FCH and double SH3 domains protein 2

Names and origin

Protein names

Recommended name:
    FCH and double SH3 domains protein 2
Alternative name(s):
    SH3 multiple domains protein 3
    Carom

Gene names

Name:	FCHSD2
Synonyms:	KIAA0769, SH3MD3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	740 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Subunit structure

Interacts with CASK and MAGI1. CASK inhibits interaction with MAGI1.

Tissue specificity

Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney.

Sequence similarities

Contains 1 FCH domain.

Contains 2 SH3 domains.

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Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat SH3 domain
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Molecular function	protein binding Ref.1 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
Cask	Q62915	1	EBI-1215612,EBI-704635	From a different organism.
MAGI1	Q96QZ7	2	EBI-1215612,EBI-924464

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O94868-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O94868-2) The sequence of this isoform differs from the canonical sequence as follows: 1-56: Missing.

Isoform 3 (identifier: O94868-3) The sequence of this isoform differs from the canonical sequence as follows: 1-56: Missing. 569-571: VCF → GKD 572-740: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 740

740

FCH and double SH3 domains protein 2

PRO_0000278214

Regions

Domain

8 – 74

67

FCH

Domain

469 – 530

62

SH3 1

Domain

567 – 629

63

SH3 2

Coiled coil

356 – 397

42

Potential

Compositional bias

718 – 721

4

Poly-Pro

Amino acid modifications

Modified residue

683

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 56

56

Missing in isoform 2 and isoform 3.

VSP_023167

Alternative sequence

569 – 571

3

VCF → GKD in isoform 3.

VSP_023168

Alternative sequence

572 – 740

169

Missing in isoform 3.

VSP_023169

Secondary structure

1

.

740

Helix Strand Turn

Details...

