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O94844 (RHBT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho-related BTB domain-containing protein 1
Gene names
Name:RHOBTB1
Synonyms:KIAA0740
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length696 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Ubiquitous, with highest levels in skeletal muscle, placenta, testis, stomach, and kidney, followed by uterus and adrenal gland. Expressed in a variety of fetal tissues. Ref.1

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Contains 2 BTB (POZ) domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 696696Rho-related BTB domain-containing protein 1
PRO_0000198960

Regions

Domain266 – 427162BTB 1
Domain485 – 55268BTB 2
Nucleotide binding21 – 288GTP Potential
Nucleotide binding84 – 885GTP Potential
Nucleotide binding140 – 1434GTP Potential
Region1 – 210210Rho-like

Sequences

Sequence LengthMass (Da)Tools
O94844 [UniParc].

Last modified May 1, 2000. Version 2.
Checksum: 41ECB4425CD32A1A

FASTA69679,417
        10         20         30         40         50         60 
MDADMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV PTVWAIDQYR 

        70         80         90        100        110        120 
VCQEVLERSR DVVDEVSVSL RLWDTFGDHH KDRRFAYGRS DVVVLCFSIA NPNSLNHVKS 

       130        140        150        160        170        180 
MWYPEIKHFC PRTPVILVGC QLDLRYADLE AVNRARRPLA RPIKRGDILP PEKGREVAKE 

       190        200        210        220        230        240 
LGLPYYETSV FDQFGIKDVF DNAIRAALIS RRHLQFWKSH LKKVQKPLLQ APFLPPKAPP 

       250        260        270        280        290        300 
PVIKIPECPS MGTNEAACLL DNPLCADVLF ILQDQEHIFA HRIYLATSSS KFYDLFLMEC 

       310        320        330        340        350        360 
EESPNGSEGA CEKEKQSRDF QGRILSVDPE EEREEGPPRI PQADQWKSSN KSLVEALGLE 

       370        380        390        400        410        420 
AEGAVPETQT LTGWSKGFIG MHREMQVNPI SKRMGPMTVV RMDASVQPGP FRTLLQFLYT 

       430        440        450        460        470        480 
GQLDEKEKDL VGLAQIAEVL EMFDLRMMVE NIMNKEAFMN QEITKAFHVR KANRIKECLS 

       490        500        510        520        530        540 
KGTFSDVTFK LDDGAISAHK PLLICSCEWM AAMFGGSFVE SANSEVYLPN INKISMQAVL 

       550        560        570        580        590        600 
DYLYTKQLSP NLDLDPLELI ALANRFCLPH LVALAEQHAV QELTKAATSG VGIDGEVLSY 

       610        620        630        640        650        660 
LELAQFHNAH QLAAWCLHHI CTNYNSVCSK FRKEIKSKSA DNQEYFERHR WPPVWYLKEE 

       670        680        690 
DHYQRVKRER EKEDIALNKH RSRRKWCFWN SSPAVA 

« Hide

References

« Hide 'large scale' references
[1]"Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse."
Ramos S., Khademi F., Somesh B.P., Rivero F.
Gene 298:147-157(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB018283 mRNA. Translation: BAA34460.2.
AK075129 mRNA. Translation: BAC11421.1.
BC032848 mRNA. Translation: AAH32848.1.
BC041791 mRNA. Translation: AAH41791.1.
CCDSCCDS7261.1.
RefSeqNP_001229288.1. NM_001242359.1.
NP_055651.1. NM_014836.4.
XP_006718147.1. XM_006718084.1.
XP_006718148.1. XM_006718085.1.
XP_006718149.1. XM_006718086.1.
UniGeneHs.737374.

3D structure databases

ProteinModelPortalO94844.
SMRO94844. Positions 13-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115217. 7 interactions.
IntActO94844. 1 interaction.
STRING9606.ENSP00000338671.

PTM databases

PhosphoSiteO94844.

Proteomic databases

PaxDbO94844.
PeptideAtlasO94844.
PRIDEO94844.

Protocols and materials databases

DNASU9886.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000337910; ENSP00000338671; ENSG00000072422.
ENST00000357917; ENSP00000350595; ENSG00000072422.
GeneID9886.
KEGGhsa:9886.
UCSCuc001jlh.3. human.

Organism-specific databases

CTD9886.
GeneCardsGC10M062629.
HGNCHGNC:18738. RHOBTB1.
HPAHPA040226.
MIM607351. gene.
neXtProtNX_O94844.
PharmGKBPA38664.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000007723.
HOVERGENHBG054987.
InParanoidO94844.
KOK07868.
OMACADVLFV.
OrthoDBEOG7SXW2N.
PhylomeDBO94844.
TreeFamTF323347.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressO94844.
BgeeO94844.
CleanExHS_RHOBTB1.
GenevestigatorO94844.

Family and domain databases

Gene3D3.30.710.10. 3 hits.
3.40.50.300. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamPF00651. BTB. 2 hits.
PF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00225. BTB. 2 hits.
SM00174. RHO. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF54695. SSF54695. 3 hits.
PROSITEPS50097. BTB. 2 hits.
PS51420. RHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRHOBTB1. human.
GeneWikiRHOBTB1.
GenomeRNAi9886.
NextBio37268.
PROO94844.
SOURCESearch...

Entry information

Entry nameRHBT1_HUMAN
AccessionPrimary (citable) accession number: O94844
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM