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O94823 (AT10B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable phospholipid-transporting ATPase VB

EC=3.6.3.1
Alternative name(s):
ATPase class V type 10B
Gene names
Name:ATP10B
Synonyms:ATPVB, KIAA0715
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1461 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Subcellular location

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note: Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B.

Tissue specificity

Found in brain and in low levels in testis.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]

Sequence caution

The sequence BAA34435.2 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: O94823-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: O94823-2)

The sequence of this isoform differs from the canonical sequence as follows:
     461-529: AKRLETPKEL...RQRSMGHRES → GIEAPKGSIP...TCKLSFVYKG
     530-1461: Missing.
Note: No experimental confirmation available.
Isoform C (identifier: O94823-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: MALSVDSSWH...INCSNIRIYE → MKKEGRKRWK...INNRECLIYS
     461-529: AKRLETPKEL...RQRSMGHRES → GIEAPKGSIP...TCKLSFVYKG
     530-1461: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14611461Probable phospholipid-transporting ATPase VB
PRO_0000046381

Regions

Topological domain1 – 8282Cytoplasmic Potential
Transmembrane83 – 10422Helical; Potential
Topological domain105 – 1106Extracellular Potential
Transmembrane111 – 13222Helical; Potential
Topological domain133 – 316184Cytoplasmic Potential
Transmembrane317 – 33822Helical; Potential
Topological domain339 – 36830Extracellular Potential
Transmembrane369 – 39022Helical; Potential
Topological domain391 – 1111721Cytoplasmic Potential
Transmembrane1112 – 113221Helical; Potential
Topological domain1133 – 114412Extracellular Potential
Transmembrane1145 – 116420Helical; Potential
Topological domain1165 – 119430Cytoplasmic Potential
Transmembrane1195 – 121622Helical; Potential
Topological domain1217 – 12237Extracellular Potential
Transmembrane1224 – 124623Helical; Potential
Topological domain1247 – 12526Cytoplasmic Potential
Transmembrane1253 – 127321Helical; Potential
Topological domain1274 – 129118Extracellular Potential
Transmembrane1292 – 131625Helical; Potential
Topological domain1317 – 1461145Cytoplasmic Potential

Sites

Active site43314-aspartylphosphate intermediate By similarity
Metal binding10551Magnesium By similarity
Metal binding10591Magnesium By similarity

Natural variations

Alternative sequence1 – 156156MALSV…IRIYE → MKKEGRKRWKRKEDKKRVVV SNLLFEGWSHKENPNRHHRG NQIKTSKYTVLSFVPKNIFE QLHRFANLYFVGIAVLNFIP VVNAFQPEVSMIPICVILAV TAIKDAWEDLRRYKSDKVIN NRECLIYS in isoform C.
VSP_007305
Alternative sequence461 – 52969AKRLE…GHRES → GIEAPKGSIPLSKRKYPALL RNEEIKDILLALLEAVWHFH KLLPVSLWSSLSQIRAVPIT CKLSFVYKG in isoform B and isoform C.
VSP_007306
Alternative sequence530 – 1461932Missing in isoform B and isoform C.
VSP_007307
Natural variant2171C → R. Ref.3
Corresponds to variant rs958912 [ dbSNP | Ensembl ].
VAR_048384

Experimental info

Sequence conflict2341F → S in BAC03528. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified April 30, 2003. Version 2.
Checksum: 2676B90416B6B541

FASTA1,461165,391
        10         20         30         40         50         60 
MALSVDSSWH RWQWRVRDGF PHCPSETTPL LSPEKGRQSY NLTQQRVVFP NNSIFHQDWE 

        70         80         90        100        110        120 
EVSRRYPGNR TCTTKYTLFT FLPRNLFEQF HRWANLYFLF LVILNWMPSM EVFHREITML 

       130        140        150        160        170        180 
PLAIVLFVIM IKDGMEDFKR HRFDKAINCS NIRIYERKEQ TYVQKCWKDV RVGDFIQMKC 

       190        200        210        220        230        240 
NEIVPADILL LFSSDPNGIC HLETASLDGE TNLKQRCVVK GFSQQEVQFE PELFHNTIVC 

       250        260        270        280        290        300 
EKPNNHLNKF KGYMEHPDQT RTGFGCESLL LRGCTIRNTE MAVGIVIYAG HETKAMLNNS 

       310        320        330        340        350        360 
GPRYKRSKIE RRMNIDIFFC IGILILMCLI GAVGHSIWNG TFEEHPPFDV PDANGSFLPS 

       370        380        390        400        410        420 
ALGGFYMFLT MIILLQVLIP ISLYVSIELV KLGQVFFLSN DLDLYDEETD LSIQCRALNI 

       430        440        450        460        470        480 
AEDLGQIQYI FSDKTGTLTE NKMVFRRCTI MGSEYSHQEN AKRLETPKEL DSDGEEWTQY 

       490        500        510        520        530        540 
QCLSFSARWA QDPATMRSQK GAQPLRRSQS ARVPIQGHYR QRSMGHRESS QPPVAFSSSI 

       550        560        570        580        590        600 
EKDVTPDKNL LTKVRDAALW LETLSDSRPA KASLSTTSSI ADFFLALTIC NSVMVSTTTE 

       610        620        630        640        650        660 
PRQRVTIKPS SKALGTSLEK IQQLFQKLKL LSLSQSFSST APSDTDLGES LGANVATTDS 

       670        680        690        700        710        720 
DERDDASVCS GGDSTDDGGY RSSMWDQGDI LESGSGTSLE EALEAPATDL ARPEFCYEAE 

       730        740        750        760        770        780 
SPDEAALVHA AHAYSFTLVS RTPEQVTVRL PQGTCLTFSL LCTLGFDSVR KRMSVVVRHP 

       790        800        810        820        830        840 
LTGEIVVYTK GADSVIMDLL EDPACVPDIN MEKKLRKIRA RTQKHLDLYA RDGLRTLCIA 

       850        860        870        880        890        900 
KKVVSEEDFR RWASFRREAE ASLDNRDELL METAQHLENQ LTLLGATGIE DRLQEGVPDT 

       910        920        930        940        950        960 
IATLREAGIQ LWVLTGDKQE TAVNIAHSCR LLNQTDTVYT INTENQETCE SILNCALEEL 

       970        980        990       1000       1010       1020 
KQFRELQKPD RKLFGFRLPS KTPSITSEAV VPEAGLVIDG KTLNAIFQGK LEKKFLELTQ 

      1030       1040       1050       1060       1070       1080 
YCRSVLCCRS TPLQKSMIVK LVRDKLRVMT LSIGDGANDV SMIQAADIGI GISGQEGMQA 

      1090       1100       1110       1120       1130       1140 
VMSSDFAITR FKHLKKLLLV HGHWCYSRLA RMVVYYLYKN VCYVNLLFWY QFFCGFSSST 

      1150       1160       1170       1180       1190       1200 
MIDYWQMIFF NLFFTSLPPL VFGVLDKDIS AETLLALPEL YKSGQNSECY NLSTFWISMV 

      1210       1220       1230       1240       1250       1260 
DAFYQSLICF FIPYLAYKGS DIDVFTFGTP INTISLTTIL LHQAMEMKTW TIFHGVVLLG 

      1270       1280       1290       1300       1310       1320 
SFLMYFLVSL LYNATCVICN SPTNPYWVME GQLSNPTFYL VCFLTPVVAL LPRYFFLSLQ 

      1330       1340       1350       1360       1370       1380 
GTCGKSLISK AQKIDKLPPD KRNLEIQSWR SRQRPAPVPE VARPTHHPVS SITGQDFSAS 

      1390       1400       1410       1420       1430       1440 
TPKSSNPPKR KHVEESVLHE QRCGTECMRD DSCSGDSSAQ LSSGEHLLGP NRIMAYSRGQ 

      1450       1460 
TDMCRCSKRS SHRRSQSSLT I 

« Hide

Isoform B [UniParc].

Checksum: 048EAC8E3D5BBA0D
Show »

FASTA52961,243
Isoform C [UniParc].

Checksum: D12B13EC2EC2E3D5
Show »

FASTA50157,465

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Tissue: Brain.
[2]Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B AND C), VARIANT ARG-217.
Tissue: Amygdala and Colon.
[4]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB018258 mRNA. Translation: BAA34435.2. Different initiation.
AK090832 mRNA. Translation: BAC03528.1.
AK025130 mRNA. Translation: BAB15074.1.
AC008456 Genomic DNA. No translation available.
RefSeqNP_079429.2. NM_025153.2.
UniGeneHs.109358.

3D structure databases

ProteinModelPortalO94823.
SMRO94823. Positions 1029-1089.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000313600.

PTM databases

PhosphoSiteO94823.

Proteomic databases

PaxDbO94823.
PRIDEO94823.

Protocols and materials databases

DNASU23120.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000327245; ENSP00000313600; ENSG00000118322. [O94823-1]
GeneID23120.
KEGGhsa:23120.
UCSCuc003lym.1. human. [O94823-1]
uc003lyo.2. human. [O94823-3]
uc003lyp.2. human. [O94823-2]

Organism-specific databases

CTD23120.
GeneCardsGC05M159922.
HGNCHGNC:13543. ATP10B.
HPAHPA034574.
neXtProtNX_O94823.
PharmGKBPA25098.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0474.
HOGENOMHOG000202528.
HOVERGENHBG107129.
InParanoidO94823.
OMAQRSMGHR.
OrthoDBEOG76471S.
PhylomeDBO94823.
TreeFamTF354252.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressO94823.
BgeeO94823.
CleanExHS_ATP10B.
GenevestigatorO94823.

Family and domain databases

Gene3D2.70.150.10. 2 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 2 hits.
InterProIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR006539. ATPase_P-typ_Plipid-transp.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PANTHERPTHR24092. PTHR24092. 1 hit.
PfamPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SUPFAMSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsTIGR01652. ATPase-Plipid. 2 hits.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi23120.
NextBio44343.
PROO94823.

Entry information

Entry nameAT10B_HUMAN
AccessionPrimary (citable) accession number: O94823
Secondary accession number(s): Q9H725
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 30, 2003
Last modified: April 16, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM