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Protein

Actin-like protein 6B

Gene

ACTL6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity).By similarity

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc
  • transcription coactivator activity Source: BHF-UCL

GO - Biological processi

  • chromatin modification Source: UniProtKB-KW
  • chromatin organization Source: UniProtKB
  • chromatin remodeling Source: BHF-UCL
  • regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • spinal cord development Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000077080-MONOMER.
ReactomeiR-HSA-3214858. RMTs methylate histone arginines.
SignaLinkiO94805.
SIGNORiO94805.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-like protein 6B
Alternative name(s):
53 kDa BRG1-associated factor B
Actin-related protein Baf53b
ArpNalpha
BRG1-associated factor 53B
Short name:
BAF53B
Gene namesi
Name:ACTL6B
Synonyms:ACTL6, BAF53B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:160. ACTL6B.

Subcellular locationi

GO - Cellular componenti

  • nBAF complex Source: UniProtKB
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
  • SWI/SNF complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51412.
OpenTargetsiENSG00000077080.
PharmGKBiPA24482.

Polymorphism and mutation databases

BioMutaiACTL6B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000891352 – 426Actin-like protein 6BAdd BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO94805.
PaxDbiO94805.
PeptideAtlasiO94805.
PRIDEiO94805.

PTM databases

iPTMnetiO94805.
PhosphoSitePlusiO94805.

Expressioni

Gene expression databases

BgeeiENSG00000077080.
CleanExiHS_ACTL6B.
ExpressionAtlasiO94805. baseline and differential.
GenevisibleiO94805. HS.

Organism-specific databases

HPAiHPA045126.

Interactioni

Subunit structurei

Component of the bBAF complex, which includes at least actin (ACTB), ARID1A/BAF250, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCC2/BAF170, SMARCD2/BAF60B and SMARCE1/BAF57. Note that the bBAF complex is polymorphic in regard to the ATPase, SMARCA2 and SMARCA4 occupying mutually exclusive positions. PBRM1 does not belong to bBAF complex. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity).By similarity

Protein-protein interaction databases

BioGridi119529. 26 interactors.
IntActiO94805. 10 interactors.
MINTiMINT-1419266.
STRINGi9606.ENSP00000160382.

Structurei

3D structure databases

ProteinModelPortaliO94805.
SMRiO94805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 82Essential for mediating its function in dendritic development; may contribute to neuronal-specific targetingBy similarityAdd BLAST44

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0679. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00840000129754.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiO94805.
KOiK11652.
OMAiPAVHYEF.
OrthoDBiEOG091G0A1S.
PhylomeDBiO94805.
TreeFamiTF312863.

Family and domain databases

InterProiIPR004000. Actin.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 2 hits.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00432. ACTINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGVYGGDE VGALVFDIGS FSVRAGYAGE DCPKADFPTT VGLLAAEEGG
60 70 80 90 100
GLELEGDKEK KGKIFHIDTN ALHVPRDGAE VMSPLKNGMI EDWECFRAIL
110 120 130 140 150
DHTYSKHVKS EPNLHPVLMS EAPWNTRAKR EKLTELMFEQ YNIPAFFLCK
160 170 180 190 200
TAVLTAFANG RSTGLVLDSG ATHTTAIPVH DGYVLQQGIV KSPLAGDFIS
210 220 230 240 250
MQCRELFQEM AIDIIPPYMI AAKEPVREGA PPNWKKKEKL PQVSKSWHNY
260 270 280 290 300
MCNEVIQDFQ ASVLQVSDSP YDEQVAAQMP TVHYEMPNGY NTDYGAERLR
310 320 330 340 350
IPEGLFDPSN VKGLSGNTML GVGHVVTTSI GMCDIDIRPG LYGSVIVTGG
360 370 380 390 400
NTLLQGFTDR LNRELSQKTP PSMRLKLIAS NSTMERKFSP WIGGSILASL
410 420
GTFQQMWISK QEYEEGGKQC VERKCP
Length:426
Mass (Da):46,877
Last modified:May 1, 1999 - v1
Checksum:i6E9CEBABB8C81E64
GO

Sequence cautioni

The sequence AAC78795 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053356 Genomic DNA. Translation: AAC78795.1. Sequence problems.
AB015906 mRNA. Translation: BAA74576.1.
AF041475 mRNA. Translation: AAD54678.1.
AK314940 mRNA. Translation: BAG37446.1.
AC099394 Genomic DNA. Translation: AAP21874.1.
CH236956 Genomic DNA. Translation: EAL23823.1.
CH471091 Genomic DNA. Translation: EAW76502.1.
BC020944 mRNA. Translation: AAH20944.1.
CCDSiCCDS5702.1.
RefSeqiNP_057272.1. NM_016188.4.
UniGeneiHs.259831.

Genome annotation databases

EnsembliENST00000160382; ENSP00000160382; ENSG00000077080.
GeneIDi51412.
KEGGihsa:51412.
UCSCiuc003uvy.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053356 Genomic DNA. Translation: AAC78795.1. Sequence problems.
AB015906 mRNA. Translation: BAA74576.1.
AF041475 mRNA. Translation: AAD54678.1.
AK314940 mRNA. Translation: BAG37446.1.
AC099394 Genomic DNA. Translation: AAP21874.1.
CH236956 Genomic DNA. Translation: EAL23823.1.
CH471091 Genomic DNA. Translation: EAW76502.1.
BC020944 mRNA. Translation: AAH20944.1.
CCDSiCCDS5702.1.
RefSeqiNP_057272.1. NM_016188.4.
UniGeneiHs.259831.

3D structure databases

ProteinModelPortaliO94805.
SMRiO94805.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119529. 26 interactors.
IntActiO94805. 10 interactors.
MINTiMINT-1419266.
STRINGi9606.ENSP00000160382.

PTM databases

iPTMnetiO94805.
PhosphoSitePlusiO94805.

Polymorphism and mutation databases

BioMutaiACTL6B.

Proteomic databases

MaxQBiO94805.
PaxDbiO94805.
PeptideAtlasiO94805.
PRIDEiO94805.

Protocols and materials databases

DNASUi51412.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000160382; ENSP00000160382; ENSG00000077080.
GeneIDi51412.
KEGGihsa:51412.
UCSCiuc003uvy.4. human.

Organism-specific databases

CTDi51412.
DisGeNETi51412.
GeneCardsiACTL6B.
HGNCiHGNC:160. ACTL6B.
HPAiHPA045126.
MIMi612458. gene.
neXtProtiNX_O94805.
OpenTargetsiENSG00000077080.
PharmGKBiPA24482.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0679. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00840000129754.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiO94805.
KOiK11652.
OMAiPAVHYEF.
OrthoDBiEOG091G0A1S.
PhylomeDBiO94805.
TreeFamiTF312863.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000077080-MONOMER.
ReactomeiR-HSA-3214858. RMTs methylate histone arginines.
SignaLinkiO94805.
SIGNORiO94805.

Miscellaneous databases

GeneWikiiACTL6B.
GenomeRNAii51412.
PROiO94805.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000077080.
CleanExiHS_ACTL6B.
ExpressionAtlasiO94805. baseline and differential.
GenevisibleiO94805. HS.

Family and domain databases

InterProiIPR004000. Actin.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 2 hits.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00432. ACTINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACL6B_HUMAN
AccessioniPrimary (citable) accession number: O94805
Secondary accession number(s): A4D2D0, O75421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.