O94875 (SRBS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sorbin and SH3 domain-containing protein 2

Alternative name(s):
Arg/Abl-interacting protein 2
Short name=ArgBP2
Sorbin

Gene names

Name:	SORBS2
Synonyms:	ARGBP2, KIAA0777

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1100 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. Ref.1 Ref.7
Subunit structure	Interacts with ABL, CBL, DNM1, DNM2, FLOT1, MLLT4/afadin, PTK2B/PYK2, SAPAP, SPTAN1, SYNJ1, SYNJ2, VCL/vinculin, and WASF By similarity. Interacts with ABL1/c-Abl, ABL2/v-Abl/Arg, ACTN, AKT1, CBL, PALLD and PAK1. Ref.1 Ref.7 Ref.8 Ref.9
Subcellular location	Cytoplasm › perinuclear region. Note: Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion. Ref.1 Ref.8
Tissue specificity	Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells. Ref.1 Ref.2
Post-translational modification	Ubiquitinated by CBL. Ref.7 Ref.9
Sequence similarities	Contains 3 SH3 domains. Contains 1 SoHo domain.
Sequence caution	The sequence BAA34497.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat SH3 domain
PTM	Amidation Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	Z disc Non-traceable author statement Ref.1. Source: UniProtKB actin cytoskeleton Traceable author statement. Source: ProtInc nucleus Non-traceable author statement Ref.1. Source: UniProtKB perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cytoskeletal adaptor activity Traceable author statement. Source: ProtInc structural constituent of cytoskeleton Traceable author statement. Source: ProtInc structural constituent of muscle Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O94875-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O94875-2)

Also known as: ArgBP2a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNTGRDSQSPDSPKGFRSVRPNLQDKRSPTQSQITVNGNSGGAVSPM
     228-228: P → PTDRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHSSGVFNE
     308-834: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: O94875-3)

The sequence of this isoform differs from the canonical sequence as follows:
     228-228: P → PPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNE
     308-834: Missing.

Isoform 4 (identifier: O94875-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNTGRDSQSPDSPKGFRSVRPNLQDKRSPTQSQITVNGNSGGAVSPM
     228-228: P → PPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNE
     308-834: Missing.

Isoform 5 (identifier: O94875-5)

Also known as: ArgBP2b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNTGRDSQSPDSPKGFRSVRPNLQDKRSPTQSQITVNGNSGGAVSPM
     228-228: P → PPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNE
     308-834: Missing.
     1050-1100: YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL → GYTLT

Isoform 6 (identifier: O94875-6)

Also known as: Sorbin;

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     82-89: GIPTAIRT → MKATTPLQ
     229-237: ASLYQSSID → VSKPQAGRR
     238-1100: Missing.

Note: Contains alanine amide at position 153.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1100	1100	Sorbin and SH3 domain-containing protein 2		PRO_0000344477
Regions
	Domain	66 – 127	62	SoHo
	Domain	863 – 922	60	SH3 1
	Domain	938 – 999	62	SH3 2
	Domain	1041 – 1100	60	SH3 3
	Compositional bias	167 – 182	16	Pro-rich
	Compositional bias	640 – 652	13	His-rich
	Compositional bias	931 – 934	4	Poly-Pro
Amino acid modifications
	Modified residue	30	1	Phosphoserine By similarity
	Modified residue	154	1	Phosphoserine By similarity
	Modified residue	157	1	Phosphoserine Ref.12
	Modified residue	259	1	Phosphoserine Ref.10 Ref.12
	Modified residue	277	1	Phosphothreonine Ref.10 Ref.12
	Modified residue	278	1	Phosphoserine By similarity
	Modified residue	298	1	Phosphoserine By similarity
	Modified residue	299	1	Phosphoserine Ref.12
	Modified residue	301	1	Phosphoserine Ref.11 Ref.12
	Modified residue	302	1	Phosphoserine Ref.12
	Modified residue	371	1	Phosphothreonine By similarity
	Modified residue	376	1	Phosphoserine By similarity
	Modified residue	750	1	Phosphoserine By similarity
	Modified residue	1017	1	Phosphoserine By similarity
	Modified residue	1018	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 81	81	Missing in isoform 6.		VSP_034791
	Alternative sequence	1	1	M → MNTGRDSQSPDSPKGFRSVR PNLQDKRSPTQSQITVNGNS GGAVSPM in isoform 2, isoform 4 and isoform 5.		VSP_034792
	Alternative sequence	82 – 89	8	GIPTAIRT → MKATTPLQ in isoform 6.		VSP_034793
	Alternative sequence	228	1	P → PTDRINPDDIDLENEPWYKF FSELEFGRPPPKKPLDYVQD HSSGVFNE in isoform 2.		VSP_034794
	Alternative sequence	228	1	P → PPPLPTTPTPVPREPGRKPL SSSRLGEVTGSPSPPPRSGA PTPSSRAPALSPTRPPKKPL DYVQDHSSGVFNE in isoform 3, isoform 4 and isoform 5.		VSP_034795
	Alternative sequence	229 – 237	9	ASLYQSSID → VSKPQAGRR in isoform 6.		VSP_034796
	Alternative sequence	238 – 1100	863	Missing in isoform 6.		VSP_034797
	Alternative sequence	308 – 834	527	Missing in isoform 2, isoform 3, isoform 4 and isoform 5.		VSP_034798
	Alternative sequence	1050 – 1100	51	YNYTP…YVKRL → GYTLT in isoform 5.		VSP_034799
	Natural variant	1048	1	A → V. Corresponds to variant rs725185 [ dbSNP | Ensembl ].		VAR_045624

