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Protein

FERM, RhoGEF and pleckstrin domain-containing protein 2

Gene

FARP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000006607-MONOMER.
ReactomeiR-HSA-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.

Names & Taxonomyi

Protein namesi
Recommended name:
FERM, RhoGEF and pleckstrin domain-containing protein 2
Alternative name(s):
FERM domain including RhoGEF
Short name:
FIR
Pleckstrin homology domain-containing family C member 3
Short name:
PH domain-containing family C member 3
Gene namesi
Name:FARP2
Synonyms:KIAA0793, PLEKHC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:16460. FARP2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytoskeleton Source: InterPro
  • cytosol Source: Reactome
  • extrinsic component of membrane Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi9855.
OpenTargetsiENSG00000006607.
PharmGKBiPA134873245.

Polymorphism and mutation databases

BioMutaiFARP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002327551 – 1054FERM, RhoGEF and pleckstrin domain-containing protein 2Add BLAST1054

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei389PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO94887.
MaxQBiO94887.
PaxDbiO94887.
PeptideAtlasiO94887.
PRIDEiO94887.

PTM databases

iPTMnetiO94887.
PhosphoSitePlusiO94887.

Expressioni

Gene expression databases

BgeeiENSG00000006607.
CleanExiHS_FARP2.
ExpressionAtlasiO94887. baseline and differential.
GenevisibleiO94887. HS.

Organism-specific databases

HPAiHPA031226.
HPA055592.

Interactioni

Subunit structurei

Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding. Interacts with RAC1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi115189. 19 interactors.
IntActiO94887. 6 interactors.
STRINGi9606.ENSP00000264042.

Structurei

3D structure databases

ProteinModelPortaliO94887.
SMRiO94887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 324FERMPROSITE-ProRule annotationAdd BLAST281
Domaini535 – 726DHPROSITE-ProRule annotationAdd BLAST192
Domaini755 – 852PH 1PROSITE-ProRule annotationAdd BLAST98
Domaini929 – 1026PH 2PROSITE-ProRule annotationAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi425 – 428Poly-Ser4
Compositional biasi453 – 511Pro-richAdd BLAST59

