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O94810

- RGS11_HUMAN

UniProt

O94810 - RGS11_HUMAN

Protein

Regulator of G-protein signaling 11

Gene

RGS11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

    GO - Molecular functioni

    1. G-protein beta-subunit binding Source: UniProt
    2. GTPase activator activity Source: RefGenome
    3. signal transducer activity Source: InterPro

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: InterPro
    2. intracellular signal transduction Source: InterPro
    3. positive regulation of GTPase activity Source: GOC
    4. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
    5. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 11
    Short name:
    RGS11
    Gene namesi
    Name:RGS11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:9993. RGS11.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. dendrite terminus Source: Ensembl
    3. heterotrimeric G-protein complex Source: InterPro
    4. plasma membrane Source: RefGenome
    5. protein complex Source: MGI

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi245 – 2451S → A: Diminishes interaction with Gbeta5. 1 Publication
    Mutagenesisi274 – 2741W → F: Diminishes interaction with Gbeta5. 1 Publication

    Organism-specific databases

    PharmGKBiPA34363.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 467467Regulator of G-protein signaling 11PRO_0000204210Add
    BLAST

    Proteomic databases

    PaxDbiO94810.
    PRIDEiO94810.

    PTM databases

    PhosphoSiteiO94810.

    Expressioni

    Gene expression databases

    ArrayExpressiO94810.
    BgeeiO94810.
    CleanExiHS_RGS11.
    GenevestigatoriO94810.

    Organism-specific databases

    HPAiHPA041692.
    HPA043039.

    Interactioni

    Subunit structurei

    Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi114314. 4 interactions.
    IntActiO94810. 2 interactions.
    STRINGi9606.ENSP00000380876.

    Structurei

    3D structure databases

    ProteinModelPortaliO94810.
    SMRiO94810. Positions 11-424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 10776DEPPROSITE-ProRule annotationAdd
    BLAST
    Domaini219 – 28264G protein gammaAdd
    BLAST
    Domaini299 – 414116RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 G protein gamma domain.Curated
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327614.
    HOGENOMiHOG000220864.
    HOVERGENiHBG007404.
    InParanoidiO94810.
    KOiK16449.
    OMAiMQDPDMG.
    OrthoDBiEOG7BZVS5.
    PhylomeDBiO94810.
    TreeFamiTF351956.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.196.10. 1 hit.
    4.10.260.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR015898. G-protein_gamma-like_dom.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00610. DEP. 1 hit.
    PF00631. G-gamma. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00049. DEP. 1 hit.
    SM00224. GGL. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF48670. SSF48670. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O94810-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH    50
    AVTGSDVVQW LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE 100
    TPYRFQTPYF WTSTLRPAAE LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH 150
    KKINHAWDLV LMQAREQLRA AKQRSKGDRL VIACQEQTYW LVNRPPPGAP 200
    DVLEQGPGRG SCAASRVLMT KSADFHKREI EYFRKALGRT RVKSSVCLEA 250
    YLSFCGQRGP HDPLVSGCLP SNPWISDNDA YWVMNAPTVA APTKLRVERW 300
    GFSFRELLED PVGRAHFMDF LGKEFSGENL SFWEACEELR YGAQAQVPTL 350
    VDAVYEQFLA PGAAHWVNID SRTMEQTLEG LRQPHRYVLD DAQLHIYMLM 400
    KKDSYPRFLK SDMYKALLAE AGIPLEMKRR VFPFTWRPRH SSPSPALLPT 450
    PVEPTAACGP GGGDGVA 467
    Length:467
    Mass (Da):52,946
    Last modified:July 15, 1999 - v2
    Checksum:i46BEE11D77C2C5F7
    GO
    Isoform 2 (identifier: O94810-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         107-123: TPYFWTSTLRPAAELDY → VRLGGA

    Show »
    Length:456
    Mass (Da):51,486
    Checksum:iCC4FA2BBE9C4D806
    GO
    Isoform 3 (identifier: O94810-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-21: Missing.

    Show »
    Length:446
    Mass (Da):50,727
    Checksum:i87DEC7BDFE8E2693
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti351 – 3511V → M.
    Corresponds to variant rs9806942 [ dbSNP | Ensembl ].
    VAR_061770
    Natural varianti427 – 4271M → T.
    Corresponds to variant rs739999 [ dbSNP | Ensembl ].
    VAR_024606

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2121Missing in isoform 3. 1 PublicationVSP_046724Add
    BLAST
    Alternative sequencei107 – 12317TPYFW…AELDY → VRLGGA in isoform 2. 1 PublicationVSP_023497Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016929 mRNA. Translation: BAA74751.1.
    AF035153 mRNA. Translation: AAC69175.1.
    AF035154 mRNA. Translation: AAC69176.1.
    AE006463 Genomic DNA. Translation: AAK61221.1.
    Z69667, AC004754 Genomic DNA. Translation: CAI95581.1.
    Z69667, AC004754 Genomic DNA. Translation: CAI95582.1.
    CH471112 Genomic DNA. Translation: EAW85839.1.
    CCDSiCCDS10403.1. [O94810-3]
    CCDS42088.1. [O94810-1]
    CCDS66884.1. [O94810-2]
    RefSeqiNP_001273414.1. NM_001286485.1. [O94810-2]
    NP_001273415.1. NM_001286486.1.
    NP_003825.1. NM_003834.2. [O94810-3]
    NP_899180.1. NM_183337.2. [O94810-1]
    UniGeneiHs.65756.

