SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O94888

- UBXN7_HUMAN

UniProt

O94888 - UBXN7_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
UBX domain-containing protein 7
Gene
UBXN7, KIAA0794, UBXD7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. transcription factor binding Source: BHF-UCL
  3. ubiquitin binding Source: BHF-UCL
  4. ubiquitin protein ligase binding Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 7
Gene namesi
Name:UBXN7
Synonyms:KIAA0794, UBXD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:29119. UBXN7.

Subcellular locationi

GO - Cellular componenti

  1. Cdc48p-Npl4p-Ufd1p AAA ATPase complex Source: BHF-UCL
  2. nucleus Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408447.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 489488UBX domain-containing protein 7
PRO_0000211035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Cross-linki99 – 99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residuei278 – 2781Phosphoserine1 Publication
Modified residuei285 – 2851Phosphoserine1 Publication
Modified residuei288 – 2881Phosphoserine6 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO94888.
PaxDbiO94888.
PRIDEiO94888.

PTM databases

PhosphoSiteiO94888.

Miscellaneous databases

PMAP-CutDBO94888.

Expressioni

Gene expression databases

ArrayExpressiO94888.
BgeeiO94888.
CleanExiHS_UBXN7.
GenevestigatoriO94888.

Organism-specific databases

HPAiHPA048441.
HPA049442.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HIF1AQ166653EBI-1993627,EBI-447269

Protein-protein interaction databases

BioGridi117507. 75 interactions.
DIPiDIP-47029N.
IntActiO94888. 37 interactions.
STRINGi9606.ENSP00000296328.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 2313
Helixi28 – 369
Turni37 – 393
Helixi42 – 5110
Turni146 – 1483
Helixi154 – 16411
Beta strandi167 – 1737
Turni177 – 1793
Helixi180 – 1867
Turni187 – 1893
Helixi191 – 1999
Beta strandi201 – 21010
Helixi211 – 22010
Beta strandi224 – 2318
Turni233 – 2353
Beta strandi240 – 2445
Helixi247 – 26014
Beta strandi412 – 4187
Beta strandi424 – 4307
Helixi435 – 44612
Turni449 – 4513
Beta strandi452 – 4554
Beta strandi457 – 4593
Beta strandi468 – 4703
Turni472 – 4765
Beta strandi479 – 4813
Beta strandi484 – 4874

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WJ4NMR-A377-487[»]
2DALNMR-A6-54[»]
2DLXNMR-A131-270[»]
ProteinModelPortaliO94888.
SMRiO94888. Positions 13-51, 130-265, 376-487.

Miscellaneous databases

EvolutionaryTraceiO94888.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini408 – 48578UBX
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi337 – 3426Poly-Glu

Sequence similaritiesi

Contains 1 UBX domain.

Phylogenomic databases

eggNOGiNOG322646.
HOGENOMiHOG000143398.
HOVERGENiHBG057394.
InParanoidiO94888.
OMAiPEKSDGI.
PhylomeDBiO94888.
TreeFamiTF323635.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
IPR017346. UCP037991_UAS/UBX.
[Graphical view]
PfamiPF00789. UBX. 1 hit.
[Graphical view]
PIRSFiPIRSF037991. UCP037991_UBX7/2. 1 hit.
SMARTiSM00594. UAS. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94888-1 [UniParc]FASTAAdd to Basket

« Hide

MAAHGGSAAS SALKGLIQQF TTITGASESV GKHMLEACNN NLEMAVTMFL    50
DGGGIAEEPS TSSASVSTVR PHTEEEVRAP IPQKQEILVE PEPLFGAPKR 100
RRPARSIFDG FRDFQTETIR QEQELRNGGA IDKKLTTLAD LFRPPIDLMH 150
KGSFETAKEC GQMQNKWLMI NIQNVQDFAC QCLNRDVWSN EAVKNIIREH 200
FIFWQVYHDS EEGQRYIQFY KLGDFPYVSI LDPRTGQKLV EWHQLDVSSF 250
LDQVTGFLGE HGQLDGLSSS PPKKCARSES LIDASEDSQL EAAIRASLQE 300
THFDSTQTKQ DSRSDEESES ELFSGSEEFI SVCGSDEEEE VENLAKSRKS 350
PHKDLGHRKE ENRRPLTEPP VRTDPGTATN HQGLPAVDSE ILEMPPEKAD 400
GVVEGIDVNG PKAQLMLRYP DGKREQITLP EQAKLLALVK HVQSKGYPNE 450
RFELLTNFPR RKLSHLDYDI TLQEAGLCPQ ETVFVQERN 489
Length:489
Mass (Da):54,862
Last modified:August 16, 2005 - v2
Checksum:i3C894533B1A2C41A
GO

