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Protein

Unconventional myosin-Id

Gene

MYO1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi102 – 109ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Id
Gene namesi
Name:MYO1D
Synonyms:KIAA0727
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000176658.16
HGNCiHGNC:7598 MYO1D
MIMi606539 gene
neXtProtiNX_O94832

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4642
OpenTargetsiENSG00000176658
PharmGKBiPA31400

Polymorphism and mutation databases

BioMutaiMYO1D

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001234472 – 1006Unconventional myosin-IdAdd BLAST1005

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei200PhosphoserineCombined sources1
Modified residuei536PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO94832
MaxQBiO94832
PaxDbiO94832
PeptideAtlasiO94832
PRIDEiO94832

PTM databases

iPTMnetiO94832
PhosphoSitePlusiO94832
SwissPalmiO94832

Expressioni

Tissue specificityi

Expressed in many tissues. Highest levels in brain, followed by lung and ovary; expression is lowest in spleen.

Gene expression databases

BgeeiENSG00000176658
CleanExiHS_MYO1D
ExpressionAtlasiO94832 baseline and differential
GenevisibleiO94832 HS

Organism-specific databases

HPAiHPA054744

Interactioni

Subunit structurei

Binds calmodulin through its IQ motifs.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110726, 43 interactors
IntActiO94832, 18 interactors
MINTiO94832
STRINGi9606.ENSP00000324527

Structurei

3D structure databases

ProteinModelPortaliO94832
SMRiO94832
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 695Myosin motorPROSITE-ProRule annotationAdd BLAST687
Domaini699 – 719IQ 1PROSITE-ProRule annotationAdd BLAST21
Domaini721 – 741IQ 2PROSITE-ProRule annotationAdd BLAST21
Domaini812 – 1005TH1PROSITE-ProRule annotationAdd BLAST194

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni572 – 594Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140778
HOGENOMiHOG000260264
HOVERGENiHBG062373
InParanoidiO94832
KOiK10356
OMAiFNRWRAS
OrthoDBiEOG091G0136
PhylomeDBiO94832
TreeFamiTF312960

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94832-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQESLEFG KADFVLMDTV SMPEFMANLR LRFEKGRIYT FIGEVVVSVN
60 70 80 90 100
PYKLLNIYGR DTIEQYKGRE LYERPPHLFA IADAAYKAMK RRSKDTCIVI
110 120 130 140 150
SGESGAGKTE ASKYIMQYIA AITNPSQRAE VERVKNMLLK SNCVLEAFGN
160 170 180 190 200
AKTNRNDNSS RFGKYMDINF DFKGDPIGGH INNYLLEKSR VIVQQPGERS
210 220 230 240 250
FHSFYQLLQG GSEQMLRSLH LQKSLSSYNY IHVGAQLKSS INDAAEFRVV
260 270 280 290 300
ADAMKVIGFK PEEIQTVYKI LAAILHLGNL KFVVDGDTPL IENGKVVSII
310 320 330 340 350
AELLSTKTDM VEKALLYRTV ATGRDIIDKQ HTEQEASYGR DAFAKAIYER
360 370 380 390 400
LFCWIVTRIN DIIEVKNYDT TIHGKNTVIG VLDIYGFEIF DNNSFEQFCI
410 420 430 440 450
NYCNEKLQQL FIQLVLKQEQ EEYQREGIPW KHIDYFNNQI IVDLVEQQHK
460 470 480 490 500
GIIAILDDAC MNVGKVTDEM FLEALNSKLG KHAHFSSRKL CASDKILEFD
510 520 530 540 550
RDFRIRHYAG DVVYSVIGFI DKNKDTLFQD FKRLMYNSSN PVLKNMWPEG
560 570 580 590 600
KLSITEVTKR PLTAATLFKN SMIALVDNLA SKEPYYVRCI KPNDKKSPQI
610 620 630 640 650
FDDERCRHQV EYLGLLENVR VRRAGFAFRQ TYEKFLHRYK MISEFTWPNH
660 670 680 690 700
DLPSDKEAVK KLIERCGFQD DVAYGKTKIF IRTPRTLFTL EELRAQMLIR
710 720 730 740 750
IVLFLQKVWR GTLARMRYKR TKAALTIIRY YRRYKVKSYI HEVARRFHGV
760 770 780 790 800
KTMRDYGKHV KWPSPPKVLR RFEEALQTIF NRWRASQLIK SIPASDLPQV
810 820 830 840 850
RAKVAAVEML KGQRADLGLQ RAWEGNYLAS KPDTPQTSGT FVPVANELKR
860 870 880 890 900
KDKYMNVLFS CHVRKVNRFS KVEDRAIFVT DRHLYKMDPT KQYKVMKTIP
910 920 930 940 950
LYNLTGLSVS NGKDQLVVFH TKDNKDLIVC LFSKQPTHES RIGELVGVLV
960 970 980 990 1000
NHFKSEKRHL QVNVTNPVQC SLHGKKCTVS VETRLNQPQP DFTKNRSGFI

LSVPGN
Length:1,006
Mass (Da):116,202
Last modified:June 20, 2003 - v2
Checksum:iA8BB08450887168E
GO

Sequence cautioni

The sequence BAA34447 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050210765P → S. Corresponds to variant dbSNP:rs7209106Ensembl.1
Natural variantiVAR_050211771R → H. Corresponds to variant dbSNP:rs7215958Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018270 mRNA Translation: BAA34447.2 Different initiation.
BC146763 mRNA Translation: AAI46764.1
CCDSiCCDS32615.1
RefSeqiNP_001290208.1, NM_001303279.1
NP_056009.1, NM_015194.2
UniGeneiHs.602063

Genome annotation databases

EnsembliENST00000318217; ENSP00000324527; ENSG00000176658
GeneIDi4642
KEGGihsa:4642
UCSCiuc002hho.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMYO1D_HUMAN
AccessioniPrimary (citable) accession number: O94832
Secondary accession number(s): A6H8V3, Q8NHP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 20, 2003
Last modified: May 23, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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