O94856 (NFASC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurofascin

Gene names

Name:	NFASC
Synonyms:	KIAA0756

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1347 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions By similarity.
Subunit structure	Horseshoe-shaped homodimer. Probable constituent of a neurofascin/NRCAM/ankyrin-G complex. Associates with the sodium channel beta-1 (SCN1B) and beta-3 (SCN3B) subunits. Interacts with GLDN/gliomedin By similarity. Ref.9
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Domain	Homophilic adhesion is primarily mediated by the interaction of the second Ig-like domains.
Sequence similarities	Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. Contains 5 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Sequence caution	The sequence BAA34476.3 differs from that shown. Reason: Erroneous initiation. The sequence BAB55195.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC87577.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW myelination Inferred from sequence or structural similarity. Source: BHF-UCL paranodal junction assembly Inferred from electronic annotation. Source: Compara peripheral nervous system development Inferred from sequence or structural similarity. Source: BHF-UCL protein localization to juxtaparanode region of axon Inferred from electronic annotation. Source: Compara protein localization to paranode region of axon Inferred from electronic annotation. Source: Compara protein targeting to plasma membrane Inferred from electronic annotation. Source: Compara synapse organization Inferred from electronic annotation. Source: Compara
Cellular_component	axon initial segment Inferred from sequence or structural similarity. Source: BHF-UCL integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular Inferred from sequence or structural similarity. Source: BHF-UCL node of Ranvier Inferred from sequence or structural similarity. Source: BHF-UCL paranodal junction Inferred from electronic annotation. Source: Compara paranode region of axon Inferred from electronic annotation. Source: Compara plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Alternative products

This entry describes 13 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O94856-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: O94856-2)

The sequence of this isoform differs from the canonical sequence as follows:
     611-619: ADQATPTNR → GNCPCSPWH
     620-1347: Missing.

Note: May be due to intron retention.

Isoform 3 (identifier: O94856-3)

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     236-236: T → NHPYNDSSLRNHPDMYSA
     611-625: Missing.
     1030-1203: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: O94856-4)

The sequence of this isoform differs from the canonical sequence as follows:
     824-930: Missing.
     931-931: V → L
     1030-1203: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: O94856-5)

The sequence of this isoform differs from the canonical sequence as follows:
     611-625: Missing.
     1030-1043: ATPTAAPPTLPPTT → GRCMAAAPGVKGPS

Note: May be due to intron retention.

Isoform 6 (identifier: O94856-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1030-1152: Missing.
     1153-1153: S → G

Note: No experimental confirmation available.

Isoform 7 (identifier: O94856-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1114-1203: Missing.

Note: No experimental confirmation available.

Isoform 8 (identifier: O94856-8)

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     236-236: T → NHPYNDSSLRNHPDMYSA
     611-625: Missing.
     1035-1203: Missing.

Note: No experimental confirmation available.

Isoform 9 (identifier: O94856-9)

The sequence of this isoform differs from the canonical sequence as follows:
     824-930: Missing.
     931-931: V → L

Note: No experimental confirmation available.

Isoform 10 (identifier: O94856-10)

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     611-625: Missing.
     1035-1203: Missing.

Note: No experimental confirmation available.

Isoform 11 (identifier: O94856-11)

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     236-236: T → NHPYNDSSLRNHPDMYSA
     1035-1203: Missing.

Note: No experimental confirmation available.

Isoform 12 (identifier: O94856-12)

The sequence of this isoform differs from the canonical sequence as follows:
     824-930: Missing.
     931-931: V → L
     1035-1203: Missing.

Note: No experimental confirmation available.

Isoform 13 (identifier: O94856-13)

The sequence of this isoform differs from the canonical sequence as follows:
     1035-1113: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

Potential

Chain

25 – 1347

1323

Neurofascin

PRO_0000015049

Regions

Topological domain

25 – 1217

1193

Extracellular Potential

Transmembrane

1218 – 1238

21

Helical; Potential

Topological domain

1239 – 1347

109

Cytoplasmic Potential

Domain

41 – 137

97

Ig-like C2-type 1

Domain

143 – 230

88

Ig-like C2-type 2

Domain

244 – 332

89

Ig-like C2-type 3

Domain

337 – 424

88

Ig-like C2-type 4

Domain

429 – 517

89

Ig-like C2-type 5

Domain

521 – 603

83

Ig-like C2-type 6

Domain

628 – 720

93

Fibronectin type-III 1

Domain

727 – 820

94

Fibronectin type-III 2

Domain

825 – 927

103

Fibronectin type-III 3

Domain

932 – 1025

94

Fibronectin type-III 4

Domain

1115 – 1201

87

Fibronectin type-III 5

Compositional bias

1031 – 1108

78

Thr-rich

Amino acid modifications

Modified residue

481

1

Phosphotyrosine Ref.8

Modified residue

485

1

Phosphoserine Ref.8

Modified residue

1333

1

Phosphoserine By similarity

Modified residue

1334

1

Phosphoserine By similarity

Glycosylation

305

1

N-linked (GlcNAc...) Potential

Glycosylation

409

1

N-linked (GlcNAc...) Ref.9

Glycosylation

446

1

N-linked (GlcNAc...) Potential

Glycosylation

483

1

N-linked (GlcNAc...) Potential

Glycosylation

752

1

N-linked (GlcNAc...) Potential

Glycosylation

778

1

N-linked (GlcNAc...) Potential

Glycosylation

973

1

N-linked (GlcNAc...) Potential

Glycosylation

988

1

N-linked (GlcNAc...) Potential

Disulfide bond

63 ↔ 118

Ref.9

Disulfide bond

162 ↔ 213

Ref.9

Disulfide bond

268 ↔ 316

Ref.9

Disulfide bond

358 ↔ 408

Ref.9

Disulfide bond

452 ↔ 501

Potential

Disulfide bond

543 ↔ 592

Potential

Natural variations

Alternative sequence

31 – 36

6

Missing in isoform 3, isoform 8, isoform 10 and isoform 11.

VSP_016424

Alternative sequence

236

1

T → NHPYNDSSLRNHPDMYSA in isoform 3, isoform 8 and isoform 11.

VSP_016425

Alternative sequence

611 – 625

15

Missing in isoform 3, isoform 5, isoform 8 and isoform 10.

VSP_008937

Alternative sequence

611 – 619

9

ADQATPTNR → GNCPCSPWH in isoform 2.

VSP_016426

Alternative sequence

620 – 1347

728

Missing in isoform 2.

VSP_008938

Alternative sequence

824 – 930

107

Missing in isoform 4, isoform 9 and isoform 12.

VSP_016427

Alternative sequence

931

1

V → L in isoform 4, isoform 9 and isoform 12.

VSP_016428

Alternative sequence

1030 – 1203

174

Missing in isoform 3 and isoform 4.

VSP_008940

Alternative sequence

1030 – 1152

123

Missing in isoform 6.

VSP_016430

Alternative sequence

1030 – 1043

14

ATPTA…LPPTT → GRCMAAAPGVKGPS in isoform 5.

VSP_016429

Alternative sequence

1035 – 1203

169

Missing in isoform 8, isoform 10, isoform 11 and isoform 12.

VSP_016432

Alternative sequence

1035 – 1113

79

Missing in isoform 13.

VSP_016431

Alternative sequence

1114 – 1203

90

Missing in isoform 7.

VSP_016433

Alternative sequence

1153

1

S → G in isoform 6.

VSP_016434

Natural variant

159

1

T → M.
Corresponds to variant rs3795564 [ dbSNP | Ensembl ].

VAR_017251

Experimental info

Sequence conflict

807

1

F → L in BAB55195. Ref.3

Sequence conflict

972

1

F → V in AK127424. Ref.3

Secondary structure

1

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1347

Helix Strand Turn

Details...

Beta strand

43 – 46

4

Beta strand

49 – 53

5

Beta strand

55 – 57

3

Beta strand

63 – 65

3

Beta strand

72 – 77

6

Helix

84 – 86

3

Beta strand

94 – 96

3

Turn

104 – 106

3

Helix

109 – 112

4

Beta strand

114 – 121

8

Beta strand

126 – 136

11

Beta strand

150 – 153

4

Beta strand

158 – 160

3

Beta strand

172 – 176

5

Beta strand

187 – 191

5

Beta strand

197 – 201

5

Helix

205 – 207

3

Beta strand

211 – 216

6

Turn

218 – 220

3

Beta strand

223 – 225

3

Beta strand

231 – 234

4

Beta strand

236 – 238

3

Beta strand

246 – 249

4

Beta strand

251 – 259

9

Beta strand

264 – 267

4

Beta strand

277 – 282

6

Turn

289 – 291

3

Beta strand

292 – 295

4

Helix

296 – 298

3

Beta strand

300 – 305

6

Helix

308 – 310

3

Beta strand

312 – 319

8

Beta strand

324 – 341

18

Beta strand

346 – 348

3

Beta strand

354 – 357

4

Beta strand

359 – 364

6

Beta strand

367 – 372

6

Helix

377 – 379

3

Beta strand

386 – 389

4

Beta strand

392 – 397

6

Beta strand

405 – 412

8

Beta strand

415 – 425

11

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 6, 2005. Version 4. Checksum: 4DC555E5AA06C223	FASTA	1,347	150,027
	10 20 30 40 50 60 MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD HIVDPRDNIL 70 80 90 100 110 120 IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV IDFRSGGRPE EYEGEYQCFA 130 140 150 160 170 180 RNKFGTALSN RIRLQVSKSP LWPKENLDPV VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM 190 200 210 220 230 240 EPITQDKRVS QGHNGDLYFS NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA 250 260 270 280 290 300 ERTPSFMYPQ GTASSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSD KAKFENFNKA 310 320 330 340 350 360 LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP GEDGRLVCRA 370 380 390 400 410 420 NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI SSRAVYQCNT SNEHGYLLAN 430 440 450 460 470 480 AFVSVLDVPP RMLSPRNQLI RVILYNRTRL DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV 490 500 510 520 530 540 YENGSLEIKM IRKEDQGIYT CVATNILGKA ENQVRLEVKD PTRIYRMPED QVARRGTTVQ 550 560 570 580 590 600 LECRVKHDPS LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCVASTELDQ 610 620 630 640 650 660 DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP GDANNSPITD 670 680 690 700 710 720 YVVQFEEDQF QPGVWHDHSK YPGSVNSAVL RLSPYVNYQF RVIAINEVGS SHPSLPSERY 730 740 750 760 770 780 RTSGAPPESN PGDVKGEGTR KNNMEITWTP MNATSAFGPN LRYIVKWRRR ETREAWNNVT 790 800 810 820 830 840 VWGSRYVVGQ TPVYVPYEIR VQAENDFGKG PEPESVIGYS GEDYPRAAPT EVKVRVMNST 850 860 870 880 890 900 AISLQWNRVY SDTVQGQLRE YRAYYWRESS LLKNLWVSQK RQQASFPGDR LRGVVSRLFP 910 920 930 940 950 960 YSNYKLEMVV VNGRGDGPRS ETKEFTTPEG VPSAPRRFRV RQPNLETINL EWDHPEHPNG 970 980 990 1000 1010 1020 IMIGYTLKYV AFNGTKVGKQ IVENFSPNQT KFTVQRTDPV SRYRFTLSAR TQVGSGEAVT 1030 1040 1050 1060 1070 1080 EESPAPPNEA TPTAAPPTLP PTTVGATGAV SSTDATAIAA TTEATTVPII PTVAPTTIAT 1090 1100 1110 1120 1130 1140 TTTVATTTTT TAAATTTTES PPTTTSGTKI HESAPDEQSI WNVTVLPNSK WANITWKHNF 1150 1160 1170 1180 1190 1200 GPGTDFVVEY IDSNHTKKTV PVKAQAQPIQ LTDLYPGMTY TLRVYSRDNE GISSTVITFM 1210 1220 1230 1240 1250 1260 TSTAYTNNQA DIATQGWFIG LMCAIALLVL ILLIVCFIKR SRGGKYPVRE KKDVPLGPED 1270 1280 1290 1300 1310 1320 PKEEDGSFDY SDEDNKPLQG SQTSLDGTIK QQESDDSLVD YGEGGEGQFN EDGSFIGQYT 1330 1340 VKKDKEETEG NESSEATSPV NAIYSLA
	Isoform 2 [UniParc]. Checksum: 19677F073EA3925E	FASTA	619	69,565
	10 20 30 40 50 60 MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD HIVDPRDNIL 70 80 90 100 110 120 IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV IDFRSGGRPE EYEGEYQCFA 130 140 150 160 170 180 RNKFGTALSN RIRLQVSKSP LWPKENLDPV VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM 190 200 210 220 230 240 EPITQDKRVS QGHNGDLYFS NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA 250 260 270 280 290 300 ERTPSFMYPQ GTASSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSD KAKFENFNKA 310 320 330 340 350 360 LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP GEDGRLVCRA 370 380 390 400 410 420 NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI SSRAVYQCNT SNEHGYLLAN 430 440 450 460 470 480 AFVSVLDVPP RMLSPRNQLI RVILYNRTRL DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV 490 500 510 520 530 540 YENGSLEIKM IRKEDQGIYT CVATNILGKA ENQVRLEVKD PTRIYRMPED QVARRGTTVQ 550 560 570 580 590 600 LECRVKHDPS LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCVASTELDQ 610 DLAKAYLTVL GNCPCSPWH
	Isoform 3 [UniParc]. Checksum: 227C4122ABA8EDAD	FASTA	1,169	131,669
	10 20 30 40 50 60 MARQPPPPWV HAAFLLCLLS LGGAIEIPMD LTQPPTITKQ SAKDHIVDPR DNILIECEAK 70 80 90 100 110 120 GNPAPSFHWT RNSRFFNIAK DPRVSMRRRS GTLVIDFRSG GRPEEYEGEY QCFARNKFGT 130 140 150 160 170 180 ALSNRIRLQV SKSPLWPKEN LDPVVVQEGA PLTLQCNPPP GLPSPVIFWM SSSMEPITQD 190 200 210 220 230 240 KRVSQGHNGD LYFSNVMLQD MQTDYSCNAR FHFTHTIQQK NPFTLKVLTN HPYNDSSLRN 250 260 270 280 290 300 HPDMYSARGV AERTPSFMYP QGTASSQMVL RGMDLLLECI ASGVPTPDIA WYKKGGDLPS 310 320 330 340 350 360 DKAKFENFNK ALRITNVSEE DSGEYFCLAS NKMGSIRHTI SVRVKAAPYW LDEPKNLILA 370 380 390 400 410 420 PGEDGRLVCR ANGNPKPTVQ WMVNGEPLQS APPNPNREVA GDTIIFRDTQ ISSRAVYQCN 430 440 450 460 470 480 TSNEHGYLLA NAFVSVLDVP PRMLSPRNQL IRVILYNRTR LDCPFFGSPI PTLRWFKNGQ 490 500 510 520 530 540 GSNLDGGNYH VYENGSLEIK MIRKEDQGIY TCVATNILGK AENQVRLEVK DPTRIYRMPE 550 560 570 580 590 600 DQVARRGTTV QLECRVKHDP SLKLTVSWLK DDEPLYIGNR MKKEDDSLTI FGVAERDQGS 610 620 630 640 650 660 YTCVASTELD QDLAKAYLTV LGRPDRPRDL ELTDLAERSV RLTWIPGDAN NSPITDYVVQ 670 680 690 700 710 720 FEEDQFQPGV WHDHSKYPGS VNSAVLRLSP YVNYQFRVIA INEVGSSHPS LPSERYRTSG 730 740 750 760 770 780 APPESNPGDV KGEGTRKNNM EITWTPMNAT SAFGPNLRYI VKWRRRETRE AWNNVTVWGS 790 800 810 820 830 840 RYVVGQTPVY VPYEIRVQAE NDFGKGPEPE SVIGYSGEDY PRAAPTEVKV RVMNSTAISL 850 860 870 880 890 900 QWNRVYSDTV QGQLREYRAY YWRESSLLKN LWVSQKRQQA SFPGDRLRGV VSRLFPYSNY 910 920 930 940 950 960 KLEMVVVNGR GDGPRSETKE FTTPEGVPSA PRRFRVRQPN LETINLEWDH PEHPNGIMIG 970 980 990 1000 1010 1020 YTLKYVAFNG TKVGKQIVEN FSPNQTKFTV QRTDPVSRYR FTLSARTQVG SGEAVTEESP 1030 1040 1050 1060 1070 1080 APPNEAYTNN QADIATQGWF IGLMCAIALL VLILLIVCFI KRSRGGKYPV REKKDVPLGP 1090 1100 1110 1120 1130 1140 EDPKEEDGSF DYSDEDNKPL QGSQTSLDGT IKQQESDDSL VDYGEGGEGQ FNEDGSFIGQ 1150 1160 YTVKKDKEET EGNESSEATS PVNAIYSLA
	Isoform 4 [UniParc]. Checksum: B254170D9F282A75	FASTA	1,066	119,470
	10 20 30 40 50 60 MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD HIVDPRDNIL 70 80 90 100 110 120 IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV IDFRSGGRPE EYEGEYQCFA 130 140 150 160 170 180 RNKFGTALSN RIRLQVSKSP LWPKENLDPV VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM 190 200 210 220 230 240 EPITQDKRVS QGHNGDLYFS NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA 250 260 270 280 290 300 ERTPSFMYPQ GTASSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSD KAKFENFNKA 310 320 330 340 350 360 LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP GEDGRLVCRA 370 380 390 400 410 420 NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI SSRAVYQCNT SNEHGYLLAN 430 440 450 460 470 480 AFVSVLDVPP RMLSPRNQLI RVILYNRTRL DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV 490 500 510 520 530 540 YENGSLEIKM IRKEDQGIYT CVATNILGKA ENQVRLEVKD PTRIYRMPED QVARRGTTVQ 550 560 570 580 590 600 LECRVKHDPS LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCVASTELDQ 610 620 630 640 650 660 DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP GDANNSPITD 670 680 690 700 710 720 YVVQFEEDQF QPGVWHDHSK YPGSVNSAVL RLSPYVNYQF RVIAINEVGS SHPSLPSERY 730 740 750 760 770 780 RTSGAPPESN PGDVKGEGTR KNNMEITWTP MNATSAFGPN LRYIVKWRRR ETREAWNNVT 790 800 810 820 830 840 VWGSRYVVGQ TPVYVPYEIR VQAENDFGKG PEPESVIGYS GEDLPSAPRR FRVRQPNLET 850 860 870 880 890 900 INLEWDHPEH PNGIMIGYTL KYVAFNGTKV GKQIVENFSP NQTKFTVQRT DPVSRYRFTL 910 920 930 940 950 960 SARTQVGSGE AVTEESPAPP NEAYTNNQAD IATQGWFIGL MCAIALLVLI LLIVCFIKRS 970 980 990 1000 1010 1020 RGGKYPVREK KDVPLGPEDP KEEDGSFDYS DEDNKPLQGS QTSLDGTIKQ QESDDSLVDY 1030 1040 1050 1060 GEGGEGQFNE DGSFIGQYTV KKDKEETEGN ESSEATSPVN AIYSLA
	Isoform 5 [UniParc]. Checksum: C8EB8885620764DF	FASTA	1,332	148,444
