Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O94850

- DEND_HUMAN

UniProt

O94850 - DEND_HUMAN

Protein

Dendrin

Gene

DDN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 3 (10 Feb 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dendrin
    Gene namesi
    Name:DDN
    Synonyms:KIAA0749
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24458. DDN.

    Subcellular locationi

    Cell projectiondendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Perikaryon By similarity. Nucleus By similarity
    Note: Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites.By similarity

    GO - Cellular componenti

    1. cell projection Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. dendritic spine membrane Source: UniProtKB-SubCell
    4. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    5. nucleus Source: UniProtKB-SubCell
    6. perikaryon Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134906790.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 711711DendrinPRO_0000079861Add
    BLAST

    Proteomic databases

    PaxDbiO94850.
    PRIDEiO94850.

    PTM databases

    PhosphoSiteiO94850.

    Expressioni

    Tissue specificityi

    Specifically expressed in brain and kidney. Expressed in kidney glomerular capillary loops (at protein level).2 Publications

    Gene expression databases

    BgeeiO94850.
    CleanExiHS_DDN.
    GenevestigatoriO94850.

    Interactioni

    Subunit structurei

    Forms a ternary complex with MAGI2 and SH3KBP1; recruits DDN to the cytoplasm. Interacts with MAGI1. Interacts with ACTN1 and may interact with WWC1. Interacts with the podocyte slit diaphragm proteins CD2AP, NPHS1 and NPHS2; the interaction with CD2AP and NPHS1 is direct By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Magi2O883823EBI-5240523,EBI-696179From a different organism.
    SH3KBP1Q96B975EBI-5240523,EBI-346595

    Protein-protein interaction databases

    BioGridi116733. 3 interactions.
    IntActiO94850. 3 interactions.
    MINTiMINT-7137613.
    STRINGi9606.ENSP00000390590.

    Structurei

    3D structure databases

    ProteinModelPortaliO94850.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni113 – 13119Nuclear localizationBy similarityAdd
    BLAST
    Regioni186 – 23651Interaction with MAGI2Add
    BLAST
    Regioni341 – 43696Interaction with ACTN1Add
    BLAST
    Regioni408 – 709302Interaction with CD2AP and NPHS1By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili102 – 13433Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG72884.
    HOGENOMiHOG000294155.
    HOVERGENiHBG107808.
    InParanoidiO94850.
    OMAiGPHRTLG.
    OrthoDBiEOG7Z95KR.
    PhylomeDBiO94850.
    TreeFamiTF337173.

    Family and domain databases

    InterProiIPR026500. Dendrin.
    [Graphical view]
    PANTHERiPTHR16757. PTHR16757. 1 hit.
    PfamiPF15498. Dendrin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O94850-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDGPLFSEG PDSPRELQDE ESGSCLWVQK SKLLVIEVKT ISCHYSRRAP    50
    SRQPMDFQAS HWARGFQNRT CGPRPGSPQP PPRRPWASRV LQEATNWRAG 100
    PLAEVRAREQ EKRKAASQER EAKETERKRR KAGGARRSPP GRPRPEPRNA 150
    PRVAQLAGLP APLRPERLAP VGRAPRPSAQ PQSDPGSAWA GPWGGRRPGP 200
    PSYEAHLLLR GSAGTAPRRR WDRPPPYVAP PSYEGPHRTL GTKRGPGNSQ 250
    VPTSSAPAAT PARTDGGRTK KRLDPRIYRD VLGAWGLRQG QGLLGGSPGC 300
    GAARARPEPG KGVVEKSLGL AAADLNSGSD SHPQAKATGS AGTEIAPAGS 350
    ATAAPCAPHP APRSRHHLKG SREGKEGEQI WFPKCWIPSP KKQPPRHSQT 400
    LPRPWAPGGT GWRESLGLGE GAGPETLEGW KATRRAHTLP RSSQGLSRGE 450
    GVFVIDATCV VIRSQYVPTP RTQQVQLLPS GVTRVVGDSP SQSKPGKEEG 500
    EGATVFPSPC QKRLSSSRLL HQPGGGRGGE AEGGRPGDST LEERTFRILG 550
    LPAPEVNLRD APTQPGSPEH QALGPAASGA QGRAEGSEVA VVQRRAGRGW 600
    ARTPGPYAGA LREAVSRIRR HTAPDSDTDE AEELSVHSGS SDGSDTEAPG 650
    ASWRNERTLP EVGNSSPEED GKTAELSDSV GEILDVISQT EEVLFGVRDI 700
    RGTQQGNRKR Q 711
    Length:711
    Mass (Da):75,996
    Last modified:February 10, 2009 - v3
    Checksum:iD55B3CBE792519D4
    GO

    Sequence cautioni

    The sequence BAA34469.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti661 – 6611E → G.
    Corresponds to variant rs10783299 [ dbSNP | Ensembl ].
    VAR_059651

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC011603 Genomic DNA. No translation available.
    AB018292 mRNA. Translation: BAA34469.1. Different initiation.
    CCDSiCCDS31791.2.
    RefSeqiNP_055901.2. NM_015086.1.
    UniGeneiHs.591044.

    Genome annotation databases

    EnsembliENST00000421952; ENSP00000390590; ENSG00000181418.
    GeneIDi23109.
    KEGGihsa:23109.
    UCSCiuc001rsv.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC011603 Genomic DNA. No translation available.
    AB018292 mRNA. Translation: BAA34469.1 . Different initiation.
    CCDSi CCDS31791.2.
    RefSeqi NP_055901.2. NM_015086.1.
    UniGenei Hs.591044.

    3D structure databases

    ProteinModelPortali O94850.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116733. 3 interactions.
    IntActi O94850. 3 interactions.
    MINTi MINT-7137613.
    STRINGi 9606.ENSP00000390590.

    PTM databases

    PhosphoSitei O94850.

    Proteomic databases

    PaxDbi O94850.
    PRIDEi O94850.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000421952 ; ENSP00000390590 ; ENSG00000181418 .
    GeneIDi 23109.
    KEGGi hsa:23109.
    UCSCi uc001rsv.1. human.

    Organism-specific databases

    CTDi 23109.
    GeneCardsi GC12M049388.
    HGNCi HGNC:24458. DDN.
    MIMi 610588. gene.
    neXtProti NX_O94850.
    PharmGKBi PA134906790.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72884.
    HOGENOMi HOG000294155.
    HOVERGENi HBG107808.
    InParanoidi O94850.
    OMAi GPHRTLG.
    OrthoDBi EOG7Z95KR.
    PhylomeDBi O94850.
    TreeFami TF337173.

    Miscellaneous databases

    GenomeRNAii 23109.
    NextBioi 44303.
    PROi O94850.
    SOURCEi Search...

    Gene expression databases

    Bgeei O94850.
    CleanExi HS_DDN.
    Genevestigatori O94850.

    Family and domain databases

    InterProi IPR026500. Dendrin.
    [Graphical view ]
    PANTHERi PTHR16757. PTHR16757. 1 hit.
    Pfami PF15498. Dendrin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-711.
      Tissue: Brain.
    3. Cited for: INTERACTION WITH WWC1.
      Tissue: Brain.
    4. "CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin."
      Kawata A., Iida J., Ikeda M., Sato Y., Mori H., Kansaku A., Sumita K., Fujiwara N., Rokukawa C., Hamano M., Hirabayashi S., Hata Y.
      J. Biochem. 139:931-939(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MAGI1; MAGI2 AND SH3KBP1.
    5. "Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring."
      Kremerskothen J., Kindler S., Finger I., Veltel S., Barnekow A.
      J. Neurochem. 96:1659-1666(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ACTN1; MAGI1 AND MAGI2, SUBCELLULAR LOCATION.
    6. "Expression and subcellular distribution of novel glomerulus-associated proteins Dendrin, Ehd3, Sh2d4a, Plekhh2, and 2310066E14Rik."
      Patrakka J., Xiao Z., Nukui M., Takemoto M., He L., Oddsson A., Perisic L., Kaukinen A., Szigyarto C.A.-K., Uhlen M., Jalanko H., Betsholtz C., Tryggvason K.
      J. Am. Soc. Nephrol. 18:689-697(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    7. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiDEND_HUMAN
    AccessioniPrimary (citable) accession number: O94850
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2002
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 85 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3