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O94855 (SC24D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein transport protein Sec24D
Alternative name(s):
SEC24-related protein D
Gene names
Name:SEC24D
Synonyms:KIAA0755
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1032 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

Subunit structure

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with TMED2 and TMED10. Ref.5

Subcellular location

Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Endoplasmic reticulum membrane By similarity. Golgi apparatus membrane By similarity.

Tissue specificity

Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver.

Sequence similarities

Belongs to the SEC23/SEC24 family. SEC24 subfamily.

Sequence caution

The sequence BAA34475.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processER-Golgi transport
Protein transport
Transport
   Cellular componentCytoplasm
Endoplasmic reticulum
Golgi apparatus
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processCOPII vesicle coating

Traceable author statement. Source: Reactome

ER to Golgi vesicle-mediated transport

Non-traceable author statement Ref.1. Source: UniProtKB

antigen processing and presentation of exogenous peptide antigen via MHC class II

Traceable author statement. Source: Reactome

antigen processing and presentation of peptide antigen via MHC class I

Traceable author statement. Source: Reactome

cellular protein metabolic process

Traceable author statement. Source: Reactome

intracellular protein transport

Inferred from electronic annotation. Source: InterPro

membrane organization

Traceable author statement. Source: Reactome

post-translational protein modification

Traceable author statement. Source: Reactome

protein N-linked glycosylation via asparagine

Traceable author statement. Source: Reactome

small molecule metabolic process

Traceable author statement. Source: Reactome

   Cellular_componentCOPII vesicle coat

Non-traceable author statement Ref.1. Source: UniProtKB

ER to Golgi transport vesicle membrane

Traceable author statement. Source: Reactome

Golgi membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytosol

Traceable author statement. Source: Reactome

endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O94855-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O94855-2)

The sequence of this isoform differs from the canonical sequence as follows:
     224-224: Q → QA
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10321032Protein transport protein Sec24D
PRO_0000205157

Regions

Region363 – 38826Zinc finger-like
Compositional bias10 – 293284Pro-rich

Natural variations

Alternative sequence2241Q → QA in isoform 2.
VSP_035761
Natural variant421M → T.
Corresponds to variant rs10029206 [ dbSNP | Ensembl ].
VAR_047472
Natural variant1931P → L.
Corresponds to variant rs6844109 [ dbSNP | Ensembl ].
VAR_047473
Natural variant4961F → I.
Corresponds to variant rs11723368 [ dbSNP | Ensembl ].
VAR_047474

Experimental info

Sequence conflict5591P → S in AAD28756. Ref.1
Sequence conflict5591P → S in BAA34475. Ref.2

Secondary structure

.............................................................................................................................................. 1032
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: B46E566F096F37F0

FASTA1,032113,010
        10         20         30         40         50         60 
MSQQGYVATP PYSQPQPGIG LSPPHYGHYG DPSHTASPTG MMKPAGPLGA TATRGMLPPG 

        70         80         90        100        110        120 
PPPPGPHQFG QNGAHATGHP PQRFPGPPPV NNVASSHAPY QPSAQSSYPG PISTSSVTQL 

       130        140        150        160        170        180 
GSQLSAMQIN SYGSGMAPPS QGPPGPLSAT SLQTPPRPPQ PSILQPGSQV LPPPPTTLNG 

       190        200        210        220        230        240 
PGASPLPLPM YRPDGLSGPP PPNAQYQPPP LPGQTLGAGY PPQQANSGPQ MAGAQLSYPG 

       250        260        270        280        290        300 
GFPGGPAQMA GPPQPQKKLD PDSIPSPIQV IENDRASRGG QVYATNTRGQ IPPLVTTDCM 

       310        320        330        340        350        360 
IQDQGNASPR FIRCTTYCFP CTSDMAKQAQ IPLAAVIKPF ATIPSNESPL YLVNHGESGP 

       370        380        390        400        410        420 
VRCNRCKAYM CPFMQFIEGG RRYQCGFCNC VNDVPPFYFQ HLDHIGRRLD HYEKPELSLG 

       430        440        450        460        470        480 
SYEYVATLDY CRKSKPPNPP AFIFMIDVSY SNIKNGLVKL ICEELKTMLE KIPKEEQEET 

       490        500        510        520        530        540 
SAIRVGFITY NKVLHFFNVK SNLAQPQMMV VTDVGEVFVP LLDGFLVNYQ ESQSVIHNLL 

       550        560        570        580        590        600 
DQIPDMFADS NENETVFAPV IQAGMEALKA ADCPGKLFIF HSSLPTAEAP GKLKNRDDKK 

       610        620        630        640        650        660 
LVNTDKEKIL FQPQTNVYDS LAKDCVAHGC SVTLFLFPSQ YVDVASLGLV PQLTGGTLYK 

       670        680        690        700        710        720 
YNNFQMHLDR QQFLNDLRND IEKKIGFDAI MRVRTSTGFR ATDFFGGILM NNTTDVEMAA 

       730        740        750        760        770        780 
IDCDKAVTVE FKHDDKLSED SGALIQCAVL YTTISGQRRL RIHNLGLNCS SQLADLYKSC 

       790        800        810        820        830        840 
ETDALINFFA KSAFKAVLHQ PLKVIREILV NQTAHMLACY RKNCASPSAA SQLILPDSMK 

       850        860        870        880        890        900 
VLPVYMNCLL KNCVLLSRPE ISTDERAYQR QLVMTMGVAD SQLFFYPQLL PIHTLDVKST 

       910        920        930        940        950        960 
MLPAAVRCSE SRLSEEGIFL LANGLHMFLW LGVSSPPELI QGIFNVPSFA HINTDMTLLP 

       970        980        990       1000       1010       1020 
EVGNPYSQQL RMIMGIIQQK RPYSMKLTIV KQREQPEMVF RQFLVEDKGL YGGSSYVDFL 

      1030 
CCVHKEICQL LN 

« Hide

Isoform 2 [UniParc].

Checksum: 4DBA3D9F630F0043
Show »

FASTA1,033113,081

References

« Hide 'large scale' references
[1]"A family of mammalian proteins homologous to yeast Sec24p."
Tang B.L., Kausalya J., Low D.Y.H., Lock M.L., Hong W.
Biochem. Biophys. Res. Commun. 258:679-684(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Pancreas.
[2]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lymph.
[5]"Selective export of human GPI-anchored proteins from the endoplasmic reticulum."
Bonnon C., Wendeler M.W., Paccaud J.P., Hauri H.P.
J. Cell Sci. 123:1705-1715(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TMED2 AND TMED10.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF130464 mRNA. Translation: AAD28756.2.
AB018298 mRNA. Translation: BAA34475.2. Different initiation.
CH471229 Genomic DNA. Translation: EAW73656.1.
BC035761 mRNA. Translation: AAH35761.1.
RefSeqNP_055637.2. NM_014822.2.
XP_005263435.1. XM_005263378.1.
XP_005263436.1. XM_005263379.1.
UniGeneHs.189641.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3EFOX-ray2.70B266-1032[»]
3EG9X-ray3.00B266-1032[»]
ProteinModelPortalO94855.
SMRO94855. Positions 263-1032.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115204. 17 interactions.
IntActO94855. 9 interactions.
MINTMINT-1184580.
STRING9606.ENSP00000280551.

PTM databases

PhosphoSiteO94855.

Proteomic databases

PaxDbO94855.
PRIDEO94855.

Protocols and materials databases

DNASU9871.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000280551; ENSP00000280551; ENSG00000150961. [O94855-1]
ENST00000379735; ENSP00000369059; ENSG00000150961. [O94855-2]
GeneID9871.
KEGGhsa:9871.
UCSCuc003ici.4. human. [O94855-1]
uc003icj.4. human. [O94855-2]

Organism-specific databases

CTD9871.
GeneCardsGC04M119643.
H-InvDBHIX0004459.
HGNCHGNC:10706. SEC24D.
HPAHPA041626.
MIM607186. gene.
neXtProtNX_O94855.
PharmGKBPA35629.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5028.
HOGENOMHOG000196365.
HOVERGENHBG062229.
KOK14007.
OMAEMAAMDC.
OrthoDBEOG700877.
PhylomeDBO94855.
TreeFamTF300464.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_11123. Membrane Trafficking.
REACT_17015. Metabolism of proteins.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressO94855.
BgeeO94855.
CleanExHS_SEC24D.
GenevestigatorO94855.

Family and domain databases

Gene3D3.40.50.410. 1 hit.
InterProIPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSEC24D. human.
EvolutionaryTraceO94855.
GeneWikiSEC24D.
GenomeRNAi9871.
NextBio37211.
PROO94855.
SOURCESearch...

Entry information

Entry nameSC24D_HUMAN
AccessionPrimary (citable) accession number: O94855
Secondary accession number(s): Q8IYI7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM