ID   KBTBB_HUMAN             Reviewed;         623 AA.
AC   O94819; Q3L1I0;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   27-MAR-2024, entry version 159.
DE   RecName: Full=Kelch repeat and BTB domain-containing protein 11;
DE   AltName: Full=Chronic myelogenous leukemia-associated protein;
DE   AltName: Full=Kelch domain-containing protein 7B;
GN   Name=KBTBD11; Synonyms=CMLAP, KIAA0711, KLHDC7C;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Li M., Liu Y., Cheng J., Liu Y., Peng W., Fu S., Cong Y.;
RT   "Homo sapiens chronic myelogenous leukemia associated protein.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=9872452; DOI=10.1093/dnares/5.5.277;
RA   Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A.,
RA   Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XI. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 5:277-286(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT   refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87 AND SER-107, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA34431.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY762229; AAW83120.1; -; mRNA.
DR   EMBL; AB018254; BAA34431.2; ALT_INIT; mRNA.
DR   EMBL; CH471181; EAW51487.1; -; Genomic_DNA.
DR   CCDS; CCDS34795.1; -.
DR   RefSeq; NP_055682.1; NM_014867.2.
DR   RefSeq; XP_011533073.1; XM_011534771.2.
DR   RefSeq; XP_011533074.1; XM_011534772.2.
DR   RefSeq; XP_016869603.1; XM_017014114.1.
DR   RefSeq; XP_016869604.1; XM_017014115.1.
DR   RefSeq; XP_016869605.1; XM_017014116.1.
DR   RefSeq; XP_016869606.1; XM_017014117.1.
DR   AlphaFoldDB; O94819; -.
DR   SMR; O94819; -.
DR   BioGRID; 115248; 5.
DR   STRING; 9606.ENSP00000321544; -.
DR   iPTMnet; O94819; -.
DR   PhosphoSitePlus; O94819; -.
DR   SwissPalm; O94819; -.
DR   BioMuta; KBTBD11; -.
DR   EPD; O94819; -.
DR   jPOST; O94819; -.
DR   MassIVE; O94819; -.
DR   MaxQB; O94819; -.
DR   PaxDb; 9606-ENSP00000321544; -.
DR   PeptideAtlas; O94819; -.
DR   ProteomicsDB; 50462; -.
DR   Pumba; O94819; -.
DR   Antibodypedia; 63434; 51 antibodies from 13 providers.
DR   DNASU; 9920; -.
DR   Ensembl; ENST00000320248.4; ENSP00000321544.3; ENSG00000176595.4.
DR   Ensembl; ENST00000617214.2; ENSP00000481889.1; ENSG00000273645.2.
DR   GeneID; 9920; -.
DR   KEGG; hsa:9920; -.
DR   MANE-Select; ENST00000320248.4; ENSP00000321544.3; NM_014867.3; NP_055682.1.
DR   UCSC; uc003wpw.5; human.
DR   AGR; HGNC:29104; -.
DR   CTD; 9920; -.
DR   DisGeNET; 9920; -.
DR   GeneCards; KBTBD11; -.
DR   HGNC; HGNC:29104; KBTBD11.
DR   HPA; ENSG00000176595; Tissue enhanced (brain).
DR   MIM; 618794; gene.
DR   neXtProt; NX_O94819; -.
DR   OpenTargets; ENSG00000176595; -.
DR   PharmGKB; PA142671642; -.
DR   VEuPathDB; HostDB:ENSG00000176595; -.
DR   eggNOG; KOG1072; Eukaryota.
DR   GeneTree; ENSGT00940000161983; -.
DR   HOGENOM; CLU_020313_2_0_1; -.
DR   InParanoid; O94819; -.
DR   OMA; HAVAPCV; -.
DR   OrthoDB; 5472491at2759; -.
DR   PhylomeDB; O94819; -.
DR   TreeFam; TF328485; -.
DR   PathwayCommons; O94819; -.
DR   SignaLink; O94819; -.
DR   BioGRID-ORCS; 9920; 19 hits in 1181 CRISPR screens.
DR   ChiTaRS; KBTBD11; human.
DR   GenomeRNAi; 9920; -.
DR   Pharos; O94819; Tdark.
DR   PRO; PR:O94819; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; O94819; Protein.
DR   Bgee; ENSG00000176595; Expressed in cortical plate and 100 other cell types or tissues.
DR   CDD; cd18484; BACK_KBTBD11_CMLAP; 1.
DR   CDD; cd18275; BTB_POZ_KBTBD11; 1.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR45972; BTB_2 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45972:SF3; KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 11; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 2.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; Kelch motif; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   Genevisible; O94819; HS.
PE   1: Evidence at protein level;
KW   Kelch repeat; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..623
FT                   /note="Kelch repeat and BTB domain-containing protein 11"
FT                   /id="PRO_0000119090"
FT   DOMAIN          140..196
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   REPEAT          311..359
FT                   /note="Kelch 1"
FT   REPEAT          360..412
FT                   /note="Kelch 2"
FT   REPEAT          413..455
FT                   /note="Kelch 3"
FT   REPEAT          458..500
FT                   /note="Kelch 4"
FT   REGION          1..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         64
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BNW9"
FT   MOD_RES         67
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BNW9"
FT   MOD_RES         87
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:24275569"
FT   MOD_RES         107
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:24275569"
SQ   SEQUENCE   623 AA;  65720 MW;  1044C753A8F478C6 CRC64;
     MEHAVAPCVL YPGTEPGAAG ESESEGAASP AQTPCSLGAS LCFSSGEESP PQSLASAAEG
     AATSPPSSGG PRVVERQWEA GSAGAASPEE LASPEERACP EEPAAPSPEP RVWLEDPASP
     EEPGEPAPVP PGFGAVYGEP DLVLEVSGRR LRAHKAVLAA RSDYFRARAS RDVLRVQGVS
     LTALRLLLAD AYSGRMAGVR PDNVAEVVAG ARRLQLPGAA QRATDAVGPQ LSLANCYEVL
     SAAKRQRLNE LRDAAYCFMS DHYLEVLREP AVFGRLSGAE RDLLLRRRLR AGRAHLLAAA
     LGPAGERAGS RPQSPSGDAD ARGDAAVYCF HAAAGEWREL TRLPEGAPAR GCGLCVLYNY
     LFVAGGVAPA GPDGRARPSD QVFCYNPATD SWSAVRPLRQ ARSQLRLLAL DGHLYAVGGE
     CLLSVERYDP RADRWAPVAP LPRGAFAVAH EATTCHGEIY VSGGSLFYRL LKYDPRRDEW
     QECPCSSSRE RSADMVALDG FIYRFDLSGS RGEAQAAGPS GVSVSRYHCL AKQWSPCVAP
     LRLPGGPTGL QPFRCAALDG AIYCVSRAGT WRFQPAREGE AGGDAGQGGG FEALGAPLDV
     RGVLIPFALS LPEKPPRGEQ GAP
//