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Protein

Protein-methionine sulfoxide oxidase MICAL2

Gene

MICAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.2 Publications

Catalytic activityi

[protein]-methionine + NADPH + O2 = [protein]-methionine-sulfoxide + NADP+ + H2O.1 Publication

Cofactori

FADBy similarity

Enzyme regulationi

Specifically inhibited by CCG-1423, a small molecule inhibitor of SRF:MKL1/MRTF-A-dependent transcription.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97FADBy similarity1
Binding sitei116FADBy similarity1
Binding sitei118FADBy similarity1
Binding sitei123FADBy similarity1
Binding sitei125FADBy similarity1
Binding sitei398FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 125FADBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

  • actin filament depolymerization Source: UniProtKB
  • cytoskeleton organization Source: UniProtKB
  • heart development Source: UniProtKB
  • heart looping Source: UniProtKB
  • oxidation-reduction process Source: UniProtKB
  • positive regulation of transcription via serum response element binding Source: UniProtKB
  • sulfur oxidation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Actin-binding, FAD, Flavoprotein, Metal-binding, NADP, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133816-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-methionine sulfoxide oxidase MICAL2 (EC:1.14.13.-)
Alternative name(s):
Molecule interacting with CasL protein 2
Short name:
MICAL-2
Gene namesi
Name:MICAL2
Synonyms:KIAA0750, MICAL2PV1, MICAL2PV2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24693. MICAL2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi95G → V: Blocks FAD binding and abolishes catalytic activity. 1 Publication1
Mutagenesisi677 – 681KRRRK → AAAAA in MICAL-2NLSMut; abolishes nuclear localization. 1 Publication5

Organism-specific databases

DisGeNETi9645.
OpenTargetsiENSG00000133816.
PharmGKBiPA142671453.

Polymorphism and mutation databases

BioMutaiMICAL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758441 – 1124Protein-methionine sulfoxide oxidase MICAL2Add BLAST1124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei631PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO94851.
MaxQBiO94851.
PaxDbiO94851.
PeptideAtlasiO94851.
PRIDEiO94851.

PTM databases

iPTMnetiO94851.
PhosphoSitePlusiO94851.

Expressioni

Gene expression databases

BgeeiENSG00000133816.
CleanExiHS_MICAL2.
ExpressionAtlasiO94851. baseline and differential.
GenevisibleiO94851. HS.

Organism-specific databases

HPAiHPA030437.

Interactioni

Subunit structurei

Interacts with VIM and PLXNA4 (By similarity). Interacts with RAB1B.By similarity1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115003. 2 interactors.
IntActiO94851. 6 interactors.
STRINGi9606.ENSP00000256194.

Structurei

Secondary structure

11124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi520 – 530Combined sources11
Beta strandi540 – 542Combined sources3
Helixi543 – 545Combined sources3
Beta strandi546 – 548Combined sources3
Helixi549 – 558Combined sources10
Turni560 – 562Combined sources3
Turni565 – 567Combined sources3
Helixi570 – 572Combined sources3
Helixi573 – 586Combined sources14
Helixi596 – 601Combined sources6
Helixi607 – 621Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9KNMR-A516-629[»]
ProteinModelPortaliO94851.
SMRiO94851.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94851.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini516 – 619CHPROSITE-ProRule annotationAdd BLAST104
Domaini1000 – 1062LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 494Monooxygenase domainBy similarityAdd BLAST493

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi660 – 681Nuclear localization signal1 PublicationAdd BLAST22

Sequence similaritiesi

Belongs to the Mical family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1700. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118856.
HOGENOMiHOG000047263.
HOVERGENiHBG052474.
InParanoidiO94851.
KOiK19947.
OMAiCSVCATT.
OrthoDBiEOG091G009H.
PhylomeDBiO94851.
TreeFamiTF324129.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
2.10.110.10. 1 hit.
3.50.50.60. 1 hit.
InterProiIPR001715. CH-domain.
IPR002938. FAD-bd.
IPR023753. FAD/NAD-binding_dom.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF01494. FAD_binding_3. 1 hit.
PF00412. LIM. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00132. LIM. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF51905. SSF51905. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94851-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGENEDEKQA QAGQVFENFV QASTCKGTLQ AFNILTRHLD LDPLDHRNFY
60 70 80 90 100
SKLKSKVTTW KAKALWYKLD KRGSHKEYKR GKSCTNTKCL IVGGGPCGLR
110 120 130 140 150
TAIELAYLGA KVVVVEKRDS FSRNNVLHLW PFTIHDLRGL GAKKFYGKFC
160 170 180 190 200
AGSIDHISIR QLQLILFKVA LMLGVEIHVN VEFVKVLEPP EDQENQKIGW
210 220 230 240 250
RAEFLPTDHS LSEFEFDVII GADGRRNTLE GFRRKEFRGK LAIAITANFI
260 270 280 290 300
NRNSTAEAKV EEISGVAFIF NQKFFQDLKE ETGIDLENIV YYKDCTHYFV
310 320 330 340 350
MTAKKQSLLD KGVIINDYID TEMLLCAENV NQDNLLSYAR EAADFATNYQ
360 370 380 390 400
LPSLDFAMNH YGQPDVAMFD FTCMYASENA ALVRERQAHQ LLVALVGDSL
410 420 430 440 450
LEPFWPMGTG CARGFLAAFD TAWMVKSWNQ GTPPLELLAE RESLYRLLPQ
460 470 480 490 500
TTPENINKNF EQYTLDPGTR YPNLNSHCVR PHQVKHLYIT KELEHYPLER
510 520 530 540 550
LGSVRRSVNL SRKESDIRPS KLLTWCQQQT EGYQHVNVTD LTTSWRSGLA
560 570 580 590 600
LCAIIHRFRP ELINFDSLNE DDAVENNQLA FDVAEREFGI PPVTTGKEMA
610 620 630 640 650
SAQEPDKLSM VMYLSKFYEL FRGTPLRPVD SWRKNYGENA DLSLAKSSIS
660 670 680 690 700
NNYLNLTFPR KRTPRVDGQT GENDMNKRRR KGFTNLDEPS NFSSRSLGSN
710 720 730 740 750
QECGSSKEGG NQNKVKSMAN QLLAKFEEST RNPSLMKQER RVSGIGKPVL
760 770 780 790 800
CSSSGPPVHS CCPKPEEATP SPSPPLKRQF PSVVVTGHVL RELKQVSAGS
810 820 830 840 850
ECLSRPWRAR AKSDLQLGGT ENFATLPSTR PRAQALSGVL WRLQQVEEKI
860 870 880 890 900
LQKRAQNLAN REFHTKNIKE KAAHLASMFG HGDFPQNKLL SKGLSHTHPP
910 920 930 940 950
SPPSRLPSPD PAASSSPSTV DSASPARKEK KSPSGFHFHP SHLRTVHPQL
960 970 980 990 1000
TVGKVSSGIG AAAEVLVNLY MNDHRPKAQA TSPDLESMRK SFPLNLGGSD
1010 1020 1030 1040 1050
TCYFCKKRVY VMERLSAEGH FFHRECFRCS ICATTLRLAA YTFDCDEGKF
1060 1070 1080 1090 1100
YCKPHFIHCK TNSKQRKRRA ELKQQREEEA TWQEQEAPRR DTPTESSCAV
1110 1120
AAIGTLEGSP PVHFSLPVLH PLLG
Length:1,124
Mass (Da):126,689
Last modified:May 1, 1999 - v1
Checksum:i1C276C42D17B64DF
GO
Isoform 2 (identifier: O94851-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.
     740-986: Missing.
     1112-1124: VHFSLPVLHPLLG → GISTSFFRKV...VLRCFPVKLR

Show »
Length:784
Mass (Da):89,890
Checksum:i114E5873F13E5C61
GO
Isoform 3 (identifier: O94851-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     929-949: Missing.

Show »
Length:1,103
Mass (Da):124,253
Checksum:iEAB33EE2B2DB4BA1
GO
Isoform 4 (identifier: O94851-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     739-928: Missing.
     950-985: Missing.
     1112-1124: VHFSLPVLHPLLG → GISTSFFRKV...VLRCFPVKLR

Show »
Length:976
Mass (Da):111,652
Checksum:iD8B4E819D43FDA7E
GO
Isoform 5 (identifier: O94851-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     739-928: Missing.

Show »
Length:934
Mass (Da):106,211
Checksum:i5CB357AB0F7D4B9E
GO
Isoform 6 (identifier: O94851-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     739-985: Missing.
     1112-1124: VHFSLPVLHPLLG → GISTSFFRKV...VLRCFPVKLR

Show »
Length:955
Mass (Da):109,216
Checksum:i583E6EF7AC29A939
GO

Sequence cautioni

The sequence BAA34470 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19F → S in BAG57951 (PubMed:14702039).Curated1
Sequence conflicti208D → G in CAD97967 (PubMed:17974005).Curated1
Sequence conflicti296T → A in CAD97967 (PubMed:17974005).Curated1
Sequence conflicti529Q → H in BAG57951 (PubMed:14702039).Curated1
Sequence conflicti563I → V in BAG57951 (PubMed:14702039).Curated1
Sequence conflicti631S → Y in CAD97967 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050155145F → L.Corresponds to variant rs2706656dbSNPEnsembl.1
Natural variantiVAR_021992220I → V.Corresponds to variant rs2306727dbSNPEnsembl.1
Natural variantiVAR_050156687D → E.Corresponds to variant rs3794084dbSNPEnsembl.1
Natural variantiVAR_0202571089R → Q.Corresponds to variant rs2270515dbSNPEnsembl.1
Natural variantiVAR_0245231106L → P.1 PublicationCorresponds to variant rs1027335dbSNPEnsembl.1
Natural variantiVAR_0501571110P → S.Corresponds to variant rs35518829dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0098591 – 171Missing in isoform 2. 1 PublicationAdd BLAST171
Alternative sequenceiVSP_042593739 – 985Missing in isoform 6. 1 PublicationAdd BLAST247
Alternative sequenceiVSP_042594739 – 928Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST190
Alternative sequenceiVSP_009860740 – 986Missing in isoform 2. 1 PublicationAdd BLAST247
Alternative sequenceiVSP_042595929 – 949Missing in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_042596950 – 985Missing in isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0098611112 – 1124VHFSL…HPLLG → GISTSFFRKVLGWPLRLPRD LCNWMQGLLQAAGLHIRDNA YNYCYMYELLSLGLPLLWAF SEVLAAMYRESEGSLESICN WVLRCFPVKLR in isoform 2, isoform 4 and isoform 6. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110785 mRNA. Translation: BAD83656.1.
AB110786 mRNA. Translation: BAD83657.1.
AB018293 mRNA. Translation: BAA34470.2. Different initiation.
AK294845 mRNA. Translation: BAG57951.1.
AK302893 mRNA. Translation: BAH13835.1.
BX538021 mRNA. Translation: CAD97967.1.
BX641163 mRNA. Translation: CAE46072.1.
AC025106 Genomic DNA. No translation available.
AC079329 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68528.1.
CH471064 Genomic DNA. Translation: EAW68529.1.
CH471064 Genomic DNA. Translation: EAW68531.1.
BC044577 mRNA. Translation: AAH44577.1.
BK000462 mRNA. Translation: DAA01341.1.
CCDSiCCDS60726.1. [O94851-3]
CCDS60727.1. [O94851-5]
CCDS60728.1. [O94851-4]
CCDS7809.1. [O94851-1]
RefSeqiNP_001269592.1. NM_001282663.1. [O94851-1]
NP_001269593.1. NM_001282664.1. [O94851-3]
NP_001269594.1. NM_001282665.1. [O94851-5]
NP_001269595.1. NM_001282666.1. [O94851-4]
NP_001269596.1. NM_001282667.1. [O94851-6]
NP_055447.1. NM_014632.3. [O94851-1]
XP_016874078.1. XM_017018589.1. [O94851-1]
XP_016874079.1. XM_017018590.1. [O94851-1]
XP_016874080.1. XM_017018591.1. [O94851-3]
UniGeneiHs.501928.

