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O94810

- RGS11_HUMAN

UniProt

O94810 - RGS11_HUMAN

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Protein

Regulator of G-protein signaling 11

Gene

RGS11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

GO - Molecular functioni

  1. G-protein beta-subunit binding Source: UniProt
  2. GTPase activator activity Source: RefGenome
  3. signal transducer activity Source: InterPro

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: InterPro
  2. intracellular signal transduction Source: InterPro
  3. positive regulation of GTPase activity Source: GOC
  4. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
  5. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 11
Short name:
RGS11
Gene namesi
Name:RGS11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:9993. RGS11.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. dendrite terminus Source: Ensembl
  3. heterotrimeric G-protein complex Source: InterPro
  4. plasma membrane Source: RefGenome
  5. protein complex Source: MGI
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi245 – 2451S → A: Diminishes interaction with Gbeta5. 1 Publication
Mutagenesisi274 – 2741W → F: Diminishes interaction with Gbeta5. 1 Publication

Organism-specific databases

PharmGKBiPA34363.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Regulator of G-protein signaling 11PRO_0000204210Add
BLAST

Proteomic databases

PaxDbiO94810.
PRIDEiO94810.

PTM databases

PhosphoSiteiO94810.

Expressioni

Gene expression databases

BgeeiO94810.
CleanExiHS_RGS11.
ExpressionAtlasiO94810. baseline and differential.
GenevestigatoriO94810.

Organism-specific databases

HPAiHPA041692.
HPA043039.

Interactioni

Subunit structurei

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).By similarity

Protein-protein interaction databases

BioGridi114314. 4 interactions.
IntActiO94810. 2 interactions.
STRINGi9606.ENSP00000380876.

Structurei

3D structure databases

ProteinModelPortaliO94810.
SMRiO94810. Positions 11-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 10776DEPPROSITE-ProRule annotationAdd
BLAST
Domaini219 – 28264G protein gammaAdd
BLAST
Domaini299 – 414116RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 G protein gamma domain.Curated
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG327614.
GeneTreeiENSGT00760000119142.
HOGENOMiHOG000220864.
HOVERGENiHBG007404.
InParanoidiO94810.
KOiK16449.
OMAiMQDPDMG.
OrthoDBiEOG7BZVS5.
PhylomeDBiO94810.
TreeFamiTF351956.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O94810-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH
60 70 80 90 100
AVTGSDVVQW LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE
110 120 130 140 150
TPYRFQTPYF WTSTLRPAAE LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH
160 170 180 190 200
KKINHAWDLV LMQAREQLRA AKQRSKGDRL VIACQEQTYW LVNRPPPGAP
210 220 230 240 250
DVLEQGPGRG SCAASRVLMT KSADFHKREI EYFRKALGRT RVKSSVCLEA
260 270 280 290 300
YLSFCGQRGP HDPLVSGCLP SNPWISDNDA YWVMNAPTVA APTKLRVERW
310 320 330 340 350
GFSFRELLED PVGRAHFMDF LGKEFSGENL SFWEACEELR YGAQAQVPTL
360 370 380 390 400
VDAVYEQFLA PGAAHWVNID SRTMEQTLEG LRQPHRYVLD DAQLHIYMLM
410 420 430 440 450
KKDSYPRFLK SDMYKALLAE AGIPLEMKRR VFPFTWRPRH SSPSPALLPT
460
PVEPTAACGP GGGDGVA
Length:467
Mass (Da):52,946
Last modified:July 15, 1999 - v2
Checksum:i46BEE11D77C2C5F7
GO
Isoform 2 (identifier: O94810-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-123: TPYFWTSTLRPAAELDY → VRLGGA

Show »
Length:456
Mass (Da):51,486
Checksum:iCC4FA2BBE9C4D806
GO
Isoform 3 (identifier: O94810-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:446
Mass (Da):50,727
Checksum:i87DEC7BDFE8E2693
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti351 – 3511V → M.
Corresponds to variant rs9806942 [ dbSNP | Ensembl ].
VAR_061770
Natural varianti427 – 4271M → T.
Corresponds to variant rs739999 [ dbSNP | Ensembl ].
VAR_024606

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2121Missing in isoform 3. 1 PublicationVSP_046724Add
BLAST
Alternative sequencei107 – 12317TPYFW…AELDY → VRLGGA in isoform 2. 1 PublicationVSP_023497Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016929 mRNA. Translation: BAA74751.1.
AF035153 mRNA. Translation: AAC69175.1.
AF035154 mRNA. Translation: AAC69176.1.
AE006463 Genomic DNA. Translation: AAK61221.1.
Z69667, AC004754 Genomic DNA. Translation: CAI95581.1.
Z69667, AC004754 Genomic DNA. Translation: CAI95582.1.
CH471112 Genomic DNA. Translation: EAW85839.1.
CCDSiCCDS10403.1. [O94810-3]
CCDS42088.1. [O94810-1]
CCDS66884.1. [O94810-2]
RefSeqiNP_001273414.1. NM_001286485.1. [O94810-2]
NP_001273415.1. NM_001286486.1.
NP_003825.1. NM_003834.2. [O94810-3]
NP_899180.1. NM_183337.2. [O94810-1]
UniGeneiHs.65756.

Genome annotation databases

EnsembliENST00000316163; ENSP00000319069; ENSG00000076344. [O94810-3]
ENST00000359740; ENSP00000352778; ENSG00000076344. [O94810-2]
ENST00000397770; ENSP00000380876; ENSG00000076344. [O94810-1]
GeneIDi8786.
KEGGihsa:8786.
UCSCiuc002cgi.1. human. [O94810-1]
uc010bqs.1. human. [O94810-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016929 mRNA. Translation: BAA74751.1 .
AF035153 mRNA. Translation: AAC69175.1 .
AF035154 mRNA. Translation: AAC69176.1 .
AE006463 Genomic DNA. Translation: AAK61221.1 .
Z69667 , AC004754 Genomic DNA. Translation: CAI95581.1 .
Z69667 , AC004754 Genomic DNA. Translation: CAI95582.1 .
CH471112 Genomic DNA. Translation: EAW85839.1 .
CCDSi CCDS10403.1. [O94810-3 ]
CCDS42088.1. [O94810-1 ]
CCDS66884.1. [O94810-2 ]
RefSeqi NP_001273414.1. NM_001286485.1. [O94810-2 ]
NP_001273415.1. NM_001286486.1.
NP_003825.1. NM_003834.2. [O94810-3 ]
NP_899180.1. NM_183337.2. [O94810-1 ]
UniGenei Hs.65756.

3D structure databases

ProteinModelPortali O94810.
SMRi O94810. Positions 11-424.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114314. 4 interactions.
IntActi O94810. 2 interactions.
STRINGi 9606.ENSP00000380876.

PTM databases

PhosphoSitei O94810.

Proteomic databases

PaxDbi O94810.
PRIDEi O94810.

Protocols and materials databases

DNASUi 8786.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316163 ; ENSP00000319069 ; ENSG00000076344 . [O94810-3 ]
ENST00000359740 ; ENSP00000352778 ; ENSG00000076344 . [O94810-2 ]
ENST00000397770 ; ENSP00000380876 ; ENSG00000076344 . [O94810-1 ]
GeneIDi 8786.
KEGGi hsa:8786.
UCSCi uc002cgi.1. human. [O94810-1 ]
uc010bqs.1. human. [O94810-2 ]

Organism-specific databases

CTDi 8786.
GeneCardsi GC16M000318.
HGNCi HGNC:9993. RGS11.
HPAi HPA041692.
HPA043039.
MIMi 603895. gene.
neXtProti NX_O94810.
PharmGKBi PA34363.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327614.
GeneTreei ENSGT00760000119142.
HOGENOMi HOG000220864.
HOVERGENi HBG007404.
InParanoidi O94810.
KOi K16449.
OMAi MQDPDMG.
OrthoDBi EOG7BZVS5.
PhylomeDBi O94810.
TreeFami TF351956.

Enzyme and pathway databases

Reactomei REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSi RGS11. human.
GeneWikii RGS11.
GenomeRNAii 8786.
NextBioi 32948.
PROi O94810.
SOURCEi Search...

Gene expression databases

Bgeei O94810.
CleanExi HS_RGS11.
ExpressionAtlasi O94810. baseline and differential.
Genevestigatori O94810.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens regulator of G-protein signaling 11 (RGS11)."
    Saito T., Seki N., Miyajima N.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain and Testis.
  2. "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits."
    Snow B.E., Krumins A.M., Brothers G.M., Lee S.-F., Wall M.A., Chung S., Mangion J., Arya S., Gilman A.G., Siderovski D.P.
    Proc. Natl. Acad. Sci. U.S.A. 95:13307-13312(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
  3. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11."
    Snow B.E., Betts L., Mangion J., Sondek J., Siderovski D.P.
    Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GBETA5, MUTAGENESIS OF SER-245 AND TRP-274.

Entry informationi

Entry nameiRGS11_HUMAN
AccessioniPrimary (citable) accession number: O94810
Secondary accession number(s): O75883, Q4TT71, Q4TT72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: October 29, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3