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 22, 2008. Version 3. Checksum: 7E98B196D4DB38E6	FASTA	1,100	124,108
	10 20 30 40 50 60 MSYYQRPFSP SAYSLPASLN SSIVMQHGTS LDSTDTYPQH AQSLDGTTSS SIPLYRSSEE 70 80 90 100 110 120 EKRVTVIKAP HYPGIGPVDE SGIPTAIRTT VDRPKDWYKT MFKQIHMVHK PDDDTDMYNT 130 140 150 160 170 180 PYTYNAGLYN PPYSAQSHPA AKTQTYRPLS KSHSDNSPNA FKDASSPVPP PHVPPPVPPL 190 200 210 220 230 240 RPRDRSSTEK HDWDPPDRKV DTRKFRSEPR SIFEYEPGKS SILQHERPAS LYQSSIDRSL 250 260 270 280 290 300 ERPMSSASMA SDFRKRRKSE PAVGPPRGLG DQSASRTSPG RVDLPGSSTT LTKSFTSSSP 310 320 330 340 350 360 SSPSRAKGGD DSKICPSLCS YSGLNGNPSS ELDYCSTYRQ HLDVPRDSPR AISFKNGWQM 370 380 390 400 410 420 ARQNAEIWSS TEETVSPKIK SRSCDDLLND DCDSFPDPKV KSESMGSLLC EEDSKESCPM 430 440 450 460 470 480 AWGSPYVPEV RSNGRSRIRH RSARNAPGFL KMYKKMHRIN RKDLMNSEVI CSVKSRILQY 490 500 510 520 530 540 ESEQQHKDLL RAWSQCSTEE VPRDMVPTRI SEFEKLIQKS KSMPNLGDDM LSPVTLEPPQ 550 560 570 580 590 600 NGLCPKRRFS IEYLLEEENQ SGPPARGRRG CQSNALVPIH IEVTSDEQPR AHVEFSDSDQ 610 620 630 640 650 660 DGVVSDHSDY IHLEGSSFCS ESDFDHFSFT SSESFYGSSH HHHHHHHHHH RHLISSCKGR 670 680 690 700 710 720 CPASYTRFTT MLKHERARHE NTEEPRRQEM DPGLSKLAFL VSPVPFRRKK NSAPKKQTEK 730 740 750 760 770 780 AKCKASVFEA LDSALKDICD QIKAEKKRGS LPDNSILHRL ISELLPDVPE RNSSLRALRR 790 800 810 820 830 840 SPLHQPLHPL PPDGAIHCPP YQNDCGRMPR SASFQDVDTA NSSCHHQDRG GALQDRESPR 850 860 870 880 890 900 SYSSTLTDMG RSAPRERRGT PEKEKLPAKA VYDFKAQTSK ELSFKKGDTV YILRKIDQNW 910 920 930 940 950 960 YEGEHHGRVG IFPISYVEKL TPPEKAQPAR PPPPAQPGEI GEAIAKYNFN ADTNVELSLR 970 980 990 1000 1010 1020 KGDRVILLKR VDQNWYEGKI PGTNRQGIFP VSYVEVVKKN TKGAEDYPDP PIPHSYSSDR 1030 1040 1050 1060 1070 1080 IHSLSSNKPQ RPVFTHENIQ GGGEPFQALY NYTPRNEDEL ELRESDVIDV MEKCDDGWFV 1090 1100 GTSRRTKFFG TFPGNYVKRL
	Isoform 2 (ArgBP2a) [UniParc]. Checksum: B549A26DC04782E0	FASTA	666	74,804
	10 20 30 40 50 60 MNTGRDSQSP DSPKGFRSVR PNLQDKRSPT QSQITVNGNS GGAVSPMSYY QRPFSPSAYS 70 80 90 100 110 120 LPASLNSSIV MQHGTSLDST DTYPQHAQSL DGTTSSSIPL YRSSEEEKRV TVIKAPHYPG 130 140 150 160 170 180 IGPVDESGIP TAIRTTVDRP KDWYKTMFKQ IHMVHKPDDD TDMYNTPYTY NAGLYNPPYS 190 200 210 220 230 240 AQSHPAAKTQ TYRPLSKSHS DNSPNAFKDA SSPVPPPHVP PPVPPLRPRD RSSTEKHDWD 250 260 270 280 290 300 PPDRKVDTRK FRSEPRSIFE YEPGKSSILQ HERPTDRINP DDIDLENEPW YKFFSELEFG 310 320 330 340 350 360 RPPPKKPLDY VQDHSSGVFN EASLYQSSID RSLERPMSSA SMASDFRKRR KSEPAVGPPR 370 380 390 400 410 420 GLGDQSASRT SPGRVDLPGS STTLTKSFTS SSPSSPSRAK DRESPRSYSS TLTDMGRSAP 430 440 450 460 470 480 RERRGTPEKE KLPAKAVYDF KAQTSKELSF KKGDTVYILR KIDQNWYEGE HHGRVGIFPI 490 500 510 520 530 540 SYVEKLTPPE KAQPARPPPP AQPGEIGEAI AKYNFNADTN VELSLRKGDR VILLKRVDQN 550 560 570 580 590 600 WYEGKIPGTN RQGIFPVSYV EVVKKNTKGA EDYPDPPIPH SYSSDRIHSL SSNKPQRPVF 610 620 630 640 650 660 THENIQGGGE PFQALYNYTP RNEDELELRE SDVIDVMEKC DDGWFVGTSR RTKFFGTFPG NYVKRL
