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Protein

Regulator of G-protein signaling 11

Gene

RGS11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

GO - Molecular functioni

  • G-protein beta-subunit binding Source: UniProtKB
  • GTPase activator activity Source: ProtInc
  • signal transducer activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 11
Short name:
RGS11
Gene namesi
Name:RGS11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:9993. RGS11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi245 – 2451S → A: Diminishes interaction with Gbeta5. 1 Publication
Mutagenesisi274 – 2741W → F: Diminishes interaction with Gbeta5. 1 Publication

Organism-specific databases

PharmGKBiPA34363.

Polymorphism and mutation databases

BioMutaiRGS11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Regulator of G-protein signaling 11PRO_0000204210Add
BLAST

Proteomic databases

PaxDbiO94810.
PRIDEiO94810.

PTM databases

PhosphoSiteiO94810.

Expressioni

Gene expression databases

BgeeiO94810.
CleanExiHS_RGS11.
ExpressionAtlasiO94810. baseline and differential.
GenevisibleiO94810. HS.

Organism-specific databases

HPAiHPA041692.
HPA043039.

Interactioni

Subunit structurei

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).By similarity

Protein-protein interaction databases

BioGridi114314. 4 interactions.
IntActiO94810. 2 interactions.
STRINGi9606.ENSP00000380876.

Structurei

3D structure databases

ProteinModelPortaliO94810.
SMRiO94810. Positions 11-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 10776DEPPROSITE-ProRule annotationAdd
BLAST
Domaini219 – 28264G protein gammaAdd
BLAST
Domaini299 – 414116RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 G protein gamma domain.Curated
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG327614.
GeneTreeiENSGT00760000119142.
HOGENOMiHOG000220864.
HOVERGENiHBG007404.
InParanoidiO94810.
KOiK16449.
OMAiFPFMRRQ.
OrthoDBiEOG7BZVS5.
PhylomeDBiO94810.
TreeFamiTF351956.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94810-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH
60 70 80 90 100
AVTGSDVVQW LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE
110 120 130 140 150
TPYRFQTPYF WTSTLRPAAE LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH
160 170 180 190 200
KKINHAWDLV LMQAREQLRA AKQRSKGDRL VIACQEQTYW LVNRPPPGAP
210 220 230 240 250
DVLEQGPGRG SCAASRVLMT KSADFHKREI EYFRKALGRT RVKSSVCLEA
260 270 280 290 300
YLSFCGQRGP HDPLVSGCLP SNPWISDNDA YWVMNAPTVA APTKLRVERW
310 320 330 340 350
GFSFRELLED PVGRAHFMDF LGKEFSGENL SFWEACEELR YGAQAQVPTL
360 370 380 390 400
VDAVYEQFLA PGAAHWVNID SRTMEQTLEG LRQPHRYVLD DAQLHIYMLM
410 420 430 440 450
KKDSYPRFLK SDMYKALLAE AGIPLEMKRR VFPFTWRPRH SSPSPALLPT
460
PVEPTAACGP GGGDGVA
Length:467
Mass (Da):52,946
Last modified:July 15, 1999 - v2
Checksum:i46BEE11D77C2C5F7
GO
Isoform 2 (identifier: O94810-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-123: TPYFWTSTLRPAAELDY → VRLGGA

Show »
Length:456
Mass (Da):51,486
Checksum:iCC4FA2BBE9C4D806
GO
Isoform 3 (identifier: O94810-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:446
Mass (Da):50,727
Checksum:i87DEC7BDFE8E2693
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti351 – 3511V → M.
Corresponds to variant rs9806942 [ dbSNP | Ensembl ].
VAR_061770
Natural varianti427 – 4271M → T.
Corresponds to variant rs739999 [ dbSNP | Ensembl ].
VAR_024606

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2121Missing in isoform 3. 1 PublicationVSP_046724Add
BLAST
Alternative sequencei107 – 12317TPYFW…AELDY → VRLGGA in isoform 2. 1 PublicationVSP_023497Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016929 mRNA. Translation: BAA74751.1.
AF035153 mRNA. Translation: AAC69175.1.
AF035154 mRNA. Translation: AAC69176.1.
AE006463 Genomic DNA. Translation: AAK61221.1.
Z69667, AC004754 Genomic DNA. Translation: CAI95581.1.
Z69667, AC004754 Genomic DNA. Translation: CAI95582.1.
CH471112 Genomic DNA. Translation: EAW85839.1.
CCDSiCCDS10403.1. [O94810-3]
CCDS42088.1. [O94810-1]
CCDS66884.1. [O94810-2]
RefSeqiNP_001273414.1. NM_001286485.1. [O94810-2]
NP_001273415.1. NM_001286486.1.
NP_003825.1. NM_003834.2. [O94810-3]
NP_899180.1. NM_183337.2. [O94810-1]
UniGeneiHs.65756.

Genome annotation databases

EnsembliENST00000316163; ENSP00000319069; ENSG00000076344. [O94810-3]
ENST00000359740; ENSP00000352778; ENSG00000076344. [O94810-2]
ENST00000397770; ENSP00000380876; ENSG00000076344.
GeneIDi8786.
KEGGihsa:8786.
UCSCiuc002cgi.1. human. [O94810-1]
uc010bqs.1. human. [O94810-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016929 mRNA. Translation: BAA74751.1.
AF035153 mRNA. Translation: AAC69175.1.
AF035154 mRNA. Translation: AAC69176.1.
AE006463 Genomic DNA. Translation: AAK61221.1.
Z69667, AC004754 Genomic DNA. Translation: CAI95581.1.
Z69667, AC004754 Genomic DNA. Translation: CAI95582.1.
CH471112 Genomic DNA. Translation: EAW85839.1.
CCDSiCCDS10403.1. [O94810-3]
CCDS42088.1. [O94810-1]
CCDS66884.1. [O94810-2]
RefSeqiNP_001273414.1. NM_001286485.1. [O94810-2]
NP_001273415.1. NM_001286486.1.
NP_003825.1. NM_003834.2. [O94810-3]
NP_899180.1. NM_183337.2. [O94810-1]
UniGeneiHs.65756.

3D structure databases

ProteinModelPortaliO94810.
SMRiO94810. Positions 11-424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114314. 4 interactions.
IntActiO94810. 2 interactions.
STRINGi9606.ENSP00000380876.

PTM databases

PhosphoSiteiO94810.

Polymorphism and mutation databases

BioMutaiRGS11.

Proteomic databases

PaxDbiO94810.
PRIDEiO94810.

Protocols and materials databases

DNASUi8786.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316163; ENSP00000319069; ENSG00000076344. [O94810-3]
ENST00000359740; ENSP00000352778; ENSG00000076344. [O94810-2]
ENST00000397770; ENSP00000380876; ENSG00000076344.
GeneIDi8786.
KEGGihsa:8786.
UCSCiuc002cgi.1. human. [O94810-1]
uc010bqs.1. human. [O94810-2]

Organism-specific databases

CTDi8786.
GeneCardsiGC16M000318.
HGNCiHGNC:9993. RGS11.
HPAiHPA041692.
HPA043039.
MIMi603895. gene.
neXtProtiNX_O94810.
PharmGKBiPA34363.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG327614.
GeneTreeiENSGT00760000119142.
HOGENOMiHOG000220864.
HOVERGENiHBG007404.
InParanoidiO94810.
KOiK16449.
OMAiFPFMRRQ.
OrthoDBiEOG7BZVS5.
PhylomeDBiO94810.
TreeFamiTF351956.

Enzyme and pathway databases

ReactomeiREACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiRGS11.
GenomeRNAii8786.
NextBioi32948.
PROiO94810.
SOURCEiSearch...

Gene expression databases

BgeeiO94810.
CleanExiHS_RGS11.
ExpressionAtlasiO94810. baseline and differential.
GenevisibleiO94810. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens regulator of G-protein signaling 11 (RGS11)."
    Saito T., Seki N., Miyajima N.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain and Testis.
  2. "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits."
    Snow B.E., Krumins A.M., Brothers G.M., Lee S.-F., Wall M.A., Chung S., Mangion J., Arya S., Gilman A.G., Siderovski D.P.
    Proc. Natl. Acad. Sci. U.S.A. 95:13307-13312(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
  3. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11."
    Snow B.E., Betts L., Mangion J., Sondek J., Siderovski D.P.
    Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GBETA5, MUTAGENESIS OF SER-245 AND TRP-274.

Entry informationi

Entry nameiRGS11_HUMAN
AccessioniPrimary (citable) accession number: O94810
Secondary accession number(s): O75883, Q4TT71, Q4TT72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: July 22, 2015
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.