Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O94868 (FCSD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FCH and double SH3 domains protein 2
Alternative name(s):
Carom
SH3 multiple domains protein 3
Gene names
Name:FCHSD2
Synonyms:KIAA0769, SH3MD3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length740 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with CASK and MAGI1. CASK inhibits interaction with MAGI1. Ref.1

Tissue specificity

Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney. Ref.1

Sequence similarities

Contains 1 FCH domain.

Contains 2 SH3 domains.

Sequence caution

The sequence BAA34489.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Repeat
SH3 domain
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionprotein binding

Inferred from physical interaction Ref.1PubMed 18654987. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CaskQ629152EBI-1215612,EBI-704635From a different organism.
MAGI1Q96QZ75EBI-1215612,EBI-924464
VCPP550722EBI-1215612,EBI-355164

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O94868-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O94868-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
Isoform 3 (identifier: O94868-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     569-571: VCF → GKD
     572-740: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 740740FCH and double SH3 domains protein 2
PRO_0000278214

Regions

Domain8 – 7467FCH
Domain469 – 53062SH3 1
Domain567 – 62963SH3 2
Coiled coil356 – 39742 Potential
Compositional bias718 – 7214Poly-Pro

Natural variations

Alternative sequence1 – 5656Missing in isoform 2 and isoform 3.
VSP_023167
Alternative sequence569 – 5713VCF → GKD in isoform 3.
VSP_023168
Alternative sequence572 – 740169Missing in isoform 3.
VSP_023169

Secondary structure

...................... 740
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 3.
Checksum: 3AF4DAC3CAD24C28

FASTA74084,276
        10         20         30         40         50         60 
MQPPPRKVKV TQELKNIQVE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE REYAQGMQKL 

        70         80         90        100        110        120 
ASQYLKRDWP GVKADDRNDY RSMYPVWKSF LEGTMQVAQS RMNICENYKN FISEPARTVR 

       130        140        150        160        170        180 
SLKEQQLKRC VDQLTKIQTE LQETVKDLAK GKKKYFETEQ MAHAVREKAD IEAKSKLSLF 

       190        200        210        220        230        240 
QSRISLQKAS VKLKARRSEC NSKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN 

       250        260        270        280        290        300 
VYDHLKDYLI AFSRTELETC QAVQNTFQFL LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ 

       310        320        330        340        350        360 
FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN DLECHGAAVS 

       370        380        390        400        410        420 
EQSRAELEQK IDEARENIRK AEIIKLKAEA RLDLLKQIGV SVDTWLKSAM NQVMEELENE 

       430        440        450        460        470        480 
RWARPPAVTS NGTLHSLNAD TEREEGEEFE DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY 

       490        500        510        520        530        540 
KASQPDELTI EEHEVLEVIE DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL 

       550        560        570        580        590        600 
AALDSRSHTS SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE 

       610        620        630        640        650        660 
NQDDDGFWEG EFNGRIGVFP SVLVEELSAS ENGDTPWMRE IQISPSPKPH ASLPPLPLYD 

       670        680        690        700        710        720 
QPPSSPYPSP DKRSSLYFPR SPSANEKSLH AESPGFSQAS RHTPETSYGK LRPVRAAPPP 

       730        740 
PTQNHRRPAE KIEDVEITLV 

« Hide

Isoform 2 [UniParc].

Checksum: FB03BEEB29F8D78F
Show »

FASTA68477,752
Isoform 3 [UniParc].

Checksum: 4243B84AF4CE48C3
Show »

FASTA51558,886

References

« Hide 'large scale' references
[1]"Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains."
Ohno H., Hirabayashi S., Kansaku A., Yao I., Tajima M., Nishimura W., Ohnishi H., Mashima H., Fujita T., Omata M., Hata Y.
Oncogene 22:8422-8431(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH CASK AND MAGI1.
Tissue: Lung.
[2]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]Okazaki N., Kikuno R.F., Nagase T., Ohara O., Koga H.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Bone marrow and Kidney.
[7]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 138-740.
Tissue: Testis.
[8]"Identification and characterization of human FCHSD1 and FCHSD2 genes in silico."
Katoh M., Katoh M.
Int. J. Mol. Med. 13:749-754(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[9]"Solution structure of the second SH3 domain of human KIAA0769 protein."
RIKEN structural genomics initiative (RSGI)
Submitted (OCT-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 464-530 AND 569-628.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB018312 mRNA. Translation: BAA34489.2. Different initiation.
AP002381 Genomic DNA. No translation available.
AP002455 Genomic DNA. No translation available.
AK297928 mRNA. Translation: BAG60245.1.
AP004241 Genomic DNA. No translation available.
BC010394 mRNA. Translation: AAH10394.1.
BC017751 mRNA. Translation: AAH17751.1.
AL133567 mRNA. Translation: CAB63720.1.
CCDSCCDS8218.2. [O94868-1]
PIRT43489.
RefSeqNP_055639.2. NM_014824.2. [O94868-1]
UniGeneHs.744959.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DL5NMR-A466-530[»]
2DL7NMR-A569-628[»]
ProteinModelPortalO94868.
SMRO94868. Positions 460-531, 564-629.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115205. 24 interactions.
IntActO94868. 23 interactions.
MINTMINT-1790472.
STRING9606.ENSP00000386722.

PTM databases

PhosphoSiteO94868.

Proteomic databases

MaxQBO94868.
PaxDbO94868.
PRIDEO94868.

Protocols and materials databases

DNASU9873.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311172; ENSP00000308978; ENSG00000137478. [O94868-2]
ENST00000409418; ENSP00000386722; ENSG00000137478. [O94868-1]
ENST00000409853; ENSP00000386314; ENSG00000137478. [O94868-3]
GeneID9873.
KEGGhsa:9873.
UCSCuc001oth.4. human. [O94868-1]
uc001oti.2. human. [O94868-3]

Organism-specific databases

CTD9873.
GeneCardsGC11M072547.
H-InvDBHIX0019675.
HGNCHGNC:29114. FCHSD2.
HPAHPA038546.
neXtProtNX_O94868.
PharmGKBPA128394562.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327979.
HOGENOMHOG000046016.
HOVERGENHBG063540.
OrthoDBEOG722J81.
PhylomeDBO94868.
TreeFamTF324557.

Gene expression databases

ArrayExpressO94868.
BgeeO94868.
CleanExHS_FCHSD2.
GenevestigatorO94868.

Family and domain databases

InterProIPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
SMARTSM00326. SH3. 2 hits.
[Graphical view]
SUPFAMSSF50044. SSF50044. 2 hits.
PROSITEPS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFCHSD2. human.
EvolutionaryTraceO94868.
GeneWikiFCHSD2.
GenomeRNAi9873.
NextBio37215.
PROO94868.

Entry information

Entry nameFCSD2_HUMAN
AccessionPrimary (citable) accession number: O94868
Secondary accession number(s): B4DNI3 expand/collapse secondary AC list , Q7L8J9, Q8WVM2, Q96FV7, Q9UF77
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM