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Protein

TOX high mobility group box family member 4

Gene

TOX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi223 – 291HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TOX high mobility group box family member 4
Alternative name(s):
Epidermal Langerhans cell protein LCP1
Gene namesi
Name:TOX4
Synonyms:C14orf92, KIAA0737
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000092203.13.
HGNCiHGNC:20161. TOX4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9878.
OpenTargetsiENSG00000092203.
PharmGKBiPA162406753.

Polymorphism and mutation databases

BioMutaiTOX4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485681 – 621TOX high mobility group box family member 4Add BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei176PhosphothreonineBy similarity1
Modified residuei178PhosphoserineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei313PhosphothreonineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei481Asymmetric dimethylarginineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei550PhosphoserineCombined sources1
Modified residuei552PhosphoserineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei562PhosphoserineCombined sources1
Modified residuei567PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO94842.
MaxQBiO94842.
PaxDbiO94842.
PeptideAtlasiO94842.
PRIDEiO94842.

PTM databases

iPTMnetiO94842.
PhosphoSitePlusiO94842.

Expressioni

Gene expression databases

BgeeiENSG00000092203.
CleanExiHS_TOX4.
ExpressionAtlasiO94842. baseline and differential.
GenevisibleiO94842. HS.

Organism-specific databases

HPAiHPA017880.
HPA027551.

Interactioni

Subunit structurei

Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115209. 56 interactors.
IntActiO94842. 46 interactors.
MINTiMINT-1193640.
STRINGi9606.ENSP00000262709.

Structurei

3D structure databases

ProteinModelPortaliO94842.
SMRiO94842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi213 – 218Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi401 – 534Gln/Pro-richAdd BLAST134
Compositional biasi426 – 434Poly-Ala9

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00560000076898.
HOGENOMiHOG000230949.
HOVERGENiHBG051013.
InParanoidiO94842.
OMAiPPTLKMQ.
OrthoDBiEOG091G12A3.
PhylomeDBiO94842.
TreeFamiTF106481.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR036910. HMG_box_dom_sf.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94842-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEFPGGNDNY LTITGPSHPF LSGAETFHTP SLGDEEFEIP PISLDSDPSL
60 70 80 90 100
AVSDVVGHFD DLADPSSSQD GSFSAQYGVQ TLDMPVGMTH GLMEQGGGLL
110 120 130 140 150
SGGLTMDLDH SIGTQYSANP PVTIDVPMTD MTSGLMGHSQ LTTIDQSELS
160 170 180 190 200
SQLGLSLGGG TILPPAQSPE DRLSTTPSPT SSLHEDGVED FRRQLPSQKT
210 220 230 240 250
VVVEAGKKQK APKKRKKKDP NEPQKPVSAY ALFFRDTQAA IKGQNPNATF
260 270 280 290 300
GEVSKIVASM WDSLGEEQKQ VYKRKTEAAK KEYLKALAAY KDNQECQATV
310 320 330 340 350
ETVELDPAPP SQTPSPPPMA TVDPASPAPA SIEPPALSPS IVVNSTLSSY
360 370 380 390 400
VANQASSGAG GQPNITKLII TKQMLPSSIT MSQGGMVTVI PATVVTSRGL
410 420 430 440 450
QLGQTSTATI QPSQQAQIVT RSVLQAAAAA AAAASMQLPP PRLQPPPLQQ
460 470 480 490 500
MPQPPTQQQV TILQQPPPLQ AMQQPPPQKV RINLQQQPPP LQIKSVPLPT
510 520 530 540 550
LKMQTTLVPP TVESSPERPM NNSPEAHTVE APSPETICEM ITDVVPEVES
560 570 580 590 600
PSQMDVELVS GSPVALSPQP RCVRSGCENP PIVSKDWDNE YCSNECVVKH
610 620
CRDVFLAWVA SRNSNTVVFV K
Length:621
Mass (Da):66,195
Last modified:May 1, 1999 - v1
Checksum:iD5EEAE6FA4756CB1
GO
Isoform 2 (identifier: O94842-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MEFPGGNDNYLTITGPSHPFLSGA → M

Note: No experimental confirmation available.
Show »
Length:598
Mass (Da):63,821
Checksum:iF157F071E5DEF8ED
GO
Isoform 3 (identifier: O94842-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-107: Missing.

Note: No experimental confirmation available.
Show »
Length:595
Mass (Da):63,595
Checksum:i4DF14D609C22E234
GO

Sequence cautioni

The sequence BAA34457 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271V → I in BAG61682 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0538731 – 24MEFPG…FLSGA → M in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_05551282 – 107Missing in isoform 3. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018280 mRNA. Translation: BAA34457.2. Different initiation.
AK298555 mRNA. Translation: BAG60750.1.
AK299807 mRNA. Translation: BAG61682.1.
BC013689 mRNA. Translation: AAH13689.1.
CCDSiCCDS32043.1. [O94842-1]
RefSeqiNP_001290452.1. NM_001303523.1. [O94842-2]
NP_055643.1. NM_014828.3. [O94842-1]
UniGeneiHs.555910.

Genome annotation databases

EnsembliENST00000448790; ENSP00000393080; ENSG00000092203. [O94842-1]
ENST00000613569; ENSP00000477868; ENSG00000092203. [O94842-1]
GeneIDi9878.
KEGGihsa:9878.
UCSCiuc058zcl.1. human. [O94842-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTOX4_HUMAN
AccessioniPrimary (citable) accession number: O94842
Secondary accession number(s): B4DPY8, B4DSM0, E7EV69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot