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O94888

- UBXN7_HUMAN

UniProt

O94888 - UBXN7_HUMAN

Protein

UBX domain-containing protein 7

Gene

UBXN7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (16 Aug 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. transcription factor binding Source: BHF-UCL
    3. ubiquitin binding Source: BHF-UCL
    4. ubiquitin protein ligase binding Source: BHF-UCL

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UBX domain-containing protein 7
    Gene namesi
    Name:UBXN7
    Synonyms:KIAA0794, UBXD7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:29119. UBXN7.

    Subcellular locationi

    GO - Cellular componenti

    1. Cdc48p-Npl4p-Ufd1p AAA ATPase complex Source: BHF-UCL
    2. nucleus Source: HPA

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162408447.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 489488UBX domain-containing protein 7PRO_0000211035Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Cross-linki99 – 99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
    Modified residuei278 – 2781Phosphoserine1 Publication
    Modified residuei285 – 2851Phosphoserine1 Publication
    Modified residuei288 – 2881Phosphoserine6 Publications

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiO94888.
    PaxDbiO94888.
    PRIDEiO94888.

    PTM databases

    PhosphoSiteiO94888.

    Miscellaneous databases

    PMAP-CutDBO94888.

    Expressioni

    Gene expression databases

    ArrayExpressiO94888.
    BgeeiO94888.
    CleanExiHS_UBXN7.
    GenevestigatoriO94888.

    Organism-specific databases

    HPAiHPA048441.
    HPA049442.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HIF1AQ166653EBI-1993627,EBI-447269

    Protein-protein interaction databases

    BioGridi117507. 75 interactions.
    DIPiDIP-47029N.
    IntActiO94888. 37 interactions.
    STRINGi9606.ENSP00000296328.

    Structurei

    Secondary structure

    1
    489
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi11 – 2313
    Helixi28 – 369
    Turni37 – 393
    Helixi42 – 5110
    Turni146 – 1483
    Helixi154 – 16411
    Beta strandi167 – 1737
    Turni177 – 1793
    Helixi180 – 1867
    Turni187 – 1893
    Helixi191 – 1999
    Beta strandi201 – 21010
    Helixi211 – 22010
    Beta strandi224 – 2318
    Turni233 – 2353
    Beta strandi240 – 2445
    Helixi247 – 26014
    Beta strandi412 – 4187
    Beta strandi424 – 4307
    Helixi435 – 44612
    Turni449 – 4513
    Beta strandi452 – 4554
    Beta strandi457 – 4593
    Beta strandi468 – 4703
    Turni472 – 4765
    Beta strandi479 – 4813
    Beta strandi484 – 4874

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WJ4NMR-A377-487[»]
    2DALNMR-A6-54[»]
    2DLXNMR-A131-270[»]
    ProteinModelPortaliO94888.
    SMRiO94888. Positions 13-51, 130-265, 376-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO94888.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini408 – 48578UBXPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi337 – 3426Poly-Glu

    Sequence similaritiesi

    Contains 1 UBX domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG322646.
    HOGENOMiHOG000143398.
    HOVERGENiHBG057394.
    InParanoidiO94888.
    OMAiPEKSDGI.
    PhylomeDBiO94888.
    TreeFamiTF323635.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR012336. Thioredoxin-like_fold.
    IPR006577. UAS.
    IPR009060. UBA-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR001012. UBX_dom.
    IPR017346. UCP037991_UAS/UBX.
    [Graphical view]
    PfamiPF00789. UBX. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037991. UCP037991_UBX7/2. 1 hit.
    SMARTiSM00594. UAS. 1 hit.
    SM00166. UBX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    SSF52833. SSF52833. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50033. UBX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O94888-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAHGGSAAS SALKGLIQQF TTITGASESV GKHMLEACNN NLEMAVTMFL    50
    DGGGIAEEPS TSSASVSTVR PHTEEEVRAP IPQKQEILVE PEPLFGAPKR 100
    RRPARSIFDG FRDFQTETIR QEQELRNGGA IDKKLTTLAD LFRPPIDLMH 150
    KGSFETAKEC GQMQNKWLMI NIQNVQDFAC QCLNRDVWSN EAVKNIIREH 200
    FIFWQVYHDS EEGQRYIQFY KLGDFPYVSI LDPRTGQKLV EWHQLDVSSF 250
    LDQVTGFLGE HGQLDGLSSS PPKKCARSES LIDASEDSQL EAAIRASLQE 300
    THFDSTQTKQ DSRSDEESES ELFSGSEEFI SVCGSDEEEE VENLAKSRKS 350
    PHKDLGHRKE ENRRPLTEPP VRTDPGTATN HQGLPAVDSE ILEMPPEKAD 400
    GVVEGIDVNG PKAQLMLRYP DGKREQITLP EQAKLLALVK HVQSKGYPNE 450
    RFELLTNFPR RKLSHLDYDI TLQEAGLCPQ ETVFVQERN 489
    Length:489
    Mass (Da):54,862
    Last modified:August 16, 2005 - v2
    Checksum:i3C894533B1A2C41A
    GO

