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O94829

- IPO13_HUMAN

UniProt

O94829 - IPO13_HUMAN

Protein

Importin-13

Gene

IPO13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 3 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus By similarity. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.By similarity2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. protein import into nucleus Source: MGI

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Importin-13
    Short name:
    Imp13
    Alternative name(s):
    Karyopherin-13
    Short name:
    Kap13
    Ran-binding protein 13
    Short name:
    RanBP13
    Gene namesi
    Name:IPO13
    Synonyms:KIAA0724, RANBP13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:16853. IPO13.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134981096.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 963963Importin-13PRO_0000120758Add
    BLAST

    Proteomic databases

    MaxQBiO94829.
    PaxDbiO94829.
    PRIDEiO94829.

    PTM databases

    PhosphoSiteiO94829.

    Expressioni

    Tissue specificityi

    Expressed in fetal brain, heart, intestine and kidney.1 Publication

    Gene expression databases

    ArrayExpressiO94829.
    BgeeiO94829.
    CleanExiHS_IPO13.
    GenevestigatoriO94829.

    Interactioni

    Subunit structurei

    Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ALX1Q156992EBI-747310,EBI-750671
    EIF1AXP4781314EBI-747310,EBI-1045377
    MAGOHP613264EBI-747310,EBI-299134
    RANP6282613EBI-747310,EBI-286642
    UBE2IP632796EBI-747310,EBI-80168

    Protein-protein interaction databases

    BioGridi115025. 20 interactions.
    IntActiO94829. 10 interactions.
    MINTiMINT-1465082.
    STRINGi9606.ENSP00000361418.

    Structurei

    Secondary structure

    1
    963
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi23 – 3513
    Helixi39 – 5416
    Helixi58 – 658
    Helixi72 – 8817
    Helixi90 – 923
    Helixi95 – 973
    Helixi98 – 11114
    Turni112 – 1143
    Helixi117 – 13418
    Turni135 – 1384
    Helixi142 – 1509
    Helixi160 – 17718
    Helixi195 – 1973
    Helixi198 – 20912
    Helixi216 – 23015
    Turni231 – 2333
    Helixi236 – 2383
    Helixi240 – 24910
    Turni253 – 2553
    Helixi256 – 26712
    Helixi272 – 2743
    Helixi276 – 28712
    Helixi290 – 2989
    Helixi302 – 32524
    Helixi327 – 3293
    Helixi330 – 34415
    Turni350 – 3534
    Helixi355 – 3606
    Helixi361 – 37111
    Helixi376 – 40126
    Helixi406 – 4105
    Helixi414 – 43825
    Helixi440 – 45516
    Helixi463 – 47614
    Turni483 – 4864
    Helixi487 – 4948
    Helixi495 – 4973
    Helixi503 – 51513
    Helixi517 – 5226
    Helixi524 – 5274
    Turni528 – 5303
    Helixi531 – 5377
    Helixi541 – 5433
    Helixi544 – 55714
    Helixi559 – 5613
    Turni563 – 5653
    Helixi566 – 57813
    Helixi584 – 59815
    Helixi603 – 62523
    Helixi631 – 65020
    Helixi676 – 69520
    Helixi699 – 71517
    Beta strandi716 – 7183
    Helixi721 – 7233
    Helixi724 – 73714
    Helixi741 – 75414
    Turni758 – 7603
    Helixi762 – 78120
    Turni783 – 7853
    Helixi787 – 80317
    Helixi805 – 8095
    Helixi815 – 82511
    Helixi831 – 84414
    Helixi845 – 8473
    Helixi853 – 8575
    Turni858 – 8603
    Helixi862 – 87312
    Turni874 – 8763
    Helixi879 – 8813
    Helixi882 – 89514
    Helixi897 – 90711
    Helixi920 – 93011
    Helixi937 – 95216

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2X19X-ray2.80B1-963[»]
    2XWUX-ray2.80B1-963[»]
    3ZJYX-ray3.60B/E/G1-963[»]
    ProteinModelPortaliO94829.
    SMRiO94829. Positions 19-953.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO94829.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati24 – 5431HEAT 11 PublicationAdd
    BLAST
    Domaini45 – 11167Importin N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Repeati56 – 8833HEAT 21 PublicationAdd
    BLAST
    Repeati95 – 13541HEAT 31 PublicationAdd
    BLAST
    Repeati142 – 17938HEAT 41 PublicationAdd
    BLAST
    Repeati194 – 23138HEAT 51 PublicationAdd
    BLAST
    Repeati236 – 26833HEAT 61 PublicationAdd
    BLAST
    Repeati276 – 32550HEAT 71 PublicationAdd
    BLAST
    Repeati330 – 37243HEAT 81 PublicationAdd
    BLAST
    Repeati375 – 43864HEAT 91 PublicationAdd
    BLAST
    Repeati440 – 47637HEAT 101 PublicationAdd
    BLAST
    Repeati487 – 52236HEAT 111 PublicationAdd
    BLAST
    Repeati524 – 55835HEAT 121 PublicationAdd
    BLAST
    Repeati562 – 60039HEAT 131 PublicationAdd
    BLAST
    Repeati603 – 64846HEAT 141 PublicationAdd
    BLAST
    Repeati676 – 71641HEAT 151 PublicationAdd
    BLAST
    Repeati720 – 75435HEAT 161 PublicationAdd
    BLAST
    Repeati761 – 80343HEAT 171 PublicationAdd
    BLAST
    Repeati815 – 84531HEAT 181 PublicationAdd
    BLAST
    Repeati860 – 89334HEAT 191 PublicationAdd
    BLAST
    Repeati897 – 93135HEAT 201 PublicationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the importin beta family.Curated
    Contains 20 HEAT repeats.Curated
    Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG237172.
    HOVERGENiHBG052141.
    InParanoidiO94829.
    OMAiQMYSTIP.
    OrthoDBiEOG718KC9.
    PhylomeDBiO94829.
    TreeFamiTF314539.

    Family and domain databases

    Gene3Di1.25.10.10. 3 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013598. Exportin-1/Importin-b-like.
    IPR001494. Importin-beta_N.
    [Graphical view]
    PfamiPF03810. IBN_N. 1 hit.
    PF08389. Xpo1. 1 hit.
    [Graphical view]
    SMARTiSM00913. IBN_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O94829-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERREEQPGA AGAGAAPALD FTVENVEKAL HQLYYDPNIE NKNLAQKWLM    50
    QAQVSPQAWH FSWQLLQPDK VPEIQYFGAS ALHIKISRYW SDIPTDQYES 100
    LKAQLFTQIT RFASGSKIVL TRLCVALASL ALSMMPDAWP CAVADMVRLF 150
    QAEDSPVDGQ GRCLALLELL TVLPEEFQTS RLPQYRKGLV RTSLAVECGA 200
    VFPLLEQLLQ QPSSPSCVRQ KVLKCFSSWV QLEVPLQDCE ALIQAAFAAL 250
    QDSELFDSSV EAIVNAISQP DAQRYVNTLL KLIPLVLGLQ EQLRQAVQNG 300
    DMETSHGICR IAVALGENHS RALLDQVEHW QSFLALVNMI MFCTGIPGHY 350
    PVNETTSSLT LTFWYTLQDD ILSFEAEKQA VYQQVYRPVY FQLVDVLLHK 400
    AQFPSDEEYG FWSSDEKEQF RIYRVDISDT LMYVYEMLGA ELLSNLYDKL 450
    GRLLTSSEEP YSWQHTEALL YGFQSIAETI DVNYSDVVPG LIGLIPRISI 500
    SNVQLADTVM FTIGALSEWL ADHPVMINSV LPLVLHALGN PELSVSSVST 550
    LKKICRECKY DLPPYAANIV AVSQDVLMKQ IHKTSQCMWL MQALGFLLSA 600
    LQVEEILKNL HSLISPYIQQ LEKLAEEIPN PSNKLAIVHI LGLLSNLFTT 650
    LDISHHEDDH EGPELRKLPV PQGPNPVVVV LQQVFQLIQK VLSKWLNDAQ 700
    VVEAVCAIFE KSVKTLLDDF APMVPQLCEM LGRMYSTIPQ ASALDLTRQL 750
    VHIFAHEPAH FPPIEALFLL VTSVTLTLFQ QGPRDHPDIV DSFMQLLAQA 800
    LKRKPDLFLC ERLDVKAVFQ CAVLALKFPE APTVKASCGF FTELLPRCGE 850
    VESVGKVVQE DGRMLLIAVL EAIGGQASRS LMDCFADILF ALNKHCFSLL 900
    SMWIKEALQP PGFPSARLSP EQKDTFSQQI LRERVNKRRV KEMVKEFTLL 950
    CRGLHGTDYT ADY 963
    Length:963
    Mass (Da):108,195
    Last modified:July 19, 2004 - v3
    Checksum:i8C696EE2B92365F0
    GO

    Sequence cautioni

    The sequence BAA34444.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAB14575.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti202 – 2021F → V in CAB55966. (PubMed:17974005)Curated
    Sequence conflicti715 – 7151T → A in BAB14575. (PubMed:14702039)Curated
    Sequence conflicti817 – 8171A → S in AAH08194. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF267987 mRNA. Translation: AAF73471.1.
    AB018267 mRNA. Translation: BAA34444.2. Different initiation.
    AL357079 Genomic DNA. Translation: CAI16798.1.
    CH471059 Genomic DNA. Translation: EAX07072.1.
    CH471059 Genomic DNA. Translation: EAX07073.1.
    BC008194 mRNA. Translation: AAH08194.1.
    AL117501 mRNA. Translation: CAB55966.1.
    AK023441 mRNA. Translation: BAB14575.1. Different initiation.
    CCDSiCCDS503.1.
    PIRiT17276.
    RefSeqiNP_055467.3. NM_014652.3.
    UniGeneiHs.158497.

    Genome annotation databases

    EnsembliENST00000372343; ENSP00000361418; ENSG00000117408.
    GeneIDi9670.
    KEGGihsa:9670.
    UCSCiuc001ckx.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF267987 mRNA. Translation: AAF73471.1 .
    AB018267 mRNA. Translation: BAA34444.2 . Different initiation.
    AL357079 Genomic DNA. Translation: CAI16798.1 .
    CH471059 Genomic DNA. Translation: EAX07072.1 .
    CH471059 Genomic DNA. Translation: EAX07073.1 .
    BC008194 mRNA. Translation: AAH08194.1 .
    AL117501 mRNA. Translation: CAB55966.1 .
    AK023441 mRNA. Translation: BAB14575.1 . Different initiation.
    CCDSi CCDS503.1.
    PIRi T17276.
    RefSeqi NP_055467.3. NM_014652.3.
    UniGenei Hs.158497.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2X19 X-ray 2.80 B 1-963 [» ]
    2XWU X-ray 2.80 B 1-963 [» ]
    3ZJY X-ray 3.60 B/E/G 1-963 [» ]
    ProteinModelPortali O94829.
    SMRi O94829. Positions 19-953.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115025. 20 interactions.
    IntActi O94829. 10 interactions.
    MINTi MINT-1465082.
    STRINGi 9606.ENSP00000361418.

    PTM databases

    PhosphoSitei O94829.

    Proteomic databases

    MaxQBi O94829.
    PaxDbi O94829.
    PRIDEi O94829.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372343 ; ENSP00000361418 ; ENSG00000117408 .
    GeneIDi 9670.
    KEGGi hsa:9670.
    UCSCi uc001ckx.3. human.

    Organism-specific databases

    CTDi 9670.
    GeneCardsi GC01P044412.
    HGNCi HGNC:16853. IPO13.
    MIMi 610411. gene.
    neXtProti NX_O94829.
    PharmGKBi PA134981096.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237172.
    HOVERGENi HBG052141.
    InParanoidi O94829.
    OMAi QMYSTIP.
    OrthoDBi EOG718KC9.
    PhylomeDBi O94829.
    TreeFami TF314539.

    Miscellaneous databases

    ChiTaRSi IPO13. human.
    EvolutionaryTracei O94829.
    GeneWikii IPO13.
    GenomeRNAii 9670.
    NextBioi 36311.
    PROi O94829.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O94829.
    Bgeei O94829.
    CleanExi HS_IPO13.
    Genevestigatori O94829.

    Family and domain databases

    Gene3Di 1.25.10.10. 3 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013598. Exportin-1/Importin-b-like.
    IPR001494. Importin-beta_N.
    [Graphical view ]
    Pfami PF03810. IBN_N. 1 hit.
    PF08389. Xpo1. 1 hit.
    [Graphical view ]
    SMARTi SM00913. IBN_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    PROSITEi PS50166. IMPORTIN_B_NT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Importin 13: a novel mediator of nuclear import and export."
      Mingot J.-M., Kostka S., Kraft R., Hartmann E., Goerlich D.
      EMBO J. 20:3685-3694(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RBM8A; UBC9 AND EIF1A.
    2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-963.
      Tissue: Testis.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 495-963.
      Tissue: Placenta.
    8. "Paired-type homeodomain transcription factors are imported into the nucleus by karyopherin 13."
      Ploski J.E., Shamsher M.K., Radu A.
      Mol. Cell. Biol. 24:4824-4834(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PAX6.
    9. "A novel karyopherin-beta homolog is developmentally and hormonally regulated in fetal lung."
      Zhang C., Sweezey N.B., Gagnon S., Muskat B., Koehler D., Post M., Kaplan F.
      Am. J. Respir. Cell Mol. Biol. 22:451-459(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13."
      Bono F., Cook A.G., Grunwald M., Ebert J., Conti E.
      Mol. Cell 37:211-222(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) IN COMPLEX WITH YEAST GSP1/RAN, REPEAT STRUCTURE.
    12. "Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation."
      Grunwald M., Bono F.
      EMBO J. 30:427-438(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) IN COMPLEX WITH UBE2I/UBC.

    Entry informationi

    Entry nameiIPO13_HUMAN
    AccessioniPrimary (citable) accession number: O94829
    Secondary accession number(s): D3DPY4
    , Q5T4X3, Q7LC04, Q96HS3, Q9H8N3, Q9UFR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3