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O94868

- FCSD2_HUMAN

UniProt

O94868 - FCSD2_HUMAN

Protein

FCH and double SH3 domains protein 2

Gene

FCHSD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FCH and double SH3 domains protein 2
    Alternative name(s):
    Carom
    SH3 multiple domains protein 3
    Gene namesi
    Name:FCHSD2
    Synonyms:KIAA0769, SH3MD3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:29114. FCHSD2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394562.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 740740FCH and double SH3 domains protein 2PRO_0000278214Add
    BLAST

    Proteomic databases

    MaxQBiO94868.
    PaxDbiO94868.
    PRIDEiO94868.

    PTM databases

    PhosphoSiteiO94868.

    Expressioni

    Tissue specificityi

    Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney.1 Publication

    Gene expression databases

    ArrayExpressiO94868.
    BgeeiO94868.
    CleanExiHS_FCHSD2.
    GenevestigatoriO94868.

    Organism-specific databases

    HPAiHPA038546.

    Interactioni

    Subunit structurei

    Interacts with CASK and MAGI1. CASK inhibits interaction with MAGI1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CaskQ629152EBI-1215612,EBI-704635From a different organism.
    MAGI1Q96QZ75EBI-1215612,EBI-924464
    VCPP550722EBI-1215612,EBI-355164

    Protein-protein interaction databases

    BioGridi115205. 25 interactions.
    IntActiO94868. 23 interactions.
    MINTiMINT-1790472.
    STRINGi9606.ENSP00000386722.

    Structurei

    Secondary structure

    1
    740
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi470 – 4767
    Beta strandi492 – 5009
    Beta strandi503 – 5119
    Beta strandi517 – 5215
    Turni522 – 5243
    Beta strandi570 – 5767
    Beta strandi593 – 5986
    Beta strandi602 – 6065
    Beta strandi608 – 6125
    Beta strandi615 – 6195
    Beta strandi621 – 6266

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DL5NMR-A466-530[»]
    2DL7NMR-A569-628[»]
    ProteinModelPortaliO94868.
    SMRiO94868. Positions 460-531, 564-629.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO94868.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 7467FCHPROSITE-ProRule annotationAdd
    BLAST
    Domaini469 – 53062SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini567 – 62963SH3 2PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili356 – 39742Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi718 – 7214Poly-Pro

    Sequence similaritiesi

    Contains 1 FCH domain.PROSITE-ProRule annotation
    Contains 2 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG327979.
    HOGENOMiHOG000046016.
    HOVERGENiHBG063540.
    OrthoDBiEOG722J81.
    PhylomeDBiO94868.
    TreeFamiTF324557.

    Family and domain databases

    InterProiIPR001060. FCH_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00611. FCH. 1 hit.
    PF00018. SH3_1. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 2 hits.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    PROSITEiPS50133. FCH. 1 hit.
    PS50002. SH3. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O94868-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQPPPRKVKV TQELKNIQVE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE    50
    REYAQGMQKL ASQYLKRDWP GVKADDRNDY RSMYPVWKSF LEGTMQVAQS 100
    RMNICENYKN FISEPARTVR SLKEQQLKRC VDQLTKIQTE LQETVKDLAK 150
    GKKKYFETEQ MAHAVREKAD IEAKSKLSLF QSRISLQKAS VKLKARRSEC 200
    NSKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN VYDHLKDYLI 250
    AFSRTELETC QAVQNTFQFL LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ 300
    FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN 350
    DLECHGAAVS EQSRAELEQK IDEARENIRK AEIIKLKAEA RLDLLKQIGV 400
    SVDTWLKSAM NQVMEELENE RWARPPAVTS NGTLHSLNAD TEREEGEEFE 450
    DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY KASQPDELTI EEHEVLEVIE 500
    DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL AALDSRSHTS 550
    SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE 600
    NQDDDGFWEG EFNGRIGVFP SVLVEELSAS ENGDTPWMRE IQISPSPKPH 650
    ASLPPLPLYD QPPSSPYPSP DKRSSLYFPR SPSANEKSLH AESPGFSQAS 700
    RHTPETSYGK LRPVRAAPPP PTQNHRRPAE KIEDVEITLV 740
    Length:740
    Mass (Da):84,276
    Last modified:February 20, 2007 - v3
    Checksum:i3AF4DAC3CAD24C28
    GO
    Isoform 2 (identifier: O94868-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-56: Missing.

    Show »
    Length:684
    Mass (Da):77,752
    Checksum:iFB03BEEB29F8D78F
    GO
    Isoform 3 (identifier: O94868-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-56: Missing.
         569-571: VCF → GKD
         572-740: Missing.

    Show »
    Length:515
    Mass (Da):58,886
    Checksum:i4243B84AF4CE48C3
    GO

    Sequence cautioni

    The sequence BAA34489.2 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5656Missing in isoform 2 and isoform 3. 3 PublicationsVSP_023167Add
    BLAST
    Alternative sequencei569 – 5713VCF → GKD in isoform 3. 1 PublicationVSP_023168
    Alternative sequencei572 – 740169Missing in isoform 3. 1 PublicationVSP_023169Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018312 mRNA. Translation: BAA34489.2. Different initiation.
    AP002381 Genomic DNA. No translation available.
    AP002455 Genomic DNA. No translation available.
    AK297928 mRNA. Translation: BAG60245.1.
    AP004241 Genomic DNA. No translation available.
    BC010394 mRNA. Translation: AAH10394.1.
    BC017751 mRNA. Translation: AAH17751.1.
    AL133567 mRNA. Translation: CAB63720.1.
    CCDSiCCDS8218.2. [O94868-1]
    PIRiT43489.
    RefSeqiNP_055639.2. NM_014824.2. [O94868-1]
    UniGeneiHs.744959.

    Genome annotation databases

    EnsembliENST00000311172; ENSP00000308978; ENSG00000137478. [O94868-2]
    ENST00000409418; ENSP00000386722; ENSG00000137478. [O94868-1]
    ENST00000409853; ENSP00000386314; ENSG00000137478. [O94868-3]
    GeneIDi9873.
    KEGGihsa:9873.
    UCSCiuc001oth.4. human. [O94868-1]
    uc001oti.2. human. [O94868-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018312 mRNA. Translation: BAA34489.2 . Different initiation.
    AP002381 Genomic DNA. No translation available.
    AP002455 Genomic DNA. No translation available.
    AK297928 mRNA. Translation: BAG60245.1 .
    AP004241 Genomic DNA. No translation available.
    BC010394 mRNA. Translation: AAH10394.1 .
    BC017751 mRNA. Translation: AAH17751.1 .
    AL133567 mRNA. Translation: CAB63720.1 .
    CCDSi CCDS8218.2. [O94868-1 ]
    PIRi T43489.
    RefSeqi NP_055639.2. NM_014824.2. [O94868-1 ]
    UniGenei Hs.744959.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DL5 NMR - A 466-530 [» ]
    2DL7 NMR - A 569-628 [» ]
    ProteinModelPortali O94868.
    SMRi O94868. Positions 460-531, 564-629.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115205. 25 interactions.
    IntActi O94868. 23 interactions.
    MINTi MINT-1790472.
    STRINGi 9606.ENSP00000386722.

    PTM databases

    PhosphoSitei O94868.

    Proteomic databases

    MaxQBi O94868.
    PaxDbi O94868.
    PRIDEi O94868.

    Protocols and materials databases

    DNASUi 9873.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311172 ; ENSP00000308978 ; ENSG00000137478 . [O94868-2 ]
    ENST00000409418 ; ENSP00000386722 ; ENSG00000137478 . [O94868-1 ]
    ENST00000409853 ; ENSP00000386314 ; ENSG00000137478 . [O94868-3 ]
    GeneIDi 9873.
    KEGGi hsa:9873.
    UCSCi uc001oth.4. human. [O94868-1 ]
    uc001oti.2. human. [O94868-3 ]

    Organism-specific databases

    CTDi 9873.
    GeneCardsi GC11M072547.
    H-InvDB HIX0019675.
    HGNCi HGNC:29114. FCHSD2.
    HPAi HPA038546.
    neXtProti NX_O94868.
    PharmGKBi PA128394562.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327979.
    HOGENOMi HOG000046016.
    HOVERGENi HBG063540.
    OrthoDBi EOG722J81.
    PhylomeDBi O94868.
    TreeFami TF324557.

    Miscellaneous databases

    ChiTaRSi FCHSD2. human.
    EvolutionaryTracei O94868.
    GeneWikii FCHSD2.
    GenomeRNAii 9873.
    NextBioi 37215.
    PROi O94868.

    Gene expression databases

    ArrayExpressi O94868.
    Bgeei O94868.
    CleanExi HS_FCHSD2.
    Genevestigatori O94868.

    Family and domain databases

    InterProi IPR001060. FCH_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00611. FCH. 1 hit.
    PF00018. SH3_1. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    PROSITEi PS50133. FCH. 1 hit.
    PS50002. SH3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains."
      Ohno H., Hirabayashi S., Kansaku A., Yao I., Tajima M., Nishimura W., Ohnishi H., Mashima H., Fujita T., Omata M., Hata Y.
      Oncogene 22:8422-8431(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH CASK AND MAGI1.
      Tissue: Lung.
    2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. Okazaki N., Kikuno R.F., Nagase T., Ohara O., Koga H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Bone marrow and Kidney.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 138-740.
      Tissue: Testis.
    8. "Identification and characterization of human FCHSD1 and FCHSD2 genes in silico."
      Katoh M., Katoh M.
      Int. J. Mol. Med. 13:749-754(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    9. "Solution structure of the second SH3 domain of human KIAA0769 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 464-530 AND 569-628.

    Entry informationi

    Entry nameiFCSD2_HUMAN
    AccessioniPrimary (citable) accession number: O94868
    Secondary accession number(s): B4DNI3
    , Q7L8J9, Q8WVM2, Q96FV7, Q9UF77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3