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified February 20, 2007. Version 3. Checksum: 3AF4DAC3CAD24C28 Show »	FASTA	740	84,276
10 20 30 40 50 60 MQPPPRKVKV TQELKNIQVE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE REYAQGMQKL 70 80 90 100 110 120 ASQYLKRDWP GVKADDRNDY RSMYPVWKSF LEGTMQVAQS RMNICENYKN FISEPARTVR 130 140 150 160 170 180 SLKEQQLKRC VDQLTKIQTE LQETVKDLAK GKKKYFETEQ MAHAVREKAD IEAKSKLSLF 190 200 210 220 230 240 QSRISLQKAS VKLKARRSEC NSKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN 250 260 270 280 290 300 VYDHLKDYLI AFSRTELETC QAVQNTFQFL LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ 310 320 330 340 350 360 FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN DLECHGAAVS 370 380 390 400 410 420 EQSRAELEQK IDEARENIRK AEIIKLKAEA RLDLLKQIGV SVDTWLKSAM NQVMEELENE 430 440 450 460 470 480 RWARPPAVTS NGTLHSLNAD TEREEGEEFE DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY 490 500 510 520 530 540 KASQPDELTI EEHEVLEVIE DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL 550 560 570 580 590 600 AALDSRSHTS SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE 610 620 630 640 650 660 NQDDDGFWEG EFNGRIGVFP SVLVEELSAS ENGDTPWMRE IQISPSPKPH ASLPPLPLYD 670 680 690 700 710 720 QPPSSPYPSP DKRSSLYFPR SPSANEKSLH AESPGFSQAS RHTPETSYGK LRPVRAAPPP 730 740 PTQNHRRPAE KIEDVEITLV « Hide
Isoform 2 [UniParc]. Checksum: FB03BEEB29F8D78F Show »		684	77,752
10 20 30 40 50 60 MQKLASQYLK RDWPGVKADD RNDYRSMYPV WKSFLEGTMQ VAQSRMNICE NYKNFISEPA 70 80 90 100 110 120 RTVRSLKEQQ LKRCVDQLTK IQTELQETVK DLAKGKKKYF ETEQMAHAVR EKADIEAKSK 130 140 150 160 170 180 LSLFQSRISL QKASVKLKAR RSECNSKATH ARNDYLLTLA AANAHQDRYY QTDLVNIMKA 190 200 210 220 230 240 LDGNVYDHLK DYLIAFSRTE LETCQAVQNT FQFLLENSSK VVRDYNLQLF LQENAVFHKP 250 260 270 280 290 300 QPFQFQPCDS DTSRQLESET GTTEEHSLNK EARKWATRVA REHKNIVHQQ RVLNDLECHG 310 320 330 340 350 360 AAVSEQSRAE LEQKIDEARE NIRKAEIIKL KAEARLDLLK QIGVSVDTWL KSAMNQVMEE 370 380 390 400 410 420 LENERWARPP AVTSNGTLHS LNADTEREEG EEFEDNMDVF DDSSSSPSGT LRNYPLTCKV 430 440 450 460 470 480 VYSYKASQPD ELTIEEHEVL EVIEDGDMED WVKARNKVGQ VGYVPEKYLQ FPTSNSLLSM 490 500 510 520 530 540 LQSLAALDSR SHTSSNSTEA ELVSGSLNGD ASVCFVKALY DYEGQTDDEL SFPEGAIIRI 550 560 570 580 590 600 LNKENQDDDG FWEGEFNGRI GVFPSVLVEE LSASENGDTP WMREIQISPS PKPHASLPPL 610 620 630 640 650 660 PLYDQPPSSP YPSPDKRSSL YFPRSPSANE KSLHAESPGF SQASRHTPET SYGKLRPVRA 670 680 APPPPTQNHR RPAEKIEDVE ITLV « Hide
Isoform 3 [UniParc]. Checksum: 4243B84AF4CE48C3 Show »		515	58,886
10 20 30 40 50 60 MQKLASQYLK RDWPGVKADD RNDYRSMYPV WKSFLEGTMQ VAQSRMNICE NYKNFISEPA 70 80 90 100 110 120 RTVRSLKEQQ LKRCVDQLTK IQTELQETVK DLAKGKKKYF ETEQMAHAVR EKADIEAKSK 130 140 150 160 170 180 LSLFQSRISL QKASVKLKAR RSECNSKATH ARNDYLLTLA AANAHQDRYY QTDLVNIMKA 190 200 210 220 230 240 LDGNVYDHLK DYLIAFSRTE LETCQAVQNT FQFLLENSSK VVRDYNLQLF LQENAVFHKP 250 260 270 280 290 300 QPFQFQPCDS DTSRQLESET GTTEEHSLNK EARKWATRVA REHKNIVHQQ RVLNDLECHG 310 320 330 340 350 360 AAVSEQSRAE LEQKIDEARE NIRKAEIIKL KAEARLDLLK QIGVSVDTWL KSAMNQVMEE 370 380 390 400 410 420 LENERWARPP AVTSNGTLHS LNADTEREEG EEFEDNMDVF DDSSSSPSGT LRNYPLTCKV 430 440 450 460 470 480 VYSYKASQPD ELTIEEHEVL EVIEDGDMED WVKARNKVGQ VGYVPEKYLQ FPTSNSLLSM 490 500 510 LQSLAALDSR SHTSSNSTEA ELVSGSLNGD ASGKD « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains." Ohno H., Hirabayashi S., Kansaku A., Yao I., Tajima M., Nishimura W., Ohnishi H., Mashima H., Fujita T., Omata M., Hata Y. Oncogene 22:8422-8431(2003) [PubMed: 14627983] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH CASK AND MAGI1. Tissue: Lung.
[2]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed: 9872452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	Okazaki N., Kikuno R.F., Nagase T., Ohara O., Koga H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Bone marrow and Kidney.
[6]	The German cDNA consortium Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 138-740. Tissue: Testis.
[7]	"Identification and characterization of human FCHSD1 and FCHSD2 genes in silico." Katoh M., Katoh M. Int. J. Mol. Med. 13:749-754(2004) [PubMed: 15067381] [Abstract] Cited for: IDENTIFICATION.
[8]	"Solution structure of the second SH3 domain of human KIAA0769 protein." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 464-530 AND 569-628.

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Cross-references

Sequence databases

AB018312 mRNA. Translation: BAA34489.2. Different initiation.
AP002381 Genomic DNA. No translation available.
AP002455 Genomic DNA. No translation available.
AP004241 Genomic DNA. No translation available.
BC010394 mRNA. Translation: AAH10394.1.
BC017751 mRNA. Translation: AAH17751.1.
AL133567 mRNA. Translation: CAB63720.1.

PIR

T43489.

RefSeq

NP_055639.2.

UniGene

Hs.577053

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DL5	NMR	-	A	464-530	[»]
2DL7	NMR	-	A	569-628	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

O94868.

PTM databases

PhosphoSite

O94868.

Genome annotation databases

Ensembl

ENSG00000137478. Homo sapiens. [Contig view]

GeneID

9873.

KEGG

hsa:9873.

Organism-specific databases

HGNC

HGNC:29114. FCHSD2.

PharmGKB

PA128394562.

HUGE

Search...

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOVERGEN

O94868.

Gene expression databases

ArrayExpress

O94868.

CleanEx

HS_FCHSD2.

Family and domain databases

InterPro

IPR001060. Cdc15_Fes_CIP4.
IPR001452. SH3.
[Graphical view]

Pfam

PF00611. FCH. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]

PRINTS

PR00452. SH3DOMAIN.

ProDom

PD000066. SH3. 2 hits.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00326. SH3. 2 hits.
[Graphical view]

PROSITE

PS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

37215.

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Entry information

Entry name

FCSD2_HUMAN

Accession

Primary (citable) accession number: O94868
Secondary accession number(s): Q7L8J9

Q9UF77

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	November 25, 2008
This is version 52 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents