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O94844

- RHBT1_HUMAN

UniProt

O94844 - RHBT1_HUMAN

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Protein

Rho-related BTB domain-containing protein 1

Gene
RHOBTB1, KIAA0740
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 288GTP Reviewed prediction
Nucleotide bindingi84 – 885GTP Reviewed prediction
Nucleotide bindingi140 – 1434GTP Reviewed prediction

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of small GTPase mediated signal transduction Source: Reactome
  2. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related BTB domain-containing protein 1
Gene namesi
Name:RHOBTB1
Synonyms:KIAA0740
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:18738. RHOBTB1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. plasma membrane Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696Rho-related BTB domain-containing protein 1PRO_0000198960Add
BLAST

Proteomic databases

PaxDbiO94844.
PeptideAtlasiO94844.
PRIDEiO94844.

PTM databases

PhosphoSiteiO94844.

Expressioni

Tissue specificityi

Ubiquitous, with highest levels in skeletal muscle, placenta, testis, stomach, and kidney, followed by uterus and adrenal gland. Expressed in a variety of fetal tissues.1 Publication

Gene expression databases

ArrayExpressiO94844.
BgeeiO94844.
CleanExiHS_RHOBTB1.
GenevestigatoriO94844.

Organism-specific databases

HPAiHPA040226.

Interactioni

Protein-protein interaction databases

BioGridi115217. 7 interactions.
IntActiO94844. 1 interaction.
STRINGi9606.ENSP00000338671.

Structurei

3D structure databases

ProteinModelPortaliO94844.
SMRiO94844. Positions 13-208.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini266 – 427162BTB 1Add
BLAST
Domaini485 – 55268BTB 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 210210Rho-likeAdd
BLAST

Sequence similaritiesi

Contains 2 BTB (POZ) domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000007723.
HOVERGENiHBG054987.
InParanoidiO94844.
KOiK07868.
OMAiCADVLFV.
OrthoDBiEOG7SXW2N.
PhylomeDBiO94844.
TreeFamiTF323347.

Family and domain databases

Gene3Di3.30.710.10. 3 hits.
3.40.50.300. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00651. BTB. 2 hits.
PF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00225. BTB. 2 hits.
SM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54695. SSF54695. 3 hits.
PROSITEiPS50097. BTB. 2 hits.
PS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94844-1 [UniParc]FASTAAdd to Basket

« Hide

MDADMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV    50
PTVWAIDQYR VCQEVLERSR DVVDEVSVSL RLWDTFGDHH KDRRFAYGRS 100
DVVVLCFSIA NPNSLNHVKS MWYPEIKHFC PRTPVILVGC QLDLRYADLE 150
AVNRARRPLA RPIKRGDILP PEKGREVAKE LGLPYYETSV FDQFGIKDVF 200
DNAIRAALIS RRHLQFWKSH LKKVQKPLLQ APFLPPKAPP PVIKIPECPS 250
MGTNEAACLL DNPLCADVLF ILQDQEHIFA HRIYLATSSS KFYDLFLMEC 300
EESPNGSEGA CEKEKQSRDF QGRILSVDPE EEREEGPPRI PQADQWKSSN 350
KSLVEALGLE AEGAVPETQT LTGWSKGFIG MHREMQVNPI SKRMGPMTVV 400
RMDASVQPGP FRTLLQFLYT GQLDEKEKDL VGLAQIAEVL EMFDLRMMVE 450
NIMNKEAFMN QEITKAFHVR KANRIKECLS KGTFSDVTFK LDDGAISAHK 500
PLLICSCEWM AAMFGGSFVE SANSEVYLPN INKISMQAVL DYLYTKQLSP 550
NLDLDPLELI ALANRFCLPH LVALAEQHAV QELTKAATSG VGIDGEVLSY 600
LELAQFHNAH QLAAWCLHHI CTNYNSVCSK FRKEIKSKSA DNQEYFERHR 650
WPPVWYLKEE DHYQRVKRER EKEDIALNKH RSRRKWCFWN SSPAVA 696
Length:696
Mass (Da):79,417
Last modified:May 1, 2000 - v2
Checksum:i41ECB4425CD32A1A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018283 mRNA. Translation: BAA34460.2.
AK075129 mRNA. Translation: BAC11421.1.
BC032848 mRNA. Translation: AAH32848.1.
BC041791 mRNA. Translation: AAH41791.1.
CCDSiCCDS7261.1.
RefSeqiNP_001229288.1. NM_001242359.1.
NP_055651.1. NM_014836.4.
XP_006718147.1. XM_006718084.1.
XP_006718148.1. XM_006718085.1.
XP_006718149.1. XM_006718086.1.
UniGeneiHs.737374.

Genome annotation databases

EnsembliENST00000337910; ENSP00000338671; ENSG00000072422.
ENST00000357917; ENSP00000350595; ENSG00000072422.
GeneIDi9886.
KEGGihsa:9886.
UCSCiuc001jlh.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018283 mRNA. Translation: BAA34460.2 .
AK075129 mRNA. Translation: BAC11421.1 .
BC032848 mRNA. Translation: AAH32848.1 .
BC041791 mRNA. Translation: AAH41791.1 .
CCDSi CCDS7261.1.
RefSeqi NP_001229288.1. NM_001242359.1.
NP_055651.1. NM_014836.4.
XP_006718147.1. XM_006718084.1.
XP_006718148.1. XM_006718085.1.
XP_006718149.1. XM_006718086.1.
UniGenei Hs.737374.

3D structure databases

ProteinModelPortali O94844.
SMRi O94844. Positions 13-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115217. 7 interactions.
IntActi O94844. 1 interaction.
STRINGi 9606.ENSP00000338671.

PTM databases

PhosphoSitei O94844.

Proteomic databases

PaxDbi O94844.
PeptideAtlasi O94844.
PRIDEi O94844.

Protocols and materials databases

DNASUi 9886.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000337910 ; ENSP00000338671 ; ENSG00000072422 .
ENST00000357917 ; ENSP00000350595 ; ENSG00000072422 .
GeneIDi 9886.
KEGGi hsa:9886.
UCSCi uc001jlh.3. human.

Organism-specific databases

CTDi 9886.
GeneCardsi GC10M062629.
HGNCi HGNC:18738. RHOBTB1.
HPAi HPA040226.
MIMi 607351. gene.
neXtProti NX_O94844.
PharmGKBi PA38664.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000007723.
HOVERGENi HBG054987.
InParanoidi O94844.
KOi K07868.
OMAi CADVLFV.
OrthoDBi EOG7SXW2N.
PhylomeDBi O94844.
TreeFami TF323347.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSi RHOBTB1. human.
GeneWikii RHOBTB1.
GenomeRNAii 9886.
NextBioi 37268.
PROi O94844.
SOURCEi Search...

Gene expression databases

ArrayExpressi O94844.
Bgeei O94844.
CleanExi HS_RHOBTB1.
Genevestigatori O94844.

Family and domain databases

Gene3Di 3.30.710.10. 3 hits.
3.40.50.300. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00651. BTB. 2 hits.
PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00225. BTB. 2 hits.
SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF54695. SSF54695. 3 hits.
PROSITEi PS50097. BTB. 2 hits.
PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse."
    Ramos S., Khademi F., Somesh B.P., Rivero F.
    Gene 298:147-157(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiRHBT1_HUMAN
AccessioniPrimary (citable) accession number: O94844
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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