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Protein

Kelch-like protein 18

Gene

KLHL18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 18
Gene namesi
Name:KLHL18
Synonyms:KIAA0795
ORF Names:OK/SW-cl.74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114648.11
HGNCiHGNC:29120 KLHL18
neXtProtiNX_O94889

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000114648
PharmGKBiPA134920201

Polymorphism and mutation databases

BioMutaiKLHL18

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191221 – 574Kelch-like protein 18Add BLAST574

Proteomic databases

MaxQBiO94889
PaxDbiO94889
PeptideAtlasiO94889
PRIDEiO94889
ProteomicsDBi50527
50528 [O94889-2]

PTM databases

iPTMnetiO94889
PhosphoSitePlusiO94889

Expressioni

Gene expression databases

BgeeiENSG00000114648
CleanExiHS_KLHL18
ExpressionAtlasiO94889 baseline and differential
GenevisibleiO94889 HS

Organism-specific databases

HPAiHPA035027
HPA035028

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EEF1GP26641-23EBI-2510096,EBI-10177695

Protein-protein interaction databases

BioGridi116877, 26 interactors
IntActiO94889, 2 interactors
MINTiO94889
STRINGi9606.ENSP00000232766

Structurei

3D structure databases

ProteinModelPortaliO94889
SMRiO94889
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 105BTBPROSITE-ProRule annotationAdd BLAST40
Domaini140 – 242BACKAdd BLAST103
Repeati289 – 336Kelch 1Add BLAST48
Repeati337 – 383Kelch 2Add BLAST47
Repeati384 – 430Kelch 3Add BLAST47
Repeati432 – 477Kelch 4Add BLAST46
Repeati479 – 524Kelch 5Add BLAST46
Repeati525 – 571Kelch 6Add BLAST47

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118931
HOGENOMiHOG000230814
HOVERGENiHBG014286
InParanoidiO94889
KOiK10455
OMAiNVQSLMV
OrthoDBiEOG091G04QJ
PhylomeDBiO94889
TreeFamiTF329218

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 6 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 2 hits
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94889-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEDGAEELE DLVHFSVSEL PSRGYGVMEE IRRQGKLCDV TLKIGDHKFS
60 70 80 90 100
AHRIVLAASI PYFHAMFTND MMECKQDEIV MQGMDPSALE ALINFAYNGN
110 120 130 140 150
LAIDQQNVQS LLMGASFLQL QSIKDACCTF LRERLHPKNC LGVRQFAETM
160 170 180 190 200
MCAVLYDAAN SFIHQHFVEV SMSEEFLALP LEDVLELVSR DELNVKSEEQ
210 220 230 240 250
VFEAALAWVR YDREQRGPYL PELLSNIRLP LCRPQFLSDR VQQDDLVRCC
260 270 280 290 300
HKCRDLVDEA KDYHLMPERR PHLPAFRTRP RCCTSIAGLI YAVGGLNSAG
310 320 330 340 350
DSLNVVEVFD PIANCWERCR PMTTARSRVG VAVVNGLLYA IGGYDGQLRL
360 370 380 390 400
STVEAYNPET DTWTRVGSMN SKRSAMGTVV LDGQIYVCGG YDGNSSLSSV
410 420 430 440 450
ETYSPETDKW TVVTSMSSNR SAAGVTVFEG RIYVSGGHDG LQIFSSVEHY
460 470 480 490 500
NHHTATWHPA AGMLNKRCRH GAASLGSKMF VCGGYDGSGF LSIAEMYSSV
510 520 530 540 550
ADQWCLIVPM HTRRSRVSLV ASCGRLYAVG GYDGQSNLSS VEMYDPETDC
560 570
WTFMAPMACH EGGVGVGCIP LLTI
Length:574
Mass (Da):63,638
Last modified:December 16, 2008 - v3
Checksum:iFAD4CD938C962830
GO
Isoform 2 (identifier: O94889-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Show »
Length:509
Mass (Da):56,357
Checksum:i61B82B98C7692036
GO

Sequence cautioni

The sequence AAH32620 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD97920 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0359741 – 65Missing in isoform 2. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062478 mRNA Translation: BAB93503.1
AK291477 mRNA Translation: BAF84166.1
BX537953 mRNA Translation: CAD97920.1 Different initiation.
AC104447 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64819.1
BC032620 mRNA Translation: AAH32620.1 Different initiation.
AB018338 mRNA Translation: BAA34515.1
CCDSiCCDS33749.1 [O94889-1]
RefSeqiNP_079286.2, NM_025010.4 [O94889-1]
UniGeneiHs.517946

Genome annotation databases

EnsembliENST00000232766; ENSP00000232766; ENSG00000114648 [O94889-1]
GeneIDi23276
KEGGihsa:23276
UCSCiuc003crd.4 human [O94889-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKLH18_HUMAN
AccessioniPrimary (citable) accession number: O94889
Secondary accession number(s): A8K612, Q7Z3E8, Q8N125
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: December 16, 2008
Last modified: June 20, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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