O94850 (DEND_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dendrin

Gene names

Name:	DDN
Synonyms:	KIAA0749

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	711 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein By similarity.
Subunit structure	Forms a ternary complex with MAGI2 and SH3KBP1; recruits DDN to the cytoplasm. Interacts with MAGI1. Interacts with ACTN1 and may interact with WWC1. Interacts with the podocyte slit diaphragm proteins CD2AP, NPHS1 and NPHS2; the interaction with CD2AP and NPHS1 is direct By similarity. Ref.3 Ref.4 Ref.5
Subcellular location	Cell projection › dendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Perikaryon By similarity. Nucleus By similarity. Note: Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites By similarity. Ref.5 Ref.6
Tissue specificity	Specifically expressed in brain and kidney. Expressed in kidney glomerular capillary loops (at protein level). Ref.6 Ref.7
Sequence caution	The sequence BAA34469.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Cell projection Cytoplasm Endoplasmic reticulum Membrane Nucleus
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cell projection Inferred from direct assay Ref.5. Source: UniProtKB cytoplasm Inferred from direct assay Ref.5. Source: UniProtKB dendritic spine membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell perikaryon Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Magi2	O88382	3	EBI-5240523,EBI-696179	From a different organism.
SH3KBP1	Q96B97	5	EBI-5240523,EBI-346595

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 711	711	Dendrin		PRO_0000079861
Regions
	Region	113 – 131	19	Nuclear localization By similarity
	Region	186 – 236	51	Interaction with MAGI2
	Region	341 – 436	96	Interaction with ACTN1
	Region	408 – 709	302	Interaction with CD2AP and NPHS1 By similarity
	Coiled coil	102 – 134	33	Potential
Natural variations
	Natural variant	661	1	E → G. Corresponds to variant rs10783299 [ dbSNP | Ensembl ].		VAR_059651

Sequences

	Sequence		Length	Mass (Da)
	O94850 [UniParc]. Last modified February 10, 2009. Version 3. Checksum: D55B3CBE792519D4	FASTA	711	75,996
	10 20 30 40 50 60 MLDGPLFSEG PDSPRELQDE ESGSCLWVQK SKLLVIEVKT ISCHYSRRAP SRQPMDFQAS 70 80 90 100 110 120 HWARGFQNRT CGPRPGSPQP PPRRPWASRV LQEATNWRAG PLAEVRAREQ EKRKAASQER 130 140 150 160 170 180 EAKETERKRR KAGGARRSPP GRPRPEPRNA PRVAQLAGLP APLRPERLAP VGRAPRPSAQ 190 200 210 220 230 240 PQSDPGSAWA GPWGGRRPGP PSYEAHLLLR GSAGTAPRRR WDRPPPYVAP PSYEGPHRTL 250 260 270 280 290 300 GTKRGPGNSQ VPTSSAPAAT PARTDGGRTK KRLDPRIYRD VLGAWGLRQG QGLLGGSPGC 310 320 330 340 350 360 GAARARPEPG KGVVEKSLGL AAADLNSGSD SHPQAKATGS AGTEIAPAGS ATAAPCAPHP 370 380 390 400 410 420 APRSRHHLKG SREGKEGEQI WFPKCWIPSP KKQPPRHSQT LPRPWAPGGT GWRESLGLGE 430 440 450 460 470 480 GAGPETLEGW KATRRAHTLP RSSQGLSRGE GVFVIDATCV VIRSQYVPTP RTQQVQLLPS 490 500 510 520 530 540 GVTRVVGDSP SQSKPGKEEG EGATVFPSPC QKRLSSSRLL HQPGGGRGGE AEGGRPGDST 550 560 570 580 590 600 LEERTFRILG LPAPEVNLRD APTQPGSPEH QALGPAASGA QGRAEGSEVA VVQRRAGRGW 610 620 630 640 650 660 ARTPGPYAGA LREAVSRIRR HTAPDSDTDE AEELSVHSGS SDGSDTEAPG ASWRNERTLP 670 680 690 700 710 EVGNSSPEED GKTAELSDSV GEILDVISQT EEVLFGVRDI RGTQQGNRKR Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-711. Tissue: Brain.
[3]	"Characterization of KIBRA, a novel WW domain-containing protein." Kremerskothen J., Plaas C., Buether K., Finger I., Veltel S., Matanis T., Liedtke T., Barnekow A. Biochem. Biophys. Res. Commun. 300:862-867(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH WWC1. Tissue: Brain.
[4]	"CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin." Kawata A., Iida J., Ikeda M., Sato Y., Mori H., Kansaku A., Sumita K., Fujiwara N., Rokukawa C., Hamano M., Hirabayashi S., Hata Y. J. Biochem. 139:931-939(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MAGI1; MAGI2 AND SH3KBP1.
[5]	"Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring." Kremerskothen J., Kindler S., Finger I., Veltel S., Barnekow A. J. Neurochem. 96:1659-1666(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ACTN1; MAGI1 AND MAGI2, SUBCELLULAR LOCATION.
[6]	"Expression and subcellular distribution of novel glomerulus-associated proteins Dendrin, Ehd3, Sh2d4a, Plekhh2, and 2310066E14Rik." Patrakka J., Xiao Z., Nukui M., Takemoto M., He L., Oddsson A., Perisic L., Kaukinen A., Szigyarto C.A.-K., Uhlen M., Jalanko H., Betsholtz C., Tryggvason K. J. Am. Soc. Nephrol. 18:689-697(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[7]	"Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome." Duner F., Patrakka J., Xiao Z., Larsson J., Vlamis-Gardikas A., Pettersson E., Tryggvason K., Hultenby K., Wernerson A. Nephrol. Dial. Transplant. 23:2504-2511(2008) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC011603 Genomic DNA. No translation available. AB018292 mRNA. Translation: BAA34469.1. Different initiation.
IPI	IPI00241886.
RefSeq	NP_055901.2. NM_015086.1.
UniGene	Hs.591044.
3D structure databases
ProteinModelPortal	O94850.
ModBase	Search...
Protein-protein interaction databases
IntAct	O94850. 3 interactions.
STRING	9606.ENSP00000390590.
PTM databases
PhosphoSite	O94850.
Proteomic databases
PaxDb	O94850.
PRIDE	O94850.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000421952; ENSP00000390590; ENSG00000181418.
GeneID	23109.
KEGG	hsa:23109.
UCSC	uc001rsv.1. human.
Organism-specific databases
CTD	23109.
GeneCards	GC12M049388.
HGNC	HGNC:24458. DDN.
MIM	610588. gene.
neXtProt	NX_O94850.
PharmGKB	PA134906790.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG72884.
HOGENOM	HOG000294155.
HOVERGEN	HBG107808.
InParanoid	O94850.
OMA	GPHRTLG.
OrthoDB	EOG4GF3F0.
Gene expression databases
Bgee	O94850.
CleanEx	HS_DDN.
Genevestigator	O94850.
GermOnline	ENSG00000181418. Homo sapiens.
Family and domain databases
InterPro	IPR026500. Dendrin. [Graphical view]
PANTHER	PTHR16757. PTHR16757. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	23109.
NextBio	44303.
SOURCE	Search...

Entry information

Entry name

DEND_HUMAN

Accession

Primary (citable) accession number: O94850

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	February 10, 2009
Last modified:	April 3, 2013
This is version 74 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.