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Protein

Contactin-5

Gene

CNTN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-5
Alternative name(s):
Neural recognition molecule NB-2
Short name:
hNB-2
Gene namesi
Name:CNTN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:2175. CNTN5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26689.

Polymorphism and mutation databases

BioMutaiCNTN5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 10721054Contactin-5PRO_0000014717Add
BLAST
Propeptidei1073 – 110028Removed in mature formSequence analysisPRO_0000014718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi123 ↔ 173PROSITE-ProRule annotation
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence analysis
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence analysis
Disulfide bondi217 ↔ 269PROSITE-ProRule annotation
Disulfide bondi322 ↔ 369PROSITE-ProRule annotation
Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence analysis
Disulfide bondi411 ↔ 458PROSITE-ProRule annotation
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence analysis
Disulfide bondi503 ↔ 551PROSITE-ProRule annotation
Glycosylationi540 – 5401N-linked (GlcNAc...)Sequence analysis
Disulfide bondi593 ↔ 650PROSITE-ProRule annotation
Glycosylationi779 – 7791N-linked (GlcNAc...)Sequence analysis
Glycosylationi816 – 8161N-linked (GlcNAc...)Sequence analysis
Glycosylationi931 – 9311N-linked (GlcNAc...)Sequence analysis
Glycosylationi1002 – 10021N-linked (GlcNAc...)Sequence analysis
Lipidationi1072 – 10721GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiO94779.
PaxDbiO94779.
PeptideAtlasiO94779.
PRIDEiO94779.

PTM databases

iPTMnetiO94779.
PhosphoSiteiO94779.

Expressioni

Tissue specificityi

Expressed in brain and kidney and at very low level in placenta. Not expressed in other tissues. In brain, it is highly expressed in the occipital lobe, amygdala, cerebral cortex, frontal lobe, thalamus and temporal lobe. Expressed at moderate level in the cerebellum, substantia nigra, putamen, medulla and hippocampus. Weakly expressed in the spinal cord and caudate nucleus. Weakly or not expressed in the corpus callosum.1 Publication

Gene expression databases

BgeeiO94779.
CleanExiHS_CNTN5.
ExpressionAtlasiO94779. baseline and differential.
GenevisibleiO94779. HS.

Organism-specific databases

HPAiHPA039492.
HPA041223.

Interactioni

Subunit structurei

Interacts with PTPRG.1 Publication

Protein-protein interaction databases

BioGridi119823. 1 interaction.
IntActiO94779. 2 interactions.
STRINGi9606.ENSP00000279463.

Structurei

Secondary structure

1
1100
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi880 – 8867Combined sources
Beta strandi888 – 8903Combined sources
Beta strandi892 – 8976Combined sources
Helixi901 – 9033Combined sources
Beta strandi907 – 9159Combined sources
Helixi920 – 9223Combined sources
Beta strandi924 – 9274Combined sources
Beta strandi934 – 9374Combined sources
Beta strandi945 – 95410Combined sources
Beta strandi965 – 9684Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4N68X-ray1.80A871-971[»]
ProteinModelPortaliO94779.
SMRiO94779. Positions 98-477, 874-972.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 19092Ig-like C2-type 1Add
BLAST
Domaini196 – 28287Ig-like C2-type 2Add
BLAST
Domaini300 – 38586Ig-like C2-type 3Add
BLAST
Domaini390 – 47485Ig-like C2-type 4Add
BLAST
Domaini480 – 56788Ig-like C2-type 5Add
BLAST
Domaini571 – 66090Ig-like C2-type 6Add
BLAST
Domaini673 – 77199Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini776 – 87398Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini878 – 97295Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini977 – 106791Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiO94779.
KOiK06763.
OMAiMIHNVNQ.
OrthoDBiEOG7J17Z5.
PhylomeDBiO94779.
TreeFamiTF351103.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR032989. Contactin-5.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF51. PTHR10489:SF51. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94779-1) [UniParc]FASTAAdd to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSWKLMLF LSVTMCLSEY SKSLPGLSTS YAALLRIKKS SSSSLFGSKT
60 70 80 90 100
RPRYSSPSLG TLSASSPSWL GAAQNYYSPI NLYHSSDAFK QDESVDYGPV
110 120 130 140 150
FVQEPDDIIF PTDSDEKKVA LNCEVRGNPV PSYRWLRNGT EIDLESDYRY
160 170 180 190 200
SLIDGTFIIS NPSEAKDSGH YQCLATNTVG SILSREATLQ FAYLGNFSGR
210 220 230 240 250
TRSAVSVREG QGVVLMCSPP PHSPEIIYSW VFNEFPSFVA EDSRRFISQE
260 270 280 290 300
TGNLYISKVQ TSDVGSYICL VKNTVTNARV LSPPTPLTLR NDGVMGEYEP
310 320 330 340 350
KIEVHFPFTV TAAKGTTVKM ECFALGNPVP TITWMKVNGY IPSKARLRKS
360 370 380 390 400
QAVLEIPNVQ LDDAGIYECR AENSRGKNSF RGQLQVYTYP HWVEKLNDTQ
410 420 430 440 450
LDSGSPLRWE CKATGKPRPT YRWLKNGVPL SPQSRVEMVN GVLMIHNVNQ
460 470 480 490 500
SDAGMYQCLA ENKYGAIYAS AELKILASAP TFALNQLKKT IIVTKDQEVV
510 520 530 540 550
IECKPQGSPK PTISWKKGDR AVRENKRIAI LPDGSLRILN ASKSDEGKYV
560 570 580 590 600
CRGENVFGSA EIIASLSVKE PTRIELTPKR TELTVGESIV LNCKAIHDAS
610 620 630 640 650
LDVTFYWTLK GQPIDFEEEG GHFESIRAQA SSADLMIRNI LLMHAGRYGC
660 670 680 690 700
RVQTTADSVS DEAELLVRGP PGPPGIVIVE EITESTATLS WSPAADNHSP
710 720 730 740 750
ISSYNLQARS PFSLGWQTVK TVPEIITGDM ESAMAVDLNP WVEYEFRVVA
760 770 780 790 800
TNPIGTGDPS TPSRMIRTNE AVPKTAPTNV SGRSGRRHEL VIAWEPVSEE
810 820 830 840 850
FQNGEGFGYI VAFRPNGTRG WKEKMVTSSE ASKFIYRDES VPPLTPFEVK
860 870 880 890 900
VGVYNNKGDG PFSQIVVICS AEGEPSAAPT DVKATSVSVS EILVAWKHIK
910 920 930 940 950
ESLGRPQGFE VGYWKDMEQE DTAETVKTRG NESFVILTGL EGNTLYHFTV
960 970 980 990 1000
RAYNGAGYGP PSSEVSATTK KSPPSQAPSN LRWEQQGSQV SLGWEPVIPL
1010 1020 1030 1040 1050
ANESEVVGYK VFYRQEGHSN SQVIETQKLQ AVVPLPDAGV YIIEVRAYSE
1060 1070 1080 1090 1100
GGDGTASSQI RVPSYSGGKI TSAQSTLHSL STSSSSVTLL LALMIPSTSW
Length:1,100
Mass (Da):120,686
Last modified:November 1, 1999 - v2
Checksum:i5883575D84AD030E
GO
Isoform 2 (identifier: O94779-2) [UniParc]FASTAAdd to basket

Also known as: Short, HNB-2s

The sequence of this isoform differs from the canonical sequence as follows:
     19-92: Missing.

Show »
Length:1,026
Mass (Da):112,706
Checksum:i0C5EF6D543EB74D8
GO
Isoform 3 (identifier: O94779-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     912-1100: Missing.

Note: No experimental confirmation available.
Show »
Length:911
Mass (Da):100,327
Checksum:i23C1BE9D77447C59
GO

Sequence cautioni

The sequence AAH39255.1 differs from that shown. Reason: Erroneous termination at position 223. Translated as Ser.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231S → A.
Corresponds to variant rs10790978 [ dbSNP | Ensembl ].
VAR_019907
Natural varianti70 – 701L → R.
Corresponds to variant rs7125822 [ dbSNP | Ensembl ].
VAR_019908
Natural varianti81 – 811N → S.
Corresponds to variant rs10893933 [ dbSNP | Ensembl ].
VAR_019909
Natural varianti530 – 5301I → V.1 Publication
Corresponds to variant rs11223168 [ dbSNP | Ensembl ].
VAR_019910
Natural varianti1065 – 10651Y → F.
Corresponds to variant rs1944169 [ dbSNP | Ensembl ].
VAR_019911
Natural varianti1079 – 10791S → T.1 Publication
Corresponds to variant rs1216183 [ dbSNP | Ensembl ].
VAR_019912
Natural varianti1094 – 10941M → V.
Corresponds to variant rs35208161 [ dbSNP | Ensembl ].
VAR_033610

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei19 – 9274Missing in isoform 2. 1 PublicationVSP_011967Add
BLAST
Alternative sequencei912 – 1100189Missing in isoform 3. 1 PublicationVSP_045995Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013802 mRNA. Translation: BAA36579.2.
AB013803 mRNA. Translation: BAA36580.2.
AP000760 Genomic DNA. No translation available.
AP000798 Genomic DNA. No translation available.
AP000923 Genomic DNA. No translation available.
AP001892 Genomic DNA. No translation available.
AP001988 Genomic DNA. No translation available.
AP002378 Genomic DNA. No translation available.
AP002428 Genomic DNA. No translation available.
AP002987 Genomic DNA. No translation available.
AP003126 Genomic DNA. No translation available.
AP003441 Genomic DNA. No translation available.
AP003558 Genomic DNA. No translation available.
AP004249 Genomic DNA. No translation available.
BC039255 mRNA. Translation: AAH39255.1. Sequence problems.
BC130619 mRNA. Translation: AAI30620.1.
BC144185 mRNA. Translation: AAI44186.1.
CCDSiCCDS53696.1. [O94779-1]
CCDS53697.1. [O94779-2]
CCDS58168.1. [O94779-4]
RefSeqiNP_001230199.1. NM_001243270.1. [O94779-1]
NP_001230200.1. NM_001243271.1. [O94779-4]
NP_055176.1. NM_014361.3. [O94779-1]
NP_780775.1. NM_175566.2. [O94779-2]
XP_011541173.1. XM_011542871.1. [O94779-2]
UniGeneiHs.656783.

