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Protein

Probable phospholipid-transporting ATPase VB

Gene

ATP10B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).Curated

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4334-aspartylphosphate intermediateBy similarity1
Metal bindingi1055MagnesiumBy similarity1
Metal bindingi1059MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • phospholipid translocation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS04213-MONOMER.
ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase VB (EC:3.6.3.1)
Alternative name(s):
ATPase class V type 10B
P4-ATPase flippase complex alpha subunit ATP10B
Gene namesi
Name:ATP10B
Synonyms:ATPVB, KIAA0715
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:13543. ATP10B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 82CytoplasmicSequence analysisAdd BLAST82
Transmembranei83 – 104HelicalSequence analysisAdd BLAST22
Topological domaini105 – 110Exoplasmic loopSequence analysis6
Transmembranei111 – 132HelicalSequence analysisAdd BLAST22
Topological domaini133 – 316CytoplasmicSequence analysisAdd BLAST184
Transmembranei317 – 338HelicalSequence analysisAdd BLAST22
Topological domaini339 – 368Exoplasmic loopSequence analysisAdd BLAST30
Transmembranei369 – 390HelicalSequence analysisAdd BLAST22
Topological domaini391 – 1111CytoplasmicSequence analysisAdd BLAST721
Transmembranei1112 – 1132HelicalSequence analysisAdd BLAST21
Topological domaini1133 – 1144Exoplasmic loopSequence analysisAdd BLAST12
Transmembranei1145 – 1164HelicalSequence analysisAdd BLAST20
Topological domaini1165 – 1194CytoplasmicSequence analysisAdd BLAST30
Transmembranei1195 – 1216HelicalSequence analysisAdd BLAST22
Topological domaini1217 – 1223Exoplasmic loopSequence analysis7
Transmembranei1224 – 1246HelicalSequence analysisAdd BLAST23
Topological domaini1247 – 1252CytoplasmicSequence analysis6
Transmembranei1253 – 1273HelicalSequence analysisAdd BLAST21
Topological domaini1274 – 1291Exoplasmic loopSequence analysisAdd BLAST18
Transmembranei1292 – 1316HelicalSequence analysisAdd BLAST25
Topological domaini1317 – 1461CytoplasmicSequence analysisAdd BLAST145

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23120.
OpenTargetsiENSG00000118322.
PharmGKBiPA25098.

Polymorphism and mutation databases

BioMutaiATP10B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463811 – 1461Probable phospholipid-transporting ATPase VBAdd BLAST1461

Proteomic databases

PaxDbiO94823.
PeptideAtlasiO94823.
PRIDEiO94823.

PTM databases

iPTMnetiO94823.
PhosphoSitePlusiO94823.

Expressioni

Tissue specificityi

Found in brain and in low levels in testis.

Gene expression databases

BgeeiENSG00000118322.
CleanExiHS_ATP10B.
ExpressionAtlasiO94823. baseline and differential.
GenevisibleiO94823. HS.

Organism-specific databases

HPAiHPA034573.
HPA034574.

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit.Curated

Protein-protein interaction databases

STRINGi9606.ENSP00000313600.

Structurei

3D structure databases

ProteinModelPortaliO94823.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
ENOG410XSS0. LUCA.
GeneTreeiENSGT00860000133775.
HOGENOMiHOG000202528.
HOVERGENiHBG107129.
InParanoidiO94823.
KOiK01530.
OMAiTWTIFHG.
OrthoDBiEOG091G0139.
PhylomeDBiO94823.
TreeFamiTF354252.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 2 hits.
InterProiIPR030359. ATP10B.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 3 hits.
PTHR24092:SF79. PTHR24092:SF79. 3 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 2 hits.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: O94823-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSVDSSWH RWQWRVRDGF PHCPSETTPL LSPEKGRQSY NLTQQRVVFP
60 70 80 90 100
NNSIFHQDWE EVSRRYPGNR TCTTKYTLFT FLPRNLFEQF HRWANLYFLF
110 120 130 140 150
LVILNWMPSM EVFHREITML PLAIVLFVIM IKDGMEDFKR HRFDKAINCS
160 170 180 190 200
NIRIYERKEQ TYVQKCWKDV RVGDFIQMKC NEIVPADILL LFSSDPNGIC
210 220 230 240 250
HLETASLDGE TNLKQRCVVK GFSQQEVQFE PELFHNTIVC EKPNNHLNKF
260 270 280 290 300
KGYMEHPDQT RTGFGCESLL LRGCTIRNTE MAVGIVIYAG HETKAMLNNS
310 320 330 340 350
GPRYKRSKIE RRMNIDIFFC IGILILMCLI GAVGHSIWNG TFEEHPPFDV
360 370 380 390 400
PDANGSFLPS ALGGFYMFLT MIILLQVLIP ISLYVSIELV KLGQVFFLSN
410 420 430 440 450
DLDLYDEETD LSIQCRALNI AEDLGQIQYI FSDKTGTLTE NKMVFRRCTI
460 470 480 490 500
MGSEYSHQEN AKRLETPKEL DSDGEEWTQY QCLSFSARWA QDPATMRSQK
510 520 530 540 550
GAQPLRRSQS ARVPIQGHYR QRSMGHRESS QPPVAFSSSI EKDVTPDKNL
560 570 580 590 600
LTKVRDAALW LETLSDSRPA KASLSTTSSI ADFFLALTIC NSVMVSTTTE
610 620 630 640 650
PRQRVTIKPS SKALGTSLEK IQQLFQKLKL LSLSQSFSST APSDTDLGES
660 670 680 690 700
LGANVATTDS DERDDASVCS GGDSTDDGGY RSSMWDQGDI LESGSGTSLE
710 720 730 740 750
EALEAPATDL ARPEFCYEAE SPDEAALVHA AHAYSFTLVS RTPEQVTVRL
760 770 780 790 800
PQGTCLTFSL LCTLGFDSVR KRMSVVVRHP LTGEIVVYTK GADSVIMDLL
810 820 830 840 850
EDPACVPDIN MEKKLRKIRA RTQKHLDLYA RDGLRTLCIA KKVVSEEDFR
860 870 880 890 900
RWASFRREAE ASLDNRDELL METAQHLENQ LTLLGATGIE DRLQEGVPDT
910 920 930 940 950
IATLREAGIQ LWVLTGDKQE TAVNIAHSCR LLNQTDTVYT INTENQETCE
960 970 980 990 1000
SILNCALEEL KQFRELQKPD RKLFGFRLPS KTPSITSEAV VPEAGLVIDG
1010 1020 1030 1040 1050
KTLNAIFQGK LEKKFLELTQ YCRSVLCCRS TPLQKSMIVK LVRDKLRVMT
1060 1070 1080 1090 1100
LSIGDGANDV SMIQAADIGI GISGQEGMQA VMSSDFAITR FKHLKKLLLV
1110 1120 1130 1140 1150
HGHWCYSRLA RMVVYYLYKN VCYVNLLFWY QFFCGFSSST MIDYWQMIFF
1160 1170 1180 1190 1200
NLFFTSLPPL VFGVLDKDIS AETLLALPEL YKSGQNSECY NLSTFWISMV
1210 1220 1230 1240 1250
DAFYQSLICF FIPYLAYKGS DIDVFTFGTP INTISLTTIL LHQAMEMKTW
1260 1270 1280 1290 1300
TIFHGVVLLG SFLMYFLVSL LYNATCVICN SPTNPYWVME GQLSNPTFYL
1310 1320 1330 1340 1350
VCFLTPVVAL LPRYFFLSLQ GTCGKSLISK AQKIDKLPPD KRNLEIQSWR
1360 1370 1380 1390 1400
SRQRPAPVPE VARPTHHPVS SITGQDFSAS TPKSSNPPKR KHVEESVLHE
1410 1420 1430 1440 1450
QRCGTECMRD DSCSGDSSAQ LSSGEHLLGP NRIMAYSRGQ TDMCRCSKRS
1460
SHRRSQSSLT I
Length:1,461
Mass (Da):165,391
Last modified:April 30, 2003 - v2
Checksum:i2676B90416B6B541
GO
Isoform B (identifier: O94823-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     461-529: AKRLETPKEL...RQRSMGHRES → GIEAPKGSIP...TCKLSFVYKG
     530-1461: Missing.

Note: No experimental confirmation available.
Show »
Length:529
Mass (Da):61,243
Checksum:i048EAC8E3D5BBA0D
GO
Isoform C (identifier: O94823-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: MALSVDSSWH...INCSNIRIYE → MKKEGRKRWK...INNRECLIYS
     461-529: AKRLETPKEL...RQRSMGHRES → GIEAPKGSIP...TCKLSFVYKG
     530-1461: Missing.

Note: No experimental confirmation available.
Show »
Length:501
Mass (Da):57,465
Checksum:iD12B13EC2EC2E3D5
GO

Sequence cautioni

The sequence BAA34435 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234F → S in BAC03528 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048384217C → R.1 PublicationCorresponds to variant rs958912dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0073051 – 156MALSV…IRIYE → MKKEGRKRWKRKEDKKRVVV SNLLFEGWSHKENPNRHHRG NQIKTSKYTVLSFVPKNIFE QLHRFANLYFVGIAVLNFIP VVNAFQPEVSMIPICVILAV TAIKDAWEDLRRYKSDKVIN NRECLIYS in isoform C. 1 PublicationAdd BLAST156
Alternative sequenceiVSP_007306461 – 529AKRLE…GHRES → GIEAPKGSIPLSKRKYPALL RNEEIKDILLALLEAVWHFH KLLPVSLWSSLSQIRAVPIT CKLSFVYKG in isoform B and isoform C. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_007307530 – 1461Missing in isoform B and isoform C. 1 PublicationAdd BLAST932

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018258 mRNA. Translation: BAA34435.2. Different initiation.
AK090832 mRNA. Translation: BAC03528.1.
AK025130 mRNA. Translation: BAB15074.1.
AC008456 Genomic DNA. No translation available.
CCDSiCCDS43394.1. [O94823-1]
RefSeqiNP_079429.2. NM_025153.2. [O94823-1]
XP_006714896.1. XM_006714833.2. [O94823-1]
XP_011532770.1. XM_011534468.2. [O94823-1]
XP_011532771.1. XM_011534469.1. [O94823-1]
UniGeneiHs.109358.

Genome annotation databases

EnsembliENST00000327245; ENSP00000313600; ENSG00000118322. [O94823-1]
GeneIDi23120.
KEGGihsa:23120.
UCSCiuc003lym.1. human. [O94823-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018258 mRNA. Translation: BAA34435.2. Different initiation.
AK090832 mRNA. Translation: BAC03528.1.
AK025130 mRNA. Translation: BAB15074.1.
AC008456 Genomic DNA. No translation available.
CCDSiCCDS43394.1. [O94823-1]
RefSeqiNP_079429.2. NM_025153.2. [O94823-1]
XP_006714896.1. XM_006714833.2. [O94823-1]
XP_011532770.1. XM_011534468.2. [O94823-1]
XP_011532771.1. XM_011534469.1. [O94823-1]
UniGeneiHs.109358.

3D structure databases

ProteinModelPortaliO94823.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000313600.

PTM databases

iPTMnetiO94823.
PhosphoSitePlusiO94823.

Polymorphism and mutation databases

BioMutaiATP10B.

Proteomic databases

PaxDbiO94823.
PeptideAtlasiO94823.
PRIDEiO94823.

Protocols and materials databases

DNASUi23120.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327245; ENSP00000313600; ENSG00000118322. [O94823-1]
GeneIDi23120.
KEGGihsa:23120.
UCSCiuc003lym.1. human. [O94823-1]

Organism-specific databases

CTDi23120.
DisGeNETi23120.
GeneCardsiATP10B.
HGNCiHGNC:13543. ATP10B.
HPAiHPA034573.
HPA034574.
neXtProtiNX_O94823.
OpenTargetsiENSG00000118322.
PharmGKBiPA25098.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
ENOG410XSS0. LUCA.
GeneTreeiENSGT00860000133775.
HOGENOMiHOG000202528.
HOVERGENiHBG107129.
InParanoidiO94823.
KOiK01530.
OMAiTWTIFHG.
OrthoDBiEOG091G0139.
PhylomeDBiO94823.
TreeFamiTF354252.

Enzyme and pathway databases

BioCyciZFISH:HS04213-MONOMER.
ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiATP10B. human.
GenomeRNAii23120.
PROiO94823.

Gene expression databases

BgeeiENSG00000118322.
CleanExiHS_ATP10B.
ExpressionAtlasiO94823. baseline and differential.
GenevisibleiO94823. HS.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 2 hits.
InterProiIPR030359. ATP10B.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 3 hits.
PTHR24092:SF79. PTHR24092:SF79. 3 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 2 hits.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT10B_HUMAN
AccessioniPrimary (citable) accession number: O94823
Secondary accession number(s): Q9H725
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 30, 2003
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.