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O94842

- TOX4_HUMAN

UniProt

O94842 - TOX4_HUMAN

Protein

TOX high mobility group box family member 4

Gene

TOX4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi223 – 29169HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TOX high mobility group box family member 4
    Alternative name(s):
    Epidermal Langerhans cell protein LCP1
    Gene namesi
    Name:TOX4
    Synonyms:C14orf92, KIAA0737
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20161. TOX4.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Associated with chromatin.

    GO - Cellular componenti

    1. chromatin Source: UniProtKB
    2. nucleus Source: HPA
    3. PTW/PP1 phosphatase complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162406753.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 621621TOX high mobility group box family member 4PRO_0000048568Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei178 – 1781Phosphoserine1 Publication
    Modified residuei182 – 1821Phosphoserine1 Publication
    Modified residuei313 – 3131Phosphothreonine1 Publication
    Modified residuei315 – 3151Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO94842.
    PaxDbiO94842.
    PeptideAtlasiO94842.
    PRIDEiO94842.

    PTM databases

    PhosphoSiteiO94842.

    Expressioni

    Gene expression databases

    ArrayExpressiO94842.
    BgeeiO94842.
    CleanExiHS_TOX4.
    GenevestigatoriO94842.

    Organism-specific databases

    HPAiHPA017880.
    HPA027551.

    Interactioni

    Subunit structurei

    Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS.1 Publication

    Protein-protein interaction databases

    BioGridi115209. 28 interactions.
    IntActiO94842. 18 interactions.
    MINTiMINT-1193640.
    STRINGi9606.ENSP00000262709.

    Structurei

    3D structure databases

    ProteinModelPortaliO94842.
    SMRiO94842. Positions 219-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi213 – 2186Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi401 – 534134Gln/Pro-richAdd
    BLAST
    Compositional biasi426 – 4349Poly-Ala

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG284736.
    HOGENOMiHOG000230949.
    HOVERGENiHBG051013.
    InParanoidiO94842.
    OMAiPPTLKMQ.
    OrthoDBiEOG7R834J.
    PhylomeDBiO94842.
    TreeFamiTF106481.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O94842-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEFPGGNDNY LTITGPSHPF LSGAETFHTP SLGDEEFEIP PISLDSDPSL    50
    AVSDVVGHFD DLADPSSSQD GSFSAQYGVQ TLDMPVGMTH GLMEQGGGLL 100
    SGGLTMDLDH SIGTQYSANP PVTIDVPMTD MTSGLMGHSQ LTTIDQSELS 150
    SQLGLSLGGG TILPPAQSPE DRLSTTPSPT SSLHEDGVED FRRQLPSQKT 200
    VVVEAGKKQK APKKRKKKDP NEPQKPVSAY ALFFRDTQAA IKGQNPNATF 250
    GEVSKIVASM WDSLGEEQKQ VYKRKTEAAK KEYLKALAAY KDNQECQATV 300
    ETVELDPAPP SQTPSPPPMA TVDPASPAPA SIEPPALSPS IVVNSTLSSY 350
    VANQASSGAG GQPNITKLII TKQMLPSSIT MSQGGMVTVI PATVVTSRGL 400
    QLGQTSTATI QPSQQAQIVT RSVLQAAAAA AAAASMQLPP PRLQPPPLQQ 450
    MPQPPTQQQV TILQQPPPLQ AMQQPPPQKV RINLQQQPPP LQIKSVPLPT 500
    LKMQTTLVPP TVESSPERPM NNSPEAHTVE APSPETICEM ITDVVPEVES 550
    PSQMDVELVS GSPVALSPQP RCVRSGCENP PIVSKDWDNE YCSNECVVKH 600
    CRDVFLAWVA SRNSNTVVFV K 621
    Length:621
    Mass (Da):66,195
    Last modified:May 1, 1999 - v1
    Checksum:iD5EEAE6FA4756CB1
    GO
    Isoform 2 (identifier: O94842-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-24: MEFPGGNDNYLTITGPSHPFLSGA → M

    Note: No experimental confirmation available.

