Reviewed,
UniProtKB/Swiss-Prot O94811 (TPPP_HUMAN)
Last modified
November 25, 2008.
Version 53.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tubulin polymerization-promoting protein Short name=TPPP Alternative name(s): 25 kDa brain-specific protein p25-alpha p24 p25 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 219 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Promotes in vitro the polymerization of tubulin into double-walled tubules and polymorphic aggregates or bundled stabilized microtubules blocks. When overexpressed, inhibits mitotic spindle assembly and nuclear envelope breakdown, apparently without affecting other cellular events. |
| Subunit structure | May form dimers. Binds tubulin; binding is inhibited by GTP. Interacts with GSK3 By similarity. |
| Tissue specificity | Widely expressed. |
| Post-translational modification | Phosphorylated by TPK II. Poor substrate for GSK3 By similarity. |
| Sequence similarities | Belongs to the TPPP family. |
Ontologies
Keywords | |
|---|---|
| PTM | Glycoprotein Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | microtubule bundle formation Inferred from sequence or structural similarity. Source: HGNC microtubule polymerizationInferred from sequence or structural similarity. Source: HGNC positive regulation of protein polymerizationInferred from direct assay. Source: HGNC |
| Cellular component | perinuclear region of cytoplasm Inferred from direct assay. Source: HGNC soluble fractionInferred from sequence or structural similarity. Source: HGNC |
| Molecular function | microtubule binding Inferred from sequence or structural similarity. Source: HGNC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 219 | 219 | Tubulin polymerization-promoting protein | PRO_0000221135 | |||||
Amino acid modifications | |||||||||
| Modified residue | 14 | 1 | Phosphothreonine | ||||||
| Modified residue | 18 | 1 | Phosphoserine | ||||||
| Modified residue | 32 | 1 | Phosphoserine | ||||||
| Glycosylation | 152 | 1 | O-linked (GlcNAc) By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3." Seki N., Hattori A., Sugano S., Suzuki Y., Nakagawara A., Muramatsu M.-A., Hori T.-A., Saito T. J. Hum. Genet. 44:121-122(1999) [PubMed: 10083737] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Neuroblastoma. |
| [2] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [4] | "Phosphoproteomic analysis of synaptosomes from human cerebral cortex." DeGiorgis J.A., Jaffe H., Moreira J.E., Carlotti C.G. Jr., Leite J.P., Pant H.C., Dosemeci A. J. Proteome Res. 4:306-315(2005) [PubMed: 15822905] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14 AND SER-18, MASS SPECTROMETRY. Tissue: Brain cortex. |
| [5] | "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB017016 mRNA. Translation: BAA36164.1. BT020035 mRNA. Translation: AAV38838.1. BC040496 mRNA. Translation: AAH40496.1. Different initiation. | |
| RefSeq | NP_008961.1. |
| UniGene | Hs.481466 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | O94811. |
Genome annotation databases | |
| Ensembl | ENSG00000171368. Homo sapiens. [Contig view] |
| GeneID | 11076. |
| KEGG | hsa:11076. |
Organism-specific databases | |
| H-InvDB | HIX0004710. |
| HGNC | HGNC:24164. TPPP. |
| MIM | 608773. gene. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | O94811. |
| HOVERGEN | O94811. |
Gene expression databases | |
| ArrayExpress | O94811. |
| CleanEx | HS_TPPP. |
Family and domain databases | |
| InterPro | IPR008907. P25-alpha. [Graphical view] |
| PANTHER | PTHR12932. P25-alpha. 1 hit. |
| Pfam | PF05517. p25-alpha. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | O94811. |
| NextBio | 42106. |
| SOURCE | Search... |
Entry information
| Entry name | TPPP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O94811 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


