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O94832

- MYO1D_HUMAN

UniProt

O94832 - MYO1D_HUMAN

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Protein

Unconventional myosin-Id

Gene

MYO1D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 1098ATPSequence Analysis

GO - Molecular functioni

  1. actin-dependent ATPase activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. microfilament motor activity Source: Ensembl

GO - Biological processi

  1. early endosome to recycling endosome transport Source: UniProt
  2. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Id
Gene namesi
Name:MYO1D
Synonyms:KIAA0727
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:7598. MYO1D.

Subcellular locationi

GO - Cellular componenti

  1. axolemma Source: Ensembl
  2. endosome Source: UniProt
  3. extracellular vesicular exosome Source: UniProtKB
  4. myosin complex Source: UniProtKB-KW
  5. smooth endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 10061005Unconventional myosin-IdPRO_0000123447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei200 – 2001Phosphoserine1 Publication
Modified residuei536 – 5361PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO94832.
PaxDbiO94832.
PeptideAtlasiO94832.
PRIDEiO94832.

PTM databases

PhosphoSiteiO94832.

Expressioni

Tissue specificityi

Expressed in many tissues. Highest levels in brain, followed by lung and ovary; expression is lowest in spleen.

Gene expression databases

BgeeiO94832.
CleanExiHS_MYO1D.
ExpressionAtlasiO94832. baseline and differential.
GenevestigatoriO94832.

Organism-specific databases

HPAiHPA053870.
HPA054744.

Interactioni

Subunit structurei

Binds calmodulin through its IQ motifs.By similarity

Protein-protein interaction databases

BioGridi110726. 22 interactions.
IntActiO94832. 9 interactions.
MINTiMINT-4999277.
STRINGi9606.ENSP00000324527.

Structurei

3D structure databases

ProteinModelPortaliO94832.
SMRiO94832. Positions 10-736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 695687Myosin motorAdd
BLAST
Domaini699 – 71921IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini721 – 74121IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini802 – 1004203Myosin tailSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 2 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 myosin tail domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00760000118956.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiO94832.
KOiK10356.
OMAiILDDACM.
OrthoDBiEOG7V49XQ.
PhylomeDBiO94832.
TreeFamiTF312960.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94832-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEQESLEFG KADFVLMDTV SMPEFMANLR LRFEKGRIYT FIGEVVVSVN
60 70 80 90 100
PYKLLNIYGR DTIEQYKGRE LYERPPHLFA IADAAYKAMK RRSKDTCIVI
110 120 130 140 150
SGESGAGKTE ASKYIMQYIA AITNPSQRAE VERVKNMLLK SNCVLEAFGN
160 170 180 190 200
AKTNRNDNSS RFGKYMDINF DFKGDPIGGH INNYLLEKSR VIVQQPGERS
210 220 230 240 250
FHSFYQLLQG GSEQMLRSLH LQKSLSSYNY IHVGAQLKSS INDAAEFRVV
260 270 280 290 300
ADAMKVIGFK PEEIQTVYKI LAAILHLGNL KFVVDGDTPL IENGKVVSII
310 320 330 340 350
AELLSTKTDM VEKALLYRTV ATGRDIIDKQ HTEQEASYGR DAFAKAIYER
360 370 380 390 400
LFCWIVTRIN DIIEVKNYDT TIHGKNTVIG VLDIYGFEIF DNNSFEQFCI
410 420 430 440 450
NYCNEKLQQL FIQLVLKQEQ EEYQREGIPW KHIDYFNNQI IVDLVEQQHK
460 470 480 490 500
GIIAILDDAC MNVGKVTDEM FLEALNSKLG KHAHFSSRKL CASDKILEFD
510 520 530 540 550
RDFRIRHYAG DVVYSVIGFI DKNKDTLFQD FKRLMYNSSN PVLKNMWPEG
560 570 580 590 600
KLSITEVTKR PLTAATLFKN SMIALVDNLA SKEPYYVRCI KPNDKKSPQI
610 620 630 640 650
FDDERCRHQV EYLGLLENVR VRRAGFAFRQ TYEKFLHRYK MISEFTWPNH
660 670 680 690 700
DLPSDKEAVK KLIERCGFQD DVAYGKTKIF IRTPRTLFTL EELRAQMLIR
710 720 730 740 750
IVLFLQKVWR GTLARMRYKR TKAALTIIRY YRRYKVKSYI HEVARRFHGV
760 770 780 790 800
KTMRDYGKHV KWPSPPKVLR RFEEALQTIF NRWRASQLIK SIPASDLPQV
810 820 830 840 850
RAKVAAVEML KGQRADLGLQ RAWEGNYLAS KPDTPQTSGT FVPVANELKR
860 870 880 890 900
KDKYMNVLFS CHVRKVNRFS KVEDRAIFVT DRHLYKMDPT KQYKVMKTIP
910 920 930 940 950
LYNLTGLSVS NGKDQLVVFH TKDNKDLIVC LFSKQPTHES RIGELVGVLV
960 970 980 990 1000
NHFKSEKRHL QVNVTNPVQC SLHGKKCTVS VETRLNQPQP DFTKNRSGFI