    Sequence cautioni

    The sequence BAC85247.1 differs from that shown. Reason: Unlikely isoform. Aberrant splice sites.
    The sequence BAA34514.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018337 mRNA. Translation: BAA34514.1. Different initiation.
    AK129880 mRNA. Translation: BAC85247.1. Sequence problems.
    CH471191 Genomic DNA. Translation: EAW53652.1.
    CH471191 Genomic DNA. Translation: EAW53654.1.
    BC028986 mRNA. Translation: AAH28986.1.
    CCDSiCCDS43191.1.
    RefSeqiNP_056377.1. NM_015562.1.
    UniGeneiHs.518524.

    Genome annotation databases

    EnsembliENST00000296328; ENSP00000296328; ENSG00000163960.
    GeneIDi26043.
    KEGGihsa:26043.
    UCSCiuc003fwm.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018337 mRNA. Translation: BAA34514.1 . Different initiation.
    AK129880 mRNA. Translation: BAC85247.1 . Sequence problems.
    CH471191 Genomic DNA. Translation: EAW53652.1 .
    CH471191 Genomic DNA. Translation: EAW53654.1 .
    BC028986 mRNA. Translation: AAH28986.1 .
    CCDSi CCDS43191.1.
    RefSeqi NP_056377.1. NM_015562.1.
    UniGenei Hs.518524.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WJ4 NMR - A 377-487 [» ]
    2DAL NMR - A 6-54 [» ]
    2DLX NMR - A 131-270 [» ]
    ProteinModelPortali O94888.
    SMRi O94888. Positions 13-51, 130-265, 376-487.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117507. 75 interactions.
    DIPi DIP-47029N.
    IntActi O94888. 37 interactions.
    STRINGi 9606.ENSP00000296328.

    PTM databases

    PhosphoSitei O94888.

    Proteomic databases

    MaxQBi O94888.
    PaxDbi O94888.
    PRIDEi O94888.

    Protocols and materials databases

    DNASUi 26043.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296328 ; ENSP00000296328 ; ENSG00000163960 .
    GeneIDi 26043.
    KEGGi hsa:26043.
    UCSCi uc003fwm.4. human.

    Organism-specific databases

    CTDi 26043.
    GeneCardsi GC03M196074.
    HGNCi HGNC:29119. UBXN7.
    HPAi HPA048441.
    HPA049442.
    neXtProti NX_O94888.
    PharmGKBi PA162408447.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322646.
    HOGENOMi HOG000143398.
    HOVERGENi HBG057394.
    InParanoidi O94888.
    OMAi PEKSDGI.
    PhylomeDBi O94888.
    TreeFami TF323635.

    Miscellaneous databases

    ChiTaRSi UBXN7. human.
    EvolutionaryTracei O94888.
    GenomeRNAii 26043.
    NextBioi 47875.
    PMAP-CutDB O94888.
    PROi O94888.

    Gene expression databases

    ArrayExpressi O94888.
    Bgeei O94888.
    CleanExi HS_UBXN7.
    Genevestigatori O94888.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR012336. Thioredoxin-like_fold.
    IPR006577. UAS.
    IPR009060. UBA-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR001012. UBX_dom.
    IPR017346. UCP037991_UAS/UBX.
    [Graphical view ]
    Pfami PF00789. UBX. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037991. UCP037991_UBX7/2. 1 hit.
    SMARTi SM00594. UAS. 1 hit.
    SM00166. UBX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    SSF52833. SSF52833. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50033. UBX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-489.
      Tissue: Testis.
    5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."
      Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S., Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.
      Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278 AND SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285 AND SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Solution structure of the UBX domain of KIAA0794 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2004) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 376-487.
    16. "Solution structure of the novel identified UBA-like domain in the N-terminal of human FAS associated factor 1 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 5-54.
    17. "Solution structure of the UAS domain of human UBX domain-containing protein 7."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 131-270.

    Entry informationi

    Entry nameiUBXN7_HUMAN
    AccessioniPrimary (citable) accession number: O94888
    Secondary accession number(s): D3DXB3
    , Q6ZP77, Q86X20, Q8N327
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3