    Genome annotation databases

    EnsembliENST00000316163; ENSP00000319069; ENSG00000076344. [O94810-3]
    ENST00000359740; ENSP00000352778; ENSG00000076344. [O94810-2]
    ENST00000397770; ENSP00000380876; ENSG00000076344. [O94810-1]
    GeneIDi8786.
    KEGGihsa:8786.
    UCSCiuc002cgi.1. human. [O94810-1]
    uc010bqs.1. human. [O94810-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016929 mRNA. Translation: BAA74751.1 .
    AF035153 mRNA. Translation: AAC69175.1 .
    AF035154 mRNA. Translation: AAC69176.1 .
    AE006463 Genomic DNA. Translation: AAK61221.1 .
    Z69667 , AC004754 Genomic DNA. Translation: CAI95581.1 .
    Z69667 , AC004754 Genomic DNA. Translation: CAI95582.1 .
    CH471112 Genomic DNA. Translation: EAW85839.1 .
    CCDSi CCDS10403.1. [O94810-3 ]
    CCDS42088.1. [O94810-1 ]
    CCDS66884.1. [O94810-2 ]
    RefSeqi NP_001273414.1. NM_001286485.1. [O94810-2 ]
    NP_001273415.1. NM_001286486.1.
    NP_003825.1. NM_003834.2. [O94810-3 ]
    NP_899180.1. NM_183337.2. [O94810-1 ]
    UniGenei Hs.65756.

    3D structure databases

    ProteinModelPortali O94810.
    SMRi O94810. Positions 11-424.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114314. 4 interactions.
    IntActi O94810. 2 interactions.
    STRINGi 9606.ENSP00000380876.

    PTM databases

    PhosphoSitei O94810.

    Proteomic databases

    PaxDbi O94810.
    PRIDEi O94810.

    Protocols and materials databases

    DNASUi 8786.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316163 ; ENSP00000319069 ; ENSG00000076344 . [O94810-3 ]
    ENST00000359740 ; ENSP00000352778 ; ENSG00000076344 . [O94810-2 ]
    ENST00000397770 ; ENSP00000380876 ; ENSG00000076344 . [O94810-1 ]
    GeneIDi 8786.
    KEGGi hsa:8786.
    UCSCi uc002cgi.1. human. [O94810-1 ]
    uc010bqs.1. human. [O94810-2 ]

    Organism-specific databases

    CTDi 8786.
    GeneCardsi GC16M000318.
    HGNCi HGNC:9993. RGS11.
    HPAi HPA041692.
    HPA043039.
    MIMi 603895. gene.
    neXtProti NX_O94810.
    PharmGKBi PA34363.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327614.
    HOGENOMi HOG000220864.
    HOVERGENi HBG007404.
    InParanoidi O94810.
    KOi K16449.
    OMAi MQDPDMG.
    OrthoDBi EOG7BZVS5.
    PhylomeDBi O94810.
    TreeFami TF351956.

    Enzyme and pathway databases

    Reactomei REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    ChiTaRSi RGS11. human.
    GeneWikii RGS11.
    GenomeRNAii 8786.
    NextBioi 32948.
    PROi O94810.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O94810.
    Bgeei O94810.
    CleanExi HS_RGS11.
    Genevestigatori O94810.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.196.10. 1 hit.
    4.10.260.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR015898. G-protein_gamma-like_dom.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00610. DEP. 1 hit.
    PF00631. G-gamma. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00049. DEP. 1 hit.
    SM00224. GGL. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF48670. SSF48670. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens regulator of G-protein signaling 11 (RGS11)."
      Saito T., Seki N., Miyajima N.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Brain and Testis.
    2. "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits."
      Snow B.E., Krumins A.M., Brothers G.M., Lee S.-F., Wall M.A., Chung S., Mangion J., Arya S., Gilman A.G., Siderovski D.P.
      Proc. Natl. Acad. Sci. U.S.A. 95:13307-13312(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    3. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
      Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
      Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11."
      Snow B.E., Betts L., Mangion J., Sondek J., Siderovski D.P.
      Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GBETA5, MUTAGENESIS OF SER-245 AND TRP-274.

    Entry informationi

    Entry nameiRGS11_HUMAN
    AccessioniPrimary (citable) accession number: O94810
    Secondary accession number(s): O75883, Q4TT71, Q4TT72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3