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O94832

- MYO1D_HUMAN

UniProt

O94832 - MYO1D_HUMAN

Protein

Unconventional myosin-Id

Gene

MYO1D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (20 Jun 2003)
      Previous versions | rss
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    Functioni

    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi102 – 1098ATPSequence Analysis

    GO - Molecular functioni

    1. actin-dependent ATPase activity Source: Ensembl
    2. ATP binding Source: UniProtKB-KW
    3. microfilament motor activity Source: Ensembl

    GO - Biological processi

    1. early endosome to recycling endosome transport Source: UniProt
    2. negative regulation of phosphatase activity Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein, Myosin

    Keywords - Ligandi

    Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Unconventional myosin-Id
    Gene namesi
    Name:MYO1D
    Synonyms:KIAA0727
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:7598. MYO1D.

    Subcellular locationi

    GO - Cellular componenti

    1. axolemma Source: Ensembl
    2. endosome Source: UniProt
    3. extracellular vesicular exosome Source: UniProt
    4. myosin complex Source: UniProtKB-KW
    5. smooth endoplasmic reticulum Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31400.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 10061005Unconventional myosin-IdPRO_0000123447Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei200 – 2001Phosphoserine1 Publication
    Modified residuei536 – 5361PhosphotyrosineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO94832.
    PaxDbiO94832.
    PeptideAtlasiO94832.
    PRIDEiO94832.

    PTM databases

    PhosphoSiteiO94832.

    Expressioni

    Tissue specificityi

    Expressed in many tissues. Highest levels in brain, followed by lung and ovary; expression is lowest in spleen.

    Gene expression databases

    ArrayExpressiO94832.
    BgeeiO94832.
    CleanExiHS_MYO1D.
    GenevestigatoriO94832.

    Organism-specific databases

    HPAiHPA053870.
    HPA054744.

    Interactioni

    Subunit structurei

    Binds calmodulin through its IQ motifs.By similarity

    Protein-protein interaction databases

    BioGridi110726. 16 interactions.
    IntActiO94832. 9 interactions.
    MINTiMINT-4999277.
    STRINGi9606.ENSP00000324527.

    Structurei

    3D structure databases

    ProteinModelPortaliO94832.
    SMRiO94832. Positions 7-735.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 695687Myosin motorAdd
    BLAST
    Domaini699 – 71921IQ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini721 – 74121IQ 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 IQ domains.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5022.
    HOGENOMiHOG000260264.
    HOVERGENiHBG062373.
    InParanoidiO94832.
    KOiK10356.
    OMAiILDDACM.
    OrthoDBiEOG7V49XQ.
    PhylomeDBiO94832.
    TreeFamiTF312960.

    Family and domain databases

    InterProiIPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR010926. Myosin_tail_2.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00612. IQ. 1 hit.
    PF00063. Myosin_head. 1 hit.
    PF06017. Myosin_TH1. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O94832-1 [UniParc]FASTAAdd to Basket

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    MAEQESLEFG KADFVLMDTV SMPEFMANLR LRFEKGRIYT FIGEVVVSVN     50
    PYKLLNIYGR DTIEQYKGRE LYERPPHLFA IADAAYKAMK RRSKDTCIVI 100
    SGESGAGKTE ASKYIMQYIA AITNPSQRAE VERVKNMLLK SNCVLEAFGN 150
    AKTNRNDNSS RFGKYMDINF DFKGDPIGGH INNYLLEKSR VIVQQPGERS 200
    FHSFYQLLQG GSEQMLRSLH LQKSLSSYNY IHVGAQLKSS INDAAEFRVV 250
    ADAMKVIGFK PEEIQTVYKI LAAILHLGNL KFVVDGDTPL IENGKVVSII 300
    AELLSTKTDM VEKALLYRTV ATGRDIIDKQ HTEQEASYGR DAFAKAIYER 350
    LFCWIVTRIN DIIEVKNYDT TIHGKNTVIG VLDIYGFEIF DNNSFEQFCI 400
    NYCNEKLQQL FIQLVLKQEQ EEYQREGIPW KHIDYFNNQI IVDLVEQQHK 450
    GIIAILDDAC MNVGKVTDEM FLEALNSKLG KHAHFSSRKL CASDKILEFD 500
    RDFRIRHYAG DVVYSVIGFI DKNKDTLFQD FKRLMYNSSN PVLKNMWPEG 550
    KLSITEVTKR PLTAATLFKN SMIALVDNLA SKEPYYVRCI KPNDKKSPQI 600
    FDDERCRHQV EYLGLLENVR VRRAGFAFRQ TYEKFLHRYK MISEFTWPNH 650
    DLPSDKEAVK KLIERCGFQD DVAYGKTKIF IRTPRTLFTL EELRAQMLIR 700
    IVLFLQKVWR GTLARMRYKR TKAALTIIRY YRRYKVKSYI HEVARRFHGV 750
    KTMRDYGKHV KWPSPPKVLR RFEEALQTIF NRWRASQLIK SIPASDLPQV 800
    RAKVAAVEML KGQRADLGLQ RAWEGNYLAS KPDTPQTSGT FVPVANELKR 850
    KDKYMNVLFS CHVRKVNRFS KVEDRAIFVT DRHLYKMDPT KQYKVMKTIP 900
    LYNLTGLSVS NGKDQLVVFH TKDNKDLIVC LFSKQPTHES RIGELVGVLV 950
    NHFKSEKRHL QVNVTNPVQC SLHGKKCTVS VETRLNQPQP DFTKNRSGFI 1000
    LSVPGN 1006
    Length:1,006
    Mass (Da):116,202
    Last modified:June 20, 2003 - v2
    Checksum:iA8BB08450887168E
    GO

    Sequence cautioni

    The sequence BAA34447.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti765 – 7651P → S.
    Corresponds to variant rs7209106 [ dbSNP | Ensembl ].
    VAR_050210
    Natural varianti771 – 7711R → H.
    Corresponds to variant rs7215958 [ dbSNP | Ensembl ].
    VAR_050211

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018270 mRNA. Translation: BAA34447.2. Different initiation.
    BC146763 mRNA. Translation: AAI46764.1.
    CCDSiCCDS32615.1.
    RefSeqiNP_056009.1. NM_015194.1.
    UniGeneiHs.602063.

    Genome annotation databases

    EnsembliENST00000318217; ENSP00000324527; ENSG00000176658.
    GeneIDi4642.
    KEGGihsa:4642.
    UCSCiuc002hho.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018270 mRNA. Translation: BAA34447.2 . Different initiation.
    BC146763 mRNA. Translation: AAI46764.1 .
    CCDSi CCDS32615.1.
    RefSeqi NP_056009.1. NM_015194.1.
    UniGenei Hs.602063.

    3D structure databases

    ProteinModelPortali O94832.
    SMRi O94832. Positions 7-735.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110726. 16 interactions.
    IntActi O94832. 9 interactions.
    MINTi MINT-4999277.
    STRINGi 9606.ENSP00000324527.

    PTM databases

    PhosphoSitei O94832.

    Proteomic databases

    MaxQBi O94832.
    PaxDbi O94832.
    PeptideAtlasi O94832.
    PRIDEi O94832.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318217 ; ENSP00000324527 ; ENSG00000176658 .
    GeneIDi 4642.
    KEGGi hsa:4642.
    UCSCi uc002hho.1. human.

    Organism-specific databases

    CTDi 4642.
    GeneCardsi GC17M030819.
    HGNCi HGNC:7598. MYO1D.
    HPAi HPA053870.
    HPA054744.
    MIMi 606539. gene.
    neXtProti NX_O94832.
    PharmGKBi PA31400.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5022.
    HOGENOMi HOG000260264.
    HOVERGENi HBG062373.
    InParanoidi O94832.
    KOi K10356.
    OMAi ILDDACM.
    OrthoDBi EOG7V49XQ.
    PhylomeDBi O94832.
    TreeFami TF312960.

    Miscellaneous databases

    ChiTaRSi MYO1D. human.
    GenomeRNAii 4642.
    NextBioi 17888.
    PROi O94832.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O94832.
    Bgeei O94832.
    CleanExi HS_MYO1D.
    Genevestigatori O94832.

    Family and domain databases

    InterProi IPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR010926. Myosin_tail_2.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00612. IQ. 1 hit.
    PF00063. Myosin_head. 1 hit.
    PF06017. Myosin_TH1. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Nagase T., Kikuno R., Yamakawa H., Ohara O.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 333-1006.
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Bienvenut W.V., Dozynkiewicz M., Norman J.C.
      Submitted (MAR-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-11; 239-248; 534-544; 791-801 AND 985-994, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Ovarian carcinoma.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMYO1D_HUMAN
    AccessioniPrimary (citable) accession number: O94832
    Secondary accession number(s): A6H8V3, Q8NHP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: June 20, 2003
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3