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O94819

- KBTBB_HUMAN

UniProt

O94819 - KBTBB_HUMAN

Protein

Kelch repeat and BTB domain-containing protein 11

Gene

KBTBD11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kelch repeat and BTB domain-containing protein 11
    Alternative name(s):
    Chronic myelogenous leukemia-associated protein
    Kelch domain-containing protein 7B
    Gene namesi
    Name:KBTBD11
    Synonyms:CMLAP, KIAA0711, KLHDC7C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:29104. KBTBD11.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671642.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 623623Kelch repeat and BTB domain-containing protein 11PRO_0000119090Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei64 – 641PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO94819.
    PaxDbiO94819.
    PeptideAtlasiO94819.
    PRIDEiO94819.

    PTM databases

    PhosphoSiteiO94819.

    Expressioni

    Gene expression databases

    BgeeiO94819.
    CleanExiHS_KBTBD11.
    GenevestigatoriO94819.

    Organism-specific databases

    HPAiHPA051159.

    Interactioni

    Protein-protein interaction databases

    BioGridi115248. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO94819.
    SMRiO94819. Positions 141-267, 289-542.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini140 – 19657BTBPROSITE-ProRule annotationAdd
    BLAST
    Repeati311 – 35949Kelch 1Add
    BLAST
    Repeati360 – 41253Kelch 2Add
    BLAST
    Repeati413 – 45543Kelch 3Add
    BLAST
    Repeati458 – 50043Kelch 4Add
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 4 Kelch repeats.Curated

    Keywords - Domaini

    Kelch repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG284393.
    HOGENOMiHOG000246990.
    HOVERGENiHBG081849.
    InParanoidiO94819.
    KOiK10476.
    OMAiGGECLFT.
    OrthoDBiEOG7NSB21.
    PhylomeDBiO94819.
    TreeFamiTF328485.

    Family and domain databases

    Gene3Di2.120.10.80. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015915. Kelch-typ_b-propeller.
    IPR006652. Kelch_1.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF01344. Kelch_1. 2 hits.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00612. Kelch. 3 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O94819-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHAVAPCVL YPGTEPGAAG ESESEGAASP AQTPCSLGAS LCFSSGEESP    50
    PQSLASAAEG AATSPPSSGG PRVVERQWEA GSAGAASPEE LASPEERACP 100
    EEPAAPSPEP RVWLEDPASP EEPGEPAPVP PGFGAVYGEP DLVLEVSGRR 150
    LRAHKAVLAA RSDYFRARAS RDVLRVQGVS LTALRLLLAD AYSGRMAGVR 200
    PDNVAEVVAG ARRLQLPGAA QRATDAVGPQ LSLANCYEVL SAAKRQRLNE 250
    LRDAAYCFMS DHYLEVLREP AVFGRLSGAE RDLLLRRRLR AGRAHLLAAA 300
    LGPAGERAGS RPQSPSGDAD ARGDAAVYCF HAAAGEWREL TRLPEGAPAR 350
    GCGLCVLYNY LFVAGGVAPA GPDGRARPSD QVFCYNPATD SWSAVRPLRQ 400
    ARSQLRLLAL DGHLYAVGGE CLLSVERYDP RADRWAPVAP LPRGAFAVAH 450
    EATTCHGEIY VSGGSLFYRL LKYDPRRDEW QECPCSSSRE RSADMVALDG 500
    FIYRFDLSGS RGEAQAAGPS GVSVSRYHCL AKQWSPCVAP LRLPGGPTGL 550
    QPFRCAALDG AIYCVSRAGT WRFQPAREGE AGGDAGQGGG FEALGAPLDV 600
    RGVLIPFALS LPEKPPRGEQ GAP 623
    Length:623
    Mass (Da):65,720
    Last modified:May 1, 1999 - v1
    Checksum:i1044C753A8F478C6
    GO

    Sequence cautioni

    The sequence BAA34431.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY762229 mRNA. Translation: AAW83120.1.
    AB018254 mRNA. Translation: BAA34431.2. Different initiation.
    CH471181 Genomic DNA. Translation: EAW51487.1.
    CCDSiCCDS34795.1.
    RefSeqiNP_055682.1. NM_014867.2.
    XP_005266100.1. XM_005266043.2.
    XP_005266101.1. XM_005266044.2.
    XP_005266102.1. XM_005266045.2.
    XP_006725175.1. XM_006725112.1.
    XP_006725176.1. XM_006725113.1.
    XP_006725177.1. XM_006725114.1.
    UniGeneiHs.5333.

    Genome annotation databases

    EnsembliENST00000320248; ENSP00000321544; ENSG00000176595.
    GeneIDi9920.
    KEGGihsa:9920.
    UCSCiuc003wpw.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY762229 mRNA. Translation: AAW83120.1 .
    AB018254 mRNA. Translation: BAA34431.2 . Different initiation.
    CH471181 Genomic DNA. Translation: EAW51487.1 .
    CCDSi CCDS34795.1.
    RefSeqi NP_055682.1. NM_014867.2.
    XP_005266100.1. XM_005266043.2.
    XP_005266101.1. XM_005266044.2.
    XP_005266102.1. XM_005266045.2.
    XP_006725175.1. XM_006725112.1.
    XP_006725176.1. XM_006725113.1.
    XP_006725177.1. XM_006725114.1.
    UniGenei Hs.5333.

    3D structure databases

    ProteinModelPortali O94819.
    SMRi O94819. Positions 141-267, 289-542.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115248. 1 interaction.

    PTM databases

    PhosphoSitei O94819.

    Proteomic databases

    MaxQBi O94819.
    PaxDbi O94819.
    PeptideAtlasi O94819.
    PRIDEi O94819.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320248 ; ENSP00000321544 ; ENSG00000176595 .
    GeneIDi 9920.
    KEGGi hsa:9920.
    UCSCi uc003wpw.4. human.

    Organism-specific databases

    CTDi 9920.
    GeneCardsi GC08P001912.
    HGNCi HGNC:29104. KBTBD11.
    HPAi HPA051159.
    neXtProti NX_O94819.
    PharmGKBi PA142671642.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284393.
    HOGENOMi HOG000246990.
    HOVERGENi HBG081849.
    InParanoidi O94819.
    KOi K10476.
    OMAi GGECLFT.
    OrthoDBi EOG7NSB21.
    PhylomeDBi O94819.
    TreeFami TF328485.

    Miscellaneous databases

    GenomeRNAii 9920.
    NextBioi 37424.
    PROi O94819.

    Gene expression databases

    Bgeei O94819.
    CleanExi HS_KBTBD11.
    Genevestigatori O94819.

    Family and domain databases

    Gene3Di 2.120.10.80. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015915. Kelch-typ_b-propeller.
    IPR006652. Kelch_1.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 2 hits.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00612. Kelch. 3 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens chronic myelogenous leukemia associated protein."
      Li M., Liu Y., Cheng J., Liu Y., Peng W., Fu S., Cong Y.
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKBTBB_HUMAN
    AccessioniPrimary (citable) accession number: O94819
    Secondary accession number(s): Q3L1I0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3