O94868 (FCSD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FCH and double SH3 domains protein 2

Alternative name(s):
Carom
SH3 multiple domains protein 3

Gene names

Name:	FCHSD2
Synonyms:	KIAA0769, SH3MD3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	740 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with CASK and MAGI1. CASK inhibits interaction with MAGI1. Ref.1
Tissue specificity	Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney. Ref.1
Sequence similarities	Contains 1 FCH domain. Contains 2 SH3 domains.
Sequence caution	The sequence BAA34489.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat SH3 domain
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Cask	Q62915	2	EBI-1215612,EBI-704635	From a different organism.
MAGI1	Q96QZ7	5	EBI-1215612,EBI-924464
VCP	P55072	2	EBI-1215612,EBI-355164

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O94868-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O94868-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Isoform 3 (identifier: O94868-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     569-571: VCF → GKD
     572-740: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 740

740

FCH and double SH3 domains protein 2

PRO_0000278214

Regions

Domain

8 – 74

67

FCH

Domain

469 – 530

62

SH3 1

Domain

567 – 629

63

SH3 2

Coiled coil

356 – 397

42

Potential

Compositional bias

718 – 721

4

Poly-Pro

Amino acid modifications

Modified residue

683

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 56

56

Missing in isoform 2 and isoform 3.

VSP_023167

Alternative sequence

569 – 571

3

VCF → GKD in isoform 3.

VSP_023168

Alternative sequence

572 – 740

169

Missing in isoform 3.

VSP_023169

Secondary structure

1

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740

Helix Strand Turn

Details...

Beta strand

470 – 476

7

Beta strand

492 – 500

9

Beta strand

503 – 511

9

Beta strand

517 – 521

5

Turn

522 – 524

3

Beta strand

570 – 576

7

Beta strand

593 – 598

6

Beta strand

602 – 606

5

Beta strand

608 – 612

5

Beta strand

615 – 619

5

Beta strand

621 – 626

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 20, 2007. Version 3. Checksum: 3AF4DAC3CAD24C28	FASTA	740	84,276
	10 20 30 40 50 60 MQPPPRKVKV TQELKNIQVE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE REYAQGMQKL 70 80 90 100 110 120 ASQYLKRDWP GVKADDRNDY RSMYPVWKSF LEGTMQVAQS RMNICENYKN FISEPARTVR 130 140 150 160 170 180 SLKEQQLKRC VDQLTKIQTE LQETVKDLAK GKKKYFETEQ MAHAVREKAD IEAKSKLSLF 190 200 210 220 230 240 QSRISLQKAS VKLKARRSEC NSKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN 250 260 270 280 290 300 VYDHLKDYLI AFSRTELETC QAVQNTFQFL LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ 310 320 330 340 350 360 FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN DLECHGAAVS 370 380 390 400 410 420 EQSRAELEQK IDEARENIRK AEIIKLKAEA RLDLLKQIGV SVDTWLKSAM NQVMEELENE 430 440 450 460 470 480 RWARPPAVTS NGTLHSLNAD TEREEGEEFE DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY 490 500 510 520 530 540 KASQPDELTI EEHEVLEVIE DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL 550 560 570 580 590 600 AALDSRSHTS SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE 610 620 630 640 650 660 NQDDDGFWEG EFNGRIGVFP SVLVEELSAS ENGDTPWMRE IQISPSPKPH ASLPPLPLYD 670 680 690 700 710 720 QPPSSPYPSP DKRSSLYFPR SPSANEKSLH AESPGFSQAS RHTPETSYGK LRPVRAAPPP 730 740 PTQNHRRPAE KIEDVEITLV
	Isoform 2 [UniParc]. Checksum: FB03BEEB29F8D78F	FASTA	684	77,752
	10 20 30 40 50 60 MQKLASQYLK RDWPGVKADD RNDYRSMYPV WKSFLEGTMQ VAQSRMNICE NYKNFISEPA 70 80 90 100 110 120 RTVRSLKEQQ LKRCVDQLTK IQTELQETVK DLAKGKKKYF ETEQMAHAVR EKADIEAKSK 130 140 150 160 170 180 LSLFQSRISL QKASVKLKAR RSECNSKATH ARNDYLLTLA AANAHQDRYY QTDLVNIMKA 190 200 210 220 230 240 LDGNVYDHLK DYLIAFSRTE LETCQAVQNT FQFLLENSSK VVRDYNLQLF LQENAVFHKP 250 260 270 280 290 300 QPFQFQPCDS DTSRQLESET GTTEEHSLNK EARKWATRVA REHKNIVHQQ RVLNDLECHG 310 320 330 340 350 360 AAVSEQSRAE LEQKIDEARE NIRKAEIIKL KAEARLDLLK QIGVSVDTWL KSAMNQVMEE 370 380 390 400 410 420 LENERWARPP AVTSNGTLHS LNADTEREEG EEFEDNMDVF DDSSSSPSGT LRNYPLTCKV 430 440 450 460 470 480 VYSYKASQPD ELTIEEHEVL EVIEDGDMED WVKARNKVGQ VGYVPEKYLQ FPTSNSLLSM 490 500 510 520 530 540 LQSLAALDSR SHTSSNSTEA ELVSGSLNGD ASVCFVKALY DYEGQTDDEL SFPEGAIIRI 550 560 570 580 590 600 LNKENQDDDG FWEGEFNGRI GVFPSVLVEE LSASENGDTP WMREIQISPS PKPHASLPPL 610 620 630 640 650 660 PLYDQPPSSP YPSPDKRSSL YFPRSPSANE KSLHAESPGF SQASRHTPET SYGKLRPVRA 670 680 APPPPTQNHR RPAEKIEDVE ITLV
	Isoform 3 [UniParc]. Checksum: 4243B84AF4CE48C3	FASTA	515	58,886
	10 20 30 40 50 60 MQKLASQYLK RDWPGVKADD RNDYRSMYPV WKSFLEGTMQ VAQSRMNICE NYKNFISEPA 70 80 90 100 110 120 RTVRSLKEQQ LKRCVDQLTK IQTELQETVK DLAKGKKKYF ETEQMAHAVR EKADIEAKSK 130 140 150 160 170 180 LSLFQSRISL QKASVKLKAR RSECNSKATH ARNDYLLTLA AANAHQDRYY QTDLVNIMKA 190 200 210 220 230 240 LDGNVYDHLK DYLIAFSRTE LETCQAVQNT FQFLLENSSK VVRDYNLQLF LQENAVFHKP 250 260 270 280 290 300 QPFQFQPCDS DTSRQLESET GTTEEHSLNK EARKWATRVA REHKNIVHQQ RVLNDLECHG 310 320 330 340 350 360 AAVSEQSRAE LEQKIDEARE NIRKAEIIKL KAEARLDLLK QIGVSVDTWL KSAMNQVMEE 370 380 390 400 410 420 LENERWARPP AVTSNGTLHS LNADTEREEG EEFEDNMDVF DDSSSSPSGT LRNYPLTCKV 430 440 450 460 470 480 VYSYKASQPD ELTIEEHEVL EVIEDGDMED WVKARNKVGQ VGYVPEKYLQ FPTSNSLLSM 490 500 510 LQSLAALDSR SHTSSNSTEA ELVSGSLNGD ASGKD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains." Ohno H., Hirabayashi S., Kansaku A., Yao I., Tajima M., Nishimura W., Ohnishi H., Mashima H., Fujita T., Omata M., Hata Y. Oncogene 22:8422-8431(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH CASK AND MAGI1. Tissue: Lung.
[2]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	Okazaki N., Kikuno R.F., Nagase T., Ohara O., Koga H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Bone marrow and Kidney.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 138-740. Tissue: Testis.
[8]	"Identification and characterization of human FCHSD1 and FCHSD2 genes in silico." Katoh M., Katoh M. Int. J. Mol. Med. 13:749-754(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[9]	"Solution structure of the second SH3 domain of human KIAA0769 protein." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 464-530 AND 569-628.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB018312 mRNA. Translation: BAA34489.2. Different initiation.
AP002381 Genomic DNA. No translation available.
AP002455 Genomic DNA. No translation available.
AK297928 mRNA. Translation: BAG60245.1.
AP004241 Genomic DNA. No translation available.
BC010394 mRNA. Translation: AAH10394.1.
BC017751 mRNA. Translation: AAH17751.1.
AL133567 mRNA. Translation: CAB63720.1.

