PELLSNIRLP LCRPQFLSDR VQQDDLVRCC 250
    HKCRDLVDEA KDYHLMPERR PHLPAFRTRP RCCTSIAGLI YAVGGLNSAG 300
    DSLNVVEVFD PIANCWERCR PMTTARSRVG VAVVNGLLYA IGGYDGQLRL 350
    STVEAYNPET DTWTRVGSMN SKRSAMGTVV LDGQIYVCGG YDGNSSLSSV 400
    ETYSPETDKW TVVTSMSSNR SAAGVTVFEG RIYVSGGHDG LQIFSSVEHY 450
    NHHTATWHPA AGMLNKRCRH GAASLGSKMF VCGGYDGSGF LSIAEMYSSV 500
    ADQWCLIVPM HTRRSRVSLV ASCGRLYAVG GYDGQSNLSS VEMYDPETDC 550
    WTFMAPMACH EGGVGVGCIP LLTI 574
    Length:574
    Mass (Da):63,638
    Last modified:December 16, 2008 - v3
    Checksum:iFAD4CD938C962830
    GO
    Isoform 2 (identifier: O94889-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-65: Missing.

    Show »
    Length:509
    Mass (Da):56,357
    Checksum:i61B82B98C7692036
    GO

    Sequence cautioni

    The sequence AAH32620.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAD97920.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6565Missing in isoform 2. 1 PublicationVSP_035974Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB062478 mRNA. Translation: BAB93503.1.
    AK291477 mRNA. Translation: BAF84166.1.
    BX537953 mRNA. Translation: CAD97920.1. Different initiation.
    AC104447 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64819.1.
    BC032620 mRNA. Translation: AAH32620.1. Different initiation.
    AB018338 mRNA. Translation: BAA34515.1.
    CCDSiCCDS33749.1. [O94889-1]
    RefSeqiNP_079286.2. NM_025010.4. [O94889-1]
    UniGeneiHs.517946.

    Genome annotation databases

    EnsembliENST00000232766; ENSP00000232766; ENSG00000114648. [O94889-1]
    GeneIDi23276.
    KEGGihsa:23276.
    UCSCiuc003crc.2. human. [O94889-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB062478 mRNA. Translation: BAB93503.1 .
    AK291477 mRNA. Translation: BAF84166.1 .
    BX537953 mRNA. Translation: CAD97920.1 . Different initiation.
    AC104447 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64819.1 .
    BC032620 mRNA. Translation: AAH32620.1 . Different initiation.
    AB018338 mRNA. Translation: BAA34515.1 .
    CCDSi CCDS33749.1. [O94889-1 ]
    RefSeqi NP_079286.2. NM_025010.4. [O94889-1 ]
    UniGenei Hs.517946.

    3D structure databases

    ProteinModelPortali O94889.
    SMRi O94889. Positions 6-566.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116877. 7 interactions.
    IntActi O94889. 2 interactions.
    MINTi MINT-3002468.
    STRINGi 9606.ENSP00000232766.

    PTM databases

    PhosphoSitei O94889.

    Proteomic databases

    MaxQBi O94889.
    PaxDbi O94889.
    PRIDEi O94889.

    Protocols and materials databases

    DNASUi 23276.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000232766 ; ENSP00000232766 ; ENSG00000114648 . [O94889-1 ]
    GeneIDi 23276.
    KEGGi hsa:23276.
    UCSCi uc003crc.2. human. [O94889-1 ]

    Organism-specific databases

    CTDi 23276.
    GeneCardsi GC03P047299.
    HGNCi HGNC:29120. KLHL18.
    HPAi HPA035027.
    HPA035028.
    neXtProti NX_O94889.
    PharmGKBi PA134920201.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG73120.
    HOGENOMi HOG000230814.
    HOVERGENi HBG014286.
    InParanoidi O94889.
    KOi K10455.
    OMAi NRWEKCH.
    OrthoDBi EOG74BJRJ.
    PhylomeDBi O94889.
    TreeFami TF329218.

    Miscellaneous databases

    GeneWikii KLHL18.
    GenomeRNAii 23276.
    NextBioi 45062.
    PROi O94889.

    Gene expression databases

    ArrayExpressi O94889.
    Bgeei O94889.
    CleanExi HS_KLHL18.
    Genevestigatori O94889.

    Family and domain databases

    Gene3Di 2.130.10.80. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015916. Gal_Oxidase_b-propeller.
    IPR017096. Kelch-like_gigaxonin-typ.
    IPR006652. Kelch_1.
    [Graphical view ]
    Pfami PF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 6 hits.
    [Graphical view ]
    PIRSFi PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
    SMARTi SM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    SM00612. Kelch. 6 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
      Shichijo S., Itoh K.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Colon adenocarcinoma.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Retina.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-574 (ISOFORM 1).
      Tissue: Melanoma.
    7. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-574 (ISOFORMS 1/2).
      Tissue: Brain.

    Entry informationi

    Entry nameiKLH18_HUMAN
    AccessioniPrimary (citable) accession number: O94889
    Secondary accession number(s): A8K612, Q7Z3E8, Q8N125
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3