	Isoform 3 [UniParc]. Checksum: 8CDEF6E34D5F972F	FASTA	645	71,899
	10 20 30 40 50 60 MSYYQRPFSP SAYSLPASLN SSIVMQHGTS LDSTDTYPQH AQSLDGTTSS SIPLYRSSEE 70 80 90 100 110 120 EKRVTVIKAP HYPGIGPVDE SGIPTAIRTT VDRPKDWYKT MFKQIHMVHK PDDDTDMYNT 130 140 150 160 170 180 PYTYNAGLYN PPYSAQSHPA AKTQTYRPLS KSHSDNSPNA FKDASSPVPP PHVPPPVPPL 190 200 210 220 230 240 RPRDRSSTEK HDWDPPDRKV DTRKFRSEPR SIFEYEPGKS SILQHERPPP LPTTPTPVPR 250 260 270 280 290 300 EPGRKPLSSS RLGEVTGSPS PPPRSGAPTP SSRAPALSPT RPPKKPLDYV QDHSSGVFNE 310 320 330 340 350 360 ASLYQSSIDR SLERPMSSAS MASDFRKRRK SEPAVGPPRG LGDQSASRTS PGRVDLPGSS 370 380 390 400 410 420 TTLTKSFTSS SPSSPSRAKD RESPRSYSST LTDMGRSAPR ERRGTPEKEK LPAKAVYDFK 430 440 450 460 470 480 AQTSKELSFK KGDTVYILRK IDQNWYEGEH HGRVGIFPIS YVEKLTPPEK AQPARPPPPA 490 500 510 520 530 540 QPGEIGEAIA KYNFNADTNV ELSLRKGDRV ILLKRVDQNW YEGKIPGTNR QGIFPVSYVE 550 560 570 580 590 600 VVKKNTKGAE DYPDPPIPHS YSSDRIHSLS SNKPQRPVFT HENIQGGGEP FQALYNYTPR 610 620 630 640 NEDELELRES DVIDVMEKCD DGWFVGTSRR TKFFGTFPGN YVKRL
	Isoform 4 [UniParc]. Checksum: 0398BFA54873EDF9	FASTA	691	76,738
	10 20 30 40 50 60 MNTGRDSQSP DSPKGFRSVR PNLQDKRSPT QSQITVNGNS GGAVSPMSYY QRPFSPSAYS 70 80 90 100 110 120 LPASLNSSIV MQHGTSLDST DTYPQHAQSL DGTTSSSIPL YRSSEEEKRV TVIKAPHYPG 130 140 150 160 170 180 IGPVDESGIP TAIRTTVDRP KDWYKTMFKQ IHMVHKPDDD TDMYNTPYTY NAGLYNPPYS 190 200 210 220 230 240 AQSHPAAKTQ TYRPLSKSHS DNSPNAFKDA SSPVPPPHVP PPVPPLRPRD RSSTEKHDWD 250 260 270 280 290 300 PPDRKVDTRK FRSEPRSIFE YEPGKSSILQ HERPPPLPTT PTPVPREPGR KPLSSSRLGE 310 320 330 340 350 360 VTGSPSPPPR SGAPTPSSRA PALSPTRPPK KPLDYVQDHS SGVFNEASLY QSSIDRSLER 370 380 390 400 410 420 PMSSASMASD FRKRRKSEPA VGPPRGLGDQ SASRTSPGRV DLPGSSTTLT KSFTSSSPSS 430 440 450 460 470 480 PSRAKDRESP RSYSSTLTDM GRSAPRERRG TPEKEKLPAK AVYDFKAQTS KELSFKKGDT 490 500 510 520 530 540 VYILRKIDQN WYEGEHHGRV GIFPISYVEK LTPPEKAQPA RPPPPAQPGE IGEAIAKYNF 550 560 570 580 590 600 NADTNVELSL RKGDRVILLK RVDQNWYEGK IPGTNRQGIF PVSYVEVVKK NTKGAEDYPD 610 620 630 640 650 660 PPIPHSYSSD RIHSLSSNKP QRPVFTHENI QGGGEPFQAL YNYTPRNEDE LELRESDVID 670 680 690 VMEKCDDGWF VGTSRRTKFF GTFPGNYVKR L
	Isoform 5 (ArgBP2b) [UniParc]. Checksum: 068FBE75BFD30A8C	FASTA	645	71,196