Domaini

Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.By similarity

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3531. Eukaryota.
ENOG410XP7Q. LUCA.
GeneTreeiENSGT00860000133686.
HOGENOMiHOG000171854.
HOVERGENiHBG081521.
InParanoidiO94887.
KOiK06082.
OMAiMHVCWYR.
OrthoDBiEOG091G015W.
PhylomeDBiO94887.
TreeFamiTF351276.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 3 hits.
InterProiIPR019749. Band_41_domain.
IPR000219. DH-domain.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00169. PH. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 3 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS00660. FERM_1. 1 hit.
PS50057. FERM_3. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94887-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEIEGTYRV LQTAGMRLGA QTPVGVSTLE PGQTLLPRMQ EKHLHLRVKL
60 70 80 90 100
LDNTMEIFDI EPKCDGQVLL TQVWKRLNLV ECDYFGMEFQ NTQSYWIWLE
110 120 130 140 150
PMKPIIRQIR RPKNVVLRLA VKFFPPDPGQ LQEEYTRYLF ALQLKRDLLE
160 170 180 190 200
ERLTCADTTA ALLTSHLLQS EIGDYDETLD REHLKVNEYL PGQQHCLEKI
210 220 230 240 250
LEFHQKHVGQ TPAESDFQVL EIARKLEMYG IRFHMASDRE GTKIQLAVSH
260 270 280 290 300
MGVLVFQGTT KINTFNWSKV RKLSFKRKRF LIKLHPEVHG PYQDTLEFLL
310 320 330 340 350
GSRDECKNFW KICVEYHTFF RLLDQPKPKA KAVFFSRGSS FRYSGRTQKQ
360 370 380 390 400
LVDYFKDSGM KRIPYERRHS KTHTSVRALT ADLPKQSISF PEGLRTPASP
410 420 430 440 450
SSANAFYSLS PSTLVPSGLP EFKDSSSSLT DPQVSYVKSP AAERRSGAVA
460 470 480 490 500
GGPDTPSAQP LGPPALQPGP GLSTKSPQPS PSSRKSPLSL SPAFQVPLGP
510 520 530 540 550
AEQGSSPLLS PVLSDAGGAG MDCEEPRHKR VPADEAYFIV KEILATERTY
560 570 580 590 600
LKDLEVITVW FRSAVVKEDA MPATLMTLLF SNIDPIYEFH RGFLREVEQR
610 620 630 640 650
LALWEGPSKA HTKGSHQRIG DILLRNMRQL KEFTSYFQRH DEVLTELEKA
660 670 680 690 700
TKRCKKLEAV YKEFELQKVC YLPLNTFLLK PIQRLLHYRL LLRRLCGHYS
710 720 730 740 750
PGHHDYADCH DALKAITEVT TTLQHILIRL ENLQKLTELQ RDLVGIENLI
760 770 780 790 800
APGREFIREG CLHKLTKKGL QQRMFFLFSD MLLYTSKGVA GTSHFRIRGL
810 820 830 840 850
LPLQGMLVEE SDNEWSVPHC FTIYAAQKTI VVAASTRLEK EKWMLDLNSA
860 870 880 890 900
IQAAKSGGDT APALPGRTVC TRPPRSPNEV SLEQESEDDA RGVRSSLEGH
910 920 930 940 950
GQHRANTTMH VCWYRNTSVS RADHSAAVEN QLSGYLLRKF KNSHGWQKLW
960 970 980 990 1000
VVFTNFCLFF YKTHQDDYPL ASLPLLGYSV SIPREADGIH KDYVFKLQFK
1010 1020 1030 1040 1050
SHVYFFRAES KYTFERWMEV IQGASSSAGR APSIVQDGPQ PSSGLEGMVR

GKEE
Length:1,054
Mass (Da):119,888
Last modified:April 18, 2006 - v3
Checksum:i7DC279F69A307E5A
GO
Isoform 2 (identifier: O94887-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-647: EFTSYFQRHDEVLTEL → VFQLHEGHVAGVTKME
     648-1054: Missing.

Show »
Length:647
Mass (Da):73,269
Checksum:i3BE8B9358E241A88
GO
Isoform 3 (identifier: O94887-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-638: EFTSYFQ → AAHEFTT
     639-1054: Missing.

Note: No experimental confirmation available.
Show »
Length:638
Mass (Da):72,263
Checksum:i13555C937B09C568
GO

Sequence cautioni

The sequence BAA34513 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti366E → G in BAH13284 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048363185K → N.Corresponds to variant rs16843643dbSNPEnsembl.1
Natural variantiVAR_048364260T → I.Corresponds to variant rs757978dbSNPEnsembl.1
Natural variantiVAR_048365643V → I.Corresponds to variant rs41342147dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017977632 – 647EFTSY…VLTEL → VFQLHEGHVAGVTKME in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_054840632 – 638EFTSYFQ → AAHEFTT in isoform 3. 1 Publication7
Alternative sequenceiVSP_054841639 – 1054Missing in isoform 3. 1 PublicationAdd BLAST416
Alternative sequenceiVSP_017978648 – 1054Missing in isoform 2. 1 PublicationAdd BLAST407

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018336 mRNA. Translation: BAA34513.2. Different initiation.
AK300435 mRNA. Translation: BAH13284.1.
AC005104 Genomic DNA. No translation available.
AC110299 Genomic DNA. Translation: AAY14682.1.
BC021301 mRNA. Translation: AAH21301.1.
AL122052 mRNA. Translation: CAB59185.1.
CCDSiCCDS33424.1. [O94887-1]
CCDS63197.1. [O94887-2]
CCDS63198.1. [O94887-3]
PIRiT34541.
RefSeqiNP_001269912.1. NM_001282983.1. [O94887-2]
NP_001269913.1. NM_001282984.1. [O94887-3]
NP_055623.1. NM_014808.3. [O94887-1]
UniGeneiHs.726316.