Sequence cautioni

The sequence BAC85247.1 differs from that shown. Reason: Unlikely isoform. Aberrant splice sites.
The sequence BAA34514.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018337 mRNA. Translation: BAA34514.1. Different initiation.
AK129880 mRNA. Translation: BAC85247.1. Sequence problems.
CH471191 Genomic DNA. Translation: EAW53652.1.
CH471191 Genomic DNA. Translation: EAW53654.1.
BC028986 mRNA. Translation: AAH28986.1.
CCDSiCCDS43191.1.
RefSeqiNP_056377.1. NM_015562.1.
UniGeneiHs.518524.

Genome annotation databases

EnsembliENST00000296328; ENSP00000296328; ENSG00000163960.
GeneIDi26043.
KEGGihsa:26043.
UCSCiuc003fwm.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018337 mRNA. Translation: BAA34514.1 . Different initiation.
AK129880 mRNA. Translation: BAC85247.1 . Sequence problems.
CH471191 Genomic DNA. Translation: EAW53652.1 .
CH471191 Genomic DNA. Translation: EAW53654.1 .
BC028986 mRNA. Translation: AAH28986.1 .
CCDSi CCDS43191.1.
RefSeqi NP_056377.1. NM_015562.1.
UniGenei Hs.518524.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WJ4 NMR - A 377-487 [» ]
2DAL NMR - A 6-54 [» ]
2DLX NMR - A 131-270 [» ]
ProteinModelPortali O94888.
SMRi O94888. Positions 13-51, 130-265, 376-487.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117507. 75 interactions.
DIPi DIP-47029N.
IntActi O94888. 37 interactions.
STRINGi 9606.ENSP00000296328.

PTM databases

PhosphoSitei O94888.

Proteomic databases

MaxQBi O94888.
PaxDbi O94888.
PRIDEi O94888.

Protocols and materials databases

DNASUi 26043.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296328 ; ENSP00000296328 ; ENSG00000163960 .
GeneIDi 26043.
KEGGi hsa:26043.
UCSCi uc003fwm.4. human.

Organism-specific databases

CTDi 26043.
GeneCardsi GC03M196074.
HGNCi HGNC:29119. UBXN7.
HPAi HPA048441.
HPA049442.
neXtProti NX_O94888.
PharmGKBi PA162408447.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322646.
HOGENOMi HOG000143398.
HOVERGENi HBG057394.
InParanoidi O94888.
OMAi PEKSDGI.
PhylomeDBi O94888.
TreeFami TF323635.

Miscellaneous databases

ChiTaRSi UBXN7. human.
EvolutionaryTracei O94888.
GenomeRNAii 26043.
NextBioi 47875.
PMAP-CutDB O94888.
PROi O94888.

Gene expression databases

ArrayExpressi O94888.
Bgeei O94888.
CleanExi HS_UBXN7.
Genevestigatori O94888.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
IPR017346. UCP037991_UAS/UBX.
[Graphical view ]
Pfami PF00789. UBX. 1 hit.
[Graphical view ]
PIRSFi PIRSF037991. UCP037991_UBX7/2. 1 hit.
SMARTi SM00594. UAS. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50033. UBX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-489.
    Tissue: Testis.
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."
    Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S., Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.
    Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278 AND SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285 AND SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Solution structure of the UBX domain of KIAA0794 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 376-487.
  16. "Solution structure of the novel identified UBA-like domain in the N-terminal of human FAS associated factor 1 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 5-54.
  17. "Solution structure of the UAS domain of human UBX domain-containing protein 7."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 131-270.

Entry informationi

Entry nameiUBXN7_HUMAN
AccessioniPrimary (citable) accession number: O94888
Secondary accession number(s): D3DXB3
, Q6ZP77, Q86X20, Q8N327
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi