O94844 (RHBT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho-related BTB domain-containing protein 1

Gene names

Name:	RHOBTB1
Synonyms:	KIAA0740

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	696 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Ubiquitous, with highest levels in skeletal muscle, placenta, testis, stomach, and kidney, followed by uterus and adrenal gland. Expressed in a variety of fetal tissues. Ref.1
Sequence similarities	Belongs to the small GTPase superfamily. Rho family. Contains 2 BTB (POZ) domains.

Ontologies

Keywords
Domain	Repeat
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of small GTPase mediated signal transduction Traceable author statement. Source: Reactome small GTPase mediated signal transduction Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome plasma membrane Traceable author statement. Source: Reactome
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 696	696	Rho-related BTB domain-containing protein 1		PRO_0000198960
Regions
	Domain	266 – 427	162	BTB 1
	Domain	485 – 552	68	BTB 2
	Nucleotide binding	21 – 28	8	GTP Potential
	Nucleotide binding	84 – 88	5	GTP Potential
	Nucleotide binding	140 – 143	4	GTP Potential
	Region	1 – 210	210	Rho-like

Sequences

	Sequence		Length	Mass (Da)
	O94844 [UniParc]. Last modified May 1, 2000. Version 2. Checksum: 41ECB4425CD32A1A	FASTA	696	79,417
	10 20 30 40 50 60 MDADMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV PTVWAIDQYR 70 80 90 100 110 120 VCQEVLERSR DVVDEVSVSL RLWDTFGDHH KDRRFAYGRS DVVVLCFSIA NPNSLNHVKS 130 140 150 160 170 180 MWYPEIKHFC PRTPVILVGC QLDLRYADLE AVNRARRPLA RPIKRGDILP PEKGREVAKE 190 200 210 220 230 240 LGLPYYETSV FDQFGIKDVF DNAIRAALIS RRHLQFWKSH LKKVQKPLLQ APFLPPKAPP 250 260 270 280 290 300 PVIKIPECPS MGTNEAACLL DNPLCADVLF ILQDQEHIFA HRIYLATSSS KFYDLFLMEC 310 320 330 340 350 360 EESPNGSEGA CEKEKQSRDF QGRILSVDPE EEREEGPPRI PQADQWKSSN KSLVEALGLE 370 380 390 400 410 420 AEGAVPETQT LTGWSKGFIG MHREMQVNPI SKRMGPMTVV RMDASVQPGP FRTLLQFLYT 430 440 450 460 470 480 GQLDEKEKDL VGLAQIAEVL EMFDLRMMVE NIMNKEAFMN QEITKAFHVR KANRIKECLS 490 500 510 520 530 540 KGTFSDVTFK LDDGAISAHK PLLICSCEWM AAMFGGSFVE SANSEVYLPN INKISMQAVL 550 560 570 580 590 600 DYLYTKQLSP NLDLDPLELI ALANRFCLPH LVALAEQHAV QELTKAATSG VGIDGEVLSY 610 620 630 640 650 660 LELAQFHNAH QLAAWCLHHI CTNYNSVCSK FRKEIKSKSA DNQEYFERHR WPPVWYLKEE 670 680 690 DHYQRVKRER EKEDIALNKH RSRRKWCFWN SSPAVA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse." Ramos S., Khademi F., Somesh B.P., Rivero F. Gene 298:147-157(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB018283 mRNA. Translation: BAA34460.2. AK075129 mRNA. Translation: BAC11421.1. BC032848 mRNA. Translation: AAH32848.1. BC041791 mRNA. Translation: AAH41791.1.
IPI	IPI00001317.
RefSeq	NP_001229288.1. NM_001242359.1. NP_055651.1. NM_014836.4.
UniGene	Hs.741292.
3D structure databases
ProteinModelPortal	O94844.
ModBase	Search...
Protein-protein interaction databases
IntAct	O94844. 1 interaction.
STRING	9606.ENSP00000338671.
PTM databases
PhosphoSite	O94844.
Proteomic databases
PaxDb	O94844.
PeptideAtlas	O94844.
PRIDE	O94844.
Protocols and materials databases
DNASU	9886.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000337910; ENSP00000338671; ENSG00000072422. ENST00000357917; ENSP00000350595; ENSG00000072422.
GeneID	9886.
KEGG	hsa:9886.
UCSC	uc001jlh.3. human.
Organism-specific databases
CTD	9886.
GeneCards	GC10M062629.
HGNC	HGNC:18738. RHOBTB1.
HPA	HPA040226.
MIM	607351. gene.
neXtProt	NX_O94844.
PharmGKB	PA38664.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000007723.
HOVERGEN	HBG054987.
InParanoid	O94844.
KO	K07868.
OMA	DLFLMEC.
OrthoDB	EOG479F6M.
PhylomeDB	O94844.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	O94844.
Bgee	O94844.
CleanEx	HS_RHOBTB1.
Genevestigator	O94844.
GermOnline	ENSG00000072422. Homo sapiens.
Family and domain databases
Gene3D	3.30.710.10. 3 hits.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR001806. Small_GTPase. IPR003578. Small_GTPase_Rho. [Graphical view]
Pfam	PF00651. BTB. 2 hits. PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00225. BTB. 2 hits. SM00174. RHO. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 2 hits.
PROSITE	PS50097. BTB. 2 hits. PS51420. RHO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RHOBTB1. human.
GenomeRNAi	9886.
NextBio	37268.
SOURCE	Search...

Entry information

Entry name

RHBT1_HUMAN

Accession

Primary (citable) accession number: O94844

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.