    Show »
    Length:598
    Mass (Da):63,821
    Checksum:iF157F071E5DEF8ED
    GO
    Isoform 3 (identifier: O94842-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         82-107: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:595
    Mass (Da):63,595
    Checksum:i4DF14D609C22E234
    GO

    Sequence cautioni

    The sequence BAA34457.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti271 – 2711V → I in BAG61682. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2424MEFPG…FLSGA → M in isoform 2. 1 PublicationVSP_053873Add
    BLAST
    Alternative sequencei82 – 10726Missing in isoform 3. 1 PublicationVSP_055512Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018280 mRNA. Translation: BAA34457.2. Different initiation.
    AK298555 mRNA. Translation: BAG60750.1.
    AK299807 mRNA. Translation: BAG61682.1.
    BC013689 mRNA. Translation: AAH13689.1.
    CCDSiCCDS32043.1. [O94842-1]
    RefSeqiNP_055643.1. NM_014828.2. [O94842-1]
    UniGeneiHs.555910.

    Genome annotation databases

    EnsembliENST00000448790; ENSP00000393080; ENSG00000092203. [O94842-2]
    GeneIDi9878.
    KEGGihsa:9878.
    UCSCiuc001way.3. human. [O94842-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018280 mRNA. Translation: BAA34457.2 . Different initiation.
    AK298555 mRNA. Translation: BAG60750.1 .
    AK299807 mRNA. Translation: BAG61682.1 .
    BC013689 mRNA. Translation: AAH13689.1 .
    CCDSi CCDS32043.1. [O94842-1 ]
    RefSeqi NP_055643.1. NM_014828.2. [O94842-1 ]
    UniGenei Hs.555910.

    3D structure databases

    ProteinModelPortali O94842.
    SMRi O94842. Positions 219-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115209. 28 interactions.
    IntActi O94842. 18 interactions.
    MINTi MINT-1193640.
    STRINGi 9606.ENSP00000262709.

    PTM databases

    PhosphoSitei O94842.

    Proteomic databases

    MaxQBi O94842.
    PaxDbi O94842.
    PeptideAtlasi O94842.
    PRIDEi O94842.

    Protocols and materials databases

    DNASUi 9878.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000448790 ; ENSP00000393080 ; ENSG00000092203 . [O94842-2 ]
    GeneIDi 9878.
    KEGGi hsa:9878.
    UCSCi uc001way.3. human. [O94842-1 ]

    Organism-specific databases

    CTDi 9878.
    GeneCardsi GC14P021944.
    HGNCi HGNC:20161. TOX4.
    HPAi HPA017880.
    HPA027551.
    MIMi 614032. gene.
    neXtProti NX_O94842.
    PharmGKBi PA162406753.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284736.
    HOGENOMi HOG000230949.
    HOVERGENi HBG051013.
    InParanoidi O94842.
    OMAi PPTLKMQ.
    OrthoDBi EOG7R834J.
    PhylomeDBi O94842.
    TreeFami TF106481.

    Miscellaneous databases

    ChiTaRSi TOX4. human.
    GeneWikii TOX4.
    GenomeRNAii 9878.
    NextBioi 35474003.
    PROi O94842.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O94842.
    Bgeei O94842.
    CleanExi HS_TOX4.
    Genevestigatori O94842.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Brain.
    3. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178 AND SER-182, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Identification and characterization of a novel human PP1 phosphatase complex."
      Lee J.H., You J., Dobrota E., Skalnik D.G.
      J. Biol. Chem. 285:24466-24476(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE PTW/PP1 PHOSPHATASE COMPLEX, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PPP1R10/PNUTS.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-313 AND SER-315, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTOX4_HUMAN
    AccessioniPrimary (citable) accession number: O94842
    Secondary accession number(s): B4DPY8, B4DSM0, E7EV69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3