	10 20 30 40 50 60 MNTGRDSQSP DSPKGFRSVR PNLQDKRSPT QSQITVNGNS GGAVSPMSYY QRPFSPSAYS 70 80 90 100 110 120 LPASLNSSIV MQHGTSLDST DTYPQHAQSL DGTTSSSIPL YRSSEEEKRV TVIKAPHYPG 130 140 150 160 170 180 IGPVDESGIP TAIRTTVDRP KDWYKTMFKQ IHMVHKPDDD TDMYNTPYTY NAGLYNPPYS 190 200 210 220 230 240 AQSHPAAKTQ TYRPLSKSHS DNSPNAFKDA SSPVPPPHVP PPVPPLRPRD RSSTEKHDWD 250 260 270 280 290 300 PPDRKVDTRK FRSEPRSIFE YEPGKSSILQ HERPPPLPTT PTPVPREPGR KPLSSSRLGE 310 320 330 340 350 360 VTGSPSPPPR SGAPTPSSRA PALSPTRPPK KPLDYVQDHS SGVFNEASLY QSSIDRSLER 370 380 390 400 410 420 PMSSASMASD FRKRRKSEPA VGPPRGLGDQ SASRTSPGRV DLPGSSTTLT KSFTSSSPSS 430 440 450 460 470 480 PSRAKDRESP RSYSSTLTDM GRSAPRERRG TPEKEKLPAK AVYDFKAQTS KELSFKKGDT 490 500 510 520 530 540 VYILRKIDQN WYEGEHHGRV GIFPISYVEK LTPPEKAQPA RPPPPAQPGE IGEAIAKYNF 550 560 570 580 590 600 NADTNVELSL RKGDRVILLK RVDQNWYEGK IPGTNRQGIF PVSYVEVVKK NTKGAEDYPD 610 620 630 640 PPIPHSYSSD RIHSLSSNKP QRPVFTHENI QGGGEPFQAL GYTLT
	Isoform 6 (Sorbin) [UniParc]. Checksum: 95AE8B49881FCC12	FASTA	156	17,976
	10 20 30 40 50 60 MKATTPLQTV DRPKDWYKTM FKQIHMVHKP DDDTDMYNTP YTYNAGLYNP PYSAQSHPAA 70 80 90 100 110 120 KTQTYRPLSK SHSDNSPNAF KDASSPVPPP HVPPPVPPLR PRDRSSTEKH DWDPPDRKVD 130 140 150 TRKFRSEPRS IFEYEPGKSS ILQHERPVSK PQAGRR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks." Wang B., Golemis E.A., Kruh G.D. J. Biol. Chem. 272:17542-17550(1997) [PubMed: 9211900] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), NUCLEOTIDE SEQUENCE [MRNA] OF 1-1049 (ISOFORM 4), PHOSPHORYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH ABL1 AND ABL2, FUNCTION. Tissue: Brain.
[2]	"Coding region of the sorbin gene in different species." Wahbi K., Magaud J.-P., Pansu D., Descroix-Vagne M. Peptides 22:2045-2053(2001) [PubMed: 11786189] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), AMIDATION AT ALA-153 (ISOFORM 6), TISSUE SPECIFICITY.
[3]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed: 9872452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Lymph.
[7]	"Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl." Soubeyran P., Barac A., Szymkiewicz I., Dikic I. Biochem. J. 370:29-34(2003) [PubMed: 12475393] [Abstract] Cited for: INTERACTION WITH CBL, UBIQUITINATION BY CBL, FUNCTION.
[8]	"Involvement of palladin and alpha-actinin in targeting of the Abl/Arg kinase adaptor ArgBP2 to the actin cytoskeleton." Roenty M., Taivainen A., Moza M., Kruh G.D., Ehler E., Carpen O. Exp. Cell Res. 310:88-98(2005) [PubMed: 16125169] [Abstract] Cited for: INTERACTION WITH PALLD AND ACTN, SUBCELLULAR LOCATION.
[9]	"ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival." Yuan Z.-Q., Kim D., Kaneko S., Sussman M., Bokoch G.M., Kruh G.D., Nicosia S.V., Testa J.R., Cheng J.Q. J. Biol. Chem. 280:21483-21490(2005) [PubMed: 15784622] [Abstract] Cited for: INTERACTION WITH AKT1 AND PAK1, UBIQUITINATION BY CBL, PHOSPHORYLATION.
[10]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259 AND THR-277, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157; SER-259; THR-277; SER-299; SER-301 AND SER-302, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF049884 mRNA. Translation: AAC05508.1. AF049885 mRNA. Translation: AAC05509.1. AB018320 mRNA. Translation: BAA34497.2. Different initiation. AC093797 Genomic DNA. No translation available. CH471056 Genomic DNA. Translation: EAX04630.1. CH471056 Genomic DNA. Translation: EAX04631.1. CH471056 Genomic DNA. Translation: EAX04632.1. CH471056 Genomic DNA. Translation: EAX04635.1. BC011883 mRNA. Translation: AAH11883.1.
IPI	IPI00477577. IPI00747799. IPI00787549. IPI00900281. IPI00900295. IPI01013920.
RefSeq	NP_001139142.1. NM_001145670.1. NP_001139143.1. NM_001145671.1. NP_001139144.1. NM_001145672.1. NP_001139145.1. NM_001145673.1. NP_003594.3. NM_003603.5. NP_066547.1. NM_021069.4.
UniGene	Hs.619806. Hs.655143.
3D structure databases
HSSP	HSSP built from PDB template 2CT3 based on UniProtKB O60504.
ProteinModelPortal	O94875.
SMR	O94875. Positions 866-1100.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-31634N.
IntAct	O94875. 8 interactions.
MINT	MINT-196404.
STRING	O94875.
PTM databases
PhosphoSite	O94875.
Proteomic databases
PRIDE	O94875.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000284776; ENSP00000284776; ENSG00000154556. ENST00000355634; ENSP00000347852; ENSG00000154556. ENST00000431808; ENSP00000411764; ENSG00000154556. ENST00000447992; ENSP00000415118; ENSG00000154556.
GeneID	8470.
KEGG	hsa:8470.
Organism-specific databases
CTD	8470.
GeneCards	GC04M186506.
HGNC	HGNC:24098. SORBS2.
HPA	HPA036754.
neXtProt	NX_O94875.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17281.
GeneTree	ENSGT00550000074287.
HOVERGEN	HBG108509.
InParanoid	O94875.
OrthoDB	EOG4J117C.
Gene expression databases
ArrayExpress	O94875.
Bgee	O94875.
CleanEx	HS_SORBS2.
Genevestigator	O94875.
Family and domain databases
InterPro	IPR000108. p67phox. IPR001452. SH3_domain. IPR003127. Sorb. IPR007087. Znf_C2H2. [Graphical view]
Pfam	PF00018. SH3_1. 3 hits. PF02208. Sorb. 1 hit. [Graphical view]
PRINTS	PR00499. P67PHOX. PR00452. SH3DOMAIN.
SMART	SM00326. SH3. 3 hits. SM00459. Sorb. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 3 hits.
PROSITE	PS50002. SH3. 3 hits. PS50831. SOHO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	31696.

Entry information

Entry name

SRBS2_HUMAN

Accession

Primary (citable) accession number: O94875
Secondary accession number(s): A6NEK9 , D3DP62, D3DP63, O60592, O60593, Q96EX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 90 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.