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UniProtKB - O94851 (MICA2_HUMAN)

UniProt

O94851 - MICA2_HUMAN

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Protein

Protein-methionine sulfoxide oxidase MICAL2

Gene

MICAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.2 Publications

Catalytic activityi

[protein]-methionine + NADPH + O2 = [protein]-methionine-sulfoxide + NADP+ + H2O.1 Publication

Cofactori

FADBy similarity

Enzyme regulationi

Specifically inhibited by CCG-1423, a small molecule inhibitor of SRF:MKL1/MRTF-A-dependent transcription.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei97 – 971FADBy similarity
Binding sitei116 – 1161FADBy similarity
Binding sitei118 – 1181FADBy similarity
Binding sitei123 – 1231FADBy similarity
Binding sitei125 – 1251FADBy similarity
Binding sitei398 – 3981FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 12529FADBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • actin filament depolymerization Source: UniProtKB
  • cytoskeleton organization Source: UniProtKB
  • heart development Source: UniProtKB
  • heart looping Source: UniProtKB
  • oxidation-reduction process Source: UniProtKB
  • positive regulation of transcription via serum response element binding Source: UniProtKB
  • sulfur oxidation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Actin-binding, FAD, Flavoprotein, Metal-binding, NADP, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-methionine sulfoxide oxidase MICAL2 (EC:1.14.13.-)
Alternative name(s):
Molecule interacting with CasL protein 2
Short name:
MICAL-2
Gene namesi
Name:MICAL2
Synonyms:KIAA0750, MICAL2PV1, MICAL2PV2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24693. MICAL2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi95 – 951G → V: Blocks FAD binding and abolishes catalytic activity. 1 Publication
Mutagenesisi677 – 6815KRRRK → AAAAA in MICAL-2NLSMut; abolishes nuclear localization. 1 Publication

Organism-specific databases

PharmGKBiPA142671453.

Polymorphism and mutation databases

BioMutaiMICAL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11241124Protein-methionine sulfoxide oxidase MICAL2PRO_0000075844Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei631 – 6311PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO94851.
MaxQBiO94851.
PaxDbiO94851.
PeptideAtlasiO94851.
PRIDEiO94851.

PTM databases

iPTMnetiO94851.
PhosphoSiteiO94851.

Expressioni

Gene expression databases

BgeeiENSG00000133816.
CleanExiHS_MICAL2.
ExpressionAtlasiO94851. baseline and differential.
GenevisibleiO94851. HS.

Organism-specific databases

HPAiHPA030437.

Interactioni

Subunit structurei

Interacts with VIM and PLXNA4 (By similarity). Interacts with RAB1B.By similarity1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115003. 2 interactions.
IntActiO94851. 6 interactions.
STRINGi9606.ENSP00000256194.

Structurei

Secondary structure

1
1124
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi520 – 53011Combined sources
Beta strandi540 – 5423Combined sources
Helixi543 – 5453Combined sources
Beta strandi546 – 5483Combined sources
Helixi549 – 55810Combined sources
Turni560 – 5623Combined sources
Turni565 – 5673Combined sources
Helixi570 – 5723Combined sources
Helixi573 – 58614Combined sources
Helixi596 – 6016Combined sources
Helixi607 – 62115Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E9KNMR-A516-629[»]
ProteinModelPortaliO94851.
SMRiO94851. Positions 511-629.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94851.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini516 – 619104CHPROSITE-ProRule annotationAdd
BLAST
Domaini1000 – 106263LIM zinc-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 494493Monooxygenase domainBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi660 – 68122Nuclear localization signal1 PublicationAdd
BLAST

Sequence similaritiesi

Belongs to the Mical family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1700. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118856.
HOGENOMiHOG000047263.
HOVERGENiHBG052474.
InParanoidiO94851.
KOiK19947.
OMAiCSVCATT.
OrthoDBiEOG091G009H.
PhylomeDBiO94851.
TreeFamiTF324129.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
2.10.110.10. 1 hit.
3.50.50.60. 1 hit.
InterProiIPR001715. CH-domain.
IPR002938. FAD-bd.
IPR023753. FAD/NAD-binding_dom.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF01494. FAD_binding_3. 1 hit.
PF00412. LIM. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00132. LIM. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF51905. SSF51905. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94851-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGENEDEKQA QAGQVFENFV QASTCKGTLQ AFNILTRHLD LDPLDHRNFY 
        60         70         80         90        100
SKLKSKVTTW KAKALWYKLD KRGSHKEYKR GKSCTNTKCL IVGGGPCGLR 
       110        120        130        140        150
TAIELAYLGA KVVVVEKRDS FSRNNVLHLW PFTIHDLRGL GAKKFYGKFC 
       160        170        180        190        200
AGSIDHISIR QLQLILFKVA LMLGVEIHVN VEFVKVLEPP EDQENQKIGW 
       210        220        230        240        250
RAEFLPTDHS LSEFEFDVII GADGRRNTLE GFRRKEFRGK LAIAITANFI 
       260        270        280        290        300
NRNSTAEAKV EEISGVAFIF NQKFFQDLKE ETGIDLENIV YYKDCTHYFV 
       310        320        330        340        350
MTAKKQSLLD KGVIINDYID TEMLLCAENV NQDNLLSYAR EAADFATNYQ 
       360        370        380        390        400
LPSLDFAMNH YGQPDVAMFD FTCMYASENA ALVRERQAHQ LLVALVGDSL 
       410        420        430        440        450
LEPFWPMGTG CARGFLAAFD TAWMVKSWNQ GTPPLELLAE RESLYRLLPQ 
       460        470        480        490        500
TTPENINKNF EQYTLDPGTR YPNLNSHCVR PHQVKHLYIT KELEHYPLER 
       510        520        530        540        550
LGSVRRSVNL SRKESDIRPS KLLTWCQQQT EGYQHVNVTD LTTSWRSGLA 
       560        570        580        590        600
LCAIIHRFRP ELINFDSLNE DDAVENNQLA FDVAEREFGI PPVTTGKEMA 
       610        620        630        640        650
SAQEPDKLSM VMYLSKFYEL FRGTPLRPVD SWRKNYGENA DLSLAKSSIS 
       660        670        680        690        700
NNYLNLTFPR KRTPRVDGQT GENDMNKRRR KGFTNLDEPS NFSSRSLGSN 
       710        720        730        740        750
QECGSSKEGG NQNKVKSMAN QLLAKFEEST RNPSLMKQER RVSGIGKPVL 
       760        770        780        790        800
CSSSGPPVHS CCPKPEEATP SPSPPLKRQF PSVVVTGHVL RELKQVSAGS 
       810        820        830        840        850
ECLSRPWRAR AKSDLQLGGT ENFATLPSTR PRAQALSGVL WRLQQVEEKI 
       860        870        880        890        900
LQKRAQNLAN REFHTKNIKE KAAHLASMFG HGDFPQNKLL SKGLSHTHPP 
       910        920        930        940        950
SPPSRLPSPD PAASSSPSTV DSASPARKEK KSPSGFHFHP SHLRTVHPQL 
       960        970        980        990       1000
TVGKVSSGIG AAAEVLVNLY MNDHRPKAQA TSPDLESMRK SFPLNLGGSD 
      1010       1020       1030       1040       1050
TCYFCKKRVY VMERLSAEGH FFHRECFRCS ICATTLRLAA YTFDCDEGKF 
      1060       1070       1080       1090       1100
YCKPHFIHCK TNSKQRKRRA ELKQQREEEA TWQEQEAPRR DTPTESSCAV 
      1110       1120 
AAIGTLEGSP PVHFSLPVLH PLLG
Length:1,124
Mass (Da):126,689
Last modified:May 1, 1999 - v1
Checksum:i1C276C42D17B64DF
GO
Isoform 2 (identifier: O94851-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.
     740-986: Missing.
     1112-1124: VHFSLPVLHPLLG → GISTSFFRKV...VLRCFPVKLR

Show »
Length:784
Mass (Da):89,890
Checksum:i114E5873F13E5C61
GO
Isoform 3 (identifier: O94851-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     929-949: Missing.

Show »
Length:1,103
Mass (Da):124,253
Checksum:iEAB33EE2B2DB4BA1
GO
Isoform 4 (identifier: O94851-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     739-928: Missing.
     950-985: Missing.
     1112-1124: VHFSLPVLHPLLG → GISTSFFRKV...VLRCFPVKLR

Show »
Length:976
Mass (Da):111,652
Checksum:iD8B4E819D43FDA7E
GO
Isoform 5 (identifier: O94851-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     739-928: Missing.

Show »
Length:934
Mass (Da):106,211
Checksum:i5CB357AB0F7D4B9E
GO
Isoform 6 (identifier: O94851-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     739-985: Missing.
     1112-1124: VHFSLPVLHPLLG → GISTSFFRKV...VLRCFPVKLR

Show »
Length:955
Mass (Da):109,216
Checksum:i583E6EF7AC29A939
GO

Sequence cautioni

The sequence BAA34470 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191F → S in BAG57951 (PubMed:14702039).Curated
Sequence conflicti208 – 2081D → G in CAD97967 (PubMed:17974005).Curated
Sequence conflicti296 – 2961T → A in CAD97967 (PubMed:17974005).Curated
Sequence conflicti529 – 5291Q → H in BAG57951 (PubMed:14702039).Curated
Sequence conflicti563 – 5631I → V in BAG57951 (PubMed:14702039).Curated
Sequence conflicti631 – 6311S → Y in CAD97967 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti145 – 1451F → L.
Corresponds to variant rs2706656 [ dbSNP | Ensembl ].		VAR_050155
Natural varianti220 – 2201I → V.
Corresponds to variant rs2306727 [ dbSNP | Ensembl ].		VAR_021992
Natural varianti687 – 6871D → E.
Corresponds to variant rs3794084 [ dbSNP | Ensembl ].		VAR_050156
Natural varianti1089 – 10891R → Q.
Corresponds to variant rs2270515 [ dbSNP | Ensembl ].		VAR_020257
Natural varianti1106 – 11061L → P.1 Publication
Corresponds to variant rs1027335 [ dbSNP | Ensembl ].		VAR_024523
Natural varianti1110 – 11101P → S.
Corresponds to variant rs35518829 [ dbSNP | Ensembl ].		VAR_050157

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 171171Missing in isoform 2. 1 PublicationVSP_009859Add
BLAST
Alternative sequencei739 – 985247Missing in isoform 6. 1 PublicationVSP_042593Add
BLAST
Alternative sequencei739 – 928190Missing in isoform 4 and isoform 5. 2 PublicationsVSP_042594Add
BLAST
Alternative sequencei740 – 986247Missing in isoform 2. 1 PublicationVSP_009860Add
BLAST
Alternative sequencei929 – 94921Missing in isoform 3. 1 PublicationVSP_042595Add
BLAST
Alternative sequencei950 – 98536Missing in isoform 4. 1 PublicationVSP_042596Add
BLAST
Alternative sequencei1112 – 112413VHFSL…HPLLG → GISTSFFRKVLGWPLRLPRD LCNWMQGLLQAAGLHIRDNA YNYCYMYELLSLGLPLLWAF SEVLAAMYRESEGSLESICN WVLRCFPVKLR in isoform 2, isoform 4 and isoform 6. 2 PublicationsVSP_009861Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110785 mRNA. Translation: BAD83656.1.
AB110786 mRNA. Translation: BAD83657.1.
AB018293 mRNA. Translation: BAA34470.2. Different initiation.
AK294845 mRNA. Translation: BAG57951.1.
AK302893 mRNA. Translation: BAH13835.1.
BX538021 mRNA. Translation: CAD97967.1.
BX641163 mRNA. Translation: CAE46072.1.
AC025106 Genomic DNA. No translation available.
AC079329 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68528.1.
CH471064 Genomic DNA. Translation: EAW68529.1.
CH471064 Genomic DNA. Translation: EAW68531.1.
BC044577 mRNA. Translation: AAH44577.1.
BK000462 mRNA. Translation: DAA01341.1.
CCDSiCCDS60726.1. [O94851-3]
CCDS60727.1. [O94851-5]
CCDS60728.1. [O94851-4]
CCDS7809.1. [O94851-1]
RefSeqiNP_001269592.1. NM_001282663.1. [O94851-1]
NP_001269593.1. NM_001282664.1. [O94851-3]
NP_001269594.1. NM_001282665.1. [O94851-5]
NP_001269595.1. NM_001282666.1. [O94851-4]
NP_001269596.1. NM_001282667.1. [O94851-6]
NP_055447.1. NM_014632.3. [O94851-1]
UniGeneiHs.501928.

Genome annotation databases

EnsembliENST00000256194; ENSP00000256194; ENSG00000133816. [O94851-1]
ENST00000342902; ENSP00000344894; ENSG00000133816. [O94851-3]
ENST00000379612; ENSP00000368932; ENSG00000133816. [O94851-4]
ENST00000527546; ENSP00000433965; ENSG00000133816. [O94851-5]
ENST00000537344; ENSP00000441689; ENSG00000133816. [O94851-1]
GeneIDi9645.
KEGGihsa:9645.
UCSCiuc001mjz.5. human. [O94851-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110785 mRNA. Translation: BAD83656.1.
AB110786 mRNA. Translation: BAD83657.1.
AB018293 mRNA. Translation: BAA34470.2. Different initiation.
AK294845 mRNA. Translation: BAG57951.1.
AK302893 mRNA. Translation: BAH13835.1.
BX538021 mRNA. Translation: CAD97967.1.
BX641163 mRNA. Translation: CAE46072.1.
AC025106 Genomic DNA. No translation available.
AC079329 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68528.1.
CH471064 Genomic DNA. Translation: EAW68529.1.
CH471064 Genomic DNA. Translation: EAW68531.1.
BC044577 mRNA. Translation: AAH44577.1.
BK000462 mRNA. Translation: DAA01341.1.
CCDSiCCDS60726.1. [O94851-3]
CCDS60727.1. [O94851-5]
CCDS60728.1. [O94851-4]
CCDS7809.1. [O94851-1]
RefSeqiNP_001269592.1. NM_001282663.1. [O94851-1]
NP_001269593.1. NM_001282664.1. [O94851-3]
NP_001269594.1. NM_001282665.1. [O94851-5]
NP_001269595.1. NM_001282666.1. [O94851-4]
NP_001269596.1. NM_001282667.1. [O94851-6]
NP_055447.1. NM_014632.3. [O94851-1]
UniGeneiHs.501928.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E9KNMR-A516-629[»]
ProteinModelPortaliO94851.
SMRiO94851. Positions 511-629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115003. 2 interactions.
IntActiO94851. 6 interactions.
STRINGi9606.ENSP00000256194.

PTM databases

iPTMnetiO94851.
PhosphoSiteiO94851.

Polymorphism and mutation databases

BioMutaiMICAL2.

Proteomic databases

EPDiO94851.
MaxQBiO94851.
PaxDbiO94851.
PeptideAtlasiO94851.
PRIDEiO94851.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256194; ENSP00000256194; ENSG00000133816. [O94851-1]
ENST00000342902; ENSP00000344894; ENSG00000133816. [O94851-3]
ENST00000379612; ENSP00000368932; ENSG00000133816. [O94851-4]
ENST00000527546; ENSP00000433965; ENSG00000133816. [O94851-5]
ENST00000537344; ENSP00000441689; ENSG00000133816. [O94851-1]
GeneIDi9645.
KEGGihsa:9645.
UCSCiuc001mjz.5. human. [O94851-1]

Organism-specific databases

CTDi9645.
GeneCardsiMICAL2.
HGNCiHGNC:24693. MICAL2.
HPAiHPA030437.
MIMi608881. gene.
neXtProtiNX_O94851.
PharmGKBiPA142671453.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1700. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118856.
HOGENOMiHOG000047263.
HOVERGENiHBG052474.
InParanoidiO94851.
KOiK19947.
OMAiCSVCATT.
OrthoDBiEOG091G009H.
PhylomeDBiO94851.
TreeFamiTF324129.

Miscellaneous databases

ChiTaRSiMICAL2. human.
EvolutionaryTraceiO94851.
GeneWikiiMICAL2.
GenomeRNAii9645.
PROiO94851.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133816.
CleanExiHS_MICAL2.
ExpressionAtlasiO94851. baseline and differential.
GenevisibleiO94851. HS.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
2.10.110.10. 1 hit.
3.50.50.60. 1 hit.
InterProiIPR001715. CH-domain.
IPR002938. FAD-bd.
IPR023753. FAD/NAD-binding_dom.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF01494. FAD_binding_3. 1 hit.
PF00412. LIM. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00132. LIM. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF51905. SSF51905. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMICA2_HUMAN
AccessioniPrimary (citable) accession number: O94851
Secondary accession number(s): B4DGZ0
, B7Z849, D3DQW5, G3XAC8, Q5KTR3, Q5KTR4, Q7Z3A8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.