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Protein

Mitochondrial import receptor subunit TOM70

Gene

TOMM70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor that accelerates the import of all mitochondrial precursor proteins.By similarity

GO - Molecular functioni

  • protein transmembrane transporter activity Source: BHF-UCL

GO - Biological processi

  • macroautophagy Source: Reactome
  • protein targeting to mitochondrion Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154174-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-5205685. Pink/Parkin Mediated Mitophagy.
R-HSA-5689880. Ub-specific processing proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM70
Alternative name(s):
Mitochondrial precursor proteins import receptor
Translocase of outer membrane 70 kDa subunit
Translocase of outer mitochondrial membrane protein 70Imported
Gene namesi
Name:TOMM70Imported
Synonyms:KIAA0719, TOM70, TOMM70A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11985. TOMM70.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 38Mitochondrial intermembraneSequence analysisAdd BLAST37
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 608CytoplasmicSequence analysisAdd BLAST549

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • mitochondrial outer membrane Source: Reactome
  • mitochondrial outer membrane translocase complex Source: BHF-UCL
  • mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9868.
OpenTargetsiENSG00000154174.
PharmGKBiPA36669.

Polymorphism and mutation databases

BioMutaiTOMM70A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001063362 – 608Mitochondrial import receptor subunit TOM70Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei71Omega-N-methylarginineCombined sources1
Modified residuei91PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei185N6-acetyllysineCombined sources1
Modified residuei434PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiO94826.
MaxQBiO94826.
PaxDbiO94826.
PeptideAtlasiO94826.
PRIDEiO94826.

PTM databases

iPTMnetiO94826.
PhosphoSitePlusiO94826.
SwissPalmiO94826.

Expressioni

Gene expression databases

BgeeiENSG00000154174.
CleanExiHS_TOMM70A.
GenevisibleiO94826. HS.

Organism-specific databases

HPAiCAB017156.
HPA014589.
HPA048020.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with CAPN8 (By similarity).By similarity

Protein-protein interaction databases

BioGridi115201. 33 interactors.
IntActiO94826. 10 interactors.
MINTiMINT-3002394.
STRINGi9606.ENSP00000284320.

Structurei

3D structure databases

ProteinModelPortaliO94826.
SMRiO94826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati114 – 147TPR 1Add BLAST34
Repeati153 – 186TPR 2Add BLAST34
Repeati294 – 327TPR 3Add BLAST34
Repeati329 – 362TPR 4Add BLAST34
Repeati367 – 400TPR 5Add BLAST34
Repeati401 – 434TPR 6Add BLAST34
Repeati440 – 475TPR 7Add BLAST36
Repeati476 – 509TPR 8Add BLAST34
Repeati511 – 544TPR 9Add BLAST34
Repeati545 – 578TPR 10Add BLAST34

Sequence similaritiesi

Belongs to the Tom70 family.Curated
Contains 10 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0547. Eukaryota.
ENOG410YVNZ. LUCA.
GeneTreeiENSGT00860000133798.
HOGENOMiHOG000264237.
HOVERGENiHBG062335.
InParanoidiO94826.
KOiK17768.
OMAiKWTEVAQ.
OrthoDBiEOG091G0CYZ.
PhylomeDBiO94826.
TreeFamiTF106203.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13181. TPR_8. 4 hits.
[Graphical view]
SMARTiSM00028. TPR. 10 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASKPVEAA VVAAAVPSSG SGVGGGGTAG PGTGGLPRWQ LALAVGAPLL
60 70 80 90 100
LGAGAIYLWS RQQRRREARG RGDASGLKRN SERKTPEGRA SPAPGSGHPE
110 120 130 140 150
GPGAHLDMNS LDRAQAAKNK GNKYFKAGKY EQAIQCYTEA ISLCPTEKNV
160 170 180 190 200
DLSTFYQNRA AAFEQLQKWK EVAQDCTKAV ELNPKYVKAL FRRAKAHEKL
210 220 230 240 250
DNKKECLEDV TAVCILEGFQ NQQSMLLADK VLKLLGKEKA KEKYKNREPL
260 270 280 290 300
MPSPQFIKSY FSSFTDDIIS QPMLKGEKSD EDKDKEGEAL EVKENSGYLK
310 320 330 340 350
AKQYMEEENY DKIISECSKE IDAEGKYMAE ALLLRATFYL LIGNANAAKP
360 370 380 390 400
DLDKVISLKE ANVKLRANAL IKRGSMYMQQ QQPLLSTQDF NMAADIDPQN
410 420 430 440 450
ADVYHHRGQL KILLDQVEEA VADFDECIRL RPESALAQAQ KCFALYRQAY
460 470 480 490 500
TGNNSSQIQA AMKGFEEVIK KFPRCAEGYA LYAQALTDQQ QFGKADEMYD
510 520 530 540 550
KCIDLEPDNA TTYVHKGLLQ LQWKQDLDRG LELISKAIEI DNKCDFAYET
560 570 580 590 600
MGTIEVQRGN MEKAIDMFNK AINLAKSEME MAHLYSLCDA AHAQTEVAKK

YGLKPPTL
Length:608
Mass (Da):67,455
Last modified:May 1, 1999 - v1
Checksum:i5AAF5CAAA8582480
GO

Sequence cautioni

The sequence BAA34439 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018262 mRNA. Translation: BAA34439.2. Different initiation.
CH471052 Genomic DNA. Translation: EAW79822.1.
CH471052 Genomic DNA. Translation: EAW79823.1.
BC003633 mRNA. Translation: AAH03633.1.
BC052994 mRNA. Translation: AAH52994.1.
CCDSiCCDS33807.1.
RefSeqiNP_055635.3. NM_014820.4.
UniGeneiHs.227253.

Genome annotation databases

EnsembliENST00000284320; ENSP00000284320; ENSG00000154174.
GeneIDi9868.
KEGGihsa:9868.
UCSCiuc003dtw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018262 mRNA. Translation: BAA34439.2. Different initiation.
CH471052 Genomic DNA. Translation: EAW79822.1.
CH471052 Genomic DNA. Translation: EAW79823.1.
BC003633 mRNA. Translation: AAH03633.1.
BC052994 mRNA. Translation: AAH52994.1.
CCDSiCCDS33807.1.
RefSeqiNP_055635.3. NM_014820.4.
UniGeneiHs.227253.

3D structure databases

ProteinModelPortaliO94826.
SMRiO94826.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115201. 33 interactors.
IntActiO94826. 10 interactors.
MINTiMINT-3002394.
STRINGi9606.ENSP00000284320.

PTM databases

iPTMnetiO94826.
PhosphoSitePlusiO94826.
SwissPalmiO94826.

Polymorphism and mutation databases

BioMutaiTOMM70A.

Proteomic databases

EPDiO94826.
MaxQBiO94826.
PaxDbiO94826.
PeptideAtlasiO94826.
PRIDEiO94826.

Protocols and materials databases

DNASUi9868.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284320; ENSP00000284320; ENSG00000154174.
GeneIDi9868.
KEGGihsa:9868.
UCSCiuc003dtw.4. human.

Organism-specific databases

CTDi9868.
DisGeNETi9868.
GeneCardsiTOMM70A.
HGNCiHGNC:11985. TOMM70.
HPAiCAB017156.
HPA014589.
HPA048020.
MIMi606081. gene.
neXtProtiNX_O94826.
OpenTargetsiENSG00000154174.
PharmGKBiPA36669.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0547. Eukaryota.
ENOG410YVNZ. LUCA.
GeneTreeiENSGT00860000133798.
HOGENOMiHOG000264237.
HOVERGENiHBG062335.
InParanoidiO94826.
KOiK17768.
OMAiKWTEVAQ.
OrthoDBiEOG091G0CYZ.
PhylomeDBiO94826.
TreeFamiTF106203.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154174-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-5205685. Pink/Parkin Mediated Mitophagy.
R-HSA-5689880. Ub-specific processing proteases.

Miscellaneous databases

ChiTaRSiTOMM70A. human.
GeneWikiiTOMM70A.
GenomeRNAii9868.
PROiO94826.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154174.
CleanExiHS_TOMM70A.
GenevisibleiO94826. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13181. TPR_8. 4 hits.
[Graphical view]
SMARTiSM00028. TPR. 10 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOM70_HUMAN
AccessioniPrimary (citable) accession number: O94826
Secondary accession number(s): D3DN48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.