##gff-version 3 O94806 UniProtKB Chain 1 890 . . . ID=PRO_0000055717;Note=Serine/threonine-protein kinase D3 O94806 UniProtKB Domain 416 532 . . . Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 O94806 UniProtKB Domain 576 832 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 O94806 UniProtKB Zinc finger 154 204 . . . Note=Phorbol-ester/DAG-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226 O94806 UniProtKB Zinc finger 271 321 . . . Note=Phorbol-ester/DAG-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00226 O94806 UniProtKB Region 332 371 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O94806 UniProtKB Compositional bias 332 351 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O94806 UniProtKB Compositional bias 352 371 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O94806 UniProtKB Active site 699 699 . . . Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 O94806 UniProtKB Binding site 582 590 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 O94806 UniProtKB Binding site 605 605 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 O94806 UniProtKB Modified residue 6 6 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 O94806 UniProtKB Modified residue 27 27 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:18691976,PMID:19369195,PMID:20068231 O94806 UniProtKB Modified residue 37 37 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 O94806 UniProtKB Modified residue 41 41 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19369195,PMID:20068231,PMID:23186163 O94806 UniProtKB Modified residue 44 44 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163 O94806 UniProtKB Modified residue 213 213 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 O94806 UniProtKB Modified residue 216 216 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 O94806 UniProtKB Modified residue 364 364 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:18691976,PMID:19369195,PMID:23186163 O94806 UniProtKB Modified residue 391 391 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15139 O94806 UniProtKB Modified residue 395 395 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15139 O94806 UniProtKB Modified residue 426 426 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15139 O94806 UniProtKB Modified residue 442 442 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15139 O94806 UniProtKB Modified residue 457 457 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9BZL6 O94806 UniProtKB Modified residue 535 535 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 O94806 UniProtKB Modified residue 539 539 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K1Y2 O94806 UniProtKB Modified residue 731 731 . . . Note=Phosphoserine%3B by PKC;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15139 O94806 UniProtKB Modified residue 735 735 . . . Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15139 O94806 UniProtKB Modified residue 742 742 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9BZL6 O94806 UniProtKB Alternative sequence 595 611 . . . ID=VSP_029405;Note=In isoform 2. HRKTGRDVAIKVIDKMR->QLQPFAYCTHYFKNWKM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 O94806 UniProtKB Alternative sequence 612 890 . . . ID=VSP_029406;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 O94806 UniProtKB Natural variant 42 42 . . . ID=VAR_037147;Note=N->D;Dbxref=dbSNP:rs11896614 O94806 UniProtKB Natural variant 128 128 . . . ID=VAR_037148;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852819,PMID:15489334 O94806 UniProtKB Natural variant 225 225 . . . ID=VAR_050561;Note=P->S;Dbxref=dbSNP:rs34280934 O94806 UniProtKB Natural variant 445 445 . . . ID=VAR_061532;Note=L->I;Dbxref=dbSNP:rs55912911 O94806 UniProtKB Natural variant 546 546 . . . ID=VAR_037149;Note=Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17856887,PMID:15489334 O94806 UniProtKB Natural variant 716 716 . . . ID=VAR_042336;Note=In a glioblastoma multiforme sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 O94806 UniProtKB Mutagenesis 156 156 . . . Note=Slight loss in ability to bind DAG and phorbol-ester%3B when associated with F-158. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18076381;Dbxref=PMID:18076381 O94806 UniProtKB Mutagenesis 158 158 . . . Note=Slight loss in ability to bind DAG and phorbol-ester%3B when associated with A-156. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18076381;Dbxref=PMID:18076381 O94806 UniProtKB Mutagenesis 165 165 . . . Note=No effect on ability to bind phorbol ester%2C loss of ability to bind DAG%2C reduced DAG-induced membrane translocation. P->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18076381;Dbxref=PMID:18076381 O94806 UniProtKB Mutagenesis 166 166 . . . Note=Slight loss in ability to bind DAG and phorbol-ester. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18076381;Dbxref=PMID:18076381 O94806 UniProtKB Mutagenesis 170 170 . . . Note=Slight loss in ability to bind DAG and phorbol-ester. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18076381;Dbxref=PMID:18076381 O94806 UniProtKB Mutagenesis 282 282 . . . Note=No effect on ability to bind phorbol ester%2C increase in ability to bind DAG. P->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18076381;Dbxref=PMID:18076381 O94806 UniProtKB Mutagenesis 284 284 . . . Note=Slight increase in ability to bind DAG%2C no effect on phorbol-ester binding. I->V O94806 UniProtKB Mutagenesis 293 293 . . . Note=Increased ability to bind DAG%2C no effect on phorbol-ester binding. K->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18076381;Dbxref=PMID:18076381 O94806 UniProtKB Beta strand 417 429 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2D9Z O94806 UniProtKB Beta strand 434 443 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2D9Z O94806 UniProtKB Beta strand 445 449 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2D9Z O94806 UniProtKB Turn 462 464 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2D9Z O94806 UniProtKB Beta strand 477 479 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2D9Z O94806 UniProtKB Beta strand 485 489 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2D9Z O94806 UniProtKB Beta strand 494 497 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2D9Z O94806 UniProtKB Turn 508 514 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2D9Z O94806 UniProtKB Helix 517 532 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2D9Z