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Protein

UBX domain-containing protein 7

Gene

UBXN7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.1 Publication

GO - Molecular functioni

  • transcription factor binding Source: BHF-UCL
  • ubiquitin binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163960-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 7
Gene namesi
Name:UBXN7
Synonyms:KIAA0794, UBXD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29119. UBXN7.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleoplasm Source: HPA
  • VCP-NPL4-UFD1 AAA ATPase complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi288S → A or D: No effect on interactions with CUL2 and HIF1A. 1 Publication1
Mutagenesisi297S → A or H: Severely reduces interaction with neddylated CUL2. 1 Publication1
Mutagenesisi459P → G: Abolishes interaction with VCP/p97. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000163960.
PharmGKBiPA162408447.

Polymorphism and mutation databases

BioMutaiUBXN7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002110352 – 489UBX domain-containing protein 7Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residuei278PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei306PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO94888.
MaxQBiO94888.
PaxDbiO94888.
PeptideAtlasiO94888.
PRIDEiO94888.

PTM databases

iPTMnetiO94888.
PhosphoSitePlusiO94888.

Miscellaneous databases

PMAP-CutDBO94888.

Expressioni

Gene expression databases

BgeeiENSG00000163960.
CleanExiHS_UBXN7.
ExpressionAtlasiO94888. baseline and differential.
GenevisibleiO94888. HS.

Organism-specific databases

HPAiHPA048441.
HPA049442.

Interactioni

Subunit structurei

Interacts with neddylated CUL2, ubiquitinated HIF1A, and VCP/p97.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HIF1AQ166653EBI-1993627,EBI-447269
VCPP5507210EBI-1993627,EBI-355164

GO - Molecular functioni

  • transcription factor binding Source: BHF-UCL
  • ubiquitin binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi117507. 113 interactors.
DIPiDIP-47029N.
IntActiO94888. 53 interactors.
STRINGi9606.ENSP00000296328.

Structurei

Secondary structure

1489
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 23Combined sources13
Helixi28 – 36Combined sources9
Turni37 – 39Combined sources3
Helixi42 – 51Combined sources10
Turni146 – 148Combined sources3
Helixi154 – 164Combined sources11
Beta strandi167 – 173Combined sources7
Turni177 – 179Combined sources3
Helixi180 – 186Combined sources7
Turni187 – 189Combined sources3
Helixi191 – 199Combined sources9
Beta strandi201 – 210Combined sources10
Helixi211 – 220Combined sources10
Beta strandi224 – 231Combined sources8
Turni233 – 235Combined sources3
Beta strandi240 – 244Combined sources5
Helixi247 – 260Combined sources14
Beta strandi412 – 418Combined sources7
Beta strandi424 – 430Combined sources7
Helixi435 – 446Combined sources12
Turni449 – 451Combined sources3
Beta strandi452 – 455Combined sources4
Beta strandi457 – 459Combined sources3
Beta strandi468 – 470Combined sources3
Turni472 – 476Combined sources5
Beta strandi479 – 481Combined sources3
Beta strandi484 – 487Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJ4NMR-A377-487[»]
2DALNMR-A6-54[»]
2DLXNMR-A131-270[»]
ProteinModelPortaliO94888.
SMRiO94888.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94888.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 54UBAAdd BLAST53
Domaini285 – 304UIMAdd BLAST20
Domaini408 – 485UBXPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi337 – 342Poly-Glu6

Domaini

The UIM (ubiquitin-interacting motif) is required to engage the NEDD8 modification on cullins.1 Publication
The UBX domain mediates interaction with VCP/p97.1 Publication
The UBA domain is required for binding ubiquitinated-protein substrates.1 Publication

Sequence similaritiesi

Contains 1 UBA domain.
Contains 1 UBX domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0260. Eukaryota.
KOG1364. Eukaryota.
ENOG410XSZZ. LUCA.
GeneTreeiENSGT00390000018687.
HOGENOMiHOG000143398.
HOVERGENiHBG057394.
InParanoidiO94888.
OMAiRFELVTN.
OrthoDBiEOG091G0FPX.
PhylomeDBiO94888.
TreeFamiTF323635.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
IPR017346. UBX_7/2.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF00789. UBX. 1 hit.
[Graphical view]
PIRSFiPIRSF037991. UCP037991_UBX7/2. 1 hit.
SMARTiSM00594. UAS. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHGGSAAS SALKGLIQQF TTITGASESV GKHMLEACNN NLEMAVTMFL
60 70 80 90 100
DGGGIAEEPS TSSASVSTVR PHTEEEVRAP IPQKQEILVE PEPLFGAPKR
110 120 130 140 150
RRPARSIFDG FRDFQTETIR QEQELRNGGA IDKKLTTLAD LFRPPIDLMH
160 170 180 190 200
KGSFETAKEC GQMQNKWLMI NIQNVQDFAC QCLNRDVWSN EAVKNIIREH
210 220 230 240 250
FIFWQVYHDS EEGQRYIQFY KLGDFPYVSI LDPRTGQKLV EWHQLDVSSF
260 270 280 290 300
LDQVTGFLGE HGQLDGLSSS PPKKCARSES LIDASEDSQL EAAIRASLQE
310 320 330 340 350
THFDSTQTKQ DSRSDEESES ELFSGSEEFI SVCGSDEEEE VENLAKSRKS
360 370 380 390 400
PHKDLGHRKE ENRRPLTEPP VRTDPGTATN HQGLPAVDSE ILEMPPEKAD
410 420 430 440 450
GVVEGIDVNG PKAQLMLRYP DGKREQITLP EQAKLLALVK HVQSKGYPNE
460 470 480
RFELLTNFPR RKLSHLDYDI TLQEAGLCPQ ETVFVQERN
Length:489
Mass (Da):54,862
Last modified:August 16, 2005 - v2
Checksum:i3C894533B1A2C41A
GO

Sequence cautioni

The sequence BAA34514 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC85247 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018337 mRNA. Translation: BAA34514.1. Different initiation.
AK129880 mRNA. Translation: BAC85247.1. Sequence problems.
CH471191 Genomic DNA. Translation: EAW53652.1.
CH471191 Genomic DNA. Translation: EAW53654.1.
BC028986 mRNA. Translation: AAH28986.1.
CCDSiCCDS43191.1.
RefSeqiNP_056377.1. NM_015562.1.
UniGeneiHs.518524.

Genome annotation databases

EnsembliENST00000296328; ENSP00000296328; ENSG00000163960.
GeneIDi26043.
KEGGihsa:26043.
UCSCiuc003fwm.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018337 mRNA. Translation: BAA34514.1. Different initiation.
AK129880 mRNA. Translation: BAC85247.1. Sequence problems.
CH471191 Genomic DNA. Translation: EAW53652.1.
CH471191 Genomic DNA. Translation: EAW53654.1.
BC028986 mRNA. Translation: AAH28986.1.
CCDSiCCDS43191.1.
RefSeqiNP_056377.1. NM_015562.1.
UniGeneiHs.518524.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJ4NMR-A377-487[»]
2DALNMR-A6-54[»]
2DLXNMR-A131-270[»]
ProteinModelPortaliO94888.
SMRiO94888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117507. 113 interactors.
DIPiDIP-47029N.
IntActiO94888. 53 interactors.
STRINGi9606.ENSP00000296328.

PTM databases

iPTMnetiO94888.
PhosphoSitePlusiO94888.

Polymorphism and mutation databases

BioMutaiUBXN7.

Proteomic databases

EPDiO94888.
MaxQBiO94888.
PaxDbiO94888.
PeptideAtlasiO94888.
PRIDEiO94888.

Protocols and materials databases

DNASUi26043.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296328; ENSP00000296328; ENSG00000163960.
GeneIDi26043.
KEGGihsa:26043.
UCSCiuc003fwm.5. human.

Organism-specific databases

CTDi26043.
GeneCardsiUBXN7.
HGNCiHGNC:29119. UBXN7.
HPAiHPA048441.
HPA049442.
MIMi616379. gene.
neXtProtiNX_O94888.
OpenTargetsiENSG00000163960.
PharmGKBiPA162408447.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0260. Eukaryota.
KOG1364. Eukaryota.
ENOG410XSZZ. LUCA.
GeneTreeiENSGT00390000018687.
HOGENOMiHOG000143398.
HOVERGENiHBG057394.
InParanoidiO94888.
OMAiRFELVTN.
OrthoDBiEOG091G0FPX.
PhylomeDBiO94888.
TreeFamiTF323635.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163960-MONOMER.

Miscellaneous databases

ChiTaRSiUBXN7. human.
EvolutionaryTraceiO94888.
GenomeRNAii26043.
PMAP-CutDBO94888.
PROiO94888.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163960.
CleanExiHS_UBXN7.
ExpressionAtlasiO94888. baseline and differential.
GenevisibleiO94888. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
IPR017346. UBX_7/2.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF00789. UBX. 1 hit.
[Graphical view]
PIRSFiPIRSF037991. UCP037991_UBX7/2. 1 hit.
SMARTiSM00594. UAS. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBXN7_HUMAN
AccessioniPrimary (citable) accession number: O94888
Secondary accession number(s): D3DXB3
, Q6ZP77, Q86X20, Q8N327
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.