	10 20 30 40 50 60 MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD HIVDPRDNIL 70 80 90 100 110 120 IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV IDFRSGGRPE EYEGEYQCFA 130 140 150 160 170 180 RNKFGTALSN RIRLQVSKSP LWPKENLDPV VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM 190 200 210 220 230 240 EPITQDKRVS QGHNGDLYFS NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA 250 260 270 280 290 300 ERTPSFMYPQ GTASSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSD KAKFENFNKA 310 320 330 340 350 360 LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP GEDGRLVCRA 370 380 390 400 410 420 NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI SSRAVYQCNT SNEHGYLLAN 430 440 450 460 470 480 AFVSVLDVPP RMLSPRNQLI RVILYNRTRL DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV 490 500 510 520 530 540 YENGSLEIKM IRKEDQGIYT CVATNILGKA ENQVRLEVKD PTRIYRMPED QVARRGTTVQ 550 560 570 580 590 600 LECRVKHDPS LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCVASTELDQ 610 620 630 640 650 660 DLAKAYLTVL GRPDRPRDLE LTDLAERSVR LTWIPGDANN SPITDYVVQF EEDQFQPGVW 670 680 690 700 710 720 HDHSKYPGSV NSAVLRLSPY VNYQFRVIAI NEVGSSHPSL PSERYRTSGA PPESNPGDVK 730 740 750 760 770 780 GEGTRKNNME ITWTPMNATS AFGPNLRYIV KWRRRETREA WNNVTVWGSR YVVGQTPVYV 790 800 810 820 830 840 PYEIRVQAEN DFGKGPEPES VIGYSGEDYP RAAPTEVKVR VMNSTAISLQ WNRVYSDTVQ 850 860 870 880 890 900 GQLREYRAYY WRESSLLKNL WVSQKRQQAS FPGDRLRGVV SRLFPYSNYK LEMVVVNGRG 910 920 930 940 950 960 DGPRSETKEF TTPEGVPSAP RRFRVRQPNL ETINLEWDHP EHPNGIMIGY TLKYVAFNGT 970 980 990 1000 1010 1020 KVGKQIVENF SPNQTKFTVQ RTDPVSRYRF TLSARTQVGS GEAVTEESPA PPNEGRCMAA 1030 1040 1050 1060 1070 1080 APGVKGPSVG ATGAVSSTDA TAIAATTEAT TVPIIPTVAP TTIATTTTVA TTTTTTAAAT 1090 1100 1110 1120 1130 1140 TTTESPPTTT SGTKIHESAP DEQSIWNVTV LPNSKWANIT WKHNFGPGTD FVVEYIDSNH 1150 1160 1170 1180 1190 1200 TKKTVPVKAQ AQPIQLTDLY PGMTYTLRVY SRDNEGISST VITFMTSTAY TNNQADIATQ 1210 1220 1230 1240 1250 1260 GWFIGLMCAI ALLVLILLIV CFIKRSRGGK YPVREKKDVP LGPEDPKEED GSFDYSDEDN 1270 1280 1290 1300 1310 1320 KPLQGSQTSL DGTIKQQESD DSLVDYGEGG EGQFNEDGSF IGQYTVKKDK EETEGNESSE 1330 ATSPVNAIYS LA
	Isoform 6 [UniParc]. Checksum: 345949AF7828A247	FASTA	1,224	137,531
	10 20 30 40 50 60 MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD HIVDPRDNIL 70 80 90 100 110 120 IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV IDFRSGGRPE EYEGEYQCFA 130 140 150 160 170 180 RNKFGTALSN RIRLQVSKSP LWPKENLDPV VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM 190 200 210 220 230 240 EPITQDKRVS QGHNGDLYFS NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA 250 260 270 280 290 300 ERTPSFMYPQ GTASSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSD KAKFENFNKA 310 320 330 340 350 360 LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP GEDGRLVCRA 370 380 390 400 410 420 NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI SSRAVYQCNT SNEHGYLLAN 430 440 450 460 470 480 AFVSVLDVPP RMLSPRNQLI RVILYNRTRL DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV 490 500 510 520 530 540 YENGSLEIKM IRKEDQGIYT CVATNILGKA ENQVRLEVKD PTRIYRMPED QVARRGTTVQ 550 560 570 580 590 600 LECRVKHDPS LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCVASTELDQ 610 620 630 640 650 660 DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP GDANNSPITD 670 680 690 700 710 720 YVVQFEEDQF QPGVWHDHSK YPGSVNSAVL RLSPYVNYQF RVIAINEVGS SHPSLPSERY 730 740 750 760 770 780 RTSGAPPESN PGDVKGEGTR KNNMEITWTP MNATSAFGPN LRYIVKWRRR ETREAWNNVT 790 800 810 820 830 840 VWGSRYVVGQ TPVYVPYEIR VQAENDFGKG PEPESVIGYS GEDYPRAAPT EVKVRVMNST 850 860 870 880 890 900 AISLQWNRVY SDTVQGQLRE YRAYYWRESS LLKNLWVSQK RQQASFPGDR LRGVVSRLFP 910 920 930 940 950 960 YSNYKLEMVV VNGRGDGPRS ETKEFTTPEG VPSAPRRFRV RQPNLETINL EWDHPEHPNG 970 980 990 1000 1010 1020 IMIGYTLKYV AFNGTKVGKQ IVENFSPNQT KFTVQRTDPV SRYRFTLSAR TQVGSGEAVT 1030 1040 1050 1060 1070 1080 EESPAPPNEG NHTKKTVPVK AQAQPIQLTD LYPGMTYTLR VYSRDNEGIS STVITFMTST 1090 1100 1110 1120 1130 1140 AYTNNQADIA TQGWFIGLMC AIALLVLILL IVCFIKRSRG GKYPVREKKD VPLGPEDPKE 1150 1160 1170 1180 1190 1200 EDGSFDYSDE DNKPLQGSQT SLDGTIKQQE SDDSLVDYGE GGEGQFNEDG SFIGQYTVKK 1210 1220 DKEETEGNES SEATSPVNAI YSLA
	Isoform 7 [UniParc]. Checksum: 4E9F5630EAB43566	FASTA	1,257	139,881
	10 20 30 40 50 60 MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD HIVDPRDNIL 70 80 90 100 110 120 IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV IDFRSGGRPE EYEGEYQCFA 130 140 150 160 170 180 RNKFGTALSN RIRLQVSKSP LWPKENLDPV VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM 190 200 210 220 230 240 EPITQDKRVS QGHNGDLYFS NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA 250 260 270 280 290 300 ERTPSFMYPQ GTASSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSD KAKFENFNKA 310 320 330 340 350 360 LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP GEDGRLVCRA 370 380 390 400 410 420 NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI SSRAVYQCNT SNEHGYLLAN 430 440 450 460 470 480 AFVSVLDVPP RMLSPRNQLI RVILYNRTRL DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV 490 500 510 520 530 540 YENGSLEIKM IRKEDQGIYT CVATNILGKA ENQVRLEVKD PTRIYRMPED QVARRGTTVQ 550 560 570 580 590 600 LECRVKHDPS LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCVASTELDQ 610 620 630 640 650 660 DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP GDANNSPITD 670 680 690 700 710 720 YVVQFEEDQF QPGVWHDHSK YPGSVNSAVL RLSPYVNYQF RVIAINEVGS SHPSLPSERY 730 740 750 760 770 780 RTSGAPPESN PGDVKGEGTR KNNMEITWTP MNATSAFGPN LRYIVKWRRR ETREAWNNVT 790 800 810 820 830 840 VWGSRYVVGQ TPVYVPYEIR VQAENDFGKG PEPESVIGYS GEDYPRAAPT EVKVRVMNST 850 860 870 880 890 900 AISLQWNRVY SDTVQGQLRE YRAYYWRESS LLKNLWVSQK RQQASFPGDR LRGVVSRLFP 910 920 930 940 950 960 YSNYKLEMVV VNGRGDGPRS ETKEFTTPEG VPSAPRRFRV RQPNLETINL EWDHPEHPNG 970 980 990 1000 1010 1020 IMIGYTLKYV AFNGTKVGKQ IVENFSPNQT KFTVQRTDPV SRYRFTLSAR TQVGSGEAVT 1030 1040 1050 1060 1070 1080 EESPAPPNEA TPTAAPPTLP PTTVGATGAV SSTDATAIAA TTEATTVPII PTVAPTTIAT 1090 1100 1110 1120 1130 1140 TTTVATTTTT TAAATTTTES PPTTTSGTKI HESAYTNNQA DIATQGWFIG LMCAIALLVL 1150 1160 1170 1180 1190 1200 ILLIVCFIKR SRGGKYPVRE KKDVPLGPED PKEEDGSFDY SDEDNKPLQG SQTSLDGTIK 1210 1220 1230 1240 1250 QQESDDSLVD YGEGGEGQFN EDGSFIGQYT VKKDKEETEG NESSEATSPV NAIYSLA
	Isoform 8 [UniParc]. Checksum: B298E5CBDF6A66B6	FASTA	1,174	132,111
	10 20 30 40 50 60 MARQPPPPWV HAAFLLCLLS LGGAIEIPMD LTQPPTITKQ SAKDHIVDPR DNILIECEAK 70 80 90 100 110 120 GNPAPSFHWT RNSRFFNIAK DPRVSMRRRS GTLVIDFRSG GRPEEYEGEY QCFARNKFGT 130 140 150 160 170 180 ALSNRIRLQV SKSPLWPKEN LDPVVVQEGA PLTLQCNPPP GLPSPVIFWM SSSMEPITQD 190 200 210 220 230 240 KRVSQGHNGD LYFSNVMLQD MQTDYSCNAR FHFTHTIQQK NPFTLKVLTN HPYNDSSLRN 250 260 270 280 290 300 HPDMYSARGV AERTPSFMYP QGTASSQMVL RGMDLLLECI ASGVPTPDIA WYKKGGDLPS 310 320 330 340 350 360 DKAKFENFNK ALRITNVSEE DSGEYFCLAS NKMGSIRHTI SVRVKAAPYW LDEPKNLILA 370 380 390 400 410 420 PGEDGRLVCR ANGNPKPTVQ WMVNGEPLQS APPNPNREVA GDTIIFRDTQ ISSRAVYQCN 430 440 450 460 470 480 TSNEHGYLLA NAFVSVLDVP PRMLSPRNQL IRVILYNRTR LDCPFFGSPI PTLRWFKNGQ 490 500 510 520 530 540 GSNLDGGNYH VYENGSLEIK MIRKEDQGIY TCVATNILGK AENQVRLEVK DPTRIYRMPE 550 560 570 580 590 600 DQVARRGTTV QLECRVKHDP SLKLTVSWLK DDEPLYIGNR MKKEDDSLTI FGVAERDQGS 610 620 630 640 650 660 YTCVASTELD QDLAKAYLTV LGRPDRPRDL ELTDLAERSV RLTWIPGDAN NSPITDYVVQ 670 680 690 700 710 720 FEEDQFQPGV WHDHSKYPGS VNSAVLRLSP YVNYQFRVIA INEVGSSHPS LPSERYRTSG 730 740 750 760 770 780 APPESNPGDV KGEGTRKNNM EITWTPMNAT SAFGPNLRYI VKWRRRETRE AWNNVTVWGS 790 800 810 820 830 840 RYVVGQTPVY VPYEIRVQAE NDFGKGPEPE SVIGYSGEDY PRAAPTEVKV RVMNSTAISL 850 860 870 880 890 900 QWNRVYSDTV QGQLREYRAY YWRESSLLKN LWVSQKRQQA SFPGDRLRGV VSRLFPYSNY 910 920 930 940 950 960 KLEMVVVNGR GDGPRSETKE FTTPEGVPSA PRRFRVRQPN LETINLEWDH PEHPNGIMIG 970 980 990 1000 1010 1020 YTLKYVAFNG TKVGKQIVEN FSPNQTKFTV QRTDPVSRYR FTLSARTQVG SGEAVTEESP 1030 1040 1050 1060 1070 1080 APPNEATPTA AYTNNQADIA TQGWFIGLMC AIALLVLILL IVCFIKRSRG GKYPVREKKD 1090 1100 1110 1120 1130 1140 VPLGPEDPKE EDGSFDYSDE DNKPLQGSQT SLDGTIKQQE SDDSLVDYGE GGEGQFNEDG 1150 1160 1170 SFIGQYTVKK DKEETEGNES SEATSPVNAI YSLA
	Isoform 9 [UniParc]. Checksum: 2A894288EB12B706	FASTA	1,240	137,609
	10 20 30 40 50 60 MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD HIVDPRDNIL 70 80 90 100 110 120 IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV IDFRSGGRPE EYEGEYQCFA 130 140 150 160 170 180 RNKFGTALSN RIRLQVSKSP LWPKENLDPV VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM 190 200 210 220 230 240 EPITQDKRVS QGHNGDLYFS NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA 250 260 270 280 290 300 ERTPSFMYPQ GTASSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSD KAKFENFNKA 310 320 330 340 350 360 LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP GEDGRLVCRA 370 380 390 400 410 420 NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI SSRAVYQCNT SNEHGYLLAN 430 440 450 460 470 480 AFVSVLDVPP RMLSPRNQLI RVILYNRTRL DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV 490 500 510 520 530 540 YENGSLEIKM IRKEDQGIYT CVATNILGKA ENQVRLEVKD PTRIYRMPED QVARRGTTVQ 550 560 570 580 590 600 LECRVKHDPS LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCVASTELDQ 610 620 630 640 650 660 DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP GDANNSPITD 670 680 690 700 710 720 YVVQFEEDQF QPGVWHDHSK YPGSVNSAVL RLSPYVNYQF RVIAINEVGS SHPSLPSERY 730 740 750 760 770 780 RTSGAPPESN PGDVKGEGTR KNNMEITWTP MNATSAFGPN LRYIVKWRRR ETREAWNNVT 790 800 810 820 830 840 VWGSRYVVGQ TPVYVPYEIR VQAENDFGKG PEPESVIGYS GEDLPSAPRR FRVRQPNLET 850 860 870 880 890 900 INLEWDHPEH PNGIMIGYTL KYVAFNGTKV GKQIVENFSP NQTKFTVQRT DPVSRYRFTL 910 920 930 940 950 960 SARTQVGSGE AVTEESPAPP NEATPTAAPP TLPPTTVGAT GAVSSTDATA IAATTEATTV 970 980 990 1000 1010 1020 PIIPTVAPTT IATTTTVATT TTTTAAATTT TESPPTTTSG TKIHESAPDE QSIWNVTVLP 1030 1040 1050 1060 1070 1080 NSKWANITWK HNFGPGTDFV VEYIDSNHTK KTVPVKAQAQ PIQLTDLYPG MTYTLRVYSR 1090 1100 1110 1120 1130 1140 DNEGISSTVI TFMTSTAYTN NQADIATQGW FIGLMCAIAL LVLILLIVCF IKRSRGGKYP 1150 1160 1170 1180 1190 1200 VREKKDVPLG PEDPKEEDGS FDYSDEDNKP LQGSQTSLDG TIKQQESDDS LVDYGEGGEG 1210 1220 1230 1240 QFNEDGSFIG QYTVKKDKEE TEGNESSEAT SPVNAIYSLA
	Isoform 10 [UniParc]. Checksum: FD0DE3EBAA072F1F	FASTA	1,157	130,112
	10 20 30 40 50 60 MARQPPPPWV HAAFLLCLLS LGGAIEIPMD LTQPPTITKQ SAKDHIVDPR DNILIECEAK 70 80 90 100 110 120 GNPAPSFHWT RNSRFFNIAK DPRVSMRRRS GTLVIDFRSG GRPEEYEGEY QCFARNKFGT 130 140 150 160 170 180 ALSNRIRLQV SKSPLWPKEN LDPVVVQEGA PLTLQCNPPP GLPSPVIFWM SSSMEPITQD 190 200 210 220 230 240 KRVSQGHNGD LYFSNVMLQD MQTDYSCNAR FHFTHTIQQK NPFTLKVLTT RGVAERTPSF 250 260 270 280 290 300 MYPQGTASSQ MVLRGMDLLL ECIASGVPTP DIAWYKKGGD LPSDKAKFEN FNKALRITNV 310 320 330 340 350 360 SEEDSGEYFC LASNKMGSIR HTISVRVKAA PYWLDEPKNL ILAPGEDGRL VCRANGNPKP 370 380 390 400 410 420 TVQWMVNGEP LQSAPPNPNR EVAGDTIIFR DTQISSRAVY QCNTSNEHGY LLANAFVSVL 430 440 450 460 470 480 DVPPRMLSPR NQLIRVILYN RTRLDCPFFG SPIPTLRWFK NGQGSNLDGG NYHVYENGSL 490 500 510 520 530 540 EIKMIRKEDQ GIYTCVATNI LGKAENQVRL EVKDPTRIYR MPEDQVARRG TTVQLECRVK 550 560 570 580 590 600 HDPSLKLTVS WLKDDEPLYI GNRMKKEDDS LTIFGVAERD QGSYTCVAST ELDQDLAKAY 610 620 630 640 650 660 LTVLGRPDRP RDLELTDLAE RSVRLTWIPG DANNSPITDY VVQFEEDQFQ PGVWHDHSKY 670 680 690 700 710 720 PGSVNSAVLR LSPYVNYQFR VIAINEVGSS HPSLPSERYR TSGAPPESNP GDVKGEGTRK 730 740 750 760 770 780 NNMEITWTPM NATSAFGPNL RYIVKWRRRE TREAWNNVTV WGSRYVVGQT PVYVPYEIRV 790 800 810 820 830 840 QAENDFGKGP EPESVIGYSG EDYPRAAPTE VKVRVMNSTA ISLQWNRVYS DTVQGQLREY 850 860 870 880 890 900 RAYYWRESSL LKNLWVSQKR QQASFPGDRL RGVVSRLFPY SNYKLEMVVV NGRGDGPRSE 910 920 930 940 950 960 TKEFTTPEGV PSAPRRFRVR QPNLETINLE WDHPEHPNGI MIGYTLKYVA FNGTKVGKQI 970 980 990 1000 1010 1020 VENFSPNQTK FTVQRTDPVS RYRFTLSART QVGSGEAVTE ESPAPPNEAT PTAAYTNNQA 1030 1040 1050 1060 1070 1080 DIATQGWFIG LMCAIALLVL ILLIVCFIKR SRGGKYPVRE KKDVPLGPED PKEEDGSFDY 1090 1100 1110 1120 1130 1140 SDEDNKPLQG SQTSLDGTIK QQESDDSLVD YGEGGEGQFN EDGSFIGQYT VKKDKEETEG 1150 NESSEATSPV NAIYSLA
	Isoform 11 [UniParc]. Checksum: 0D8B3BD1CF541D66	FASTA	1,189	133,659
	10 20 30 40 50 60 MARQPPPPWV HAAFLLCLLS LGGAIEIPMD LTQPPTITKQ SAKDHIVDPR DNILIECEAK 70 80 90 100 110 120 GNPAPSFHWT RNSRFFNIAK DPRVSMRRRS GTLVIDFRSG GRPEEYEGEY QCFARNKFGT 130 140 150 160 170 180 ALSNRIRLQV SKSPLWPKEN LDPVVVQEGA PLTLQCNPPP GLPSPVIFWM SSSMEPITQD 190 200 210 220 230 240 KRVSQGHNGD LYFSNVMLQD MQTDYSCNAR FHFTHTIQQK NPFTLKVLTN HPYNDSSLRN 250 260 270 280 290 300 HPDMYSARGV AERTPSFMYP QGTASSQMVL RGMDLLLECI ASGVPTPDIA WYKKGGDLPS 310 320 330 340 350 360 DKAKFENFNK ALRITNVSEE DSGEYFCLAS NKMGSIRHTI SVRVKAAPYW LDEPKNLILA 370 380 390 400 410 420 PGEDGRLVCR ANGNPKPTVQ WMVNGEPLQS APPNPNREVA GDTIIFRDTQ ISSRAVYQCN 430 440 450 460 470 480 TSNEHGYLLA NAFVSVLDVP PRMLSPRNQL IRVILYNRTR LDCPFFGSPI PTLRWFKNGQ 490 500 510 520 530 540 GSNLDGGNYH VYENGSLEIK MIRKEDQGIY TCVATNILGK AENQVRLEVK DPTRIYRMPE 550 560 570 580 590 600 DQVARRGTTV QLECRVKHDP SLKLTVSWLK DDEPLYIGNR MKKEDDSLTI FGVAERDQGS 610 620 630 640 650 660 YTCVASTELD QDLAKAYLTV LADQATPTNR LAALPKGRPD RPRDLELTDL AERSVRLTWI 670 680 690 700 710 720 PGDANNSPIT DYVVQFEEDQ FQPGVWHDHS KYPGSVNSAV LRLSPYVNYQ FRVIAINEVG 730 740 750 760 770 780 SSHPSLPSER YRTSGAPPES NPGDVKGEGT RKNNMEITWT PMNATSAFGP NLRYIVKWRR 790 800 810 820 830 840 RETREAWNNV TVWGSRYVVG QTPVYVPYEI RVQAENDFGK GPEPESVIGY SGEDYPRAAP 850 860 870 880 890 900 TEVKVRVMNS TAISLQWNRV YSDTVQGQLR EYRAYYWRES SLLKNLWVSQ KRQQASFPGD 910 920 930 940 950 960 RLRGVVSRLF PYSNYKLEMV VVNGRGDGPR SETKEFTTPE GVPSAPRRFR VRQPNLETIN 970 980 990 1000 1010 1020 LEWDHPEHPN GIMIGYTLKY VAFNGTKVGK QIVENFSPNQ TKFTVQRTDP VSRYRFTLSA 1030 1040 1050 1060 1070 1080 RTQVGSGEAV TEESPAPPNE ATPTAAYTNN QADIATQGWF IGLMCAIALL VLILLIVCFI 1090 1100 1110 1120 1130 1140 KRSRGGKYPV REKKDVPLGP EDPKEEDGSF DYSDEDNKPL QGSQTSLDGT IKQQESDDSL 1150 1160 1170 1180 VDYGEGGEGQ FNEDGSFIGQ YTVKKDKEET EGNESSEATS PVNAIYSLA
	Isoform 12 [UniParc]. Checksum: 8D23FD7B6D7A4EE0	FASTA	1,071	119,911
	10 20 30 40 50 60 MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD HIVDPRDNIL 70 80 90 100 110 120 IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV IDFRSGGRPE EYEGEYQCFA 130 140 150 160 170 180 RNKFGTALSN RIRLQVSKSP LWPKENLDPV VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM 190 200 210 220 230 240 EPITQDKRVS QGHNGDLYFS NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA 250 260 270 280 290 300 ERTPSFMYPQ GTASSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSD KAKFENFNKA 310 320 330 340 350 360 LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP GEDGRLVCRA 370 380 390 400 410 420 NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI SSRAVYQCNT SNEHGYLLAN 430 440 450 460 470 480 AFVSVLDVPP RMLSPRNQLI RVILYNRTRL DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV 490 500 510 520 530 540 YENGSLEIKM IRKEDQGIYT CVATNILGKA ENQVRLEVKD PTRIYRMPED QVARRGTTVQ 550 560 570 580 590 600 LECRVKHDPS LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCVASTELDQ 610 620 630 640 650 660 DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP GDANNSPITD 670 680 690 700 710 720 YVVQFEEDQF QPGVWHDHSK YPGSVNSAVL RLSPYVNYQF RVIAINEVGS SHPSLPSERY 730 740 750 760 770 780 RTSGAPPESN PGDVKGEGTR KNNMEITWTP MNATSAFGPN LRYIVKWRRR ETREAWNNVT 790 800 810 820 830 840 VWGSRYVVGQ TPVYVPYEIR VQAENDFGKG PEPESVIGYS GEDLPSAPRR FRVRQPNLET 850 860 870 880 890 900 INLEWDHPEH PNGIMIGYTL KYVAFNGTKV GKQIVENFSP NQTKFTVQRT DPVSRYRFTL 910 920 930 940 950 960 SARTQVGSGE AVTEESPAPP NEATPTAAYT NNQADIATQG WFIGLMCAIA LLVLILLIVC 970 980 990 1000 1010 1020 FIKRSRGGKY PVREKKDVPL GPEDPKEEDG SFDYSDEDNK PLQGSQTSLD GTIKQQESDD 1030 1040 1050 1060 1070 SLVDYGEGGE GQFNEDGSFI GQYTVKKDKE ETEGNESSEA TSPVNAIYSL A
