Reviewed, UniProtKB/Swiss-Prot O94810 (RGS11_HUMAN)

Names and origin

Protein names

Recommended name:
    Regulator of G-protein signaling 11
      Short name=RGS11

Gene names

Name:

RGS11

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
Subunit structure	Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 By similarity.
Sequence similarities	Contains 1 DEP domain. Contains 1 G protein gamma domain. Contains 1 RGS domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Signal transduction inhibitor
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro negative regulation of signal transduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of G-protein coupled receptor protein signaling pathway Ref.2 Traceable author statement. Source: ProtInc
Cellular component	heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro
Molecular function	GTPase activator activity Ref.2 Traceable author statement. Source: ProtInc signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O94810-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O94810-2)

The sequence of this isoform differs from the canonical sequence as follows:
     107-123: TPYFWTSTLRPAAELDY → VRLGGA

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Regulator of G-protein signaling 11		PRO_0000204210
Regions
	Domain	32 – 107	76	DEP
	Domain	219 – 282	64	G protein gamma
	Domain	299 – 414	116	RGS
Natural variations
	Alternative sequence	107 – 123	17	TPYFW…AELDY → VRLGGA in isoform 2.		VSP_023497
	Natural variant	427	1	M → T: dbSNP rs739999.		VAR_024606
Experimental info
	Mutagenesis	245	1	S → A: Diminishes interaction with Gbeta5
	Mutagenesis	274	1	W → F: Diminishes interaction with Gbeta5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 46BEE11D77C2C5F7	FASTA	467	52,946
	10 20 30 40 50 60 MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH AVTGSDVVQW 70 80 90 100 110 120 LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE TPYRFQTPYF WTSTLRPAAE 130 140 150 160 170 180 LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH KKINHAWDLV LMQAREQLRA AKQRSKGDRL 190 200 210 220 230 240 VIACQEQTYW LVNRPPPGAP DVLEQGPGRG SCAASRVLMT KSADFHKREI EYFRKALGRT 250 260 270 280 290 300 RVKSSVCLEA YLSFCGQRGP HDPLVSGCLP SNPWISDNDA YWVMNAPTVA APTKLRVERW 310 320 330 340 350 360 GFSFRELLED PVGRAHFMDF LGKEFSGENL SFWEACEELR YGAQAQVPTL VDAVYEQFLA 370 380 390 400 410 420 PGAAHWVNID SRTMEQTLEG LRQPHRYVLD DAQLHIYMLM KKDSYPRFLK SDMYKALLAE 430 440 450 460 AGIPLEMKRR VFPFTWRPRH SSPSPALLPT PVEPTAACGP GGGDGVA
	Isoform 2 [UniParc]. Checksum: CC4FA2BBE9C4D806		456	51,486
	10 20 30 40 50 60 MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH AVTGSDVVQW 70 80 90 100 110 120 LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE TPYRFQVRLG GAAIYLAKKN 130 140 150 160 170 180 IRKRGTLVDY EKDCYDRLHK KINHAWDLVL MQAREQLRAA KQRSKGDRLV IACQEQTYWL 190 200 210 220 230 240 VNRPPPGAPD VLEQGPGRGS CAASRVLMTK SADFHKREIE YFRKALGRTR VKSSVCLEAY 250 260 270 280 290 300 LSFCGQRGPH DPLVSGCLPS NPWISDNDAY WVMNAPTVAA PTKLRVERWG FSFRELLEDP 310 320 330 340 350 360 VGRAHFMDFL GKEFSGENLS FWEACEELRY GAQAQVPTLV DAVYEQFLAP GAAHWVNIDS 370 380 390 400 410 420 RTMEQTLEGL RQPHRYVLDD AQLHIYMLMK KDSYPRFLKS DMYKALLAEA GIPLEMKRRV 430 440 450 FPFTWRPRHS SPSPALLPTP VEPTAACGPG GGDGVA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens regulator of G-protein signaling 11 (RGS11)." Saito T., Seki N., Miyajima N. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain and Testis.
[2]	"A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits." Snow B.E., Krumins A.M., Brothers G.M., Lee S.-F., Wall M.A., Chung S., Mangion J., Arya S., Gilman A.G., Siderovski D.P. Proc. Natl. Acad. Sci. U.S.A. 95:13307-13312(1998) [PubMed: 9789084] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11." Snow B.E., Betts L., Mangion J., Sondek J., Siderovski D.P. Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999) [PubMed: 10339615] [Abstract] Cited for: INTERACTION WITH GBETA5, MUTAGENESIS OF SER-245 AND TRP-274.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB016929 mRNA. Translation: BAA74751.1. AF035153 mRNA. Translation: AAC69175.1. AF035154 mRNA. Translation: AAC69176.1. AE006463 Genomic DNA. Translation: AAK61221.1. Z69667, AC004754 Genomic DNA. Translation: CAI95582.1.
RefSeq	NP_003825.1. NP_899180.1.
UniGene	Hs.65756
3D structure databases
HSSP	HSSP built from PDB template 1FQI based on UniProtKB O46469.
ModBase	Search...
PTM databases
PhosphoSite	O94810.
Genome annotation databases
Ensembl	ENSG00000076344. Homo sapiens. [Contig view]
GeneID	8786.
KEGG	hsa:8786.
Organism-specific databases
HGNC	HGNC:9993. RGS11.
MIM	603895. gene.
PharmGKB	PA34363.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	O94810.
Gene expression databases
ArrayExpress	O94810.
CleanEx	HS_RGS11.
GermOnline	ENSG00000076344. Homo sapiens.
Family and domain databases
InterPro	IPR000591. DEP. IPR015898. G-protein_gamma-like. IPR001770. Gprotein-gamma. IPR000342. Regulat_G_prot_signal. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF00610. DEP. 1 hit. PF00631. G-gamma. 1 hit. PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
ProDom	PD001580. Regl_Gprotein. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00049. DEP. 1 hit. SM00224. GGL. 1 hit. SM00315. RGS. 1 hit. [Graphical view]
PROSITE	PS50186. DEP. 1 hit. PS50058. G_PROTEIN_GAMMA. False negative. PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	32948.
SOURCE	Search...

Entry information

Entry name

RGS11_HUMAN

Accession

Primary (citable) accession number: O94810
Secondary accession number(s): O75883, Q4TT71

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 15, 1999
Last modified:	November 25, 2008
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)