Genome annotation databases

EnsembliENST00000256194; ENSP00000256194; ENSG00000133816. [O94851-1]
ENST00000342902; ENSP00000344894; ENSG00000133816. [O94851-3]
ENST00000379612; ENSP00000368932; ENSG00000133816. [O94851-4]
ENST00000527546; ENSP00000433965; ENSG00000133816. [O94851-5]
ENST00000537344; ENSP00000441689; ENSG00000133816. [O94851-1]
GeneIDi9645.
KEGGihsa:9645.
UCSCiuc001mjz.5. human. [O94851-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110785 mRNA. Translation: BAD83656.1.
AB110786 mRNA. Translation: BAD83657.1.
AB018293 mRNA. Translation: BAA34470.2. Different initiation.
AK294845 mRNA. Translation: BAG57951.1.
AK302893 mRNA. Translation: BAH13835.1.
BX538021 mRNA. Translation: CAD97967.1.
BX641163 mRNA. Translation: CAE46072.1.
AC025106 Genomic DNA. No translation available.
AC079329 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68528.1.
CH471064 Genomic DNA. Translation: EAW68529.1.
CH471064 Genomic DNA. Translation: EAW68531.1.
BC044577 mRNA. Translation: AAH44577.1.
BK000462 mRNA. Translation: DAA01341.1.
CCDSiCCDS60726.1. [O94851-3]
CCDS60727.1. [O94851-5]
CCDS60728.1. [O94851-4]
CCDS7809.1. [O94851-1]
RefSeqiNP_001269592.1. NM_001282663.1. [O94851-1]
NP_001269593.1. NM_001282664.1. [O94851-3]
NP_001269594.1. NM_001282665.1. [O94851-5]
NP_001269595.1. NM_001282666.1. [O94851-4]
NP_001269596.1. NM_001282667.1. [O94851-6]
NP_055447.1. NM_014632.3. [O94851-1]
XP_016874078.1. XM_017018589.1. [O94851-1]
XP_016874079.1. XM_017018590.1. [O94851-1]
XP_016874080.1. XM_017018591.1. [O94851-3]
UniGeneiHs.501928.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9KNMR-A516-629[»]
ProteinModelPortaliO94851.
SMRiO94851.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115003. 2 interactors.
IntActiO94851. 6 interactors.
STRINGi9606.ENSP00000256194.

PTM databases

iPTMnetiO94851.
PhosphoSitePlusiO94851.

Polymorphism and mutation databases

BioMutaiMICAL2.

Proteomic databases

EPDiO94851.
MaxQBiO94851.
PaxDbiO94851.
PeptideAtlasiO94851.
PRIDEiO94851.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256194; ENSP00000256194; ENSG00000133816. [O94851-1]
ENST00000342902; ENSP00000344894; ENSG00000133816. [O94851-3]
ENST00000379612; ENSP00000368932; ENSG00000133816. [O94851-4]
ENST00000527546; ENSP00000433965; ENSG00000133816. [O94851-5]
ENST00000537344; ENSP00000441689; ENSG00000133816. [O94851-1]
GeneIDi9645.
KEGGihsa:9645.
UCSCiuc001mjz.5. human. [O94851-1]

Organism-specific databases

CTDi9645.
DisGeNETi9645.
GeneCardsiMICAL2.
HGNCiHGNC:24693. MICAL2.
HPAiHPA030437.
MIMi608881. gene.
neXtProtiNX_O94851.
OpenTargetsiENSG00000133816.
PharmGKBiPA142671453.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1700. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118856.
HOGENOMiHOG000047263.
HOVERGENiHBG052474.
InParanoidiO94851.
KOiK19947.
OMAiCSVCATT.
OrthoDBiEOG091G009H.
PhylomeDBiO94851.
TreeFamiTF324129.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133816-MONOMER.

Miscellaneous databases

ChiTaRSiMICAL2. human.
EvolutionaryTraceiO94851.
GeneWikiiMICAL2.
GenomeRNAii9645.
PROiO94851.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133816.
CleanExiHS_MICAL2.
ExpressionAtlasiO94851. baseline and differential.
GenevisibleiO94851. HS.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
2.10.110.10. 1 hit.
3.50.50.60. 1 hit.
InterProiIPR001715. CH-domain.
IPR002938. FAD-bd.
IPR023753. FAD/NAD-binding_dom.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF01494. FAD_binding_3. 1 hit.
PF00412. LIM. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00132. LIM. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF51905. SSF51905. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMICA2_HUMAN
AccessioniPrimary (citable) accession number: O94851
Secondary accession number(s): B4DGZ0
, B7Z849, D3DQW5, G3XAC8, Q5KTR3, Q5KTR4, Q7Z3A8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.