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Protein

Kelch repeat and BTB domain-containing protein 11

Gene

KBTBD11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176595-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 11
Alternative name(s):
Chronic myelogenous leukemia-associated protein
Kelch domain-containing protein 7B
Gene namesi
Name:KBTBD11
Synonyms:CMLAP, KIAA0711, KLHDC7C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:29104. KBTBD11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi9920.
OpenTargetsiENSG00000176595.
ENSG00000273645.
PharmGKBiPA142671642.

Polymorphism and mutation databases

BioMutaiKBTBD11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190901 – 623Kelch repeat and BTB domain-containing protein 11Add BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Modified residuei87PhosphoserineCombined sources1
Modified residuei107PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO94819.
MaxQBiO94819.
PaxDbiO94819.
PeptideAtlasiO94819.
PRIDEiO94819.

PTM databases

iPTMnetiO94819.
PhosphoSitePlusiO94819.
SwissPalmiO94819.

Expressioni

Gene expression databases

BgeeiENSG00000176595.
CleanExiHS_KBTBD11.
GenevisibleiO94819. HS.

Organism-specific databases

HPAiHPA051159.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321544.

Structurei

3D structure databases

ProteinModelPortaliO94819.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini140 – 196BTBPROSITE-ProRule annotationAdd BLAST57
Repeati311 – 359Kelch 1Add BLAST49
Repeati360 – 412Kelch 2Add BLAST53
Repeati413 – 455Kelch 3Add BLAST43
Repeati458 – 500Kelch 4Add BLAST43

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000246990.
HOVERGENiHBG081849.
InParanoidiO94819.
KOiK10476.
OMAiVGGECLF.
OrthoDBiEOG091G02D9.
PhylomeDBiO94819.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHAVAPCVL YPGTEPGAAG ESESEGAASP AQTPCSLGAS LCFSSGEESP
60 70 80 90 100
PQSLASAAEG AATSPPSSGG PRVVERQWEA GSAGAASPEE LASPEERACP
110 120 130 140 150
EEPAAPSPEP RVWLEDPASP EEPGEPAPVP PGFGAVYGEP DLVLEVSGRR
160 170 180 190 200
LRAHKAVLAA RSDYFRARAS RDVLRVQGVS LTALRLLLAD AYSGRMAGVR
210 220 230 240 250
PDNVAEVVAG ARRLQLPGAA QRATDAVGPQ LSLANCYEVL SAAKRQRLNE
260 270 280 290 300
LRDAAYCFMS DHYLEVLREP AVFGRLSGAE RDLLLRRRLR AGRAHLLAAA
310 320 330 340 350
LGPAGERAGS RPQSPSGDAD ARGDAAVYCF HAAAGEWREL TRLPEGAPAR
360 370 380 390 400
GCGLCVLYNY LFVAGGVAPA GPDGRARPSD QVFCYNPATD SWSAVRPLRQ
410 420 430 440 450
ARSQLRLLAL DGHLYAVGGE CLLSVERYDP RADRWAPVAP LPRGAFAVAH
460 470 480 490 500
EATTCHGEIY VSGGSLFYRL LKYDPRRDEW QECPCSSSRE RSADMVALDG
510 520 530 540 550
FIYRFDLSGS RGEAQAAGPS GVSVSRYHCL AKQWSPCVAP LRLPGGPTGL
560 570 580 590 600
QPFRCAALDG AIYCVSRAGT WRFQPAREGE AGGDAGQGGG FEALGAPLDV
610 620
RGVLIPFALS LPEKPPRGEQ GAP
Length:623
Mass (Da):65,720
Last modified:May 1, 1999 - v1
Checksum:i1044C753A8F478C6
GO

Sequence cautioni

The sequence BAA34431 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY762229 mRNA. Translation: AAW83120.1.
AB018254 mRNA. Translation: BAA34431.2. Different initiation.
CH471181 Genomic DNA. Translation: EAW51487.1.
CCDSiCCDS34795.1.
RefSeqiNP_055682.1. NM_014867.2.
XP_011533073.1. XM_011534771.2.
XP_011533074.1. XM_011534772.2.
XP_016869603.1. XM_017014114.1.
XP_016869604.1. XM_017014115.1.
XP_016869605.1. XM_017014116.1.
XP_016869606.1. XM_017014117.1.
UniGeneiHs.5333.

Genome annotation databases

EnsembliENST00000320248; ENSP00000321544; ENSG00000176595.
ENST00000617214; ENSP00000481889; ENSG00000273645.
GeneIDi9920.
KEGGihsa:9920.
UCSCiuc003wpw.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY762229 mRNA. Translation: AAW83120.1.
AB018254 mRNA. Translation: BAA34431.2. Different initiation.
CH471181 Genomic DNA. Translation: EAW51487.1.
CCDSiCCDS34795.1.
RefSeqiNP_055682.1. NM_014867.2.
XP_011533073.1. XM_011534771.2.
XP_011533074.1. XM_011534772.2.
XP_016869603.1. XM_017014114.1.
XP_016869604.1. XM_017014115.1.
XP_016869605.1. XM_017014116.1.
XP_016869606.1. XM_017014117.1.
UniGeneiHs.5333.

3D structure databases

ProteinModelPortaliO94819.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000321544.

PTM databases

iPTMnetiO94819.
PhosphoSitePlusiO94819.
SwissPalmiO94819.

Polymorphism and mutation databases

BioMutaiKBTBD11.

Proteomic databases

EPDiO94819.
MaxQBiO94819.
PaxDbiO94819.
PeptideAtlasiO94819.
PRIDEiO94819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320248; ENSP00000321544; ENSG00000176595.
ENST00000617214; ENSP00000481889; ENSG00000273645.
GeneIDi9920.
KEGGihsa:9920.
UCSCiuc003wpw.5. human.

Organism-specific databases

CTDi9920.
DisGeNETi9920.
GeneCardsiKBTBD11.
HGNCiHGNC:29104. KBTBD11.
HPAiHPA051159.
neXtProtiNX_O94819.
OpenTargetsiENSG00000176595.
ENSG00000273645.
PharmGKBiPA142671642.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000246990.
HOVERGENiHBG081849.
InParanoidiO94819.
KOiK10476.
OMAiVGGECLF.
OrthoDBiEOG091G02D9.
PhylomeDBiO94819.
TreeFamiTF328485.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176595-MONOMER.

Miscellaneous databases

GenomeRNAii9920.
PROiO94819.

Gene expression databases

BgeeiENSG00000176595.
CleanExiHS_KBTBD11.
GenevisibleiO94819. HS.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKBTBB_HUMAN
AccessioniPrimary (citable) accession number: O94819
Secondary accession number(s): Q3L1I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.