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O94819 (KBTBB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kelch repeat and BTB domain-containing protein 11
Alternative name(s):
Chronic myelogenous leukemia-associated protein
Kelch domain-containing protein 7B
Gene names
Name:KBTBD11
Synonyms:CMLAP, KIAA0711, KLHDC7C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length623 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 BTB (POZ) domain.

Contains 4 Kelch repeats.

Sequence caution

The sequence BAA34431.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   DomainKelch repeat
Repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 623623Kelch repeat and BTB domain-containing protein 11
PRO_0000119090

Regions

Domain140 – 19657BTB
Repeat311 – 35949Kelch 1
Repeat360 – 41253Kelch 2
Repeat413 – 45543Kelch 3
Repeat458 – 50043Kelch 4

Amino acid modifications

Modified residue641Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
O94819 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 1044C753A8F478C6

FASTA62365,720
        10         20         30         40         50         60 
MEHAVAPCVL YPGTEPGAAG ESESEGAASP AQTPCSLGAS LCFSSGEESP PQSLASAAEG 

        70         80         90        100        110        120 
AATSPPSSGG PRVVERQWEA GSAGAASPEE LASPEERACP EEPAAPSPEP RVWLEDPASP 

       130        140        150        160        170        180 
EEPGEPAPVP PGFGAVYGEP DLVLEVSGRR LRAHKAVLAA RSDYFRARAS RDVLRVQGVS 

       190        200        210        220        230        240 
LTALRLLLAD AYSGRMAGVR PDNVAEVVAG ARRLQLPGAA QRATDAVGPQ LSLANCYEVL 

       250        260        270        280        290        300 
SAAKRQRLNE LRDAAYCFMS DHYLEVLREP AVFGRLSGAE RDLLLRRRLR AGRAHLLAAA 

       310        320        330        340        350        360 
LGPAGERAGS RPQSPSGDAD ARGDAAVYCF HAAAGEWREL TRLPEGAPAR GCGLCVLYNY 

       370        380        390        400        410        420 
LFVAGGVAPA GPDGRARPSD QVFCYNPATD SWSAVRPLRQ ARSQLRLLAL DGHLYAVGGE 

       430        440        450        460        470        480 
CLLSVERYDP RADRWAPVAP LPRGAFAVAH EATTCHGEIY VSGGSLFYRL LKYDPRRDEW 

       490        500        510        520        530        540 
QECPCSSSRE RSADMVALDG FIYRFDLSGS RGEAQAAGPS GVSVSRYHCL AKQWSPCVAP 

       550        560        570        580        590        600 
LRLPGGPTGL QPFRCAALDG AIYCVSRAGT WRFQPAREGE AGGDAGQGGG FEALGAPLDV 

       610        620 
RGVLIPFALS LPEKPPRGEQ GAP 

« Hide

References

« Hide 'large scale' references
[1]"Homo sapiens chronic myelogenous leukemia associated protein."
Li M., Liu Y., Cheng J., Liu Y., Peng W., Fu S., Cong Y.
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY762229 mRNA. Translation: AAW83120.1.
AB018254 mRNA. Translation: BAA34431.2. Different initiation.
CH471181 Genomic DNA. Translation: EAW51487.1.
RefSeqNP_055682.1. NM_014867.2.
XP_005266100.1. XM_005266043.2.
XP_005266101.1. XM_005266044.2.
XP_005266102.1. XM_005266045.2.
UniGeneHs.5333.

3D structure databases

ProteinModelPortalO94819.
SMRO94819. Positions 138-604.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115248. 1 interaction.

PTM databases

PhosphoSiteO94819.

Proteomic databases

PaxDbO94819.
PeptideAtlasO94819.
PRIDEO94819.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320248; ENSP00000321544; ENSG00000176595.
GeneID9920.
KEGGhsa:9920.
UCSCuc003wpw.4. human.

Organism-specific databases

CTD9920.
GeneCardsGC08P001912.
HGNCHGNC:29104. KBTBD11.
HPAHPA051159.
neXtProtNX_O94819.
PharmGKBPA142671642.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284393.
HOGENOMHOG000246990.
HOVERGENHBG081849.
InParanoidO94819.
KOK10476.
OMAIYRFDLC.
OrthoDBEOG7NSB21.
PhylomeDBO94819.
TreeFamTF328485.

Gene expression databases

BgeeO94819.
CleanExHS_KBTBD11.
GenevestigatorO94819.

Family and domain databases

Gene3D2.120.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamPF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9920.
NextBio37424.
PROO94819.

Entry information

Entry nameKBTBB_HUMAN
AccessionPrimary (citable) accession number: O94819
Secondary accession number(s): Q3L1I0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM