Reviewed,
UniProtKB/Swiss-Prot O94810 (RGS11_HUMAN)
Last modified
November 25, 2008.
Version 70.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Regulator of G-protein signaling 11 Short name=RGS11 | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 467 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. |
| Subunit structure | Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 By similarity. |
| Sequence similarities | Contains 1 DEP domain. Contains 1 G protein gamma domain. Contains 1 RGS domain. |
Ontologies
Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing Polymorphism |
| Molecular function | Signal transduction inhibitor |
Gene Ontology (GO) | |
| Biological process | intracellular signaling cascade Inferred from electronic annotation. Source: InterPro negative regulation of signal transductionInferred from electronic annotation. Source: UniProtKB-KW regulation of G-protein coupled receptor protein signaling pathway Ref.2Traceable author statement. Source: ProtInc |
| Cellular component | heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | GTPase activator activity Ref.2 Traceable author statement. Source: ProtInc signal transducer activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: O94810-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: O94810-2) The sequence of this isoform differs from the canonical sequence as follows: 107-123: TPYFWTSTLRPAAELDY → VRLGGA |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 467 | 467 | Regulator of G-protein signaling 11 | PRO_0000204210 | |||||
Regions | |||||||||
| Domain | 32 – 107 | 76 | DEP | ||||||
| Domain | 219 – 282 | 64 | G protein gamma | ||||||
| Domain | 299 – 414 | 116 | RGS | ||||||
Natural variations | |||||||||
| Alternative sequence | 107 – 123 | 17 | TPYFW…AELDY → VRLGGA in isoform 2. | VSP_023497 | |||||
| Natural variant | 427 | 1 | M → T: dbSNP rs739999. | VAR_024606 | |||||
Experimental info | |||||||||
| Mutagenesis | 245 | 1 | S → A: Diminishes interaction with Gbeta5 | ||||||
| Mutagenesis | 274 | 1 | W → F: Diminishes interaction with Gbeta5 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Homo sapiens regulator of G-protein signaling 11 (RGS11)." Saito T., Seki N., Miyajima N. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain and Testis. |
| [2] | "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits." Snow B.E., Krumins A.M., Brothers G.M., Lee S.-F., Wall M.A., Chung S., Mangion J., Arya S., Gilman A.G., Siderovski D.P. Proc. Natl. Acad. Sci. U.S.A. 95:13307-13312(1998) [PubMed: 9789084] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). |
| [3] | "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. Pennacchio L.A.Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11." Snow B.E., Betts L., Mangion J., Sondek J., Siderovski D.P. Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999) [PubMed: 10339615] [Abstract] Cited for: INTERACTION WITH GBETA5, MUTAGENESIS OF SER-245 AND TRP-274. |
Cross-references
Sequence databases | |
|---|---|
| AB016929 mRNA. Translation: BAA74751.1. AF035153 mRNA. Translation: AAC69175.1. AF035154 mRNA. Translation: AAC69176.1. AE006463 Genomic DNA. Translation: AAK61221.1. Z69667, AC004754 Genomic DNA. Translation: CAI95582.1. | |
| RefSeq | NP_003825.1. NP_899180.1. |
| UniGene | Hs.65756 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FQI based on UniProtKB O46469. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | O94810. |
Genome annotation databases | |
| Ensembl | ENSG00000076344. Homo sapiens. [Contig view] |
| GeneID | 8786. |
| KEGG | hsa:8786. |
Organism-specific databases | |
| HGNC | HGNC:9993. RGS11. |
| MIM | 603895. gene. |
| PharmGKB | PA34363. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | O94810. |
Gene expression databases | |
| ArrayExpress | O94810. |
| CleanEx | HS_RGS11. |
| GermOnline | ENSG00000076344. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000591. DEP. IPR015898. G-protein_gamma-like. IPR001770. Gprotein-gamma. IPR000342. Regulat_G_prot_signal. IPR011991. Wing_hlx_DNA_bd. [Graphical view] |
| Gene3D | G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit. |
| Pfam | PF00610. DEP. 1 hit. PF00631. G-gamma. 1 hit. PF00615. RGS. 1 hit. [Graphical view] |
| PRINTS | PR01301. RGSPROTEIN. |
| ProDom | PD001580. Regl_Gprotein. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00049. DEP. 1 hit. SM00224. GGL. 1 hit. SM00315. RGS. 1 hit. [Graphical view] |
| PROSITE | PS50186. DEP. 1 hit. PS50058. G_PROTEIN_GAMMA. False negative. PS50132. RGS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 32948. |
| SOURCE | Search... |
Entry information
| Entry name | RGS11_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O94810 Secondary accession number(s): O75883, Q4TT71 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


