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Protein

Neurofascin

Gene

NFASC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163531-MONOMER.
ReactomeiR-HSA-445095. Interaction between L1 and Ankyrins.
R-HSA-447043. Neurofascin interactions.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurofascin
Gene namesi
Name:NFASC
Synonyms:KIAA0756
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29866. NFASC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 1217ExtracellularSequence analysisAdd BLAST1193
Transmembranei1218 – 1238HelicalSequence analysisAdd BLAST21
Topological domaini1239 – 1347CytoplasmicSequence analysisAdd BLAST109

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23114.
OpenTargetsiENSG00000163531.
PharmGKBiPA128395771.

Polymorphism and mutation databases

BioMutaiNFASC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001504925 – 1347NeurofascinAdd BLAST1323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 118PROSITE-ProRule annotation1 Publication
Disulfide bondi162 ↔ 213PROSITE-ProRule annotation1 Publication
Disulfide bondi268 ↔ 316PROSITE-ProRule annotation1 Publication
Glycosylationi305N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi358 ↔ 408PROSITE-ProRule annotation1 Publication
Glycosylationi409N-linked (GlcNAc...)1 Publication1
Glycosylationi446N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi452 ↔ 501PROSITE-ProRule annotation
Modified residuei481PhosphotyrosineCombined sources1
Glycosylationi483N-linked (GlcNAc...)Sequence analysis1
Modified residuei485PhosphoserineCombined sources1
Disulfide bondi543 ↔ 592PROSITE-ProRule annotation
Glycosylationi752N-linked (GlcNAc...)Sequence analysis1
Glycosylationi778N-linked (GlcNAc...)Sequence analysis1
Glycosylationi973N-linked (GlcNAc...)Sequence analysis1
Glycosylationi988N-linked (GlcNAc...)Sequence analysis1
Modified residuei1267PhosphoserineBy similarity1
Modified residuei1281PhosphoserineBy similarity1
Modified residuei1294PhosphoserineBy similarity1
Modified residuei1297PhosphoserineBy similarity1
Modified residuei1333PhosphoserineBy similarity1
Modified residuei1334PhosphoserineBy similarity1
Modified residuei1338PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO94856.
MaxQBiO94856.
PaxDbiO94856.
PeptideAtlasiO94856.
PRIDEiO94856.
TopDownProteomicsiO94856-2. [O94856-2]

PTM databases

iPTMnetiO94856.
PhosphoSitePlusiO94856.
SwissPalmiO94856.

Expressioni

Gene expression databases

BgeeiENSG00000163531.
ExpressionAtlasiO94856. baseline and differential.
GenevisibleiO94856. HS.

Organism-specific databases

HPAiHPA008832.

Interactioni

Subunit structurei

Horseshoe-shaped homodimer. Probable constituent of a neurofascin/NRCAM/ankyrin-G complex. Associates with the sodium channel beta-1 (SCN1B) and beta-3 (SCN3B) subunits. Interacts with GLDN/gliomedin (By similarity). Interacts with MYOC.By similarity2 Publications

Protein-protein interaction databases

IntActiO94856. 7 interactors.
STRINGi9606.ENSP00000344786.

Structurei

Secondary structure

11347
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi43 – 46Combined sources4
Beta strandi49 – 53Combined sources5
Beta strandi55 – 57Combined sources3
Beta strandi63 – 65Combined sources3
Beta strandi72 – 77Combined sources6
Helixi84 – 86Combined sources3
Beta strandi94 – 96Combined sources3
Turni104 – 106Combined sources3
Helixi109 – 112Combined sources4
Beta strandi114 – 121Combined sources8
Beta strandi126 – 136Combined sources11
Beta strandi150 – 153Combined sources4
Beta strandi158 – 160Combined sources3
Beta strandi172 – 176Combined sources5
Beta strandi187 – 191Combined sources5
Beta strandi197 – 201Combined sources5
Helixi205 – 207Combined sources3
Beta strandi211 – 216Combined sources6
Turni218 – 220Combined sources3
Beta strandi223 – 225Combined sources3
Beta strandi231 – 234Combined sources4
Beta strandi236 – 238Combined sources3
Beta strandi246 – 249Combined sources4
Beta strandi251 – 259Combined sources9
Beta strandi264 – 267Combined sources4
Beta strandi277 – 282Combined sources6
Turni289 – 291Combined sources3
Beta strandi292 – 295Combined sources4
Helixi296 – 298Combined sources3
Beta strandi300 – 305Combined sources6
Helixi308 – 310Combined sources3
Beta strandi312 – 319Combined sources8
Beta strandi324 – 341Combined sources18
Beta strandi346 – 348Combined sources3
Beta strandi354 – 357Combined sources4
Beta strandi359 – 364Combined sources6
Beta strandi367 – 372Combined sources6
Helixi377 – 379Combined sources3
Beta strandi386 – 389Combined sources4
Beta strandi392 – 397Combined sources6
Beta strandi405 – 412Combined sources8
Beta strandi415 – 425Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P3YX-ray2.60A25-428[»]
3P40X-ray3.20A25-428[»]
ProteinModelPortaliO94856.
SMRiO94856.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94856.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 137Ig-like C2-type 1Add BLAST97
Domaini143 – 230Ig-like C2-type 2Add BLAST88
Domaini244 – 332Ig-like C2-type 3Add BLAST89
Domaini337 – 424Ig-like C2-type 4Add BLAST88
Domaini429 – 517Ig-like C2-type 5Add BLAST89
Domaini521 – 603Ig-like C2-type 6Add BLAST83
Domaini630 – 725Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini730 – 823Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94
Domaini828 – 930Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST103
Domaini934 – 1030Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST97
Domaini1114 – 1206Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1031 – 1108Thr-richAdd BLAST78

Domaini

Homophilic adhesion is primarily mediated by the interaction of the second Ig-like domains.

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOVERGENiHBG000144.
InParanoidiO94856.
KOiK06757.
OMAiNRVYPDT.
OrthoDBiEOG091G00LY.
PhylomeDBiO94856.
TreeFamiTF351098.

Family and domain databases

CDDicd00063. FN3. 5 hits.
Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR026966. Neurofascin/L1/NrCAM_C.
IPR026965. NFASC.
[Graphical view]
PANTHERiPTHR10489:SF715. PTHR10489:SF715. 3 hits.
PfamiPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 5 hits.
PF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (13)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 13 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94856-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD
60 70 80 90 100
HIVDPRDNIL IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV
110 120 130 140 150
IDFRSGGRPE EYEGEYQCFA RNKFGTALSN RIRLQVSKSP LWPKENLDPV
160 170 180 190 200
VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM EPITQDKRVS QGHNGDLYFS
210 220 230 240 250
NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA ERTPSFMYPQ
260 270 280 290 300
GTASSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSD KAKFENFNKA
310 320 330 340 350
LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP
360 370 380 390 400
GEDGRLVCRA NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI
410 420 430 440 450
SSRAVYQCNT SNEHGYLLAN AFVSVLDVPP RMLSPRNQLI RVILYNRTRL
460 470 480 490 500
DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV YENGSLEIKM IRKEDQGIYT
510 520 530 540 550
CVATNILGKA ENQVRLEVKD PTRIYRMPED QVARRGTTVQ LECRVKHDPS
560 570 580 590 600
LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCVASTELDQ
610 620 630 640 650
DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP
660 670 680 690 700
GDANNSPITD YVVQFEEDQF QPGVWHDHSK YPGSVNSAVL RLSPYVNYQF
710 720 730 740 750
RVIAINEVGS SHPSLPSERY RTSGAPPESN PGDVKGEGTR KNNMEITWTP
760 770 780 790 800
MNATSAFGPN LRYIVKWRRR ETREAWNNVT VWGSRYVVGQ TPVYVPYEIR
810 820 830 840 850
VQAENDFGKG PEPESVIGYS GEDYPRAAPT EVKVRVMNST AISLQWNRVY
860 870 880 890 900
SDTVQGQLRE YRAYYWRESS LLKNLWVSQK RQQASFPGDR LRGVVSRLFP
910 920 930 940 950
YSNYKLEMVV VNGRGDGPRS ETKEFTTPEG VPSAPRRFRV RQPNLETINL
960 970 980 990 1000
EWDHPEHPNG IMIGYTLKYV AFNGTKVGKQ IVENFSPNQT KFTVQRTDPV
1010 1020 1030 1040 1050
SRYRFTLSAR TQVGSGEAVT EESPAPPNEA TPTAAPPTLP PTTVGATGAV
1060 1070 1080 1090 1100
SSTDATAIAA TTEATTVPII PTVAPTTIAT TTTVATTTTT TAAATTTTES
1110 1120 1130 1140 1150
PPTTTSGTKI HESAPDEQSI WNVTVLPNSK WANITWKHNF GPGTDFVVEY
1160 1170 1180 1190 1200
IDSNHTKKTV PVKAQAQPIQ LTDLYPGMTY TLRVYSRDNE GISSTVITFM
1210 1220 1230 1240 1250
TSTAYTNNQA DIATQGWFIG LMCAIALLVL ILLIVCFIKR SRGGKYPVRE
1260 1270 1280 1290 1300
KKDVPLGPED PKEEDGSFDY SDEDNKPLQG SQTSLDGTIK QQESDDSLVD
1310 1320 1330 1340
YGEGGEGQFN EDGSFIGQYT VKKDKEETEG NESSEATSPV NAIYSLA
Note: No experimental confirmation available.
Length:1,347
Mass (Da):150,027
Last modified:December 6, 2005 - v4
Checksum:i4DC555E5AA06C223
GO
Isoform 2 (identifier: O94856-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     611-619: ADQATPTNR → GNCPCSPWH
     620-1347: Missing.

Note: May be due to intron retention.
Show »
Length:619
Mass (Da):69,565
Checksum:i19677F073EA3925E
GO
Isoform 3 (identifier: O94856-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     236-236: T → NHPYNDSSLRNHPDMYSA
     611-625: Missing.
     1030-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,169
Mass (Da):131,669
Checksum:i227C4122ABA8EDAD
GO
Isoform 4 (identifier: O94856-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     824-930: Missing.
     931-931: V → L
     1030-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,066
Mass (Da):119,470
Checksum:iB254170D9F282A75
GO
Isoform 5 (identifier: O94856-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     611-625: Missing.
     1030-1043: ATPTAAPPTLPPTT → GRCMAAAPGVKGPS

Note: May be due to intron retention.
Show »
Length:1,332
Mass (Da):148,444
Checksum:iC8EB8885620764DF
GO
Isoform 6 (identifier: O94856-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1030-1152: Missing.
     1153-1153: S → G

Note: No experimental confirmation available.
Show »
Length:1,224
Mass (Da):137,531
Checksum:i345949AF7828A247
GO
Isoform 7 (identifier: O94856-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1114-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,257
Mass (Da):139,881
Checksum:i4E9F5630EAB43566
GO
Isoform 8 (identifier: O94856-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     236-236: T → NHPYNDSSLRNHPDMYSA
     611-625: Missing.
     1035-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,174
Mass (Da):132,111
Checksum:iB298E5CBDF6A66B6
GO
Isoform 9 (identifier: O94856-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     824-930: Missing.
     931-931: V → L

Note: No experimental confirmation available.
Show »
Length:1,240
Mass (Da):137,609
Checksum:i2A894288EB12B706
GO
Isoform 10 (identifier: O94856-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     611-625: Missing.
     1035-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,157
Mass (Da):130,112
Checksum:iFD0DE3EBAA072F1F
GO
Isoform 11 (identifier: O94856-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     236-236: T → NHPYNDSSLRNHPDMYSA
     1035-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,189
Mass (Da):133,659
Checksum:i0D8B3BD1CF541D66
GO
Isoform 12 (identifier: O94856-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     824-930: Missing.
     931-931: V → L
     1035-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,071
Mass (Da):119,911
Checksum:i8D23FD7B6D7A4EE0
GO
Isoform 13 (identifier: O94856-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1035-1113: Missing.

Note: No experimental confirmation available.
Show »
Length:1,268
Mass (Da):142,474
Checksum:i860AFD7BD11A1BFE
GO

Sequence cautioni

The sequence BAA34476 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55195 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC87577 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti807F → L in BAB55195 (PubMed:14702039).Curated1
Sequence conflicti972F → V in AK127424 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017251159T → M.Corresponds to variant rs3795564dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01642431 – 36Missing in isoform 3, isoform 8, isoform 10 and isoform 11. 2 Publications6
Alternative sequenceiVSP_016425236T → NHPYNDSSLRNHPDMYSA in isoform 3, isoform 8 and isoform 11. 2 Publications1
Alternative sequenceiVSP_008937611 – 625Missing in isoform 3, isoform 5, isoform 8 and isoform 10. 3 PublicationsAdd BLAST15
Alternative sequenceiVSP_016426611 – 619ADQATPTNR → GNCPCSPWH in isoform 2. 2 Publications9
Alternative sequenceiVSP_008938620 – 1347Missing in isoform 2. 2 PublicationsAdd BLAST728
Alternative sequenceiVSP_016427824 – 930Missing in isoform 4, isoform 9 and isoform 12. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_016428931V → L in isoform 4, isoform 9 and isoform 12. 1 Publication1
Alternative sequenceiVSP_0089401030 – 1203Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST174
Alternative sequenceiVSP_0164301030 – 1152Missing in isoform 6. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_0164291030 – 1043ATPTA…LPPTT → GRCMAAAPGVKGPS in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0164321035 – 1203Missing in isoform 8, isoform 10, isoform 11 and isoform 12. CuratedAdd BLAST169
Alternative sequenceiVSP_0164311035 – 1113Missing in isoform 13. CuratedAdd BLAST79
Alternative sequenceiVSP_0164331114 – 1203Missing in isoform 7. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_0164341153S → G in isoform 6. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018299 mRNA. Translation: BAA34476.3. Different initiation.
AK027553 mRNA. Translation: BAB55195.1. Different initiation.
AK090639 mRNA. Translation: BAG52203.1.
AK127424 mRNA. No translation available.
AK128699 mRNA. Translation: BAC87577.1. Different initiation.
AC096675 Genomic DNA. No translation available.
AL391822 Genomic DNA. Translation: CAI14656.1.
AL391822 Genomic DNA. Translation: CAI14657.1.
AL391822 Genomic DNA. Translation: CAI14658.1.
AL391822 Genomic DNA. Translation: CAI14659.1.
AL391822 Genomic DNA. Translation: CAI14660.1.
AL391822 Genomic DNA. Translation: CAI14661.1.
AL391822 Genomic DNA. Translation: CAI14662.1.
AL391822 Genomic DNA. Translation: CAI14664.1.
AL391822 Genomic DNA. Translation: CAI14665.1.
AL391822 Genomic DNA. Translation: CAI14666.1.
AL391822 Genomic DNA. Translation: CAI14667.1.
BC008124 mRNA. Translation: AAH08124.2.
BC117674 mRNA. Translation: AAI17675.2.
BC137013 mRNA. Translation: AAI37014.1.
BC144454 mRNA. Translation: AAI44455.1.
AB177861 mRNA. Translation: BAD66839.1.
BX537841 mRNA. Translation: CAD97852.1.
CR749402 mRNA. Translation: CAH18247.1.
CCDSiCCDS30982.1. [O94856-3]
CCDS53460.1. [O94856-9]
CCDS53461.1. [O94856-2]
CCDS53462.1. [O94856-8]
RefSeqiNP_001005388.2. NM_001005388.2. [O94856-9]
NP_001005389.2. NM_001005389.1. [O94856-2]
NP_001153803.1. NM_001160331.1. [O94856-11]
NP_001153804.1. NM_001160332.1. [O94856-8]
NP_001153805.1. NM_001160333.1.
NP_055905.2. NM_015090.3. [O94856-3]
XP_011507621.1. XM_011509319.1. [O94856-1]
XP_011507630.1. XM_011509328.1. [O94856-12]
UniGeneiHs.13349.

Genome annotation databases

EnsembliENST00000339876; ENSP00000344786; ENSG00000163531. [O94856-9]
ENST00000360049; ENSP00000353154; ENSG00000163531. [O94856-3]
ENST00000401399; ENSP00000385637; ENSG00000163531. [O94856-9]
ENST00000403080; ENSP00000384875; ENSG00000163531. [O94856-2]
ENST00000404076; ENSP00000385676; ENSG00000163531. [O94856-10]
ENST00000404907; ENSP00000384061; ENSG00000163531. [O94856-8]
ENST00000513543; ENSP00000425908; ENSG00000163531. [O94856-3]
ENST00000539706; ENSP00000438614; ENSG00000163531. [O94856-8]
GeneIDi23114.
KEGGihsa:23114.
UCSCiuc001hbh.4. human. [O94856-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018299 mRNA. Translation: BAA34476.3. Different initiation.
AK027553 mRNA. Translation: BAB55195.1. Different initiation.
AK090639 mRNA. Translation: BAG52203.1.
AK127424 mRNA. No translation available.
AK128699 mRNA. Translation: BAC87577.1. Different initiation.
AC096675 Genomic DNA. No translation available.
AL391822 Genomic DNA. Translation: CAI14656.1.
AL391822 Genomic DNA. Translation: CAI14657.1.
AL391822 Genomic DNA. Translation: CAI14658.1.
AL391822 Genomic DNA. Translation: CAI14659.1.
AL391822 Genomic DNA. Translation: CAI14660.1.
AL391822 Genomic DNA. Translation: CAI14661.1.
AL391822 Genomic DNA. Translation: CAI14662.1.
AL391822 Genomic DNA. Translation: CAI14664.1.
AL391822 Genomic DNA. Translation: CAI14665.1.
AL391822 Genomic DNA. Translation: CAI14666.1.
AL391822 Genomic DNA. Translation: CAI14667.1.
BC008124 mRNA. Translation: AAH08124.2.
BC117674 mRNA. Translation: AAI17675.2.
BC137013 mRNA. Translation: AAI37014.1.
BC144454 mRNA. Translation: AAI44455.1.
AB177861 mRNA. Translation: BAD66839.1.
BX537841 mRNA. Translation: CAD97852.1.
CR749402 mRNA. Translation: CAH18247.1.
CCDSiCCDS30982.1. [O94856-3]
CCDS53460.1. [O94856-9]
CCDS53461.1. [O94856-2]
CCDS53462.1. [O94856-8]
RefSeqiNP_001005388.2. NM_001005388.2. [O94856-9]
NP_001005389.2. NM_001005389.1. [O94856-2]
NP_001153803.1. NM_001160331.1. [O94856-11]
NP_001153804.1. NM_001160332.1. [O94856-8]
NP_001153805.1. NM_001160333.1.
NP_055905.2. NM_015090.3. [O94856-3]
XP_011507621.1. XM_011509319.1. [O94856-1]
XP_011507630.1. XM_011509328.1. [O94856-12]
UniGeneiHs.13349.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P3YX-ray2.60A25-428[»]
3P40X-ray3.20A25-428[»]
ProteinModelPortaliO94856.
SMRiO94856.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO94856. 7 interactors.
STRINGi9606.ENSP00000344786.

PTM databases

iPTMnetiO94856.
PhosphoSitePlusiO94856.
SwissPalmiO94856.

Polymorphism and mutation databases

BioMutaiNFASC.

Proteomic databases

EPDiO94856.
MaxQBiO94856.
PaxDbiO94856.
PeptideAtlasiO94856.
PRIDEiO94856.
TopDownProteomicsiO94856-2. [O94856-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339876; ENSP00000344786; ENSG00000163531. [O94856-9]
ENST00000360049; ENSP00000353154; ENSG00000163531. [O94856-3]
ENST00000401399; ENSP00000385637; ENSG00000163531. [O94856-9]
ENST00000403080; ENSP00000384875; ENSG00000163531. [O94856-2]
ENST00000404076; ENSP00000385676; ENSG00000163531. [O94856-10]
ENST00000404907; ENSP00000384061; ENSG00000163531. [O94856-8]
ENST00000513543; ENSP00000425908; ENSG00000163531. [O94856-3]
ENST00000539706; ENSP00000438614; ENSG00000163531. [O94856-8]
GeneIDi23114.
KEGGihsa:23114.
UCSCiuc001hbh.4. human. [O94856-1]

Organism-specific databases

CTDi23114.
DisGeNETi23114.
GeneCardsiNFASC.
HGNCiHGNC:29866. NFASC.
HPAiHPA008832.
MIMi609145. gene.
neXtProtiNX_O94856.
OpenTargetsiENSG00000163531.
PharmGKBiPA128395771.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOVERGENiHBG000144.
InParanoidiO94856.
KOiK06757.
OMAiNRVYPDT.
OrthoDBiEOG091G00LY.
PhylomeDBiO94856.
TreeFamiTF351098.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163531-MONOMER.
ReactomeiR-HSA-445095. Interaction between L1 and Ankyrins.
R-HSA-447043. Neurofascin interactions.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiNFASC. human.
EvolutionaryTraceiO94856.
GeneWikiiNFASC.
GenomeRNAii23114.
PROiO94856.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163531.
ExpressionAtlasiO94856. baseline and differential.
GenevisibleiO94856. HS.

Family and domain databases

CDDicd00063. FN3. 5 hits.
Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR026966. Neurofascin/L1/NrCAM_C.
IPR026965. NFASC.
[Graphical view]
PANTHERiPTHR10489:SF715. PTHR10489:SF715. 3 hits.
PfamiPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 5 hits.
PF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNFASC_HUMAN
AccessioniPrimary (citable) accession number: O94856
Secondary accession number(s): B2RNN8
, B3KQZ1, B5MDP6, B5MDR6, B7ZMD8, Q149P5, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: December 6, 2005
Last modified: November 30, 2016
This is version 156 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.