Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O94810 (RGS11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 11

Short name=RGS11
Gene names
Name:RGS11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Subunit structure

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 By similarity. Ref.6

Sequence similarities

Contains 1 DEP domain.

Contains 1 G protein gamma domain.

Contains 1 RGS domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O94810-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O94810-2)

The sequence of this isoform differs from the canonical sequence as follows:
     107-123: TPYFWTSTLRPAAELDY → VRLGGA
Isoform 3 (identifier: O94810-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 467467Regulator of G-protein signaling 11
PRO_0000204210

Regions

Domain32 – 10776DEP
Domain219 – 28264G protein gamma
Domain299 – 414116RGS

Natural variations

Alternative sequence1 – 2121Missing in isoform 3.
VSP_046724
Alternative sequence107 – 12317TPYFW…AELDY → VRLGGA in isoform 2.
VSP_023497
Natural variant3511V → M.
Corresponds to variant rs9806942 [ dbSNP | Ensembl ].
VAR_061770
Natural variant4271M → T.
Corresponds to variant rs739999 [ dbSNP | Ensembl ].
VAR_024606

Experimental info

Mutagenesis2451S → A: Diminishes interaction with Gbeta5. Ref.6
Mutagenesis2741W → F: Diminishes interaction with Gbeta5. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 46BEE11D77C2C5F7

FASTA46752,946
        10         20         30         40         50         60 
MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH AVTGSDVVQW 

        70         80         90        100        110        120 
LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE TPYRFQTPYF WTSTLRPAAE 

       130        140        150        160        170        180 
LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH KKINHAWDLV LMQAREQLRA AKQRSKGDRL 

       190        200        210        220        230        240 
VIACQEQTYW LVNRPPPGAP DVLEQGPGRG SCAASRVLMT KSADFHKREI EYFRKALGRT 

       250        260        270        280        290        300 
RVKSSVCLEA YLSFCGQRGP HDPLVSGCLP SNPWISDNDA YWVMNAPTVA APTKLRVERW 

       310        320        330        340        350        360 
GFSFRELLED PVGRAHFMDF LGKEFSGENL SFWEACEELR YGAQAQVPTL VDAVYEQFLA 

       370        380        390        400        410        420 
PGAAHWVNID SRTMEQTLEG LRQPHRYVLD DAQLHIYMLM KKDSYPRFLK SDMYKALLAE 

       430        440        450        460 
AGIPLEMKRR VFPFTWRPRH SSPSPALLPT PVEPTAACGP GGGDGVA 

« Hide

Isoform 2 [UniParc].

Checksum: CC4FA2BBE9C4D806
Show »

FASTA45651,486
Isoform 3 [UniParc].

Checksum: 87DEC7BDFE8E2693
Show »

FASTA44650,727

References

« Hide 'large scale' references
[1]"Homo sapiens regulator of G-protein signaling 11 (RGS11)."
Saito T., Seki N., Miyajima N.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Brain and Testis.
[2]"A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits."
Snow B.E., Krumins A.M., Brothers G.M., Lee S.-F., Wall M.A., Chung S., Mangion J., Arya S., Gilman A.G., Siderovski D.P.
Proc. Natl. Acad. Sci. U.S.A. 95:13307-13312(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
[3]"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11."
Snow B.E., Betts L., Mangion J., Sondek J., Siderovski D.P.
Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GBETA5, MUTAGENESIS OF SER-245 AND TRP-274.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB016929 mRNA. Translation: BAA74751.1.
AF035153 mRNA. Translation: AAC69175.1.
AF035154 mRNA. Translation: AAC69176.1.
AE006463 Genomic DNA. Translation: AAK61221.1.
Z69667, AC004754 Genomic DNA. Translation: CAI95581.1.
Z69667, AC004754 Genomic DNA. Translation: CAI95582.1.
CH471112 Genomic DNA. Translation: EAW85839.1.
RefSeqNP_001273414.1. NM_001286485.1.
NP_001273415.1. NM_001286486.1.
NP_003825.1. NM_003834.2.
NP_899180.1. NM_183337.2.
UniGeneHs.65756.

3D structure databases

ProteinModelPortalO94810.
SMRO94810. Positions 11-424.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114314. 3 interactions.
IntActO94810. 2 interactions.
STRING9606.ENSP00000380876.

PTM databases

PhosphoSiteO94810.

Proteomic databases

PaxDbO94810.
PRIDEO94810.

Protocols and materials databases

DNASU8786.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316163; ENSP00000319069; ENSG00000076344. [O94810-3]
ENST00000359740; ENSP00000352778; ENSG00000076344. [O94810-2]
ENST00000397770; ENSP00000380876; ENSG00000076344. [O94810-1]
GeneID8786.
KEGGhsa:8786.
UCSCuc002cgi.1. human. [O94810-1]
uc010bqs.1. human. [O94810-2]

Organism-specific databases

CTD8786.
GeneCardsGC16M000318.
HGNCHGNC:9993. RGS11.
HPAHPA041692.
HPA043039.
MIM603895. gene.
neXtProtNX_O94810.
PharmGKBPA34363.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327614.
HOGENOMHOG000220864.
HOVERGENHBG007404.
InParanoidO94810.
KOK16449.
OMALKSDMYK.
OrthoDBEOG7BZVS5.
PhylomeDBO94810.
TreeFamTF351956.

Gene expression databases

ArrayExpressO94810.
BgeeO94810.
CleanExHS_RGS11.
GenevestigatorO94810.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRGS11. human.
GeneWikiRGS11.
GenomeRNAi8786.
NextBio32948.
PROO94810.
SOURCESearch...

Entry information

Entry nameRGS11_HUMAN
AccessionPrimary (citable) accession number: O94810
Secondary accession number(s): O75883, Q4TT71, Q4TT72
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: April 16, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM