O94819 (KBTBB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kelch repeat and BTB domain-containing protein 11

Alternative name(s):
Chronic myelogenous leukemia-associated protein
Kelch domain-containing protein 7B

Gene names

Name:	KBTBD11
Synonyms:	CMLAP, KIAA0711, KLHDC7C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	623 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Contains 1 BTB (POZ) domain. Contains 4 Kelch repeats.
Sequence caution	The sequence BAA34431.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Domain	Kelch repeat Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 623	623	Kelch repeat and BTB domain-containing protein 11		PRO_0000119090
Regions
	Domain	140 – 196	57	BTB
	Repeat	311 – 359	49	Kelch 1
	Repeat	360 – 412	53	Kelch 2
	Repeat	413 – 455	43	Kelch 3
	Repeat	458 – 500	43	Kelch 4
Amino acid modifications
	Modified residue	64	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O94819 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 1044C753A8F478C6	FASTA	623	65,720
	10 20 30 40 50 60 MEHAVAPCVL YPGTEPGAAG ESESEGAASP AQTPCSLGAS LCFSSGEESP PQSLASAAEG 70 80 90 100 110 120 AATSPPSSGG PRVVERQWEA GSAGAASPEE LASPEERACP EEPAAPSPEP RVWLEDPASP 130 140 150 160 170 180 EEPGEPAPVP PGFGAVYGEP DLVLEVSGRR LRAHKAVLAA RSDYFRARAS RDVLRVQGVS 190 200 210 220 230 240 LTALRLLLAD AYSGRMAGVR PDNVAEVVAG ARRLQLPGAA QRATDAVGPQ LSLANCYEVL 250 260 270 280 290 300 SAAKRQRLNE LRDAAYCFMS DHYLEVLREP AVFGRLSGAE RDLLLRRRLR AGRAHLLAAA 310 320 330 340 350 360 LGPAGERAGS RPQSPSGDAD ARGDAAVYCF HAAAGEWREL TRLPEGAPAR GCGLCVLYNY 370 380 390 400 410 420 LFVAGGVAPA GPDGRARPSD QVFCYNPATD SWSAVRPLRQ ARSQLRLLAL DGHLYAVGGE 430 440 450 460 470 480 CLLSVERYDP RADRWAPVAP LPRGAFAVAH EATTCHGEIY VSGGSLFYRL LKYDPRRDEW 490 500 510 520 530 540 QECPCSSSRE RSADMVALDG FIYRFDLSGS RGEAQAAGPS GVSVSRYHCL AKQWSPCVAP 550 560 570 580 590 600 LRLPGGPTGL QPFRCAALDG AIYCVSRAGT WRFQPAREGE AGGDAGQGGG FEALGAPLDV 610 620 RGVLIPFALS LPEKPPRGEQ GAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens chronic myelogenous leukemia associated protein." Li M., Liu Y., Cheng J., Liu Y., Peng W., Fu S., Cong Y. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY762229 mRNA. Translation: AAW83120.1. AB018254 mRNA. Translation: BAA34431.2. Different initiation. CH471181 Genomic DNA. Translation: EAW51487.1.
IPI	IPI00015568.
RefSeq	NP_055682.1. NM_014867.2.
UniGene	Hs.5333.
3D structure databases
ProteinModelPortal	O94819.
ModBase	Search...
PTM databases
PhosphoSite	O94819.
Proteomic databases
PaxDb	O94819.
PeptideAtlas	O94819.
PRIDE	O94819.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320248; ENSP00000321544; ENSG00000176595.
GeneID	9920.
KEGG	hsa:9920.
UCSC	uc003wpw.4. human.
Organism-specific databases
CTD	9920.
GeneCards	GC08P001912.
HGNC	HGNC:29104. KBTBD11.
HPA	HPA051159.
neXtProt	NX_O94819.
PharmGKB	PA142671642.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG284393.
HOGENOM	HOG000246990.
HOVERGEN	HBG081849.
InParanoid	O94819.
KO	K10476.
OMA	IYRFDLC.
OrthoDB	EOG4QZ7KT.
PhylomeDB	O94819.
Gene expression databases
Bgee	O94819.
CleanEx	HS_KBTBD11.
Genevestigator	O94819.
GermOnline	ENSG00000176595. Homo sapiens.
Family and domain databases
Gene3D	2.120.10.80. 1 hit. 3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR015915. Kelch-typ_b-propeller. IPR006652. Kelch_1. [Graphical view]
Pfam	PF00651. BTB. 1 hit. PF01344. Kelch_1. 2 hits. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00612. Kelch. 3 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9920.
NextBio	37424.

Entry information

Entry name

KBTBB_HUMAN

Accession

Primary (citable) accession number: O94819
Secondary accession number(s): Q3L1I0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.