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Protein

STAGA complex 65 subunit gamma

Gene

SUPT7L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • histone H3 acetylation Source: UniProtKB
  • maintenance of protein location in nucleus Source: HGNC
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119760-MONOMER.
ReactomeiR-HSA-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
STAGA complex 65 subunit gamma
Alternative name(s):
Adenocarcinoma antigen ART1
SPTF-associated factor 65 gamma
Short name:
STAF65gamma
Suppressor of Ty 7-like
Gene namesi
Name:SUPT7L
Synonyms:KIAA0764
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:30632. SUPT7L.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • STAGA complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9913.
OpenTargetsiENSG00000119760.
PharmGKBiPA142670854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722331 – 414STAGA complex 65 subunit gammaAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108PhosphoserineCombined sources1
Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei323PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1

Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO94864.
MaxQBiO94864.
PaxDbiO94864.
PeptideAtlasiO94864.
PRIDEiO94864.

PTM databases

iPTMnetiO94864.
PhosphoSitePlusiO94864.

Expressioni

Tissue specificityi

Expressed at high levels in adenocarcinomas and gliomas and low in esophageal cancers and malignant hematological disease. Also expressed at high level in the thymus, low in peripheral blood mononuclear cells, and lowest in the stomach, small intestine, and skeletal muscle.

Gene expression databases

BgeeiENSG00000119760.
CleanExiHS_SUPT7L.
GenevisibleiO94864. HS.

Organism-specific databases

HPAiHPA039565.
HPA063643.

Interactioni

Subunit structurei

Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, SUPT7L, GCN5L2, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12 and TAF9.1 Publication

Protein-protein interaction databases

BioGridi115242. 27 interactors.
IntActiO94864. 6 interactors.
MINTiMINT-1428430.
STRINGi9606.ENSP00000336750.

Structurei

3D structure databases

ProteinModelPortaliO94864.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410INFQ. Eukaryota.
ENOG410YK24. LUCA.
GeneTreeiENSGT00390000005572.
HOGENOMiHOG000072711.
HOVERGENiHBG023396.
InParanoidiO94864.
KOiK11316.
OMAiMRYWGEI.
OrthoDBiEOG091G0C0B.
PhylomeDBiO94864.
TreeFamiTF328615.

Family and domain databases

InterProiIPR006565. BTP.
[Graphical view]
PfamiPF07524. Bromo_TP. 1 hit.
[Graphical view]
SMARTiSM00576. BTP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94864-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLQRYWGEI PISSSQTNRS SFDLLPREFR LVEVHDPPLH QPSANKPKPP
60 70 80 90 100
TMLDIPSEPC SLTIHTIQLI QHNRRLRNLI ATAQAQNQQQ TEGVKTEESE
110 120 130 140 150
PLPSCPGSPP LPDDLLPLDC KNPNAPFQIR HSDPESDFYR GKGEPVTELS
160 170 180 190 200
WHSCRQLLYQ AVATILAHAG FDCANESVLE TLTDVAHEYC LKFTKLLRFA
210 220 230 240 250
VDREARLGQT PFPDVMEQVF HEVGIGSVLS LQKFWQHRIK DYHSYMLQIS
260 270 280 290 300
KQLSEEYERI VNPEKATEDA KPVKIKEEPV SDITFPVSEE LEADLASGDQ
310 320 330 340 350
SLPMGVLGAQ SERFPSNLEV EASPQASSAE VNASPLWNLA HVKMEPQESE
360 370 380 390 400
EGNVSGHGVL GSDVFEEPMS GMSEAGIPQS PDDSDSSYGS HSTDSLMGSS
410
PVFNQRCKKR MRKI
Length:414
Mass (Da):46,193
Last modified:May 1, 1999 - v1
Checksum:i59724A96353D44D5
GO
Isoform 2 (identifier: O94864-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MNLQ → ML

Note: No experimental confirmation available.
Show »
Length:412
Mass (Da):45,951
Checksum:i99A3830B2E4D3E22
GO
Isoform 3 (identifier: O94864-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5-140: RYWGEIPISS...HSDPESDFYR → S

Note: No experimental confirmation available.
Show »
Length:279
Mass (Da):30,876
Checksum:i5200DB7BD9101EEE
GO

Sequence cautioni

The sequence BAA34484 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0039741 – 4MNLQ → ML in isoform 2. 1 Publication4
Alternative sequenceiVSP_0548395 – 140RYWGE…SDFYR → S in isoform 3. 1 PublicationAdd BLAST136

