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Protein

Importin-13

Gene

IPO13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • protein import into nucleus Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117408-MONOMER.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-13
Short name:
Imp13
Alternative name(s):
Karyopherin-13
Short name:
Kap13
Ran-binding protein 13
Short name:
RanBP13
Gene namesi
Name:IPO13
Synonyms:KIAA0724, RANBP13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16853. IPO13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9670.
OpenTargetsiENSG00000117408.
PharmGKBiPA134981096.

Polymorphism and mutation databases

BioMutaiIPO13.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207581 – 963Importin-13Add BLAST963

Proteomic databases

EPDiO94829.
MaxQBiO94829.
PaxDbiO94829.
PeptideAtlasiO94829.
PRIDEiO94829.

PTM databases

iPTMnetiO94829.
PhosphoSitePlusiO94829.

Expressioni

Tissue specificityi

Expressed in fetal brain, heart, intestine and kidney.1 Publication

Gene expression databases

BgeeiENSG00000117408.
CleanExiHS_IPO13.
ExpressionAtlasiO94829. baseline and differential.
GenevisibleiO94829. HS.

Organism-specific databases

HPAiCAB070425.

Interactioni

Subunit structurei

Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ALX1Q156992EBI-747310,EBI-750671
DUX4Q9UBX22EBI-747310,EBI-11600078
DUX4L9Q6RFH82EBI-747310,EBI-11599882
EIF1AXP4781314EBI-747310,EBI-1045377
MAGOHP613264EBI-747310,EBI-299134
PBX4Q9BYU15EBI-747310,EBI-10302990
RANP6282613EBI-747310,EBI-286642
UBE2IP632796EBI-747310,EBI-80168

Protein-protein interaction databases

BioGridi115025. 35 interactors.
IntActiO94829. 16 interactors.
MINTiMINT-1465082.
STRINGi9606.ENSP00000361418.

Structurei

Secondary structure

1963
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi23 – 35Combined sources13
Helixi39 – 54Combined sources16
Helixi58 – 65Combined sources8
Helixi72 – 88Combined sources17
Helixi90 – 92Combined sources3
Helixi95 – 97Combined sources3
Helixi98 – 111Combined sources14
Turni112 – 114Combined sources3
Helixi117 – 134Combined sources18
Turni135 – 138Combined sources4
Helixi142 – 150Combined sources9
Helixi160 – 177Combined sources18
Helixi195 – 197Combined sources3
Helixi198 – 209Combined sources12
Helixi216 – 230Combined sources15
Turni231 – 233Combined sources3
Helixi236 – 238Combined sources3
Helixi240 – 249Combined sources10
Turni253 – 255Combined sources3
Helixi256 – 267Combined sources12
Helixi272 – 274Combined sources3
Helixi276 – 287Combined sources12
Helixi290 – 298Combined sources9
Helixi302 – 325Combined sources24
Helixi327 – 329Combined sources3
Helixi330 – 344Combined sources15
Turni350 – 353Combined sources4
Helixi355 – 360Combined sources6
Helixi361 – 371Combined sources11
Helixi376 – 401Combined sources26
Helixi406 – 410Combined sources5
Helixi414 – 438Combined sources25
Helixi440 – 455Combined sources16
Helixi463 – 476Combined sources14
Turni483 – 486Combined sources4
Helixi487 – 494Combined sources8
Helixi495 – 497Combined sources3
Helixi503 – 515Combined sources13
Helixi517 – 522Combined sources6
Helixi524 – 527Combined sources4
Turni528 – 530Combined sources3
Helixi531 – 537Combined sources7
Helixi541 – 543Combined sources3
Helixi544 – 557Combined sources14
Helixi559 – 561Combined sources3
Turni563 – 565Combined sources3
Helixi566 – 578Combined sources13
Helixi584 – 598Combined sources15
Helixi603 – 625Combined sources23
Helixi631 – 650Combined sources20
Helixi676 – 695Combined sources20
Helixi699 – 715Combined sources17
Beta strandi716 – 718Combined sources3
Helixi721 – 723Combined sources3
Helixi724 – 737Combined sources14
Helixi741 – 754Combined sources14
Turni758 – 760Combined sources3
Helixi762 – 781Combined sources20
Turni783 – 785Combined sources3
Helixi787 – 803Combined sources17
Helixi805 – 809Combined sources5
Helixi815 – 825Combined sources11
Helixi831 – 844Combined sources14
Helixi845 – 847Combined sources3
Helixi853 – 857Combined sources5
Turni858 – 860Combined sources3
Helixi862 – 873Combined sources12
Turni874 – 876Combined sources3
Helixi879 – 881Combined sources3
Helixi882 – 895Combined sources14
Helixi897 – 907Combined sources11
Helixi920 – 930Combined sources11
Helixi937 – 952Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X19X-ray2.80B1-963[»]
2XWUX-ray2.80B1-963[»]
3ZJYX-ray3.60B/E/G1-963[»]
ProteinModelPortaliO94829.
SMRiO94829.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94829.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 54HEAT 11 PublicationAdd BLAST31
Domaini45 – 111Importin N-terminalPROSITE-ProRule annotationAdd BLAST67
Repeati56 – 88HEAT 21 PublicationAdd BLAST33
Repeati95 – 135HEAT 31 PublicationAdd BLAST41
Repeati142 – 179HEAT 41 PublicationAdd BLAST38
Repeati194 – 231HEAT 51 PublicationAdd BLAST38
Repeati236 – 268HEAT 61 PublicationAdd BLAST33
Repeati276 – 325HEAT 71 PublicationAdd BLAST50
Repeati330 – 372HEAT 81 PublicationAdd BLAST43
Repeati375 – 438HEAT 91 PublicationAdd BLAST64
Repeati440 – 476HEAT 101 PublicationAdd BLAST37
Repeati487 – 522HEAT 111 PublicationAdd BLAST36
Repeati524 – 558HEAT 121 PublicationAdd BLAST35
Repeati562 – 600HEAT 131 PublicationAdd BLAST39
Repeati603 – 648HEAT 141 PublicationAdd BLAST46
Repeati676 – 716HEAT 151 PublicationAdd BLAST41
Repeati720 – 754HEAT 161 PublicationAdd BLAST35
Repeati761 – 803HEAT 171 PublicationAdd BLAST43
Repeati815 – 845HEAT 181 PublicationAdd BLAST31
Repeati860 – 893HEAT 191 PublicationAdd BLAST34
Repeati897 – 931HEAT 201 PublicationAdd BLAST35

Sequence similaritiesi

Belongs to the importin beta family.Curated
Contains 20 HEAT repeats.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2022. Eukaryota.
ENOG410XT8Y. LUCA.
GeneTreeiENSGT00530000063347.
HOVERGENiHBG052141.
InParanoidiO94829.
OMAiQMYSTIP.
OrthoDBiEOG091G01CP.
PhylomeDBiO94829.
TreeFamiTF314539.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERREEQPGA AGAGAAPALD FTVENVEKAL HQLYYDPNIE NKNLAQKWLM
60 70 80 90 100
QAQVSPQAWH FSWQLLQPDK VPEIQYFGAS ALHIKISRYW SDIPTDQYES
110 120 130 140 150
LKAQLFTQIT RFASGSKIVL TRLCVALASL ALSMMPDAWP CAVADMVRLF
160 170 180 190 200
QAEDSPVDGQ GRCLALLELL TVLPEEFQTS RLPQYRKGLV RTSLAVECGA
210 220 230 240 250
VFPLLEQLLQ QPSSPSCVRQ KVLKCFSSWV QLEVPLQDCE ALIQAAFAAL
260 270 280 290 300
QDSELFDSSV EAIVNAISQP DAQRYVNTLL KLIPLVLGLQ EQLRQAVQNG
310 320 330 340 350
DMETSHGICR IAVALGENHS RALLDQVEHW QSFLALVNMI MFCTGIPGHY
360 370 380 390 400
PVNETTSSLT LTFWYTLQDD ILSFEAEKQA VYQQVYRPVY FQLVDVLLHK
410 420 430 440 450
AQFPSDEEYG FWSSDEKEQF RIYRVDISDT LMYVYEMLGA ELLSNLYDKL
460 470 480 490 500
GRLLTSSEEP YSWQHTEALL YGFQSIAETI DVNYSDVVPG LIGLIPRISI
510 520 530 540 550
SNVQLADTVM FTIGALSEWL ADHPVMINSV LPLVLHALGN PELSVSSVST
560 570 580 590 600
LKKICRECKY DLPPYAANIV AVSQDVLMKQ IHKTSQCMWL MQALGFLLSA
610 620 630 640 650
LQVEEILKNL HSLISPYIQQ LEKLAEEIPN PSNKLAIVHI LGLLSNLFTT
660 670 680 690 700
LDISHHEDDH EGPELRKLPV PQGPNPVVVV LQQVFQLIQK VLSKWLNDAQ
710 720 730 740 750
VVEAVCAIFE KSVKTLLDDF APMVPQLCEM LGRMYSTIPQ ASALDLTRQL
760 770 780 790 800
VHIFAHEPAH FPPIEALFLL VTSVTLTLFQ QGPRDHPDIV DSFMQLLAQA
810 820 830 840 850
LKRKPDLFLC ERLDVKAVFQ CAVLALKFPE APTVKASCGF FTELLPRCGE
860 870 880 890 900
VESVGKVVQE DGRMLLIAVL EAIGGQASRS LMDCFADILF ALNKHCFSLL
910 920 930 940 950
SMWIKEALQP PGFPSARLSP EQKDTFSQQI LRERVNKRRV KEMVKEFTLL
960
CRGLHGTDYT ADY
Length:963
Mass (Da):108,195
Last modified:July 19, 2004 - v3
Checksum:i8C696EE2B92365F0
GO

Sequence cautioni

The sequence BAA34444 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB14575 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202F → V in CAB55966 (PubMed:17974005).Curated1
Sequence conflicti715T → A in BAB14575 (PubMed:14702039).Curated1
Sequence conflicti817A → S in AAH08194 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267987 mRNA. Translation: AAF73471.1.
AB018267 mRNA. Translation: BAA34444.2. Different initiation.
AL357079 Genomic DNA. Translation: CAI16798.1.
CH471059 Genomic DNA. Translation: EAX07072.1.
CH471059 Genomic DNA. Translation: EAX07073.1.
BC008194 mRNA. Translation: AAH08194.1.
AL117501 mRNA. Translation: CAB55966.1.
AK023441 mRNA. Translation: BAB14575.1. Different initiation.
CCDSiCCDS503.1.
PIRiT17276.
RefSeqiNP_055467.3. NM_014652.3.
UniGeneiHs.158497.

Genome annotation databases

EnsembliENST00000372343; ENSP00000361418; ENSG00000117408.
GeneIDi9670.
KEGGihsa:9670.
UCSCiuc001ckx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267987 mRNA. Translation: AAF73471.1.
AB018267 mRNA. Translation: BAA34444.2. Different initiation.
AL357079 Genomic DNA. Translation: CAI16798.1.
CH471059 Genomic DNA. Translation: EAX07072.1.
CH471059 Genomic DNA. Translation: EAX07073.1.
BC008194 mRNA. Translation: AAH08194.1.
AL117501 mRNA. Translation: CAB55966.1.
AK023441 mRNA. Translation: BAB14575.1. Different initiation.
CCDSiCCDS503.1.
PIRiT17276.
RefSeqiNP_055467.3. NM_014652.3.
UniGeneiHs.158497.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X19X-ray2.80B1-963[»]
2XWUX-ray2.80B1-963[»]
3ZJYX-ray3.60B/E/G1-963[»]
ProteinModelPortaliO94829.
SMRiO94829.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115025. 35 interactors.
IntActiO94829. 16 interactors.
MINTiMINT-1465082.
STRINGi9606.ENSP00000361418.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiO94829.
PhosphoSitePlusiO94829.

Polymorphism and mutation databases

BioMutaiIPO13.

Proteomic databases

EPDiO94829.
MaxQBiO94829.
PaxDbiO94829.
PeptideAtlasiO94829.
PRIDEiO94829.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372343; ENSP00000361418; ENSG00000117408.
GeneIDi9670.
KEGGihsa:9670.
UCSCiuc001ckx.4. human.

Organism-specific databases

CTDi9670.
DisGeNETi9670.
GeneCardsiIPO13.
HGNCiHGNC:16853. IPO13.
HPAiCAB070425.
MIMi610411. gene.
neXtProtiNX_O94829.
OpenTargetsiENSG00000117408.
PharmGKBiPA134981096.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2022. Eukaryota.
ENOG410XT8Y. LUCA.
GeneTreeiENSGT00530000063347.
HOVERGENiHBG052141.
InParanoidiO94829.
OMAiQMYSTIP.
OrthoDBiEOG091G01CP.
PhylomeDBiO94829.
TreeFamiTF314539.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117408-MONOMER.

Miscellaneous databases

ChiTaRSiIPO13. human.
EvolutionaryTraceiO94829.
GeneWikiiIPO13.
GenomeRNAii9670.
PROiO94829.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117408.
CleanExiHS_IPO13.
ExpressionAtlasiO94829. baseline and differential.
GenevisibleiO94829. HS.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPO13_HUMAN
AccessioniPrimary (citable) accession number: O94829
Secondary accession number(s): D3DPY4
, Q5T4X3, Q7LC04, Q96HS3, Q9H8N3, Q9UFR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.