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Protein

Uncharacterized protein KIAA0754

Gene

KIAA0754

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA0754
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:29111. KIAA0754.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394598.

Polymorphism and mutation databases

BioMutaiKIAA0754.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12911291Uncharacterized protein KIAA0754PRO_0000295722Add
BLAST

Proteomic databases

EPDiO94854.
MaxQBiO94854.
PaxDbiO94854.
PRIDEiO94854.

PTM databases

iPTMnetiO94854.
PhosphoSiteiO94854.

Interactioni

Protein-protein interaction databases

BioGridi568672. 6 interactions.
IntActiO94854. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliO94854.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati876 – 889141Add
BLAST
Repeati890 – 901122Add
BLAST
Repeati902 – 915143Add
BLAST
Repeati916 – 928134Add
BLAST
Repeati929 – 941135Add
BLAST
Repeati942 – 954136Add
BLAST
Repeati955 – 967137Add
BLAST
Repeati968 – 980138Add
BLAST
Repeati981 – 993139Add
BLAST
Repeati994 – 10061310Add
BLAST
Repeati1007 – 10191311Add
BLAST
Repeati1020 – 10321312Add
BLAST
Repeati1033 – 10421013

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 1098913 X 13 AA approximate tandem repeat of P-T-S-P-A-A-A-V-P-T-P-E-EAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi762 – 1189428Ala-richAdd
BLAST

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IREM. Eukaryota.
ENOG410YPF6. LUCA.
HOVERGENiHBG108023.
InParanoidiO94854.
OrthoDBiEOG73V6JT.
PhylomeDBiO94854.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94854-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPNFPEFAE RIEASLSEVS EAGASNPSLQ EKKESSSALT ESSGHLDHRE
60 70 80 90 100
PQSESVTLEH VSKSIGIPEV QDFKNLSGDC QDFRFQQHSA NPPHEFQPVE
110 120 130 140 150
SEAVATSGNT DVMQESRFSS ATWPRATKSL AKGGFSEKQH PLGDTACTVE
160 170 180 190 200
MPPLSPCLSE ELLDPELHVL ITPSLREKTE SELKFEEDER WIMMEAEGEW
210 220 230 240 250
EEEKLSDREK TFLMADEKNS LADIFEEREQ ANTAVVEDGS DCLAAVLRTF
260 270 280 290 300
GHLSLGQICC PDDPQPAKDQ LATVPKDIPL DCDCVLTGED ILGEVANRTA
310 320 330 340 350
QGLEGLVSDS ACTVGTIDAE QLSDTDSVQM FLELEKECLC EEGVTPLVEL
360 370 380 390 400
QNQISSEGLA ASQDAENLLV ISHFSGAALE KEQHLGLLHV RAKDYDTRLD
410 420 430 440 450
CGYFNTLDSS QVPNAVELIA HVDIMRDTST VSKEECEKVP FSPRTAEFKS
460 470 480 490 500
RQPADLDSLE KLDPGGLLNS DHRVSHEEKL SGFIASELAK DNGSLSQGDC
510 520 530 540 550
SQTEGNGEEC IERVTFSFAF NHELTDVTSG PEVEVLYESN LLTDEIHLES
560 570 580 590 600
GNVTVNQENN SLTSMGNVVT CELSVEKVCD EDGEAKELDY QATLLEDQAP
610 620 630 640 650
AHFHRNFPEQ VFQDLQRKSP ESEILSLHLL VEELRLNPDG VETVNDTKPE
660 670 680 690 700
LNVASSEGGE MERRDSDSFL NIFPEKQVTK AGNTEPVLEE WIPVLQRPSR
710 720 730 740 750
TAAVPTVKDA LDAALPSPEE GTSIAAVPAP EGTAVVAALV PFPHEDILVA
760 770 780 790 800
SIVSLEEEDV TAAAVSAPER ATVPAVTVSV PEGTAAVAAV SSPEETAPAV
810 820 830 840 850
AAAITQEGMS AVAGFSPEWA ALAITVPITE EDGTPEGPVT PATTVHAPEE
860 870 880 890 900
PDTAAVRVST PEEPASPAAA VPTPEEPTSP AAAVPTPEEP TSPAAAVPPP
910 920 930 940 950
EEPTSPAAAV PTPEEPTSPA AAVPTPEEPT SPAAAVPTPE EPTSPAAAVP
960 970 980 990 1000
TPEEPTSPAA AVPTPEEPTS PAAAVPTPEE PASPAAAVPT PEEPASPAAA
1010 1020 1030 1040 1050
VPTPEEPAFP APAVPTPEES ASAAVAVPTP EESASPAAAV PTPAESASFA
1060 1070 1080 1090 1100
AVVATLEEPT SPAASVPTPA AMVATLEEFT SPAASVPTSE EPASLAAAVS
1110 1120 1130 1140 1150
NPEEPTSPAA AVPTLEEPTS SAAAVLTPEE LSSPAASVPT PEEPASPAAA
1160 1170 1180 1190 1200
VSNLEEPASP AAAVPTPEVA AIPAASVPTP EVPAIPAAAV PPMEEVSPIG
1210 1220 1230 1240 1250
VPFLGVSAHT DSVPISEEGT PVLEEASSTG MWIKEDLDSL VFGIKEVTST
1260 1270 1280 1290
VLHGKVPLAA TAGLNSDEVI VHFDSGKGLK SKVRFAGLTW W
Length:1,291
Mass (Da):135,148
Last modified:October 3, 2012 - v4
Checksum:i3D555AA3519B4B65
GO
Isoform 2 (identifier: O94854-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     967-980: EPTSPAAAVPTPEE → DAPHPTTHSKNPYT
     981-1291: Missing.

Note: No experimental confirmation available.
Show »
Length:980
Mass (Da):104,656
Checksum:iC3753C3DD5F9922C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951E → K in BAC87042 (PubMed:14702039).Curated
Sequence conflicti387 – 3871L → P in BAC87042 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti824 – 8241I → V.
Corresponds to variant rs1746842 [ dbSNP | Ensembl ].
VAR_033338
Natural varianti969 – 9691T → A.
Corresponds to variant rs783822 [ dbSNP | Ensembl ].
VAR_033339
Natural varianti1058 – 10581E → K.
Corresponds to variant rs587523 [ dbSNP | Ensembl ].
VAR_033340

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei967 – 98014EPTSP…PTPEE → DAPHPTTHSKNPYT in isoform 2. 1 PublicationVSP_027016Add
BLAST
Alternative sequencei981 – 1291311Missing in isoform 2. 1 PublicationVSP_027017Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127581 mRNA. Translation: BAC87042.1.
AL137853 Genomic DNA. No translation available.
AB018297 mRNA. Translation: BAA34474.2.
RefSeqiNP_055853.1. NM_015038.1.
UniGeneiHs.658760.

Genome annotation databases

GeneIDi643314.
KEGGihsa:643314.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127581 mRNA. Translation: BAC87042.1.
AL137853 Genomic DNA. No translation available.
AB018297 mRNA. Translation: BAA34474.2.
RefSeqiNP_055853.1. NM_015038.1.
UniGeneiHs.658760.

3D structure databases

ProteinModelPortaliO94854.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi568672. 6 interactions.
IntActiO94854. 3 interactions.

PTM databases

iPTMnetiO94854.
PhosphoSiteiO94854.

Polymorphism and mutation databases

BioMutaiKIAA0754.

Proteomic databases

EPDiO94854.
MaxQBiO94854.
PaxDbiO94854.
PRIDEiO94854.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi643314.
KEGGihsa:643314.

Organism-specific databases

CTDi643314.
GeneCardsiKIAA0754.
HGNCiHGNC:29111. KIAA0754.
neXtProtiNX_O94854.
PharmGKBiPA128394598.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IREM. Eukaryota.
ENOG410YPF6. LUCA.
HOVERGENiHBG108023.
InParanoidiO94854.
OrthoDBiEOG73V6JT.
PhylomeDBiO94854.

Miscellaneous databases

GenomeRNAii643314.
PROiO94854.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 118-1291 (ISOFORM 1).
    Tissue: Brain.
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiK0754_HUMAN
AccessioniPrimary (citable) accession number: O94854
Secondary accession number(s): E9PMC2, Q6ZSB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 80 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.