O94810 (RGS11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 11
Short name=RGS11

Gene names

Name:

RGS11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
Subunit structure	Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 By similarity. Ref.5
Sequence similarities	Contains 1 DEP domain. Contains 1 G protein gamma domain. Contains 1 RGS domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Signal transduction inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro intracellular signal transduction Inferred from electronic annotation. Source: InterPro regulation of G-protein coupled receptor protein signaling pathway Traceable author statement Ref.2. Source: ProtInc termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome dendrite terminus Inferred from electronic annotation. Source: Compara heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome protein complex Inferred from direct assay PubMed 18468998. Source: MGI
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O94810-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O94810-2)

The sequence of this isoform differs from the canonical sequence as follows:
     107-123: TPYFWTSTLRPAAELDY → VRLGGA

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Regulator of G-protein signaling 11		PRO_0000204210
Regions
	Domain	32 – 107	76	DEP
	Domain	219 – 282	64	G protein gamma
	Domain	299 – 414	116	RGS
Natural variations
	Alternative sequence	107 – 123	17	TPYFW…AELDY → VRLGGA in isoform 2.		VSP_023497
	Natural variant	351	1	V → M. Corresponds to variant rs9806942 [ dbSNP | Ensembl ].		VAR_061770
	Natural variant	427	1	M → T. Corresponds to variant rs739999 [ dbSNP | Ensembl ].		VAR_024606
Experimental info
	Mutagenesis	245	1	S → A: Diminishes interaction with Gbeta5. Ref.5
	Mutagenesis	274	1	W → F: Diminishes interaction with Gbeta5. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 46BEE11D77C2C5F7	FASTA	467	52,946
	10 20 30 40 50 60 MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH AVTGSDVVQW 70 80 90 100 110 120 LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE TPYRFQTPYF WTSTLRPAAE 130 140 150 160 170 180 LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH KKINHAWDLV LMQAREQLRA AKQRSKGDRL 190 200 210 220 230 240 VIACQEQTYW LVNRPPPGAP DVLEQGPGRG SCAASRVLMT KSADFHKREI EYFRKALGRT 250 260 270 280 290 300 RVKSSVCLEA YLSFCGQRGP HDPLVSGCLP SNPWISDNDA YWVMNAPTVA APTKLRVERW 310 320 330 340 350 360 GFSFRELLED PVGRAHFMDF LGKEFSGENL SFWEACEELR YGAQAQVPTL VDAVYEQFLA 370 380 390 400 410 420 PGAAHWVNID SRTMEQTLEG LRQPHRYVLD DAQLHIYMLM KKDSYPRFLK SDMYKALLAE 430 440 450 460 AGIPLEMKRR VFPFTWRPRH SSPSPALLPT PVEPTAACGP GGGDGVA
	Isoform 2 [UniParc]. Checksum: CC4FA2BBE9C4D806	FASTA	456	51,486
	10 20 30 40 50 60 MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH AVTGSDVVQW 70 80 90 100 110 120 LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE TPYRFQVRLG GAAIYLAKKN 130 140 150 160 170 180 IRKRGTLVDY EKDCYDRLHK KINHAWDLVL MQAREQLRAA KQRSKGDRLV IACQEQTYWL 190 200 210 220 230 240 VNRPPPGAPD VLEQGPGRGS CAASRVLMTK SADFHKREIE YFRKALGRTR VKSSVCLEAY 250 260 270 280 290 300 LSFCGQRGPH DPLVSGCLPS NPWISDNDAY WVMNAPTVAA PTKLRVERWG FSFRELLEDP 310 320 330 340 350 360 VGRAHFMDFL GKEFSGENLS FWEACEELRY GAQAQVPTLV DAVYEQFLAP GAAHWVNIDS 370 380 390 400 410 420 RTMEQTLEGL RQPHRYVLDD AQLHIYMLMK KDSYPRFLKS DMYKALLAEA GIPLEMKRRV 430 440 450 FPFTWRPRHS SPSPALLPTP VEPTAACGPG GGDGVA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens regulator of G-protein signaling 11 (RGS11)." Saito T., Seki N., Miyajima N. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain and Testis.
[2]	"A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits." Snow B.E., Krumins A.M., Brothers G.M., Lee S.-F., Wall M.A., Chung S., Mangion J., Arya S., Gilman A.G., Siderovski D.P. Proc. Natl. Acad. Sci. U.S.A. 95:13307-13312(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11." Snow B.E., Betts L., Mangion J., Sondek J., Siderovski D.P. Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GBETA5, MUTAGENESIS OF SER-245 AND TRP-274.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB016929 mRNA. Translation: BAA74751.1. AF035153 mRNA. Translation: AAC69175.1. AF035154 mRNA. Translation: AAC69176.1. AE006463 Genomic DNA. Translation: AAK61221.1. Z69667, AC004754 Genomic DNA. Translation: CAI95582.1.
IPI	IPI00015558. IPI00642088.
RefSeq	NP_003825.1. NM_003834.1. NP_899180.1. NM_183337.1.
UniGene	Hs.65756.
3D structure databases
ProteinModelPortal	O94810.
ModBase	Search...
Protein-protein interaction databases
IntAct	O94810. 2 interactions.
STRING	9606.ENSP00000380876.
PTM databases
PhosphoSite	O94810.
Proteomic databases
PaxDb	O94810.
PRIDE	O94810.
Protocols and materials databases
DNASU	8786.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359740; ENSP00000352778; ENSG00000076344. ENST00000397770; ENSP00000380876; ENSG00000076344.
GeneID	8786.
KEGG	hsa:8786.
UCSC	uc002cgi.1. human. uc010bqs.1. human.
Organism-specific databases
CTD	8786.
GeneCards	GC16M000318.
HGNC	HGNC:9993. RGS11.
HPA	HPA041692. HPA043039.
MIM	603895. gene.
neXtProt	NX_O94810.
PharmGKB	PA34363.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG327614.
HOGENOM	HOG000220864.
HOVERGEN	HBG007404.
InParanoid	O94810.
KO	K16449.
OMA	LKSDMYK.
OrthoDB	EOG44XJGT.
Gene expression databases
ArrayExpress	O94810.
Bgee	O94810.
CleanEx	HS_RGS11.
Genevestigator	O94810.
GermOnline	ENSG00000076344. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 1.10.196.10. 1 hit. 4.10.260.10. 1 hit.
InterPro	IPR000591. DEP_dom. IPR015898. G-protein_gamma-like_dom. IPR000342. Regulat_G_prot_signal. IPR024066. Regulat_G_prot_signal_dom1. IPR016137. Regulat_G_prot_signal_superfam. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00610. DEP. 1 hit. PF00631. G-gamma. 1 hit. PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SMART	SM00049. DEP. 1 hit. SM00224. GGL. 1 hit. SM00315. RGS. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit. SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50186. DEP. 1 hit. PS50058. G_PROTEIN_GAMMA. False negative. PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RGS11. human.
GenomeRNAi	8786.
NextBio	32948.
SOURCE	Search...

Entry information

Entry name

RGS11_HUMAN

Accession

Primary (citable) accession number: O94810
Secondary accession number(s): O75883, Q4TT71

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 15, 1999
Last modified:	May 1, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.