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Protein

F-BAR and double SH3 domains protein 2

Gene

FCHSD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
F-BAR and double SH3 domains protein 2
Alternative name(s):
Carom
SH3 multiple domains protein 3
Gene namesi
Name:FCHSD2
Synonyms:KIAA0769, SH3MD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29114. FCHSD2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394562.

Polymorphism and mutation databases

BioMutaiFCHSD2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 740740F-BAR and double SH3 domains protein 2PRO_0000278214Add
BLAST

Proteomic databases

MaxQBiO94868.
PaxDbiO94868.
PRIDEiO94868.

PTM databases

PhosphoSiteiO94868.

Expressioni

Tissue specificityi

Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney.1 Publication

Gene expression databases

BgeeiO94868.
CleanExiHS_FCHSD2.
ExpressionAtlasiO94868. baseline and differential.
GenevestigatoriO94868.

Organism-specific databases

HPAiHPA038545.
HPA038546.

Interactioni

Subunit structurei

Interacts with CASK and MAGI1. CASK inhibits interaction with MAGI1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ABCF3Q9NUQ83EBI-1215612,EBI-717672
CaskQ629152EBI-1215612,EBI-704635From a different organism.
FAM9BQ8IZU03EBI-1215612,EBI-10175124
KIFC3Q9BVG83EBI-1215612,EBI-2125614
MAGI1Q96QZ75EBI-1215612,EBI-924464
MTUS2Q5JR594EBI-1215612,EBI-742948
VCPP550722EBI-1215612,EBI-355164

Protein-protein interaction databases

BioGridi115205. 30 interactions.
IntActiO94868. 26 interactions.
MINTiMINT-1790472.
STRINGi9606.ENSP00000386722.

Structurei

Secondary structure

1
740
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi470 – 4767Combined sources
Beta strandi492 – 5009Combined sources
Beta strandi503 – 5119Combined sources
Beta strandi517 – 5215Combined sources
Turni522 – 5243Combined sources
Beta strandi570 – 5767Combined sources
Beta strandi593 – 5986Combined sources
Beta strandi602 – 6065Combined sources
Beta strandi608 – 6125Combined sources
Beta strandi615 – 6195Combined sources
Beta strandi621 – 6266Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DL5NMR-A466-530[»]
2DL7NMR-A569-628[»]
ProteinModelPortaliO94868.
SMRiO94868. Positions 460-531, 564-629.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94868.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 282275F-BARPROSITE-ProRule annotationAdd
BLAST
Domaini469 – 53062SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini567 – 62963SH3 2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili356 – 39742Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi718 – 7214Poly-Pro

Sequence similaritiesi

Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG327979.
GeneTreeiENSGT00510000046732.
HOGENOMiHOG000046016.
HOVERGENiHBG063540.
InParanoidiO94868.
OrthoDBiEOG722J81.
PhylomeDBiO94868.
TreeFamiTF324557.

Family and domain databases

InterProiIPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51741. F_BAR. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94868-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPPPRKVKV TQELKNIQVE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE
60 70 80 90 100
REYAQGMQKL ASQYLKRDWP GVKADDRNDY RSMYPVWKSF LEGTMQVAQS
110 120 130 140 150
RMNICENYKN FISEPARTVR SLKEQQLKRC VDQLTKIQTE LQETVKDLAK
160 170 180 190 200
GKKKYFETEQ MAHAVREKAD IEAKSKLSLF QSRISLQKAS VKLKARRSEC
210 220 230 240 250
NSKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN VYDHLKDYLI
260 270 280 290 300
AFSRTELETC QAVQNTFQFL LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ
310 320 330 340 350
FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN
360 370 380 390 400
DLECHGAAVS EQSRAELEQK IDEARENIRK AEIIKLKAEA RLDLLKQIGV
410 420 430 440 450
SVDTWLKSAM NQVMEELENE RWARPPAVTS NGTLHSLNAD TEREEGEEFE
460 470 480 490 500
DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY KASQPDELTI EEHEVLEVIE
510 520 530 540 550
DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL AALDSRSHTS
560 570 580 590 600
SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE
610 620 630 640 650
NQDDDGFWEG EFNGRIGVFP SVLVEELSAS ENGDTPWMRE IQISPSPKPH
660 670 680 690 700
ASLPPLPLYD QPPSSPYPSP DKRSSLYFPR SPSANEKSLH AESPGFSQAS
710 720 730 740
RHTPETSYGK LRPVRAAPPP PTQNHRRPAE KIEDVEITLV
Length:740
Mass (Da):84,276
Last modified:February 20, 2007 - v3
Checksum:i3AF4DAC3CAD24C28
GO
Isoform 2 (identifier: O94868-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Show »
Length:684
Mass (Da):77,752
Checksum:iFB03BEEB29F8D78F
GO
Isoform 3 (identifier: O94868-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     569-571: VCF → GKD
     572-740: Missing.

