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Protein

Nucleolar protein 4

Gene

NOL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 4
Alternative name(s):
Nucleolar-localized protein
Gene namesi
Name:NOL4
Synonyms:NOLP
ORF Names:HRIHFB2255
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:7870. NOL4.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: ProtInc
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31674.

Polymorphism and mutation databases

BioMutaiNOL4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Nucleolar protein 4PRO_0000096935Add
BLAST

Proteomic databases

EPDiO94818.
PaxDbiO94818.
PeptideAtlasiO94818.
PRIDEiO94818.

PTM databases

iPTMnetiO94818.
PhosphoSiteiO94818.

Expressioni

Tissue specificityi

Expressed predominantly in fetal brain, adult brain and testis.1 Publication

Gene expression databases

BgeeiENSG00000101746.
CleanExiHS_NOL4.
ExpressionAtlasiO94818. baseline and differential.
GenevisibleiO94818. HS.

Organism-specific databases

HPAiHPA046740.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTBP1Q13363-23EBI-10190763,EBI-10171858
CTBP2P565453EBI-10190763,EBI-741533
CTBP2Q8IY443EBI-10190763,EBI-10171902
FAM9BQ8IZU03EBI-10190763,EBI-10175124
SNAPC5O759713EBI-10190763,EBI-749483

Protein-protein interaction databases

BioGridi114256. 9 interactions.
IntActiO94818. 9 interactions.
MINTiMINT-1429799.
STRINGi9606.ENSP00000261592.

Structurei

3D structure databases

ProteinModelPortaliO94818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEBQ. Eukaryota.
ENOG411245F. LUCA.
GeneTreeiENSGT00390000017363.
HOGENOMiHOG000220856.
HOVERGENiHBG031438.
InParanoidiO94818.
OMAiSEYRIED.
OrthoDBiEOG091G03G2.
PhylomeDBiO94818.
TreeFamiTF325594.

Family and domain databases

InterProiIPR026747. NOL4.
[Graphical view]
PANTHERiPTHR12449:SF17. PTHR12449:SF17. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94818-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESERDMYRQ FQDWCLRTYG DSGKTKTVTR KKYERIVQLL NGSESSSTDN
60 70 80 90 100
AKFKFWVKSK GFQLGQPDEV RGGGGGAKQV LYVPVKTTDG VGVDEKLSLR
110 120 130 140 150
RVAVVEDFFD IIYSMHVETG PNGEQIRKHA GQKRTYKAIS ESYAFLPREA
160 170 180 190 200
VTRFLMSCSE CQKRMHLNPD GTDHKDNGKP PTLVTSMIDY NMPITMAYMK
210 220 230 240 250
HMKLQLLNSQ QDEDESSIES DEFDMSDSTR MSAVNSDLSS NLEERMQSPQ
260 270 280 290 300
NLHGQQDDDS AAESFNGNET LGHSSIASGG THSREMGDSN SDGKTGLEQD
310 320 330 340 350
EQPLNLSDSP LSAQLTSEYR IDDHNSNGKN KYKNLLISDL KMEREARENG
360 370 380 390 400
SKSPAHSYSS YDSGKNESVD RGAEDLSLNR GDEDEDDHED HDDSEKVNET
410 420 430 440 450
DGVEAERLKA FNMFVRLFVD ENLDRMVPIS KQPKEKIQAI IDSCRRQFPE
460 470 480 490 500
YQERARKRIR TYLKSCRRMK RSGFEMSRPI PSHLTSAVAE SILASACESE
510 520 530 540 550
SRNAAKRMRL ERQQDESAPA DKQCKPEATQ ATYSTSAVPG SQDVLYINGN
560 570 580 590 600
GTYSYHSYRG LGGGLLNLND ASSSGPTDLS MKRQLATSSG SSSSSNSRPQ
610 620 630
LSPTEINAVR QLVAGYRESA AFLLRSADEL ENLILQQN
Length:638
Mass (Da):71,357
Last modified:April 5, 2011 - v2
Checksum:i02DF0130F10E0B3F
GO
Isoform 2 (identifier: O94818-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     413-514: Missing.

Show »
Length:536
Mass (Da):59,300
Checksum:i3264872F49A76C1C
GO
Isoform 3 (identifier: O94818-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: MESERDMYRQ...KQVLYVPVKT → MADLMQETFLHHA

Note: No experimental confirmation available.
Show »
Length:564
Mass (Da):62,970
Checksum:iF9F37733388F664D
GO
Isoform 4 (identifier: O94818-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-285: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):39,293
Checksum:i3CF8C54C76B703FA
GO

Sequence cautioni

The sequence AAH00313 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAA34576 differs from that shown. Reason: Frameshift at position 82. Curated
The sequence BAA34576 differs from that shown. Reason: Erroneous termination at position 38. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti637 – 6371Q → H in BAH12383 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 285285Missing in isoform 4. 1 PublicationVSP_045836Add
BLAST
Alternative sequencei1 – 8787MESER…VPVKT → MADLMQETFLHHA in isoform 3. 1 PublicationVSP_043344Add
BLAST
Alternative sequencei413 – 514102Missing in isoform 2. 3 PublicationsVSP_010080Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017800 mRNA. Translation: BAA34576.1. Sequence problems.
AK296539 mRNA. Translation: BAH12383.1.
AK299850 mRNA. Translation: BAG61712.1.
AC010798 Genomic DNA. No translation available.
AC018972 Genomic DNA. No translation available.
AC087397 Genomic DNA. No translation available.
AC104985 Genomic DNA. No translation available.
BC000313 mRNA. Translation: AAH00313.1. Sequence problems.
BT006763 mRNA. Translation: AAP35409.1.
CR456730 mRNA. Translation: CAG33011.1.
AB015339 mRNA. Translation: BAA34797.1.
CCDSiCCDS11907.2. [O94818-1]
CCDS56058.1. [O94818-4]
CCDS56059.1. [O94818-3]
CCDS59308.1. [O94818-2]
PIRiJE0335.
RefSeqiNP_001185475.1. NM_001198546.1.
NP_001185476.1. NM_001198547.1. [O94818-3]
NP_001185477.1. NM_001198548.1. [O94818-2]
NP_001185478.1. NM_001198549.1. [O94818-4]
NP_001269456.1. NM_001282527.1.
NP_003778.2. NM_003787.4. [O94818-1]
XP_006722626.1. XM_006722563.2. [O94818-1]
XP_011524539.1. XM_011526237.1. [O94818-1]
XP_011524540.1. XM_011526238.1.
UniGeneiHs.514795.

Genome annotation databases

EnsembliENST00000261592; ENSP00000261592; ENSG00000101746. [O94818-1]
ENST00000535384; ENSP00000445733; ENSG00000101746. [O94818-4]
ENST00000538587; ENSP00000443472; ENSG00000101746. [O94818-3]
ENST00000589544; ENSP00000465450; ENSG00000101746. [O94818-2]
GeneIDi8715.
KEGGihsa:8715.
UCSCiuc002kxt.5. human. [O94818-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017800 mRNA. Translation: BAA34576.1. Sequence problems.
AK296539 mRNA. Translation: BAH12383.1.
AK299850 mRNA. Translation: BAG61712.1.
AC010798 Genomic DNA. No translation available.
AC018972 Genomic DNA. No translation available.
AC087397 Genomic DNA. No translation available.
AC104985 Genomic DNA. No translation available.
BC000313 mRNA. Translation: AAH00313.1. Sequence problems.
BT006763 mRNA. Translation: AAP35409.1.
CR456730 mRNA. Translation: CAG33011.1.
AB015339 mRNA. Translation: BAA34797.1.
CCDSiCCDS11907.2. [O94818-1]
CCDS56058.1. [O94818-4]
CCDS56059.1. [O94818-3]
CCDS59308.1. [O94818-2]
PIRiJE0335.
RefSeqiNP_001185475.1. NM_001198546.1.
NP_001185476.1. NM_001198547.1. [O94818-3]
NP_001185477.1. NM_001198548.1. [O94818-2]
NP_001185478.1. NM_001198549.1. [O94818-4]
NP_001269456.1. NM_001282527.1.
NP_003778.2. NM_003787.4. [O94818-1]
XP_006722626.1. XM_006722563.2. [O94818-1]
XP_011524539.1. XM_011526237.1. [O94818-1]
XP_011524540.1. XM_011526238.1.
UniGeneiHs.514795.

3D structure databases

ProteinModelPortaliO94818.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114256. 9 interactions.
IntActiO94818. 9 interactions.
MINTiMINT-1429799.
STRINGi9606.ENSP00000261592.

PTM databases

iPTMnetiO94818.
PhosphoSiteiO94818.

Polymorphism and mutation databases

BioMutaiNOL4.

Proteomic databases

EPDiO94818.
PaxDbiO94818.
PeptideAtlasiO94818.
PRIDEiO94818.

Protocols and materials databases

DNASUi8715.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261592; ENSP00000261592; ENSG00000101746. [O94818-1]
ENST00000535384; ENSP00000445733; ENSG00000101746. [O94818-4]
ENST00000538587; ENSP00000443472; ENSG00000101746. [O94818-3]
ENST00000589544; ENSP00000465450; ENSG00000101746. [O94818-2]
GeneIDi8715.
KEGGihsa:8715.
UCSCiuc002kxt.5. human. [O94818-1]

Organism-specific databases

CTDi8715.
GeneCardsiNOL4.
HGNCiHGNC:7870. NOL4.
HPAiHPA046740.
MIMi603577. gene.
neXtProtiNX_O94818.
PharmGKBiPA31674.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEBQ. Eukaryota.
ENOG411245F. LUCA.
GeneTreeiENSGT00390000017363.
HOGENOMiHOG000220856.
HOVERGENiHBG031438.
InParanoidiO94818.
OMAiSEYRIED.
OrthoDBiEOG091G03G2.
PhylomeDBiO94818.
TreeFamiTF325594.

Miscellaneous databases

ChiTaRSiNOL4. human.
GenomeRNAii8715.
PROiO94818.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101746.
CleanExiHS_NOL4.
ExpressionAtlasiO94818. baseline and differential.
GenevisibleiO94818. HS.

Family and domain databases

InterProiIPR026747. NOL4.
[Graphical view]
PANTHERiPTHR12449:SF17. PTHR12449:SF17. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNOL4_HUMAN
AccessioniPrimary (citable) accession number: O94818
Secondary accession number(s): B4DSQ0
, B7Z3Z7, F5H1E3, Q6IBS2, Q9BWF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.