LSVPGN
Length:1,006
Mass (Da):116,202
Last modified:June 20, 2003 - v2
Checksum:iA8BB08450887168E
GO

Sequence cautioni

The sequence BAA34447.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti765 – 7651P → S.
Corresponds to variant rs7209106 [ dbSNP | Ensembl ].
VAR_050210
Natural varianti771 – 7711R → H.
Corresponds to variant rs7215958 [ dbSNP | Ensembl ].
VAR_050211

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018270 mRNA. Translation: BAA34447.2. Different initiation.
BC146763 mRNA. Translation: AAI46764.1.
CCDSiCCDS32615.1.
RefSeqiNP_056009.1. NM_015194.1.
UniGeneiHs.602063.

Genome annotation databases

EnsembliENST00000318217; ENSP00000324527; ENSG00000176658.
GeneIDi4642.
KEGGihsa:4642.
UCSCiuc002hho.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018270 mRNA. Translation: BAA34447.2 . Different initiation.
BC146763 mRNA. Translation: AAI46764.1 .
CCDSi CCDS32615.1.
RefSeqi NP_056009.1. NM_015194.1.
UniGenei Hs.602063.

3D structure databases

ProteinModelPortali O94832.
SMRi O94832. Positions 10-736.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110726. 22 interactions.
IntActi O94832. 9 interactions.
MINTi MINT-4999277.
STRINGi 9606.ENSP00000324527.

PTM databases

PhosphoSitei O94832.

Proteomic databases

MaxQBi O94832.
PaxDbi O94832.
PeptideAtlasi O94832.
PRIDEi O94832.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318217 ; ENSP00000324527 ; ENSG00000176658 .
GeneIDi 4642.
KEGGi hsa:4642.
UCSCi uc002hho.1. human.

Organism-specific databases

CTDi 4642.
GeneCardsi GC17M030819.
HGNCi HGNC:7598. MYO1D.
HPAi HPA053870.
HPA054744.
MIMi 606539. gene.
neXtProti NX_O94832.
PharmGKBi PA31400.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5022.
GeneTreei ENSGT00760000118956.
HOGENOMi HOG000260264.
HOVERGENi HBG062373.
InParanoidi O94832.
KOi K10356.
OMAi ILDDACM.
OrthoDBi EOG7V49XQ.
PhylomeDBi O94832.
TreeFami TF312960.

Miscellaneous databases

ChiTaRSi MYO1D. human.
GenomeRNAii 4642.
NextBioi 17888.
PROi O94832.
SOURCEi Search...

Gene expression databases

Bgeei O94832.
CleanExi HS_MYO1D.
ExpressionAtlasi O94832. baseline and differential.
Genevestigatori O94832.

Family and domain databases

InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Nagase T., Kikuno R., Yamakawa H., Ohara O.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 333-1006.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Bienvenut W.V., Dozynkiewicz M., Norman J.C.
    Submitted (MAR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-11; 239-248; 534-544; 791-801 AND 985-994, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Ovarian carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMYO1D_HUMAN
AccessioniPrimary (citable) accession number: O94832
Secondary accession number(s): A6H8V3, Q8NHP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 20, 2003
Last modified: October 29, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3