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Protein

Rho-related BTB domain-containing protein 1

Gene

RHOBTB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 288GTPSequence Analysis
Nucleotide bindingi84 – 885GTPSequence Analysis
Nucleotide bindingi140 – 1434GTPSequence Analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related BTB domain-containing protein 1
Gene namesi
Name:RHOBTB1
Synonyms:KIAA0740
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:18738. RHOBTB1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38664.

Polymorphism and mutation databases

BioMutaiRHOBTB1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696Rho-related BTB domain-containing protein 1PRO_0000198960Add
BLAST

Proteomic databases

PaxDbiO94844.
PeptideAtlasiO94844.
PRIDEiO94844.

PTM databases

PhosphoSiteiO94844.

Expressioni

Tissue specificityi

Ubiquitous, with highest levels in skeletal muscle, placenta, testis, stomach, and kidney, followed by uterus and adrenal gland. Expressed in a variety of fetal tissues.1 Publication

Gene expression databases

BgeeiO94844.
CleanExiHS_RHOBTB1.
ExpressionAtlasiO94844. baseline and differential.
GenevisibleiO94844. HS.

Organism-specific databases

HPAiHPA040205.
HPA040226.

Interactioni

Protein-protein interaction databases

BioGridi115217. 7 interactions.
IntActiO94844. 1 interaction.
STRINGi9606.ENSP00000338671.

Structurei

3D structure databases

ProteinModelPortaliO94844.
SMRiO94844. Positions 13-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini266 – 427162BTB 1PROSITE-ProRule annotationAdd
BLAST
Domaini485 – 55268BTB 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 210210Rho-likeAdd
BLAST

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated
Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00800000124089.
HOGENOMiHOG000007723.
HOVERGENiHBG054987.
InParanoidiO94844.
KOiK07868.
OMAiLMECEET.
OrthoDBiEOG7SXW2N.
PhylomeDBiO94844.
TreeFamiTF323347.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00651. BTB. 2 hits.
PF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00225. BTB. 2 hits.
SM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54695. SSF54695. 3 hits.
PROSITEiPS50097. BTB. 2 hits.
PS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDADMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV
60 70 80 90 100
PTVWAIDQYR VCQEVLERSR DVVDEVSVSL RLWDTFGDHH KDRRFAYGRS
110 120 130 140 150
DVVVLCFSIA NPNSLNHVKS MWYPEIKHFC PRTPVILVGC QLDLRYADLE
160 170 180 190 200
AVNRARRPLA RPIKRGDILP PEKGREVAKE LGLPYYETSV FDQFGIKDVF
210 220 230 240 250
DNAIRAALIS RRHLQFWKSH LKKVQKPLLQ APFLPPKAPP PVIKIPECPS
260 270 280 290 300
MGTNEAACLL DNPLCADVLF ILQDQEHIFA HRIYLATSSS KFYDLFLMEC
310 320 330 340 350
EESPNGSEGA CEKEKQSRDF QGRILSVDPE EEREEGPPRI PQADQWKSSN
360 370 380 390 400
KSLVEALGLE AEGAVPETQT LTGWSKGFIG MHREMQVNPI SKRMGPMTVV
410 420 430 440 450
RMDASVQPGP FRTLLQFLYT GQLDEKEKDL VGLAQIAEVL EMFDLRMMVE
460 470 480 490 500
NIMNKEAFMN QEITKAFHVR KANRIKECLS KGTFSDVTFK LDDGAISAHK
510 520 530 540 550
PLLICSCEWM AAMFGGSFVE SANSEVYLPN INKISMQAVL DYLYTKQLSP
560 570 580 590 600
NLDLDPLELI ALANRFCLPH LVALAEQHAV QELTKAATSG VGIDGEVLSY
610 620 630 640 650
LELAQFHNAH QLAAWCLHHI CTNYNSVCSK FRKEIKSKSA DNQEYFERHR
660 670 680 690
WPPVWYLKEE DHYQRVKRER EKEDIALNKH RSRRKWCFWN SSPAVA
Length:696
Mass (Da):79,417
Last modified:May 1, 2000 - v2
Checksum:i41ECB4425CD32A1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018283 mRNA. Translation: BAA34460.2.
AK075129 mRNA. Translation: BAC11421.1.
BC032848 mRNA. Translation: AAH32848.1.
BC041791 mRNA. Translation: AAH41791.1.
CCDSiCCDS7261.1.
RefSeqiNP_001229288.1. NM_001242359.1.
NP_055651.1. NM_014836.4.
XP_006718147.1. XM_006718084.1.
XP_006718148.1. XM_006718085.1.
XP_011538724.1. XM_011540422.1.
XP_011538726.1. XM_011540424.1.
UniGeneiHs.737374.

Genome annotation databases

EnsembliENST00000337910; ENSP00000338671; ENSG00000072422.
ENST00000357917; ENSP00000350595; ENSG00000072422.
GeneIDi9886.
KEGGihsa:9886.
UCSCiuc001jlh.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018283 mRNA. Translation: BAA34460.2.
AK075129 mRNA. Translation: BAC11421.1.
BC032848 mRNA. Translation: AAH32848.1.
BC041791 mRNA. Translation: AAH41791.1.
CCDSiCCDS7261.1.
RefSeqiNP_001229288.1. NM_001242359.1.
NP_055651.1. NM_014836.4.
XP_006718147.1. XM_006718084.1.
XP_006718148.1. XM_006718085.1.
XP_011538724.1. XM_011540422.1.
XP_011538726.1. XM_011540424.1.
UniGeneiHs.737374.

3D structure databases

ProteinModelPortaliO94844.
SMRiO94844. Positions 13-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115217. 7 interactions.
IntActiO94844. 1 interaction.
STRINGi9606.ENSP00000338671.

PTM databases

PhosphoSiteiO94844.

Polymorphism and mutation databases

BioMutaiRHOBTB1.

Proteomic databases

PaxDbiO94844.
PeptideAtlasiO94844.
PRIDEiO94844.

Protocols and materials databases

DNASUi9886.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337910; ENSP00000338671; ENSG00000072422.
ENST00000357917; ENSP00000350595; ENSG00000072422.
GeneIDi9886.
KEGGihsa:9886.
UCSCiuc001jlh.3. human.

Organism-specific databases

CTDi9886.
GeneCardsiGC10M062629.
HGNCiHGNC:18738. RHOBTB1.
HPAiHPA040205.
HPA040226.
MIMi607351. gene.
neXtProtiNX_O94844.
PharmGKBiPA38664.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00800000124089.
HOGENOMiHOG000007723.
HOVERGENiHBG054987.
InParanoidiO94844.
KOiK07868.
OMAiLMECEET.
OrthoDBiEOG7SXW2N.
PhylomeDBiO94844.
TreeFamiTF323347.

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiRHOBTB1. human.
GeneWikiiRHOBTB1.
GenomeRNAii9886.
NextBioi37268.
PROiO94844.
SOURCEiSearch...

Gene expression databases

BgeeiO94844.
CleanExiHS_RHOBTB1.
ExpressionAtlasiO94844. baseline and differential.
GenevisibleiO94844. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00651. BTB. 2 hits.
PF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00225. BTB. 2 hits.
SM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54695. SSF54695. 3 hits.
PROSITEiPS50097. BTB. 2 hits.
PS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse."
    Ramos S., Khademi F., Somesh B.P., Rivero F.
    Gene 298:147-157(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiRHBT1_HUMAN
AccessioniPrimary (citable) accession number: O94844
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 1, 2000
Last modified: July 22, 2015
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.