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197954 mRNA. Translation: AAG28523.1.
AF224759 mRNA. Translation: AAG47636.1.
AB018307 mRNA. Translation: BAA34484.2. Different initiation.
AK304889 mRNA. Translation: BAG65625.1.
CR456983 mRNA. Translation: CAG33264.1.
AC074091 Genomic DNA. Translation: AAX93202.1.
BC074000 mRNA. Translation: AAH74000.1.
CCDSiCCDS42667.1. [O94864-1]
CCDS62885.1. [O94864-2]
CCDS62886.1. [O94864-4]
RefSeqiNP_001269658.1. NM_001282729.1. [O94864-1]
NP_001269659.1. NM_001282730.1. [O94864-2]
NP_001269660.1. NM_001282731.1. [O94864-2]
NP_001269661.1. NM_001282732.1. [O94864-4]
NP_055675.1. NM_014860.2. [O94864-1]
XP_005264729.1. XM_005264672.4. [O94864-2]
UniGeneiHs.6232.

Genome annotation databases

EnsembliENST00000337768; ENSP00000336750; ENSG00000119760. [O94864-1]
ENST00000404798; ENSP00000385218; ENSG00000119760. [O94864-4]
ENST00000405491; ENSP00000384469; ENSG00000119760. [O94864-2]
ENST00000406540; ENSP00000385436; ENSG00000119760. [O94864-2]
ENST00000464789; ENSP00000441110; ENSG00000119760. [O94864-2]
GeneIDi9913.
KEGGihsa:9913.
UCSCiuc002rli.3. human. [O94864-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197954 mRNA. Translation: AAG28523.1.
AF224759 mRNA. Translation: AAG47636.1.
AB018307 mRNA. Translation: BAA34484.2. Different initiation.
AK304889 mRNA. Translation: BAG65625.1.
CR456983 mRNA. Translation: CAG33264.1.
AC074091 Genomic DNA. Translation: AAX93202.1.
BC074000 mRNA. Translation: AAH74000.1.
CCDSiCCDS42667.1. [O94864-1]
CCDS62885.1. [O94864-2]
CCDS62886.1. [O94864-4]
RefSeqiNP_001269658.1. NM_001282729.1. [O94864-1]
NP_001269659.1. NM_001282730.1. [O94864-2]
NP_001269660.1. NM_001282731.1. [O94864-2]
NP_001269661.1. NM_001282732.1. [O94864-4]
NP_055675.1. NM_014860.2. [O94864-1]
XP_005264729.1. XM_005264672.4. [O94864-2]
UniGeneiHs.6232.

3D structure databases

ProteinModelPortaliO94864.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115242. 27 interactors.
IntActiO94864. 6 interactors.
MINTiMINT-1428430.
STRINGi9606.ENSP00000336750.

PTM databases

iPTMnetiO94864.
PhosphoSitePlusiO94864.

Proteomic databases

EPDiO94864.
MaxQBiO94864.
PaxDbiO94864.
PeptideAtlasiO94864.
PRIDEiO94864.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337768; ENSP00000336750; ENSG00000119760. [O94864-1]
ENST00000404798; ENSP00000385218; ENSG00000119760. [O94864-4]
ENST00000405491; ENSP00000384469; ENSG00000119760. [O94864-2]
ENST00000406540; ENSP00000385436; ENSG00000119760. [O94864-2]
ENST00000464789; ENSP00000441110; ENSG00000119760. [O94864-2]
GeneIDi9913.
KEGGihsa:9913.
UCSCiuc002rli.3. human. [O94864-1]

Organism-specific databases

CTDi9913.
DisGeNETi9913.
GeneCardsiSUPT7L.
HGNCiHGNC:30632. SUPT7L.
HPAiHPA039565.
HPA063643.
MIMi612762. gene.
neXtProtiNX_O94864.
OpenTargetsiENSG00000119760.
PharmGKBiPA142670854.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INFQ. Eukaryota.
ENOG410YK24. LUCA.
GeneTreeiENSGT00390000005572.
HOGENOMiHOG000072711.
HOVERGENiHBG023396.
InParanoidiO94864.
KOiK11316.
OMAiMRYWGEI.
OrthoDBiEOG091G0C0B.
PhylomeDBiO94864.
TreeFamiTF328615.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119760-MONOMER.
ReactomeiR-HSA-3214847. HATs acetylate histones.

Miscellaneous databases

ChiTaRSiSUPT7L. human.
GeneWikiiSUPT7L.
GenomeRNAii9913.
PROiO94864.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119760.
CleanExiHS_SUPT7L.
GenevisibleiO94864. HS.

Family and domain databases

InterProiIPR006565. BTP.
[Graphical view]
PfamiPF07524. Bromo_TP. 1 hit.
[Graphical view]
SMARTiSM00576. BTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiST65G_HUMAN
AccessioniPrimary (citable) accession number: O94864
Secondary accession number(s): B4E3W3, Q6IB21, Q9H2T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.