IPI

IPI00410639.
IPI00827702.
IPI00828164.

PIR

T43489.

RefSeq

NP_055639.2. NM_014824.2.

UniGene

Hs.577053.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DL5	NMR	-	A	464-530	[»]
2DL7	NMR	-	A	569-628	[»]

ProteinModelPortal

O94868.

ModBase

Search...

Protein-protein interaction databases

IntAct

O94868. 21 interactions.

MINT

MINT-1790472.

STRING

9606.ENSP00000386722.

PTM databases

PhosphoSite

O94868.

Proteomic databases

PaxDb

O94868.

PRIDE

O94868.

Protocols and materials databases

DNASU

9873.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000311172; ENSP00000308978; ENSG00000137478.
ENST00000409418; ENSP00000386722; ENSG00000137478.
ENST00000409853; ENSP00000386314; ENSG00000137478.

GeneID

9873.

KEGG

hsa:9873.

UCSC

uc001oth.4. human.
uc001oti.2. human.

Organism-specific databases

CTD

9873.

GeneCards

GC11M072547.

H-InvDB

HIX0019675.

HGNC

HGNC:29114. FCHSD2.

HPA

HPA038546.

neXtProt

NX_O94868.

PharmGKB

PA128394562.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG327979.

HOGENOM

HOG000046016.

HOVERGEN

HBG063540.

Gene expression databases

ArrayExpress

O94868.

Bgee

O94868.

CleanEx

HS_FCHSD2.

Genevestigator

O94868.

Family and domain databases

InterPro

IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]

Pfam

PF00611. FCH. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]

PRINTS

PR00452. SH3DOMAIN.

SMART

SM00326. SH3. 2 hits.
[Graphical view]

SUPFAM

SSF50044. SH3. 2 hits.

PROSITE

PS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

FCHSD2. human.

EvolutionaryTrace

O94868.

GenomeRNAi

9873.

NextBio

37215.

Entry information

Entry name

FCSD2_HUMAN

Accession

Primary (citable) accession number: O94868
Secondary accession number(s): B4DNI3 , Q7L8J9, Q8WVM2, Q96FV7, Q9UF77

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 91 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.