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O94844

- RHBT1_HUMAN

UniProt

O94844 - RHBT1_HUMAN

Protein

Rho-related BTB domain-containing protein 1

Gene

RHOBTB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (01 May 2000)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi21 – 288GTPSequence Analysis
    Nucleotide bindingi84 – 885GTPSequence Analysis
    Nucleotide bindingi140 – 1434GTPSequence Analysis

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of small GTPase mediated signal transduction Source: Reactome
    2. small GTPase mediated signal transduction Source: Reactome

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho-related BTB domain-containing protein 1
    Gene namesi
    Name:RHOBTB1
    Synonyms:KIAA0740
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:18738. RHOBTB1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. plasma membrane Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38664.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 696696Rho-related BTB domain-containing protein 1PRO_0000198960Add
    BLAST

    Proteomic databases

    PaxDbiO94844.
    PeptideAtlasiO94844.
    PRIDEiO94844.

    PTM databases

    PhosphoSiteiO94844.

    Expressioni

    Tissue specificityi

    Ubiquitous, with highest levels in skeletal muscle, placenta, testis, stomach, and kidney, followed by uterus and adrenal gland. Expressed in a variety of fetal tissues.1 Publication

    Gene expression databases

    ArrayExpressiO94844.
    BgeeiO94844.
    CleanExiHS_RHOBTB1.
    GenevestigatoriO94844.

    Organism-specific databases

    HPAiHPA040226.

    Interactioni

    Protein-protein interaction databases

    BioGridi115217. 7 interactions.
    IntActiO94844. 1 interaction.
    STRINGi9606.ENSP00000338671.

    Structurei

    3D structure databases

    ProteinModelPortaliO94844.
    SMRiO94844. Positions 13-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini266 – 427162BTB 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini485 – 55268BTB 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 210210Rho-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rho family.Curated
    Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000007723.
    HOVERGENiHBG054987.
    InParanoidiO94844.
    KOiK07868.
    OMAiCADVLFV.
    OrthoDBiEOG7SXW2N.
    PhylomeDBiO94844.
    TreeFamiTF323347.

    Family and domain databases

    Gene3Di3.30.710.10. 3 hits.
    3.40.50.300. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR027417. P-loop_NTPase.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view]
    PfamiPF00651. BTB. 2 hits.
    PF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00225. BTB. 2 hits.
    SM00174. RHO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF54695. SSF54695. 3 hits.
    PROSITEiPS50097. BTB. 2 hits.
    PS51420. RHO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O94844-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDADMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV    50
    PTVWAIDQYR VCQEVLERSR DVVDEVSVSL RLWDTFGDHH KDRRFAYGRS 100
    DVVVLCFSIA NPNSLNHVKS MWYPEIKHFC PRTPVILVGC QLDLRYADLE 150
    AVNRARRPLA RPIKRGDILP PEKGREVAKE LGLPYYETSV FDQFGIKDVF 200
    DNAIRAALIS RRHLQFWKSH LKKVQKPLLQ APFLPPKAPP PVIKIPECPS 250
    MGTNEAACLL DNPLCADVLF ILQDQEHIFA HRIYLATSSS KFYDLFLMEC 300
    EESPNGSEGA CEKEKQSRDF QGRILSVDPE EEREEGPPRI PQADQWKSSN 350
    KSLVEALGLE AEGAVPETQT LTGWSKGFIG MHREMQVNPI SKRMGPMTVV 400
    RMDASVQPGP FRTLLQFLYT GQLDEKEKDL VGLAQIAEVL EMFDLRMMVE 450
    NIMNKEAFMN QEITKAFHVR KANRIKECLS KGTFSDVTFK LDDGAISAHK 500
    PLLICSCEWM AAMFGGSFVE SANSEVYLPN INKISMQAVL DYLYTKQLSP 550
    NLDLDPLELI ALANRFCLPH LVALAEQHAV QELTKAATSG VGIDGEVLSY 600
    LELAQFHNAH QLAAWCLHHI CTNYNSVCSK FRKEIKSKSA DNQEYFERHR 650
    WPPVWYLKEE DHYQRVKRER EKEDIALNKH RSRRKWCFWN SSPAVA 696
    Length:696
    Mass (Da):79,417
    Last modified:May 1, 2000 - v2
    Checksum:i41ECB4425CD32A1A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018283 mRNA. Translation: BAA34460.2.
    AK075129 mRNA. Translation: BAC11421.1.
    BC032848 mRNA. Translation: AAH32848.1.
    BC041791 mRNA. Translation: AAH41791.1.
    CCDSiCCDS7261.1.
    RefSeqiNP_001229288.1. NM_001242359.1.
    NP_055651.1. NM_014836.4.
    XP_006718147.1. XM_006718084.1.
    XP_006718148.1. XM_006718085.1.
    XP_006718149.1. XM_006718086.1.
    UniGeneiHs.737374.

    Genome annotation databases

    EnsembliENST00000337910; ENSP00000338671; ENSG00000072422.
    ENST00000357917; ENSP00000350595; ENSG00000072422.
    GeneIDi9886.
    KEGGihsa:9886.
    UCSCiuc001jlh.3. human.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018283 mRNA. Translation: BAA34460.2 .
    AK075129 mRNA. Translation: BAC11421.1 .
    BC032848 mRNA. Translation: AAH32848.1 .
    BC041791 mRNA. Translation: AAH41791.1 .
    CCDSi CCDS7261.1.
    RefSeqi NP_001229288.1. NM_001242359.1.
    NP_055651.1. NM_014836.4.
    XP_006718147.1. XM_006718084.1.
    XP_006718148.1. XM_006718085.1.
    XP_006718149.1. XM_006718086.1.
    UniGenei Hs.737374.

    3D structure databases

    ProteinModelPortali O94844.
    SMRi O94844. Positions 13-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115217. 7 interactions.
    IntActi O94844. 1 interaction.
    STRINGi 9606.ENSP00000338671.

    PTM databases

    PhosphoSitei O94844.

    Proteomic databases

    PaxDbi O94844.
    PeptideAtlasi O94844.
    PRIDEi O94844.

    Protocols and materials databases

    DNASUi 9886.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000337910 ; ENSP00000338671 ; ENSG00000072422 .
    ENST00000357917 ; ENSP00000350595 ; ENSG00000072422 .
    GeneIDi 9886.
    KEGGi hsa:9886.
    UCSCi uc001jlh.3. human.

    Organism-specific databases

    CTDi 9886.
    GeneCardsi GC10M062629.
    HGNCi HGNC:18738. RHOBTB1.
    HPAi HPA040226.
    MIMi 607351. gene.
    neXtProti NX_O94844.
    PharmGKBi PA38664.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000007723.
    HOVERGENi HBG054987.
    InParanoidi O94844.
    KOi K07868.
    OMAi CADVLFV.
    OrthoDBi EOG7SXW2N.
    PhylomeDBi O94844.
    TreeFami TF323347.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.

    Miscellaneous databases

    ChiTaRSi RHOBTB1. human.
    GeneWikii RHOBTB1.
    GenomeRNAii 9886.
    NextBioi 37268.
    PROi O94844.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O94844.
    Bgeei O94844.
    CleanExi HS_RHOBTB1.
    Genevestigatori O94844.

    Family and domain databases

    Gene3Di 3.30.710.10. 3 hits.
    3.40.50.300. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR027417. P-loop_NTPase.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view ]
    Pfami PF00651. BTB. 2 hits.
    PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00225. BTB. 2 hits.
    SM00174. RHO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF54695. SSF54695. 3 hits.
    PROSITEi PS50097. BTB. 2 hits.
    PS51420. RHO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse."
      Ramos S., Khademi F., Somesh B.P., Rivero F.
      Gene 298:147-157(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiRHBT1_HUMAN
    AccessioniPrimary (citable) accession number: O94844
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3