Genome annotation databases

EnsembliENST00000264042; ENSP00000264042; ENSG00000006607. [O94887-1]
ENST00000373287; ENSP00000362384; ENSG00000006607. [O94887-2]
ENST00000627550; ENSP00000486597; ENSG00000006607. [O94887-3]
GeneIDi9855.
KEGGihsa:9855.
UCSCiuc002wbi.4. human. [O94887-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018336 mRNA. Translation: BAA34513.2. Different initiation.
AK300435 mRNA. Translation: BAH13284.1.
AC005104 Genomic DNA. No translation available.
AC110299 Genomic DNA. Translation: AAY14682.1.
BC021301 mRNA. Translation: AAH21301.1.
AL122052 mRNA. Translation: CAB59185.1.
CCDSiCCDS33424.1. [O94887-1]
CCDS63197.1. [O94887-2]
CCDS63198.1. [O94887-3]
PIRiT34541.
RefSeqiNP_001269912.1. NM_001282983.1. [O94887-2]
NP_001269913.1. NM_001282984.1. [O94887-3]
NP_055623.1. NM_014808.3. [O94887-1]
UniGeneiHs.726316.

3D structure databases

ProteinModelPortaliO94887.
SMRiO94887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115189. 19 interactors.
IntActiO94887. 6 interactors.
STRINGi9606.ENSP00000264042.

PTM databases

iPTMnetiO94887.
PhosphoSitePlusiO94887.

Polymorphism and mutation databases

BioMutaiFARP2.

Proteomic databases

EPDiO94887.
MaxQBiO94887.
PaxDbiO94887.
PeptideAtlasiO94887.
PRIDEiO94887.

Protocols and materials databases

DNASUi9855.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264042; ENSP00000264042; ENSG00000006607. [O94887-1]
ENST00000373287; ENSP00000362384; ENSG00000006607. [O94887-2]
ENST00000627550; ENSP00000486597; ENSG00000006607. [O94887-3]
GeneIDi9855.
KEGGihsa:9855.
UCSCiuc002wbi.4. human. [O94887-1]

Organism-specific databases

CTDi9855.
DisGeNETi9855.
GeneCardsiFARP2.
HGNCiHGNC:16460. FARP2.
HPAiHPA031226.
HPA055592.
neXtProtiNX_O94887.
OpenTargetsiENSG00000006607.
PharmGKBiPA134873245.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3531. Eukaryota.
ENOG410XP7Q. LUCA.
GeneTreeiENSGT00860000133686.
HOGENOMiHOG000171854.
HOVERGENiHBG081521.
InParanoidiO94887.
KOiK06082.
OMAiMHVCWYR.
OrthoDBiEOG091G015W.
PhylomeDBiO94887.
TreeFamiTF351276.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000006607-MONOMER.
ReactomeiR-HSA-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.

Miscellaneous databases

ChiTaRSiFARP2. human.
GeneWikiiFARP2.
GenomeRNAii9855.
PROiO94887.

Gene expression databases

BgeeiENSG00000006607.
CleanExiHS_FARP2.
ExpressionAtlasiO94887. baseline and differential.
GenevisibleiO94887. HS.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 3 hits.
InterProiIPR019749. Band_41_domain.
IPR000219. DH-domain.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00169. PH. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 3 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS00660. FERM_1. 1 hit.
PS50057. FERM_3. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFARP2_HUMAN
AccessioniPrimary (citable) accession number: O94887
Secondary accession number(s): B7Z6J8
, F5GZ84, Q53QM5, Q8WU27, Q9UFE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: November 30, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.