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Protein

Dendrin

Gene

DDN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Dendrin
Gene namesi
Name:DDN
Synonyms:KIAA0749
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000181418.7
HGNCiHGNC:24458 DDN
MIMi610588 gene
neXtProtiNX_O94850

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23109
OpenTargetsiENSG00000181418
PharmGKBiPA134906790

Polymorphism and mutation databases

BioMutaiDDN

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000798611 – 711DendrinAdd BLAST711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei389PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO94850
PaxDbiO94850
PeptideAtlasiO94850
PRIDEiO94850

PTM databases

iPTMnetiO94850
PhosphoSitePlusiO94850

Expressioni

Tissue specificityi

Specifically expressed in brain and kidney. Expressed in kidney glomerular capillary loops (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000181418
CleanExiHS_DDN
GenevisibleiO94850 HS

Organism-specific databases

HPAiHPA060952

Interactioni

Subunit structurei

Forms a ternary complex with MAGI2 and SH3KBP1; recruits DDN to the cytoplasm. Interacts with MAGI1. Interacts with ACTN1 and may interact with WWC1. Interacts with the podocyte slit diaphragm proteins CD2AP, NPHS1 and NPHS2; the interaction with CD2AP and NPHS1 is direct (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116733, 3 interactors
CORUMiO94850
IntActiO94850, 3 interactors
STRINGi9606.ENSP00000390590

Structurei

3D structure databases

ProteinModelPortaliO94850
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 131Nuclear localizationBy similarityAdd BLAST19
Regioni186 – 236Interaction with MAGI2Add BLAST51
Regioni341 – 436Interaction with ACTN11 PublicationAdd BLAST96
Regioni408 – 709Interaction with CD2AP and NPHS1By similarityAdd BLAST302

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili102 – 134Sequence analysisAdd BLAST33

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEIV Eukaryota
ENOG41116CR LUCA
GeneTreeiENSGT00390000016495
HOGENOMiHOG000294155
HOVERGENiHBG107808
InParanoidiO94850
OMAiGPHRTLG
OrthoDBiEOG091G06UP
PhylomeDBiO94850
TreeFamiTF337173

Family and domain databases

InterProiView protein in InterPro
IPR026500 Dendrin
PANTHERiPTHR16757 PTHR16757, 1 hit
PfamiView protein in Pfam
PF15498 Dendrin, 1 hit

Sequencei

Sequence statusi: Complete.

O94850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDGPLFSEG PDSPRELQDE ESGSCLWVQK SKLLVIEVKT ISCHYSRRAP
60 70 80 90 100
SRQPMDFQAS HWARGFQNRT CGPRPGSPQP PPRRPWASRV LQEATNWRAG
110 120 130 140 150
PLAEVRAREQ EKRKAASQER EAKETERKRR KAGGARRSPP GRPRPEPRNA
160 170 180 190 200
PRVAQLAGLP APLRPERLAP VGRAPRPSAQ PQSDPGSAWA GPWGGRRPGP
210 220 230 240 250
PSYEAHLLLR GSAGTAPRRR WDRPPPYVAP PSYEGPHRTL GTKRGPGNSQ
260 270 280 290 300
VPTSSAPAAT PARTDGGRTK KRLDPRIYRD VLGAWGLRQG QGLLGGSPGC
310 320 330 340 350
GAARARPEPG KGVVEKSLGL AAADLNSGSD SHPQAKATGS AGTEIAPAGS
360 370 380 390 400
ATAAPCAPHP APRSRHHLKG SREGKEGEQI WFPKCWIPSP KKQPPRHSQT
410 420 430 440 450
LPRPWAPGGT GWRESLGLGE GAGPETLEGW KATRRAHTLP RSSQGLSRGE
460 470 480 490 500
GVFVIDATCV VIRSQYVPTP RTQQVQLLPS GVTRVVGDSP SQSKPGKEEG
510 520 530 540 550
EGATVFPSPC QKRLSSSRLL HQPGGGRGGE AEGGRPGDST LEERTFRILG
560 570 580 590 600
LPAPEVNLRD APTQPGSPEH QALGPAASGA QGRAEGSEVA VVQRRAGRGW
610 620 630 640 650
ARTPGPYAGA LREAVSRIRR HTAPDSDTDE AEELSVHSGS SDGSDTEAPG
660 670 680 690 700
ASWRNERTLP EVGNSSPEED GKTAELSDSV GEILDVISQT EEVLFGVRDI
710
RGTQQGNRKR Q
Length:711
Mass (Da):75,996
Last modified:February 10, 2009 - v3
Checksum:iD55B3CBE792519D4
GO

Sequence cautioni

The sequence BAA34469 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059651661E → G. Corresponds to variant dbSNP:rs10783299Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011603 Genomic DNA No translation available.
AB018292 mRNA Translation: BAA34469.1 Different initiation.
CCDSiCCDS31791.2
RefSeqiNP_055901.2, NM_015086.1
UniGeneiHs.591044

Genome annotation databases

EnsembliENST00000421952; ENSP00000390590; ENSG00000181418
GeneIDi23109
KEGGihsa:23109
UCSCiuc001rsv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDEND_HUMAN
AccessioniPrimary (citable) accession number: O94850
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: February 10, 2009
Last modified: March 28, 2018
This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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