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O94832 (MYO1D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Unconventional myosin-Id
Gene names
Name:MYO1D
Synonyms:KIAA0727
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1006 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments By similarity.

Subunit structure

Binds calmodulin through its IQ motifs By similarity.

Tissue specificity

Expressed in many tissues. Highest levels in brain, followed by lung and ovary; expression is lowest in spleen.

Sequence similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Contains 2 IQ domains.

Contains 1 myosin motor domain.

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).

Sequence caution

The sequence BAA34447.2 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 10061005Unconventional myosin-Id
PRO_0000123447

Regions

Domain9 – 695687Myosin motor
Domain699 – 71921IQ 1
Domain721 – 74121IQ 2
Nucleotide binding102 – 1098ATP Potential

Amino acid modifications

Modified residue21N-acetylalanine Ref.4
Modified residue2001Phosphoserine Ref.5
Modified residue5361Phosphotyrosine By similarity

Natural variations

Natural variant7651P → S.
Corresponds to variant rs7209106 [ dbSNP | Ensembl ].
VAR_050210
Natural variant7711R → H.
Corresponds to variant rs7215958 [ dbSNP | Ensembl ].
VAR_050211

Sequences

Sequence LengthMass (Da)Tools
O94832 [UniParc].

Last modified June 20, 2003. Version 2.
Checksum: A8BB08450887168E

FASTA1,006116,202
        10         20         30         40         50         60 
MAEQESLEFG KADFVLMDTV SMPEFMANLR LRFEKGRIYT FIGEVVVSVN PYKLLNIYGR 

        70         80         90        100        110        120 
DTIEQYKGRE LYERPPHLFA IADAAYKAMK RRSKDTCIVI SGESGAGKTE ASKYIMQYIA 

       130        140        150        160        170        180 
AITNPSQRAE VERVKNMLLK SNCVLEAFGN AKTNRNDNSS RFGKYMDINF DFKGDPIGGH 

       190        200        210        220        230        240 
INNYLLEKSR VIVQQPGERS FHSFYQLLQG GSEQMLRSLH LQKSLSSYNY IHVGAQLKSS 

       250        260        270        280        290        300 
INDAAEFRVV ADAMKVIGFK PEEIQTVYKI LAAILHLGNL KFVVDGDTPL IENGKVVSII 

       310        320        330        340        350        360 
AELLSTKTDM VEKALLYRTV ATGRDIIDKQ HTEQEASYGR DAFAKAIYER LFCWIVTRIN 

       370        380        390        400        410        420 
DIIEVKNYDT TIHGKNTVIG VLDIYGFEIF DNNSFEQFCI NYCNEKLQQL FIQLVLKQEQ 

       430        440        450        460        470        480 
EEYQREGIPW KHIDYFNNQI IVDLVEQQHK GIIAILDDAC MNVGKVTDEM FLEALNSKLG 

       490        500        510        520        530        540 
KHAHFSSRKL CASDKILEFD RDFRIRHYAG DVVYSVIGFI DKNKDTLFQD FKRLMYNSSN 

       550        560        570        580        590        600 
PVLKNMWPEG KLSITEVTKR PLTAATLFKN SMIALVDNLA SKEPYYVRCI KPNDKKSPQI 

       610        620        630        640        650        660 
FDDERCRHQV EYLGLLENVR VRRAGFAFRQ TYEKFLHRYK MISEFTWPNH DLPSDKEAVK 

       670        680        690        700        710        720 
KLIERCGFQD DVAYGKTKIF IRTPRTLFTL EELRAQMLIR IVLFLQKVWR GTLARMRYKR 

       730        740        750        760        770        780 
TKAALTIIRY YRRYKVKSYI HEVARRFHGV KTMRDYGKHV KWPSPPKVLR RFEEALQTIF 

       790        800        810        820        830        840 
NRWRASQLIK SIPASDLPQV RAKVAAVEML KGQRADLGLQ RAWEGNYLAS KPDTPQTSGT 

       850        860        870        880        890        900 
FVPVANELKR KDKYMNVLFS CHVRKVNRFS KVEDRAIFVT DRHLYKMDPT KQYKVMKTIP 

       910        920        930        940        950        960 
LYNLTGLSVS NGKDQLVVFH TKDNKDLIVC LFSKQPTHES RIGELVGVLV NHFKSEKRHL 

       970        980        990       1000 
QVNVTNPVQC SLHGKKCTVS VETRLNQPQP DFTKNRSGFI LSVPGN 

« Hide

References

« Hide 'large scale' references
[1]Nagase T., Kikuno R., Yamakawa H., Ohara O.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 333-1006.
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]Bienvenut W.V., Dozynkiewicz M., Norman J.C.
Submitted (MAR-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-11; 239-248; 534-544; 791-801 AND 985-994, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Ovarian carcinoma.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB018270 mRNA. Translation: BAA34447.2. Different initiation.
BC146763 mRNA. Translation: AAI46764.1.
CCDSCCDS32615.1.
RefSeqNP_056009.1. NM_015194.1.
UniGeneHs.602063.

3D structure databases

ProteinModelPortalO94832.
SMRO94832. Positions 7-735.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110726. 16 interactions.
IntActO94832. 8 interactions.
MINTMINT-4999277.
STRING9606.ENSP00000324527.

PTM databases

PhosphoSiteO94832.

Proteomic databases

MaxQBO94832.
PaxDbO94832.
PeptideAtlasO94832.
PRIDEO94832.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318217; ENSP00000324527; ENSG00000176658.
GeneID4642.
KEGGhsa:4642.
UCSCuc002hho.1. human.

Organism-specific databases

CTD4642.
GeneCardsGC17M030819.
HGNCHGNC:7598. MYO1D.
HPAHPA053870.
HPA054744.
MIM606539. gene.
neXtProtNX_O94832.
PharmGKBPA31400.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5022.
HOGENOMHOG000260264.
HOVERGENHBG062373.
InParanoidO94832.
KOK10356.
OMAILDDACM.
OrthoDBEOG7V49XQ.
PhylomeDBO94832.
TreeFamTF312960.

Gene expression databases

ArrayExpressO94832.
BgeeO94832.
CleanExHS_MYO1D.
GenevestigatorO94832.

Family and domain databases

InterProIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSPR00193. MYOSINHEAVY.
SMARTSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMYO1D. human.
GenomeRNAi4642.
NextBio17888.
PROO94832.
SOURCESearch...

Entry information

Entry nameMYO1D_HUMAN
AccessionPrimary (citable) accession number: O94832
Secondary accession number(s): A6H8V3, Q8NHP9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 20, 2003
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM