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Protein

Tubulin polymerization-promoting protein

Gene

TPPP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.3 Publications

Miscellaneous

Unstructured protein. Interacts with aggregated SNCA and may have a pro-aggregatory role in synucleinopathies.

GO - Molecular functioni

  • microtubule binding Source: HGNC
  • tubulin binding Source: UniProtKB

GO - Biological processi

  • microtubule bundle formation Source: UniProtKB
  • microtubule polymerization Source: UniProtKB
  • positive regulation of protein complex assembly Source: HGNC
  • positive regulation of protein polymerization Source: HGNC

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin polymerization-promoting protein
Short name:
TPPP
Alternative name(s):
25 kDa brain-specific protein
TPPP/p25
p24
p25-alpha
Gene namesi
Name:TPPP
Synonyms:TPPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000171368.11.
HGNCiHGNC:24164. TPPP.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11076.
OpenTargetsiENSG00000171368.
PharmGKBiPA162406809.

Polymorphism and mutation databases

BioMutaiTPPP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211351 – 219Tubulin polymerization-promoting proteinAdd BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14Phosphothreonine; by CDK5; in vitroCombined sources1 Publication1
Modified residuei18Phosphoserine; by CDK5 and MAPK1; in vitroCombined sources1 Publication1
Modified residuei32Phosphoserine; by PKA; in vitroCombined sources1 Publication1
Modified residuei35PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei92Phosphothreonine; by PKA; in vitro1 Publication1
Glycosylationi152O-linked (GlcNAc) serineBy similarity1
Modified residuei159Phosphoserine; by PKA; in vitroCombined sources1 Publication1
Modified residuei160Phosphoserine; by CDK5 and MAPK1; in vitro1 Publication1

Post-translational modificationi

Poor substrate for GSK3 (By similarity). Phosphorylated by LIMK1 on serine residues. Phosphorylation may alter the tubulin polymerization activity.By similarity2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO94811.
PaxDbiO94811.
PeptideAtlasiO94811.
PRIDEiO94811.

2D gel databases

UCD-2DPAGEiO94811.

PTM databases

iPTMnetiO94811.
PhosphoSitePlusiO94811.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000171368.
CleanExiHS_TPPP.
ExpressionAtlasiO94811. baseline and differential.
GenevisibleiO94811. HS.

Organism-specific databases

HPAiHPA036575.
HPA036576.

Interactioni

Subunit structurei

Homodimer. Binds tubulin; binding is inhibited by GTP (By similarity). Interacts with GSK3 (By similarity). Interacts with MAPK1 (By similarity). Interacts with GAPDH; the interaction is direct (By similarity). Interacts with LIMK1 (via the PDZ domain); the interaction is direct.By similarity2 Publications

GO - Molecular functioni

  • microtubule binding Source: HGNC
  • tubulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116259. 12 interactors.
IntActiO94811. 3 interactors.
MINTiMINT-2798227.
STRINGi9606.ENSP00000353785.

Chemistry databases

BindingDBiO94811.

Structurei

3D structure databases

ProteinModelPortaliO94811.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 116Mediates interaction with LIMK11 PublicationAdd BLAST116

Sequence similaritiesi

Belongs to the TPPP family.Curated

Phylogenomic databases

eggNOGiKOG4070. Eukaryota.
ENOG4111H9J. LUCA.
GeneTreeiENSGT00390000014993.
HOGENOMiHOG000260314.
HOVERGENiHBG036683.
InParanoidiO94811.
OMAiFRRFAIH.
OrthoDBiEOG091G0PC4.
PhylomeDBiO94811.
TreeFamiTF314440.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR008907. P25-alpha.
IPR030792. TPPP1.
PANTHERiPTHR12932. PTHR12932. 1 hit.
PTHR12932:SF18. PTHR12932:SF18. 1 hit.
PfamiView protein in Pfam
PF05517. p25-alpha. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.

Sequencei

Sequence statusi: Complete.

O94811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKAKPAKA ANRTPPKSPG DPSKDRAAKR LSLESEGAGE GAAASPELSA
60 70 80 90 100
LEEAFRRFAV HGDARATGRE MHGKNWSKLC KDCQVIDGRN VTVTDVDIVF
110 120 130 140 150
SKIKGKSCRT ITFEQFQEAL EELAKKRFKD KSSEEAVREV HRLIEGKAPI
160 170 180 190 200
ISGVTKAISS PTVSRLTDTT KFTGSHKERF DPSGKGKGKA GRVDLVDESG
210
YVSGYKHAGT YDQKVQGGK
Length:219
Mass (Da):23,694
Last modified:May 1, 1999 - v1
Checksum:iF8B2C814EA59129A
GO

Sequence cautioni

O94811: The sequence AAH40496 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017016 mRNA. Translation: BAA36164.1.
BT020035 mRNA. Translation: AAV38838.1.
BC040496 mRNA. Translation: AAH40496.1. Different initiation.
CCDSiCCDS3856.1.
RefSeqiNP_008961.1. NM_007030.2.
XP_005248294.2. XM_005248237.3.
XP_016864483.1. XM_017008994.1.
UniGeneiHs.481466.

Genome annotation databases

EnsembliENST00000360578; ENSP00000353785; ENSG00000171368.
GeneIDi11076.
KEGGihsa:11076.

Similar proteinsi

Entry informationi

Entry nameiTPPP_HUMAN
AccessioniPrimary (citable) accession number: O94811
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families