	Isoform 13 [UniParc]. Checksum: 860AFD7BD11A1BFE	FASTA	1,268	142,474
	10 20 30 40 50 60 MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD HIVDPRDNIL 70 80 90 100 110 120 IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV IDFRSGGRPE EYEGEYQCFA 130 140 150 160 170 180 RNKFGTALSN RIRLQVSKSP LWPKENLDPV VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM 190 200 210 220 230 240 EPITQDKRVS QGHNGDLYFS NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA 250 260 270 280 290 300 ERTPSFMYPQ GTASSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSD KAKFENFNKA 310 320 330 340 350 360 LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP GEDGRLVCRA 370 380 390 400 410 420 NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI SSRAVYQCNT SNEHGYLLAN 430 440 450 460 470 480 AFVSVLDVPP RMLSPRNQLI RVILYNRTRL DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV 490 500 510 520 530 540 YENGSLEIKM IRKEDQGIYT CVATNILGKA ENQVRLEVKD PTRIYRMPED QVARRGTTVQ 550 560 570 580 590 600 LECRVKHDPS LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCVASTELDQ 610 620 630 640 650 660 DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP GDANNSPITD 670 680 690 700 710 720 YVVQFEEDQF QPGVWHDHSK YPGSVNSAVL RLSPYVNYQF RVIAINEVGS SHPSLPSERY 730 740 750 760 770 780 RTSGAPPESN PGDVKGEGTR KNNMEITWTP MNATSAFGPN LRYIVKWRRR ETREAWNNVT 790 800 810 820 830 840 VWGSRYVVGQ TPVYVPYEIR VQAENDFGKG PEPESVIGYS GEDYPRAAPT EVKVRVMNST 850 860 870 880 890 900 AISLQWNRVY SDTVQGQLRE YRAYYWRESS LLKNLWVSQK RQQASFPGDR LRGVVSRLFP 910 920 930 940 950 960 YSNYKLEMVV VNGRGDGPRS ETKEFTTPEG VPSAPRRFRV RQPNLETINL EWDHPEHPNG 970 980 990 1000 1010 1020 IMIGYTLKYV AFNGTKVGKQ IVENFSPNQT KFTVQRTDPV SRYRFTLSAR TQVGSGEAVT 1030 1040 1050 1060 1070 1080 EESPAPPNEA TPTAAPDEQS IWNVTVLPNS KWANITWKHN FGPGTDFVVE YIDSNHTKKT 1090 1100 1110 1120 1130 1140 VPVKAQAQPI QLTDLYPGMT YTLRVYSRDN EGISSTVITF MTSTAYTNNQ ADIATQGWFI 1150 1160 1170 1180 1190 1200 GLMCAIALLV LILLIVCFIK RSRGGKYPVR EKKDVPLGPE DPKEEDGSFD YSDEDNKPLQ 1210 1220 1230 1240 1250 1260 GSQTSLDGTI KQQESDDSLV DYGEGGEGQF NEDGSFIGQY TVKKDKEETE GNESSEATSP VNAIYSLA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 804-1347 (ISOFORMS 3/4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 931-1347 (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 972-1347 (ISOFORM 1). Tissue: Teratocarcinoma and Uterus.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 9), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 326-1347 (ISOFORM 2). Tissue: Brain.
[6]	"Alternative splice variants encoding unstable protein domains exist in the human brain." Homma K., Kikuno R.F., Nagase T., Ohara O., Nishikawa K. J. Mol. Biol. 343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 193-1347 (ISOFORM 5).
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1040-1347 (ISOFORM 7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1204-1347 (ISOFORMS 1/3/4/6/7). Tissue: Amygdala and Esophageal carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-481 AND SER-485, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Homophilic adhesion mechanism of neurofascin, a member of the L1 family of neural cell adhesion molecules." Liu H., Focia P.J., He X. J. Biol. Chem. 286:797-805(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 25-428, GLYCOSYLATION AT ASN-409, SUBUNIT, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB018299 mRNA. Translation: BAA34476.3. Different initiation.
AK027553 mRNA. Translation: BAB55195.1. Different initiation.
AK090639 mRNA. Translation: BAG52203.1.
AK127424 mRNA. No translation available.
AK128699 mRNA. Translation: BAC87577.1. Different initiation.
AC096675 Genomic DNA. No translation available.
AL391822 Genomic DNA. Translation: CAI14656.1.
AL391822 Genomic DNA. Translation: CAI14657.1.
AL391822 Genomic DNA. Translation: CAI14658.1.
AL391822 Genomic DNA. Translation: CAI14659.1.
AL391822 Genomic DNA. Translation: CAI14660.1.
AL391822 Genomic DNA. Translation: CAI14661.1.
AL391822 Genomic DNA. Translation: CAI14662.1.
AL391822 Genomic DNA. Translation: CAI14664.1.
AL391822 Genomic DNA. Translation: CAI14665.1.
AL391822 Genomic DNA. Translation: CAI14666.1.
AL391822 Genomic DNA. Translation: CAI14667.1.
BC008124 mRNA. Translation: AAH08124.2.
BC117674 mRNA. Translation: AAI17675.2.
BC137013 mRNA. Translation: AAI37014.1.
BC144454 mRNA. Translation: AAI44455.1.
AB177861 mRNA. Translation: BAD66839.1.
BX537841 mRNA. Translation: CAD97852.1.
CR749402 mRNA. Translation: CAH18247.1.

IPI

IPI00384998.
IPI00394653.
IPI00394655.
IPI00443574.
IPI00470575.
IPI00477765.
IPI00477942.
IPI00513695.
IPI00513705.
IPI00655702.
IPI00655858.
IPI00655890.
IPI00656129.

RefSeq

NP_001005388.2. NM_001005388.2.
NP_001005389.2. NM_001005389.1.
NP_001153803.1. NM_001160331.1.
NP_001153804.1. NM_001160332.1.
NP_001153805.1. NM_001160333.1.
NP_055905.2. NM_015090.3.

UniGene

Hs.13349.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3P3Y	X-ray	2.60	A	25-428	[»]
3P40	X-ray	3.20	A	25-428	[»]

ProteinModelPortal

O94856.

ModBase

Search...

Protein-protein interaction databases

IntAct

O94856. 5 interactions.

MINT

MINT-2798373.

PTM databases

PhosphoSite

O94856.

Proteomic databases

PaxDb

O94856.

PRIDE

O94856.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000339876; ENSP00000344786; ENSG00000163531.
ENST00000360049; ENSP00000353154; ENSG00000163531.
ENST00000401399; ENSP00000385637; ENSG00000163531.
ENST00000403080; ENSP00000384875; ENSG00000163531.
ENST00000404076; ENSP00000385676; ENSG00000163531.
ENST00000404907; ENSP00000384061; ENSG00000163531.
ENST00000430393; ENSP00000415031; ENSG00000163531.
ENST00000446412; ENSP00000412161; ENSG00000163531.
ENST00000447819; ENSP00000416891; ENSG00000163531.
ENST00000513543; ENSP00000425908; ENSG00000163531.
ENST00000539706; ENSP00000438614; ENSG00000163531.

GeneID

23114.

KEGG

hsa:23114.

UCSC

uc001hbh.3. human.
uc001hbi.3. human.
uc001hbj.3. human.
uc010pra.2. human.
uc010prb.2. human.
uc010prc.2. human.

Organism-specific databases

CTD

23114.

GeneCards

GC01P204797.

HGNC

HGNC:29866. NFASC.

HPA

HPA008832.

MIM

609145. gene.

neXtProt

NX_O94856.

PharmGKB

PA128395771.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG293951.

HOVERGEN

HBG000144.

KO

K06757.

Enzyme and pathway databases

Reactome

REACT_111045. Developmental Biology.

Gene expression databases

ArrayExpress

O94856.

Bgee

O94856.

Genevestigator

O94856.

GermOnline

ENSG00000163531. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 11 hits.

InterPro

IPR026966. Fibronectin_III_C.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026965. NFASC.
[Graphical view]

PANTHER

PTHR10489:SF41. PTHR10489:SF41. 1 hit.

Pfam

PF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 5 hits.
PF07679. I-set. 4 hits.
[Graphical view]

SMART

SM00060. FN3. 5 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 4 hits.
[Graphical view]

SUPFAM

SSF49265. FN_III-like. 5 hits.

PROSITE

PS50853. FN3. 5 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

NFASC. human.

EvolutionaryTrace

O94856.

GenomeRNAi

23114.

NextBio

44320.

SOURCE

Search...

Entry information

Entry name

NFASC_HUMAN

Accession

Primary (citable) accession number: O94856
Secondary accession number(s): B2RNN8 , B3KQZ1, B5MDP6, B5MDR6, B7ZMD8, Q149P5, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 121 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.