Show »
Length:515
Mass (Da):58,886
Checksum:i4243B84AF4CE48C3
GO

Sequence cautioni

The sequence BAA34489.2 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5656Missing in isoform 2 and isoform 3. 3 PublicationsVSP_023167Add
BLAST
Alternative sequencei569 – 5713VCF → GKD in isoform 3. 1 PublicationVSP_023168
Alternative sequencei572 – 740169Missing in isoform 3. 1 PublicationVSP_023169Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018312 mRNA. Translation: BAA34489.2. Different initiation.
AP002381 Genomic DNA. No translation available.
AP002455 Genomic DNA. No translation available.
AK297928 mRNA. Translation: BAG60245.1.
AP004241 Genomic DNA. No translation available.
BC010394 mRNA. Translation: AAH10394.1.
BC017751 mRNA. Translation: AAH17751.1.
AL133567 mRNA. Translation: CAB63720.1.
CCDSiCCDS8218.2. [O94868-1]
PIRiT43489.
RefSeqiNP_055639.2. NM_014824.2. [O94868-1]
UniGeneiHs.744959.

Genome annotation databases

EnsembliENST00000311172; ENSP00000308978; ENSG00000137478. [O94868-2]
ENST00000409418; ENSP00000386722; ENSG00000137478. [O94868-1]
ENST00000409853; ENSP00000386314; ENSG00000137478. [O94868-3]
GeneIDi9873.
KEGGihsa:9873.
UCSCiuc001oth.4. human. [O94868-1]
uc001oti.2. human. [O94868-3]

Polymorphism and mutation databases

BioMutaiFCHSD2.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018312 mRNA. Translation: BAA34489.2. Different initiation.
AP002381 Genomic DNA. No translation available.
AP002455 Genomic DNA. No translation available.
AK297928 mRNA. Translation: BAG60245.1.
AP004241 Genomic DNA. No translation available.
BC010394 mRNA. Translation: AAH10394.1.
BC017751 mRNA. Translation: AAH17751.1.
AL133567 mRNA. Translation: CAB63720.1.
CCDSiCCDS8218.2. [O94868-1]
PIRiT43489.
RefSeqiNP_055639.2. NM_014824.2. [O94868-1]
UniGeneiHs.744959.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DL5NMR-A466-530[»]
2DL7NMR-A569-628[»]
ProteinModelPortaliO94868.
SMRiO94868. Positions 460-531, 564-629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115205. 30 interactions.
IntActiO94868. 26 interactions.
MINTiMINT-1790472.
STRINGi9606.ENSP00000386722.

PTM databases

PhosphoSiteiO94868.

Polymorphism and mutation databases

BioMutaiFCHSD2.

Proteomic databases

MaxQBiO94868.
PaxDbiO94868.
PRIDEiO94868.

Protocols and materials databases

DNASUi9873.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311172; ENSP00000308978; ENSG00000137478. [O94868-2]
ENST00000409418; ENSP00000386722; ENSG00000137478. [O94868-1]
ENST00000409853; ENSP00000386314; ENSG00000137478. [O94868-3]
GeneIDi9873.
KEGGihsa:9873.
UCSCiuc001oth.4. human. [O94868-1]
uc001oti.2. human. [O94868-3]

Organism-specific databases

CTDi9873.
GeneCardsiGC11M072547.
H-InvDBHIX0019675.
HGNCiHGNC:29114. FCHSD2.
HPAiHPA038545.
HPA038546.
neXtProtiNX_O94868.
PharmGKBiPA128394562.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG327979.
GeneTreeiENSGT00510000046732.
HOGENOMiHOG000046016.
HOVERGENiHBG063540.
InParanoidiO94868.
OrthoDBiEOG722J81.
PhylomeDBiO94868.
TreeFamiTF324557.

Miscellaneous databases

ChiTaRSiFCHSD2. human.
EvolutionaryTraceiO94868.
GeneWikiiFCHSD2.
GenomeRNAii9873.
NextBioi37215.
PROiO94868.

Gene expression databases

BgeeiO94868.
CleanExiHS_FCHSD2.
ExpressionAtlasiO94868. baseline and differential.
GenevestigatoriO94868.

Family and domain databases

InterProiIPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51741. F_BAR. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains."
    Ohno H., Hirabayashi S., Kansaku A., Yao I., Tajima M., Nishimura W., Ohnishi H., Mashima H., Fujita T., Omata M., Hata Y.
    Oncogene 22:8422-8431(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH CASK AND MAGI1.
    Tissue: Lung.
  2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. Okazaki N., Kikuno R.F., Nagase T., Ohara O., Koga H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Bone marrow and Kidney.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 138-740.
    Tissue: Testis.
  8. "Identification and characterization of human FCHSD1 and FCHSD2 genes in silico."
    Katoh M., Katoh M.
    Int. J. Mol. Med. 13:749-754(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  9. "Solution structure of the second SH3 domain of human KIAA0769 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 464-530 AND 569-628.

Entry informationi

Entry nameiFCSD2_HUMAN
AccessioniPrimary (citable) accession number: O94868
Secondary accession number(s): B4DNI3
, Q7L8J9, Q8WVM2, Q96FV7, Q9UF77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 29, 2015
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.