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Protein

Kelch-like protein 18

Gene

KLHL18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 18
Gene namesi
Name:KLHL18
Synonyms:KIAA0795
ORF Names:OK/SW-cl.74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29120. KLHL18.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134920201.

Polymorphism and mutation databases

BioMutaiKLHL18.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 574574Kelch-like protein 18PRO_0000119122Add
BLAST

Proteomic databases

MaxQBiO94889.
PaxDbiO94889.
PRIDEiO94889.

PTM databases

PhosphoSiteiO94889.

Expressioni

Gene expression databases

BgeeiO94889.
CleanExiHS_KLHL18.
ExpressionAtlasiO94889. baseline and differential.
GenevisibleiO94889. HS.

Organism-specific databases

HPAiHPA035027.
HPA035028.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EEF1GP26641-23EBI-2510096,EBI-10177695

Protein-protein interaction databases

BioGridi116877. 13 interactions.
IntActiO94889. 2 interactions.
MINTiMINT-3002468.
STRINGi9606.ENSP00000232766.

Structurei

3D structure databases

ProteinModelPortaliO94889.
SMRiO94889. Positions 6-266, 273-566.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 10540BTBPROSITE-ProRule annotationAdd
BLAST
Domaini140 – 242103BACKAdd
BLAST
Repeati289 – 33648Kelch 1Add
BLAST
Repeati337 – 38347Kelch 2Add
BLAST
Repeati384 – 43047Kelch 3Add
BLAST
Repeati432 – 47746Kelch 4Add
BLAST
Repeati479 – 52446Kelch 5Add
BLAST
Repeati525 – 57147Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG73120.
GeneTreeiENSGT00760000118931.
HOGENOMiHOG000230814.
HOVERGENiHBG014286.
InParanoidiO94889.
KOiK10455.
OMAiNRWEKCH.
OrthoDBiEOG74BJRJ.
PhylomeDBiO94889.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030603. KLHL18.
[Graphical view]
PANTHERiPTHR24412:SF139. PTHR24412:SF139. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94889-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEDGAEELE DLVHFSVSEL PSRGYGVMEE IRRQGKLCDV TLKIGDHKFS
60 70 80 90 100
AHRIVLAASI PYFHAMFTND MMECKQDEIV MQGMDPSALE ALINFAYNGN
110 120 130 140 150
LAIDQQNVQS LLMGASFLQL QSIKDACCTF LRERLHPKNC LGVRQFAETM
160 170 180 190 200
MCAVLYDAAN SFIHQHFVEV SMSEEFLALP LEDVLELVSR DELNVKSEEQ
210 220 230 240 250
VFEAALAWVR YDREQRGPYL PELLSNIRLP LCRPQFLSDR VQQDDLVRCC
260 270 280 290 300
HKCRDLVDEA KDYHLMPERR PHLPAFRTRP RCCTSIAGLI YAVGGLNSAG
310 320 330 340 350
DSLNVVEVFD PIANCWERCR PMTTARSRVG VAVVNGLLYA IGGYDGQLRL
360 370 380 390 400
STVEAYNPET DTWTRVGSMN SKRSAMGTVV LDGQIYVCGG YDGNSSLSSV
410 420 430 440 450
ETYSPETDKW TVVTSMSSNR SAAGVTVFEG RIYVSGGHDG LQIFSSVEHY
460 470 480 490 500
NHHTATWHPA AGMLNKRCRH GAASLGSKMF VCGGYDGSGF LSIAEMYSSV
510 520 530 540 550
ADQWCLIVPM HTRRSRVSLV ASCGRLYAVG GYDGQSNLSS VEMYDPETDC
560 570
WTFMAPMACH EGGVGVGCIP LLTI
Length:574
Mass (Da):63,638
Last modified:December 16, 2008 - v3
Checksum:iFAD4CD938C962830
GO
Isoform 2 (identifier: O94889-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Show »
Length:509
Mass (Da):56,357
Checksum:i61B82B98C7692036
GO

Sequence cautioni

The sequence AAH32620.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD97920.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6565Missing in isoform 2. 1 PublicationVSP_035974Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062478 mRNA. Translation: BAB93503.1.
AK291477 mRNA. Translation: BAF84166.1.
BX537953 mRNA. Translation: CAD97920.1. Different initiation.
AC104447 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64819.1.
BC032620 mRNA. Translation: AAH32620.1. Different initiation.
AB018338 mRNA. Translation: BAA34515.1.
CCDSiCCDS33749.1. [O94889-1]
RefSeqiNP_079286.2. NM_025010.4. [O94889-1]
UniGeneiHs.517946.

Genome annotation databases

EnsembliENST00000232766; ENSP00000232766; ENSG00000114648.
GeneIDi23276.
KEGGihsa:23276.
UCSCiuc003crc.2. human. [O94889-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062478 mRNA. Translation: BAB93503.1.
AK291477 mRNA. Translation: BAF84166.1.
BX537953 mRNA. Translation: CAD97920.1. Different initiation.
AC104447 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64819.1.
BC032620 mRNA. Translation: AAH32620.1. Different initiation.
AB018338 mRNA. Translation: BAA34515.1.
CCDSiCCDS33749.1. [O94889-1]
RefSeqiNP_079286.2. NM_025010.4. [O94889-1]
UniGeneiHs.517946.

3D structure databases

ProteinModelPortaliO94889.
SMRiO94889. Positions 6-266, 273-566.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116877. 13 interactions.
IntActiO94889. 2 interactions.
MINTiMINT-3002468.
STRINGi9606.ENSP00000232766.

PTM databases

PhosphoSiteiO94889.

Polymorphism and mutation databases

BioMutaiKLHL18.

Proteomic databases

MaxQBiO94889.
PaxDbiO94889.
PRIDEiO94889.

Protocols and materials databases

DNASUi23276.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232766; ENSP00000232766; ENSG00000114648.
GeneIDi23276.
KEGGihsa:23276.
UCSCiuc003crc.2. human. [O94889-1]

Organism-specific databases

CTDi23276.
GeneCardsiGC03P047325.
HGNCiHGNC:29120. KLHL18.
HPAiHPA035027.
HPA035028.
neXtProtiNX_O94889.
PharmGKBiPA134920201.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG73120.
GeneTreeiENSGT00760000118931.
HOGENOMiHOG000230814.
HOVERGENiHBG014286.
InParanoidiO94889.
KOiK10455.
OMAiNRWEKCH.
OrthoDBiEOG74BJRJ.
PhylomeDBiO94889.
TreeFamiTF329218.

Miscellaneous databases

GeneWikiiKLHL18.
GenomeRNAii23276.
NextBioi45062.
PROiO94889.

Gene expression databases

BgeeiO94889.
CleanExiHS_KLHL18.
ExpressionAtlasiO94889. baseline and differential.
GenevisibleiO94889. HS.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030603. KLHL18.
[Graphical view]
PANTHERiPTHR24412:SF139. PTHR24412:SF139. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
    Shichijo S., Itoh K.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon adenocarcinoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Retina.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-574 (ISOFORM 1).
    Tissue: Melanoma.
  7. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-574 (ISOFORMS 1/2).
    Tissue: Brain.

Entry informationi

Entry nameiKLH18_HUMAN
AccessioniPrimary (citable) accession number: O94889
Secondary accession number(s): A8K612, Q7Z3E8, Q8N125
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: December 16, 2008
Last modified: July 22, 2015
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.