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Protein

Rho-related BTB domain-containing protein 1

Gene

RHOBTB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28GTPSequence analysis8
Nucleotide bindingi84 – 88GTPSequence analysis5
Nucleotide bindingi140 – 143GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related BTB domain-containing protein 1
Gene namesi
Name:RHOBTB1
Synonyms:KIAA0740
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000072422.16.
HGNCiHGNC:18738. RHOBTB1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9886.
OpenTargetsiENSG00000072422.
PharmGKBiPA38664.

Polymorphism and mutation databases

BioMutaiRHOBTB1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989601 – 696Rho-related BTB domain-containing protein 1Add BLAST696

Proteomic databases

EPDiO94844.
PaxDbiO94844.
PeptideAtlasiO94844.
PRIDEiO94844.

PTM databases

iPTMnetiO94844.
PhosphoSitePlusiO94844.

Expressioni

Tissue specificityi

Ubiquitous, with highest levels in skeletal muscle, placenta, testis, stomach, and kidney, followed by uterus and adrenal gland. Expressed in a variety of fetal tissues.1 Publication

Gene expression databases

BgeeiENSG00000072422.
CleanExiHS_RHOBTB1.
ExpressionAtlasiO94844. baseline and differential.
GenevisibleiO94844. HS.

Organism-specific databases

HPAiHPA040205.
HPA040226.

Interactioni

Protein-protein interaction databases

BioGridi115217. 22 interactors.
IntActiO94844. 2 interactors.
STRINGi9606.ENSP00000338671.

Structurei

3D structure databases

ProteinModelPortaliO94844.
SMRiO94844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini266 – 427BTB 1PROSITE-ProRule annotationAdd BLAST162
Domaini485 – 552BTB 2PROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 210Rho-likeAdd BLAST210

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000007723.
HOVERGENiHBG054987.
InParanoidiO94844.
KOiK07868.
OMAiINKMSMQ.
OrthoDBiEOG091G03I3.
PhylomeDBiO94844.
TreeFamiTF323347.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR027417. P-loop_NTPase.
IPR011333. SKP1/BTB/POZ.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
PfamiView protein in Pfam
PF00651. BTB. 2 hits.
PF00071. Ras. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 2 hits.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54695. SSF54695. 3 hits.
PROSITEiView protein in PROSITE
PS50097. BTB. 2 hits.
PS51420. RHO. 1 hit.

Sequencei

Sequence statusi: Complete.

O94844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDADMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV
60 70 80 90 100
PTVWAIDQYR VCQEVLERSR DVVDEVSVSL RLWDTFGDHH KDRRFAYGRS
110 120 130 140 150
DVVVLCFSIA NPNSLNHVKS MWYPEIKHFC PRTPVILVGC QLDLRYADLE
160 170 180 190 200
AVNRARRPLA RPIKRGDILP PEKGREVAKE LGLPYYETSV FDQFGIKDVF
210 220 230 240 250
DNAIRAALIS RRHLQFWKSH LKKVQKPLLQ APFLPPKAPP PVIKIPECPS
260 270 280 290 300
MGTNEAACLL DNPLCADVLF ILQDQEHIFA HRIYLATSSS KFYDLFLMEC
310 320 330 340 350
EESPNGSEGA CEKEKQSRDF QGRILSVDPE EEREEGPPRI PQADQWKSSN
360 370 380 390 400
KSLVEALGLE AEGAVPETQT LTGWSKGFIG MHREMQVNPI SKRMGPMTVV
410 420 430 440 450
RMDASVQPGP FRTLLQFLYT GQLDEKEKDL VGLAQIAEVL EMFDLRMMVE
460 470 480 490 500
NIMNKEAFMN QEITKAFHVR KANRIKECLS KGTFSDVTFK LDDGAISAHK
510 520 530 540 550
PLLICSCEWM AAMFGGSFVE SANSEVYLPN INKISMQAVL DYLYTKQLSP
560 570 580 590 600
NLDLDPLELI ALANRFCLPH LVALAEQHAV QELTKAATSG VGIDGEVLSY
610 620 630 640 650
LELAQFHNAH QLAAWCLHHI CTNYNSVCSK FRKEIKSKSA DNQEYFERHR
660 670 680 690
WPPVWYLKEE DHYQRVKRER EKEDIALNKH RSRRKWCFWN SSPAVA
Length:696
Mass (Da):79,417
Last modified:May 1, 2000 - v2
Checksum:i41ECB4425CD32A1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018283 mRNA. Translation: BAA34460.2.
AK075129 mRNA. Translation: BAC11421.1.
BC032848 mRNA. Translation: AAH32848.1.
BC041791 mRNA. Translation: AAH41791.1.
CCDSiCCDS7261.1.
RefSeqiNP_001229288.1. NM_001242359.1.
NP_055651.1. NM_014836.4.
XP_006718147.1. XM_006718084.1.
XP_006718148.1. XM_006718085.1.
XP_011538726.1. XM_011540424.1.
XP_016872489.1. XM_017017000.1.
XP_016872490.1. XM_017017001.1.
UniGeneiHs.737374.

Genome annotation databases

EnsembliENST00000337910; ENSP00000338671; ENSG00000072422.
ENST00000357917; ENSP00000350595; ENSG00000072422.
GeneIDi9886.
KEGGihsa:9886.
UCSCiuc001jlh.4. human.

Similar proteinsi

Entry informationi

Entry nameiRHBT1_HUMAN
AccessioniPrimary (citable) accession number: O94844
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families