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Protein

F-BAR and double SH3 domains protein 2

Gene

FCHSD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137478-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
F-BAR and double SH3 domains protein 2
Alternative name(s):
Carom
SH3 multiple domains protein 3
Gene namesi
Name:FCHSD2
Synonyms:KIAA0769, SH3MD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29114. FCHSD2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi9873.
OpenTargetsiENSG00000137478.
PharmGKBiPA128394562.

Polymorphism and mutation databases

BioMutaiFCHSD2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002782141 – 740F-BAR and double SH3 domains protein 2Add BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei675PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO94868.
MaxQBiO94868.
PaxDbiO94868.
PeptideAtlasiO94868.
PRIDEiO94868.

PTM databases

iPTMnetiO94868.
PhosphoSitePlusiO94868.

Expressioni

Tissue specificityi

Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney.1 Publication

Gene expression databases

BgeeiENSG00000137478.
CleanExiHS_FCHSD2.
ExpressionAtlasiO94868. baseline and differential.
GenevisibleiO94868. HS.

Organism-specific databases

HPAiHPA038545.
HPA038546.

Interactioni

Subunit structurei

Interacts with CASK and MAGI1. CASK inhibits interaction with MAGI1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ABCF3Q9NUQ83EBI-1215612,EBI-717672
CaskQ629152EBI-1215612,EBI-704635From a different organism.
FAM9BQ8IZU03EBI-1215612,EBI-10175124
KIFC3Q9BVG83EBI-1215612,EBI-2125614
MAGI1Q96QZ75EBI-1215612,EBI-924464
MTUS2Q5JR594EBI-1215612,EBI-742948
VCPP550722EBI-1215612,EBI-355164

Protein-protein interaction databases

BioGridi115205. 30 interactors.
IntActiO94868. 35 interactors.
MINTiMINT-1790472.
STRINGi9606.ENSP00000386722.

Structurei

Secondary structure

1740
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi470 – 476Combined sources7
Beta strandi492 – 500Combined sources9
Beta strandi503 – 511Combined sources9
Beta strandi517 – 521Combined sources5
Turni522 – 524Combined sources3
Beta strandi570 – 576Combined sources7
Beta strandi593 – 598Combined sources6
Beta strandi602 – 606Combined sources5
Beta strandi608 – 612Combined sources5
Beta strandi615 – 619Combined sources5
Beta strandi621 – 626Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DL5NMR-A466-530[»]
2DL7NMR-A569-628[»]
ProteinModelPortaliO94868.
SMRiO94868.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94868.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 282F-BARPROSITE-ProRule annotationAdd BLAST275
Domaini469 – 530SH3 1PROSITE-ProRule annotationAdd BLAST62
Domaini567 – 629SH3 2PROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili356 – 397Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi718 – 721Poly-Pro4

Sequence similaritiesi

Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410INNZ. Eukaryota.
ENOG410XSX6. LUCA.
GeneTreeiENSGT00510000046732.
HOGENOMiHOG000046016.
HOVERGENiHBG063540.
InParanoidiO94868.
KOiK20125.
PhylomeDBiO94868.
TreeFamiTF324557.

Family and domain databases

InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00055. FCH. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51741. F_BAR. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94868-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPPPRKVKV TQELKNIQVE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE
60 70 80 90 100
REYAQGMQKL ASQYLKRDWP GVKADDRNDY RSMYPVWKSF LEGTMQVAQS
110 120 130 140 150
RMNICENYKN FISEPARTVR SLKEQQLKRC VDQLTKIQTE LQETVKDLAK
160 170 180 190 200
GKKKYFETEQ MAHAVREKAD IEAKSKLSLF QSRISLQKAS VKLKARRSEC
210 220 230 240 250
NSKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN VYDHLKDYLI
260 270 280 290 300
AFSRTELETC QAVQNTFQFL LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ
310 320 330 340 350
FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN
360 370 380 390 400
DLECHGAAVS EQSRAELEQK IDEARENIRK AEIIKLKAEA RLDLLKQIGV
410 420 430 440 450
SVDTWLKSAM NQVMEELENE RWARPPAVTS NGTLHSLNAD TEREEGEEFE
460 470 480 490 500
DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY KASQPDELTI EEHEVLEVIE
510 520 530 540 550
DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL AALDSRSHTS
560 570 580 590 600
SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE
610 620 630 640 650
NQDDDGFWEG EFNGRIGVFP SVLVEELSAS ENGDTPWMRE IQISPSPKPH
660 670 680 690 700
ASLPPLPLYD QPPSSPYPSP DKRSSLYFPR SPSANEKSLH AESPGFSQAS
710 720 730 740
RHTPETSYGK LRPVRAAPPP PTQNHRRPAE KIEDVEITLV
Length:740
Mass (Da):84,276
Last modified:February 20, 2007 - v3
Checksum:i3AF4DAC3CAD24C28
GO
Isoform 2 (identifier: O94868-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Show »
Length:684
Mass (Da):77,752
Checksum:iFB03BEEB29F8D78F
GO
Isoform 3 (identifier: O94868-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     569-571: VCF → GKD
     572-740: Missing.

Show »
Length:515
Mass (Da):58,886
Checksum:i4243B84AF4CE48C3
GO

Sequence cautioni

The sequence BAA34489 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0231671 – 56Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST56
Alternative sequenceiVSP_023168569 – 571VCF → GKD in isoform 3. 1 Publication3
Alternative sequenceiVSP_023169572 – 740Missing in isoform 3. 1 PublicationAdd BLAST169

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018312 mRNA. Translation: BAA34489.2. Different initiation.
AP002381 Genomic DNA. No translation available.
AP002455 Genomic DNA. No translation available.
AK297928 mRNA. Translation: BAG60245.1.
AP004241 Genomic DNA. No translation available.
BC010394 mRNA. Translation: AAH10394.1.
BC017751 mRNA. Translation: AAH17751.1.
AL133567 mRNA. Translation: CAB63720.1.
CCDSiCCDS8218.2. [O94868-1]
PIRiT43489.
RefSeqiNP_055639.2. NM_014824.2. [O94868-1]
UniGeneiHs.744959.

Genome annotation databases

EnsembliENST00000311172; ENSP00000308978; ENSG00000137478. [O94868-2]
ENST00000409418; ENSP00000386722; ENSG00000137478. [O94868-1]
ENST00000409853; ENSP00000386314; ENSG00000137478. [O94868-3]
GeneIDi9873.
KEGGihsa:9873.
UCSCiuc001oth.5. human. [O94868-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018312 mRNA. Translation: BAA34489.2. Different initiation.
AP002381 Genomic DNA. No translation available.
AP002455 Genomic DNA. No translation available.
AK297928 mRNA. Translation: BAG60245.1.
AP004241 Genomic DNA. No translation available.
BC010394 mRNA. Translation: AAH10394.1.
BC017751 mRNA. Translation: AAH17751.1.
AL133567 mRNA. Translation: CAB63720.1.
CCDSiCCDS8218.2. [O94868-1]
PIRiT43489.
RefSeqiNP_055639.2. NM_014824.2. [O94868-1]
UniGeneiHs.744959.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DL5NMR-A466-530[»]
2DL7NMR-A569-628[»]
ProteinModelPortaliO94868.
SMRiO94868.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115205. 30 interactors.
IntActiO94868. 35 interactors.
MINTiMINT-1790472.
STRINGi9606.ENSP00000386722.

PTM databases

iPTMnetiO94868.
PhosphoSitePlusiO94868.

Polymorphism and mutation databases

BioMutaiFCHSD2.

Proteomic databases

EPDiO94868.
MaxQBiO94868.
PaxDbiO94868.
PeptideAtlasiO94868.
PRIDEiO94868.

Protocols and materials databases

DNASUi9873.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311172; ENSP00000308978; ENSG00000137478. [O94868-2]
ENST00000409418; ENSP00000386722; ENSG00000137478. [O94868-1]
ENST00000409853; ENSP00000386314; ENSG00000137478. [O94868-3]
GeneIDi9873.
KEGGihsa:9873.
UCSCiuc001oth.5. human. [O94868-1]

Organism-specific databases

CTDi9873.
DisGeNETi9873.
GeneCardsiFCHSD2.
H-InvDBHIX0019675.
HGNCiHGNC:29114. FCHSD2.
HPAiHPA038545.
HPA038546.
neXtProtiNX_O94868.
OpenTargetsiENSG00000137478.
PharmGKBiPA128394562.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INNZ. Eukaryota.
ENOG410XSX6. LUCA.
GeneTreeiENSGT00510000046732.
HOGENOMiHOG000046016.
HOVERGENiHBG063540.
InParanoidiO94868.
KOiK20125.
PhylomeDBiO94868.
TreeFamiTF324557.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137478-MONOMER.

Miscellaneous databases

ChiTaRSiFCHSD2. human.
EvolutionaryTraceiO94868.
GeneWikiiFCHSD2.
GenomeRNAii9873.
PROiO94868.

Gene expression databases

BgeeiENSG00000137478.
CleanExiHS_FCHSD2.
ExpressionAtlasiO94868. baseline and differential.
GenevisibleiO94868. HS.

Family and domain databases

InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00055. FCH. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51741. F_BAR. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCSD2_HUMAN
AccessioniPrimary (citable) accession number: O94868
Secondary accession number(s): B4DNI3
, Q7L8J9, Q8WVM2, Q96FV7, Q9UF77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.