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O94850

- DEND_HUMAN

UniProt

O94850 - DEND_HUMAN

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Protein

Dendrin

Gene

DDN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Dendrin
Gene namesi
Name:DDN
Synonyms:KIAA0749
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:24458. DDN.

Subcellular locationi

Cell projectiondendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Perikaryon By similarity. Nucleus By similarity
Note: Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites.By similarity

GO - Cellular componenti

  1. cell projection Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. dendrite Source: Ensembl
  4. endoplasmic reticulum Source: UniProtKB-KW
  5. nucleus Source: UniProtKB-KW
  6. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134906790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711DendrinPRO_0000079861Add
BLAST

Proteomic databases

MaxQBiO94850.
PaxDbiO94850.
PRIDEiO94850.

PTM databases

PhosphoSiteiO94850.

Expressioni

Tissue specificityi

Specifically expressed in brain and kidney. Expressed in kidney glomerular capillary loops (at protein level).2 Publications

Gene expression databases

BgeeiO94850.
CleanExiHS_DDN.
GenevestigatoriO94850.

Interactioni

Subunit structurei

Forms a ternary complex with MAGI2 and SH3KBP1; recruits DDN to the cytoplasm. Interacts with MAGI1. Interacts with ACTN1 and may interact with WWC1. Interacts with the podocyte slit diaphragm proteins CD2AP, NPHS1 and NPHS2; the interaction with CD2AP and NPHS1 is direct (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Magi2O883823EBI-5240523,EBI-696179From a different organism.
SH3KBP1Q96B975EBI-5240523,EBI-346595

Protein-protein interaction databases

BioGridi116733. 3 interactions.
IntActiO94850. 3 interactions.
MINTiMINT-7137613.
STRINGi9606.ENSP00000390590.

Structurei

3D structure databases

ProteinModelPortaliO94850.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni113 – 13119Nuclear localizationBy similarityAdd
BLAST
Regioni186 – 23651Interaction with MAGI2Add
BLAST
Regioni341 – 43696Interaction with ACTN1Add
BLAST
Regioni408 – 709302Interaction with CD2AP and NPHS1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili102 – 13433Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG72884.
GeneTreeiENSGT00390000016495.
HOGENOMiHOG000294155.
HOVERGENiHBG107808.
InParanoidiO94850.
OMAiGPHRTLG.
OrthoDBiEOG7Z95KR.
PhylomeDBiO94850.
TreeFamiTF337173.

Family and domain databases

InterProiIPR026500. Dendrin.
[Graphical view]
PANTHERiPTHR16757. PTHR16757. 1 hit.
PfamiPF15498. Dendrin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94850-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLDGPLFSEG PDSPRELQDE ESGSCLWVQK SKLLVIEVKT ISCHYSRRAP
60 70 80 90 100
SRQPMDFQAS HWARGFQNRT CGPRPGSPQP PPRRPWASRV LQEATNWRAG
110 120 130 140 150
PLAEVRAREQ EKRKAASQER EAKETERKRR KAGGARRSPP GRPRPEPRNA
160 170 180 190 200
PRVAQLAGLP APLRPERLAP VGRAPRPSAQ PQSDPGSAWA GPWGGRRPGP
210 220 230 240 250
PSYEAHLLLR GSAGTAPRRR WDRPPPYVAP PSYEGPHRTL GTKRGPGNSQ
260 270 280 290 300
VPTSSAPAAT PARTDGGRTK KRLDPRIYRD VLGAWGLRQG QGLLGGSPGC
310 320 330 340 350
GAARARPEPG KGVVEKSLGL AAADLNSGSD SHPQAKATGS AGTEIAPAGS
360 370 380 390 400
ATAAPCAPHP APRSRHHLKG SREGKEGEQI WFPKCWIPSP KKQPPRHSQT
410 420 430 440 450
LPRPWAPGGT GWRESLGLGE GAGPETLEGW KATRRAHTLP RSSQGLSRGE
460 470 480 490 500
GVFVIDATCV VIRSQYVPTP RTQQVQLLPS GVTRVVGDSP SQSKPGKEEG
510 520 530 540 550
EGATVFPSPC QKRLSSSRLL HQPGGGRGGE AEGGRPGDST LEERTFRILG
560 570 580 590 600
LPAPEVNLRD APTQPGSPEH QALGPAASGA QGRAEGSEVA VVQRRAGRGW
610 620 630 640 650
ARTPGPYAGA LREAVSRIRR HTAPDSDTDE AEELSVHSGS SDGSDTEAPG
660 670 680 690 700
ASWRNERTLP EVGNSSPEED GKTAELSDSV GEILDVISQT EEVLFGVRDI
710
RGTQQGNRKR Q
Length:711
Mass (Da):75,996
Last modified:February 10, 2009 - v3
Checksum:iD55B3CBE792519D4
GO

Sequence cautioni

The sequence BAA34469.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti661 – 6611E → G.
Corresponds to variant rs10783299 [ dbSNP | Ensembl ].
VAR_059651

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011603 Genomic DNA. No translation available.
AB018292 mRNA. Translation: BAA34469.1. Different initiation.
CCDSiCCDS31791.2.
RefSeqiNP_055901.2. NM_015086.1.
UniGeneiHs.591044.

Genome annotation databases

EnsembliENST00000421952; ENSP00000390590; ENSG00000181418.
GeneIDi23109.
KEGGihsa:23109.
UCSCiuc001rsv.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011603 Genomic DNA. No translation available.
AB018292 mRNA. Translation: BAA34469.1 . Different initiation.
CCDSi CCDS31791.2.
RefSeqi NP_055901.2. NM_015086.1.
UniGenei Hs.591044.

3D structure databases

ProteinModelPortali O94850.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116733. 3 interactions.
IntActi O94850. 3 interactions.
MINTi MINT-7137613.
STRINGi 9606.ENSP00000390590.

PTM databases

PhosphoSitei O94850.

Proteomic databases

MaxQBi O94850.
PaxDbi O94850.
PRIDEi O94850.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000421952 ; ENSP00000390590 ; ENSG00000181418 .
GeneIDi 23109.
KEGGi hsa:23109.
UCSCi uc001rsv.1. human.

Organism-specific databases

CTDi 23109.
GeneCardsi GC12M049388.
HGNCi HGNC:24458. DDN.
MIMi 610588. gene.
neXtProti NX_O94850.
PharmGKBi PA134906790.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72884.
GeneTreei ENSGT00390000016495.
HOGENOMi HOG000294155.
HOVERGENi HBG107808.
InParanoidi O94850.
OMAi GPHRTLG.
OrthoDBi EOG7Z95KR.
PhylomeDBi O94850.
TreeFami TF337173.

Miscellaneous databases

ChiTaRSi DDN. human.
GenomeRNAii 23109.
NextBioi 44303.
PROi O94850.
SOURCEi Search...

Gene expression databases

Bgeei O94850.
CleanExi HS_DDN.
Genevestigatori O94850.

Family and domain databases

InterProi IPR026500. Dendrin.
[Graphical view ]
PANTHERi PTHR16757. PTHR16757. 1 hit.
Pfami PF15498. Dendrin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-711.
    Tissue: Brain.
  3. Cited for: INTERACTION WITH WWC1.
    Tissue: Brain.
  4. "CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin."
    Kawata A., Iida J., Ikeda M., Sato Y., Mori H., Kansaku A., Sumita K., Fujiwara N., Rokukawa C., Hamano M., Hirabayashi S., Hata Y.
    J. Biochem. 139:931-939(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAGI1; MAGI2 AND SH3KBP1.
  5. "Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring."
    Kremerskothen J., Kindler S., Finger I., Veltel S., Barnekow A.
    J. Neurochem. 96:1659-1666(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ACTN1; MAGI1 AND MAGI2, SUBCELLULAR LOCATION.
  6. "Expression and subcellular distribution of novel glomerulus-associated proteins Dendrin, Ehd3, Sh2d4a, Plekhh2, and 2310066E14Rik."
    Patrakka J., Xiao Z., Nukui M., Takemoto M., He L., Oddsson A., Perisic L., Kaukinen A., Szigyarto C.A.-K., Uhlen M., Jalanko H., Betsholtz C., Tryggvason K.
    J. Am. Soc. Nephrol. 18:689-697(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiDEND_HUMAN
AccessioniPrimary (citable) accession number: O94850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: February 10, 2009
Last modified: November 26, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3