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Protein

Unconventional myosin-Id

Gene

MYO1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 1098ATPSequence Analysis

GO - Molecular functioni

  1. actin-dependent ATPase activity Source: UniProtKB
  2. actin filament binding Source: UniProtKB
  3. ATP binding Source: UniProtKB-KW
  4. microfilament motor activity Source: Ensembl
  5. protein domain specific binding Source: UniProtKB

GO - Biological processi

  1. ATP catabolic process Source: Ensembl
  2. cellular localization Source: UniProtKB
  3. early endosome to recycling endosome transport Source: UniProtKB
  4. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Id
Gene namesi
Name:MYO1D
Synonyms:KIAA0727
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:7598. MYO1D.

Subcellular locationi

GO - Cellular componenti

  1. axolemma Source: Ensembl
  2. axon Source: UniProtKB
  3. basolateral plasma membrane Source: UniProtKB
  4. brush border Source: UniProtKB
  5. cytoplasmic vesicle Source: UniProtKB
  6. endosome Source: UniProtKB
  7. extracellular vesicular exosome Source: UniProtKB
  8. myelin sheath Source: UniProtKB
  9. myosin complex Source: UniProtKB-KW
  10. neuronal cell body Source: UniProtKB
  11. neuron projection Source: UniProtKB
  12. smooth endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 10061005Unconventional myosin-IdPRO_0000123447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei200 – 2001Phosphoserine1 Publication
Modified residuei536 – 5361PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO94832.
PaxDbiO94832.
PeptideAtlasiO94832.
PRIDEiO94832.

PTM databases

PhosphoSiteiO94832.

Expressioni

Tissue specificityi

Expressed in many tissues. Highest levels in brain, followed by lung and ovary; expression is lowest in spleen.

Gene expression databases

BgeeiO94832.
CleanExiHS_MYO1D.
ExpressionAtlasiO94832. baseline and differential.
GenevestigatoriO94832.

Organism-specific databases

HPAiHPA053870.
HPA054744.

Interactioni

Subunit structurei

Binds calmodulin through its IQ motifs.By similarity

Protein-protein interaction databases

BioGridi110726. 22 interactions.
IntActiO94832. 9 interactions.
MINTiMINT-4999277.
STRINGi9606.ENSP00000324527.

Structurei

3D structure databases

ProteinModelPortaliO94832.
SMRiO94832. Positions 10-736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 695687Myosin motorAdd
BLAST
Domaini699 – 71921IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini721 – 74121IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini802 – 1004203Myosin tailSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 2 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 myosin tail domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00760000118956.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiO94832.
KOiK10356.
OMAiVKSYIHE.
OrthoDBiEOG7V49XQ.
PhylomeDBiO94832.
TreeFamiTF312960.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94832-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQESLEFG KADFVLMDTV SMPEFMANLR LRFEKGRIYT FIGEVVVSVN
60 70 80 90 100
PYKLLNIYGR DTIEQYKGRE LYERPPHLFA IADAAYKAMK RRSKDTCIVI
110 120 130 140 150
SGESGAGKTE ASKYIMQYIA AITNPSQRAE VERVKNMLLK SNCVLEAFGN
160 170 180 190 200
AKTNRNDNSS RFGKYMDINF DFKGDPIGGH INNYLLEKSR VIVQQPGERS
210 220 230 240 250
FHSFYQLLQG GSEQMLRSLH LQKSLSSYNY IHVGAQLKSS INDAAEFRVV
260 270 280 290 300
ADAMKVIGFK PEEIQTVYKI LAAILHLGNL KFVVDGDTPL IENGKVVSII
310 320 330 340 350
AELLSTKTDM VEKALLYRTV ATGRDIIDKQ HTEQEASYGR DAFAKAIYER
360 370 380 390 400
LFCWIVTRIN DIIEVKNYDT TIHGKNTVIG VLDIYGFEIF DNNSFEQFCI
410 420 430 440 450
NYCNEKLQQL FIQLVLKQEQ EEYQREGIPW KHIDYFNNQI IVDLVEQQHK
460 470 480 490 500
GIIAILDDAC MNVGKVTDEM FLEALNSKLG KHAHFSSRKL CASDKILEFD
510 520 530 540 550
RDFRIRHYAG DVVYSVIGFI DKNKDTLFQD FKRLMYNSSN PVLKNMWPEG
560 570 580 590 600
KLSITEVTKR PLTAATLFKN SMIALVDNLA SKEPYYVRCI KPNDKKSPQI
610 620 630 640 650
FDDERCRHQV EYLGLLENVR VRRAGFAFRQ TYEKFLHRYK MISEFTWPNH
660 670 680 690 700
DLPSDKEAVK KLIERCGFQD DVAYGKTKIF IRTPRTLFTL EELRAQMLIR
710 720 730 740 750
IVLFLQKVWR GTLARMRYKR TKAALTIIRY YRRYKVKSYI HEVARRFHGV
760 770 780 790 800
KTMRDYGKHV KWPSPPKVLR RFEEALQTIF NRWRASQLIK SIPASDLPQV
810 820 830 840 850
RAKVAAVEML KGQRADLGLQ RAWEGNYLAS KPDTPQTSGT FVPVANELKR
860 870 880 890 900
KDKYMNVLFS CHVRKVNRFS KVEDRAIFVT DRHLYKMDPT KQYKVMKTIP
910 920 930 940 950
LYNLTGLSVS NGKDQLVVFH TKDNKDLIVC LFSKQPTHES RIGELVGVLV
960 970 980 990 1000
NHFKSEKRHL QVNVTNPVQC SLHGKKCTVS VETRLNQPQP DFTKNRSGFI

LSVPGN
Length:1,006
Mass (Da):116,202
Last modified:June 20, 2003 - v2
Checksum:iA8BB08450887168E
GO

Sequence cautioni

The sequence BAA34447.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti765 – 7651P → S.
Corresponds to variant rs7209106 [ dbSNP | Ensembl ].
VAR_050210
Natural varianti771 – 7711R → H.
Corresponds to variant rs7215958 [ dbSNP | Ensembl ].
VAR_050211

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018270 mRNA. Translation: BAA34447.2. Different initiation.
BC146763 mRNA. Translation: AAI46764.1.
CCDSiCCDS32615.1.
RefSeqiNP_001290208.1. NM_001303279.1.
NP_056009.1. NM_015194.2.
UniGeneiHs.602063.

Genome annotation databases

EnsembliENST00000318217; ENSP00000324527; ENSG00000176658.
GeneIDi4642.
KEGGihsa:4642.
UCSCiuc002hho.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018270 mRNA. Translation: BAA34447.2. Different initiation.
BC146763 mRNA. Translation: AAI46764.1.
CCDSiCCDS32615.1.
RefSeqiNP_001290208.1. NM_001303279.1.
NP_056009.1. NM_015194.2.
UniGeneiHs.602063.

3D structure databases

ProteinModelPortaliO94832.
SMRiO94832. Positions 10-736.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110726. 22 interactions.
IntActiO94832. 9 interactions.
MINTiMINT-4999277.
STRINGi9606.ENSP00000324527.

PTM databases

PhosphoSiteiO94832.

Proteomic databases

MaxQBiO94832.
PaxDbiO94832.
PeptideAtlasiO94832.
PRIDEiO94832.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318217; ENSP00000324527; ENSG00000176658.
GeneIDi4642.
KEGGihsa:4642.
UCSCiuc002hho.1. human.

Organism-specific databases

CTDi4642.
GeneCardsiGC17M030819.
HGNCiHGNC:7598. MYO1D.
HPAiHPA053870.
HPA054744.
MIMi606539. gene.
neXtProtiNX_O94832.
PharmGKBiPA31400.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00760000118956.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiO94832.
KOiK10356.
OMAiVKSYIHE.
OrthoDBiEOG7V49XQ.
PhylomeDBiO94832.
TreeFamiTF312960.

Miscellaneous databases

ChiTaRSiMYO1D. human.
GenomeRNAii4642.
NextBioi17888.
PROiO94832.
SOURCEiSearch...

Gene expression databases

BgeeiO94832.
CleanExiHS_MYO1D.
ExpressionAtlasiO94832. baseline and differential.
GenevestigatoriO94832.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Nagase T., Kikuno R., Yamakawa H., Ohara O.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 333-1006.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Bienvenut W.V., Dozynkiewicz M., Norman J.C.
    Submitted (MAR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-11; 239-248; 534-544; 791-801 AND 985-994, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Ovarian carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMYO1D_HUMAN
AccessioniPrimary (citable) accession number: O94832
Secondary accession number(s): A6H8V3, Q8NHP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 20, 2003
Last modified: March 4, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.