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O94826

- TOM70_HUMAN

UniProt

O94826 - TOM70_HUMAN

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Protein

Mitochondrial import receptor subunit TOM70

Gene

TOMM70A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor that accelerates the import of all mitochondrial precursor proteins.By similarity

GO - Molecular functioni

  1. protein transmembrane transporter activity Source: BHF-UCL

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. protein targeting to mitochondrion Source: BHF-UCL
  3. protein transmembrane transport Source: GOC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_118595. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM70
Alternative name(s):
Mitochondrial precursor proteins import receptor
Translocase of outer membrane 70 kDa subunit
Gene namesi
Name:TOMM70A
Synonyms:KIAA0719, TOM70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:11985. TOMM70A.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: UniProtKB
  3. mitochondrial outer membrane translocase complex Source: BHF-UCL
  4. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36669.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 608607Mitochondrial import receptor subunit TOM70PRO_0000106336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications
Modified residuei91 – 911Phosphoserine4 Publications
Modified residuei185 – 1851N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO94826.
PaxDbiO94826.
PeptideAtlasiO94826.
PRIDEiO94826.

PTM databases

PhosphoSiteiO94826.

Expressioni

Gene expression databases

BgeeiO94826.
CleanExiHS_TOMM70A.
ExpressionAtlasiO94826. baseline and differential.
GenevestigatoriO94826.

Organism-specific databases

HPAiCAB017156.
HPA014589.
HPA048020.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with CAPN8 (By similarity).By similarity

Protein-protein interaction databases

BioGridi115201. 29 interactions.
IntActiO94826. 7 interactions.
MINTiMINT-3002394.
STRINGi9606.ENSP00000284320.

Structurei

3D structure databases

ProteinModelPortaliO94826.
SMRiO94826. Positions 81-586.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3837Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini60 – 608549CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati114 – 14734TPR 1Add
BLAST
Repeati153 – 18634TPR 2Add
BLAST
Repeati294 – 32734TPR 3Add
BLAST
Repeati329 – 36234TPR 4Add
BLAST
Repeati367 – 40034TPR 5Add
BLAST
Repeati401 – 43434TPR 6Add
BLAST
Repeati440 – 47536TPR 7Add
BLAST
Repeati476 – 50934TPR 8Add
BLAST
Repeati511 – 54434TPR 9Add
BLAST
Repeati545 – 57834TPR 10Add
BLAST

Sequence similaritiesi

Belongs to the Tom70 family.Curated
Contains 10 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00750000117222.
HOGENOMiHOG000264237.
HOVERGENiHBG062335.
InParanoidiO94826.
KOiK17768.
OMAiCILEAFQ.
OrthoDBiEOG7DVD9R.
PhylomeDBiO94826.
TreeFamiTF106203.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 2 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 8 hits.
[Graphical view]
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94826-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASKPVEAA VVAAAVPSSG SGVGGGGTAG PGTGGLPRWQ LALAVGAPLL
60 70 80 90 100
LGAGAIYLWS RQQRRREARG RGDASGLKRN SERKTPEGRA SPAPGSGHPE
110 120 130 140 150
GPGAHLDMNS LDRAQAAKNK GNKYFKAGKY EQAIQCYTEA ISLCPTEKNV
160 170 180 190 200
DLSTFYQNRA AAFEQLQKWK EVAQDCTKAV ELNPKYVKAL FRRAKAHEKL
210 220 230 240 250
DNKKECLEDV TAVCILEGFQ NQQSMLLADK VLKLLGKEKA KEKYKNREPL
260 270 280 290 300
MPSPQFIKSY FSSFTDDIIS QPMLKGEKSD EDKDKEGEAL EVKENSGYLK
310 320 330 340 350
AKQYMEEENY DKIISECSKE IDAEGKYMAE ALLLRATFYL LIGNANAAKP
360 370 380 390 400
DLDKVISLKE ANVKLRANAL IKRGSMYMQQ QQPLLSTQDF NMAADIDPQN
410 420 430 440 450
ADVYHHRGQL KILLDQVEEA VADFDECIRL RPESALAQAQ KCFALYRQAY
460 470 480 490 500
TGNNSSQIQA AMKGFEEVIK KFPRCAEGYA LYAQALTDQQ QFGKADEMYD
510 520 530 540 550
KCIDLEPDNA TTYVHKGLLQ LQWKQDLDRG LELISKAIEI DNKCDFAYET
560 570 580 590 600
MGTIEVQRGN MEKAIDMFNK AINLAKSEME MAHLYSLCDA AHAQTEVAKK

YGLKPPTL
Length:608
Mass (Da):67,455
Last modified:May 1, 1999 - v1
Checksum:i5AAF5CAAA8582480
GO

Sequence cautioni

The sequence BAA34439.2 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018262 mRNA. Translation: BAA34439.2. Different initiation.
CH471052 Genomic DNA. Translation: EAW79822.1.
CH471052 Genomic DNA. Translation: EAW79823.1.
BC003633 mRNA. Translation: AAH03633.1.
BC052994 mRNA. Translation: AAH52994.1.
CCDSiCCDS33807.1.
RefSeqiNP_055635.3. NM_014820.4.
UniGeneiHs.227253.

Genome annotation databases

EnsembliENST00000284320; ENSP00000284320; ENSG00000154174.
GeneIDi9868.
KEGGihsa:9868.
UCSCiuc003dtw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018262 mRNA. Translation: BAA34439.2 . Different initiation.
CH471052 Genomic DNA. Translation: EAW79822.1 .
CH471052 Genomic DNA. Translation: EAW79823.1 .
BC003633 mRNA. Translation: AAH03633.1 .
BC052994 mRNA. Translation: AAH52994.1 .
CCDSi CCDS33807.1.
RefSeqi NP_055635.3. NM_014820.4.
UniGenei Hs.227253.

3D structure databases

ProteinModelPortali O94826.
SMRi O94826. Positions 81-586.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115201. 29 interactions.
IntActi O94826. 7 interactions.
MINTi MINT-3002394.
STRINGi 9606.ENSP00000284320.

PTM databases

PhosphoSitei O94826.

Proteomic databases

MaxQBi O94826.
PaxDbi O94826.
PeptideAtlasi O94826.
PRIDEi O94826.

Protocols and materials databases

DNASUi 9868.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000284320 ; ENSP00000284320 ; ENSG00000154174 .
GeneIDi 9868.
KEGGi hsa:9868.
UCSCi uc003dtw.3. human.

Organism-specific databases

CTDi 9868.
GeneCardsi GC03M100082.
HGNCi HGNC:11985. TOMM70A.
HPAi CAB017156.
HPA014589.
HPA048020.
MIMi 606081. gene.
neXtProti NX_O94826.
PharmGKBi PA36669.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0457.
GeneTreei ENSGT00750000117222.
HOGENOMi HOG000264237.
HOVERGENi HBG062335.
InParanoidi O94826.
KOi K17768.
OMAi CILEAFQ.
OrthoDBi EOG7DVD9R.
PhylomeDBi O94826.
TreeFami TF106203.

Enzyme and pathway databases

Reactomei REACT_118595. Mitochondrial protein import.

Miscellaneous databases

ChiTaRSi TOMM70A. human.
GeneWikii TOMM70A.
GenomeRNAii 9868.
NextBioi 37199.
PROi O94826.
SOURCEi Search...

Gene expression databases

Bgeei O94826.
CleanExi HS_TOMM70A.
ExpressionAtlasi O94826. baseline and differential.
Genevestigatori O94826.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF00515. TPR_1. 2 hits.
PF13181. TPR_8. 1 hit.
[Graphical view ]
SMARTi SM00028. TPR. 8 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin and Uterus.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane."
    Kato H., Mihara K.
    Biochem. Biophys. Res. Commun. 369:958-963(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TOM COMPLEX.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-185, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTOM70_HUMAN
AccessioniPrimary (citable) accession number: O94826
Secondary accession number(s): D3DN48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3