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Protein

Kelch repeat and BTB domain-containing protein 11

Gene

KBTBD11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 11
Alternative name(s):
Chronic myelogenous leukemia-associated protein
Kelch domain-containing protein 7B
Gene namesi
Name:KBTBD11
Synonyms:CMLAP, KIAA0711, KLHDC7C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:29104. KBTBD11.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671642.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623Kelch repeat and BTB domain-containing protein 11PRO_0000119090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641PhosphoserineBy similarity
Modified residuei87 – 871Phosphoserine1 Publication
Modified residuei107 – 1071Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO94819.
PaxDbiO94819.
PeptideAtlasiO94819.
PRIDEiO94819.

PTM databases

PhosphoSiteiO94819.

Expressioni

Gene expression databases

BgeeiO94819.
CleanExiHS_KBTBD11.
GenevestigatoriO94819.

Organism-specific databases

HPAiHPA051159.

Interactioni

Protein-protein interaction databases

BioGridi115248. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO94819.
SMRiO94819. Positions 141-267, 289-542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini140 – 19657BTBPROSITE-ProRule annotationAdd
BLAST
Repeati311 – 35949Kelch 1Add
BLAST
Repeati360 – 41253Kelch 2Add
BLAST
Repeati413 – 45543Kelch 3Add
BLAST
Repeati458 – 50043Kelch 4Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG284393.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000246990.
HOVERGENiHBG081849.
InParanoidiO94819.
KOiK10476.
OMAiVGGECLF.
OrthoDBiEOG7NSB21.
PhylomeDBiO94819.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHAVAPCVL YPGTEPGAAG ESESEGAASP AQTPCSLGAS LCFSSGEESP
60 70 80 90 100
PQSLASAAEG AATSPPSSGG PRVVERQWEA GSAGAASPEE LASPEERACP
110 120 130 140 150
EEPAAPSPEP RVWLEDPASP EEPGEPAPVP PGFGAVYGEP DLVLEVSGRR
160 170 180 190 200
LRAHKAVLAA RSDYFRARAS RDVLRVQGVS LTALRLLLAD AYSGRMAGVR
210 220 230 240 250
PDNVAEVVAG ARRLQLPGAA QRATDAVGPQ LSLANCYEVL SAAKRQRLNE
260 270 280 290 300
LRDAAYCFMS DHYLEVLREP AVFGRLSGAE RDLLLRRRLR AGRAHLLAAA
310 320 330 340 350
LGPAGERAGS RPQSPSGDAD ARGDAAVYCF HAAAGEWREL TRLPEGAPAR
360 370 380 390 400
GCGLCVLYNY LFVAGGVAPA GPDGRARPSD QVFCYNPATD SWSAVRPLRQ
410 420 430 440 450
ARSQLRLLAL DGHLYAVGGE CLLSVERYDP RADRWAPVAP LPRGAFAVAH
460 470 480 490 500
EATTCHGEIY VSGGSLFYRL LKYDPRRDEW QECPCSSSRE RSADMVALDG
510 520 530 540 550
FIYRFDLSGS RGEAQAAGPS GVSVSRYHCL AKQWSPCVAP LRLPGGPTGL
560 570 580 590 600
QPFRCAALDG AIYCVSRAGT WRFQPAREGE AGGDAGQGGG FEALGAPLDV
610 620
RGVLIPFALS LPEKPPRGEQ GAP
Length:623
Mass (Da):65,720
Last modified:May 1, 1999 - v1
Checksum:i1044C753A8F478C6
GO

Sequence cautioni

The sequence BAA34431.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY762229 mRNA. Translation: AAW83120.1.
AB018254 mRNA. Translation: BAA34431.2. Different initiation.
CH471181 Genomic DNA. Translation: EAW51487.1.
CCDSiCCDS34795.1.
RefSeqiNP_055682.1. NM_014867.2.
XP_005266100.1. XM_005266043.2.
XP_005266101.1. XM_005266044.2.
XP_005266102.1. XM_005266045.2.
XP_006725175.1. XM_006725112.1.
XP_006725176.1. XM_006725113.1.
XP_006725177.1. XM_006725114.1.
UniGeneiHs.5333.

Genome annotation databases

EnsembliENST00000320248; ENSP00000321544; ENSG00000176595.
ENST00000617214; ENSP00000481889; ENSG00000273645.
GeneIDi9920.
KEGGihsa:9920.
UCSCiuc003wpw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY762229 mRNA. Translation: AAW83120.1.
AB018254 mRNA. Translation: BAA34431.2. Different initiation.
CH471181 Genomic DNA. Translation: EAW51487.1.
CCDSiCCDS34795.1.
RefSeqiNP_055682.1. NM_014867.2.
XP_005266100.1. XM_005266043.2.
XP_005266101.1. XM_005266044.2.
XP_005266102.1. XM_005266045.2.
XP_006725175.1. XM_006725112.1.
XP_006725176.1. XM_006725113.1.
XP_006725177.1. XM_006725114.1.
UniGeneiHs.5333.

3D structure databases

ProteinModelPortaliO94819.
SMRiO94819. Positions 141-267, 289-542.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115248. 1 interaction.

PTM databases

PhosphoSiteiO94819.

Proteomic databases

MaxQBiO94819.
PaxDbiO94819.
PeptideAtlasiO94819.
PRIDEiO94819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320248; ENSP00000321544; ENSG00000176595.
ENST00000617214; ENSP00000481889; ENSG00000273645.
GeneIDi9920.
KEGGihsa:9920.
UCSCiuc003wpw.4. human.

Organism-specific databases

CTDi9920.
GeneCardsiGC08P001912.
HGNCiHGNC:29104. KBTBD11.
HPAiHPA051159.
neXtProtiNX_O94819.
PharmGKBiPA142671642.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG284393.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000246990.
HOVERGENiHBG081849.
InParanoidiO94819.
KOiK10476.
OMAiVGGECLF.
OrthoDBiEOG7NSB21.
PhylomeDBiO94819.
TreeFamiTF328485.

Miscellaneous databases

GenomeRNAii9920.
NextBioi37424.
PROiO94819.

Gene expression databases

BgeeiO94819.
CleanExiHS_KBTBD11.
GenevestigatoriO94819.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens chronic myelogenous leukemia associated protein."
    Li M., Liu Y., Cheng J., Liu Y., Peng W., Fu S., Cong Y.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87 AND SER-107, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiKBTBB_HUMAN
AccessioniPrimary (citable) accession number: O94819
Secondary accession number(s): Q3L1I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: March 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.