Genome annotation databases

EnsembliENST00000418526; ENSP00000393229; ENSG00000149972. [O94779-2]
ENST00000524871; ENSP00000435637; ENSG00000149972. [O94779-1]
ENST00000527185; ENSP00000433575; ENSG00000149972. [O94779-4]
ENST00000528682; ENSP00000436185; ENSG00000149972. [O94779-1]
GeneIDi53942.
KEGGihsa:53942.
UCSCiuc001pfz.4. human. [O94779-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013802 mRNA. Translation: BAA36579.2.
AB013803 mRNA. Translation: BAA36580.2.
AP000760 Genomic DNA. No translation available.
AP000798 Genomic DNA. No translation available.
AP000923 Genomic DNA. No translation available.
AP001892 Genomic DNA. No translation available.
AP001988 Genomic DNA. No translation available.
AP002378 Genomic DNA. No translation available.
AP002428 Genomic DNA. No translation available.
AP002987 Genomic DNA. No translation available.
AP003126 Genomic DNA. No translation available.
AP003441 Genomic DNA. No translation available.
AP003558 Genomic DNA. No translation available.
AP004249 Genomic DNA. No translation available.
BC039255 mRNA. Translation: AAH39255.1. Sequence problems.
BC130619 mRNA. Translation: AAI30620.1.
BC144185 mRNA. Translation: AAI44186.1.
CCDSiCCDS53696.1. [O94779-1]
CCDS53697.1. [O94779-2]
CCDS58168.1. [O94779-4]
RefSeqiNP_001230199.1. NM_001243270.1. [O94779-1]
NP_001230200.1. NM_001243271.1. [O94779-4]
NP_055176.1. NM_014361.3. [O94779-1]
NP_780775.1. NM_175566.2. [O94779-2]
XP_011541173.1. XM_011542871.1. [O94779-2]
UniGeneiHs.656783.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4N68X-ray1.80A871-971[»]
ProteinModelPortaliO94779.
SMRiO94779. Positions 98-477, 874-972.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119823. 1 interaction.
IntActiO94779. 2 interactions.
STRINGi9606.ENSP00000279463.

PTM databases

iPTMnetiO94779.
PhosphoSiteiO94779.

Polymorphism and mutation databases

BioMutaiCNTN5.

Proteomic databases

EPDiO94779.
PaxDbiO94779.
PeptideAtlasiO94779.
PRIDEiO94779.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000418526; ENSP00000393229; ENSG00000149972. [O94779-2]
ENST00000524871; ENSP00000435637; ENSG00000149972. [O94779-1]
ENST00000527185; ENSP00000433575; ENSG00000149972. [O94779-4]
ENST00000528682; ENSP00000436185; ENSG00000149972. [O94779-1]
GeneIDi53942.
KEGGihsa:53942.
UCSCiuc001pfz.4. human. [O94779-1]

Organism-specific databases

CTDi53942.
GeneCardsiCNTN5.
HGNCiHGNC:2175. CNTN5.
HPAiHPA039492.
HPA041223.
MIMi607219. gene.
neXtProtiNX_O94779.
PharmGKBiPA26689.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiO94779.
KOiK06763.
OMAiMIHNVNQ.
OrthoDBiEOG7J17Z5.
PhylomeDBiO94779.
TreeFamiTF351103.

Miscellaneous databases

ChiTaRSiCNTN5. human.
GenomeRNAii53942.
PROiO94779.
SOURCEiSearch...

Gene expression databases

BgeeiO94779.
CleanExiHS_CNTN5.
ExpressionAtlasiO94779. baseline and differential.
GenevisibleiO94779. HS.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR032989. Contactin-5.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF51. PTHR10489:SF51. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members."
    Kamei Y., Takeda Y., Teramoto K., Tsutsumi O., Taketani Y., Watanabe K.
    Genomics 69:113-119(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS VAL-530 AND THR-1079.
    Tissue: Brain.
  4. "The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."
    Bouyain S., Watkins D.J.
    Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTPRG.

Entry informationi

Entry nameiCNTN5_HUMAN
AccessioniPrimary (citable) accession number: O94779
Secondary accession number(s): A1L4P0
, B7ZM07, E9PKE8, O94780, Q49AF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.