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Protein

Aquaporin-8

Gene

AQP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.

GO - Molecular functioni

GO - Biological processi

  • cellular response to cAMP Source: UniProtKB
  • cellular water homeostasis Source: GO_Central
  • ion transmembrane transport Source: GO_Central
  • transport Source: ProtInc
  • water transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103375-MONOMER.
ReactomeiR-HSA-3299685. Detoxification of Reactive Oxygen Species.
R-HSA-432047. Passive transport by Aquaporins.

Protein family/group databases

TCDBi1.A.8.16.1. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-8
Short name:
AQP-8
Gene namesi
Name:AQP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:642. AQP8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 84ExtracellularSequence analysisAdd BLAST27
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 107CytoplasmicSequence analysis2
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 156ExtracellularSequence analysisAdd BLAST28
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 183CytoplasmicSequence analysis6
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 228ExtracellularSequence analysisAdd BLAST24
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 261CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • apical part of cell Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi343.
OpenTargetsiENSG00000103375.
PharmGKBiPA24926.

Polymorphism and mutation databases

BioMutaiAQP8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639611 – 261Aquaporin-8Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Glycosylationi139N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO94778.
PeptideAtlasiO94778.
PRIDEiO94778.

Expressioni

Tissue specificityi

Expressed only in pancreas and colon.

Gene expression databases

BgeeiENSG00000103375.
CleanExiHS_AQP8.
ExpressionAtlasiO94778. baseline and differential.
GenevisibleiO94778. HS.

Organism-specific databases

HPAiHPA046259.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000219660.

Structurei

3D structure databases

ProteinModelPortaliO94778.
SMRiO94778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi92 – 94NPA 13
Motifi210 – 212NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG100478.
InParanoidiO94778.
KOiK09869.
OMAiWYERLVQ.
OrthoDBiEOG091G166T.
PhylomeDBiO94778.
TreeFamiTF312940.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023277. Aquaporin_8.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02020. AQUAPORIN8.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEIAMCEP EFGNDKAREP SVGGRWRVSW YERFVQPCLV ELLGSALFIF
60 70 80 90 100
IGCLSVIENG TDTGLLQPAL AHGLALGLVI ATLGNISGGH FNPAVSLAAM
110 120 130 140 150
LIGGLNLVML LPYWVSQLLG GMLGAALAKA VSPEERFWNA SGAAFVTVQE
160 170 180 190 200
QGQVAGALVA EIILTTLLAL AVCMGAINEK TKGPLAPFSI GFAVTVDILA
210 220 230 240 250
GGPVSGGCMN PARAFGPAVV ANHWNFHWIY WLGPLLAGLL VGLLIRCFIG
260
DGKTRLILKA R
Length:261
Mass (Da):27,381
Last modified:May 10, 2004 - v2
Checksum:iB5328B07A2049B3B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130A → V in BAA34223 (PubMed:9806845).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036484229I → M in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_021933260A → P.Corresponds to variant rs2287798dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013456 mRNA. Translation: BAA34223.1.
AF067797 mRNA. Translation: AAF19050.1.
BC040630 mRNA. Translation: AAH40630.1.
CCDSiCCDS10626.1.
RefSeqiNP_001160.2. NM_001169.2.
UniGeneiHs.176658.

Genome annotation databases

EnsembliENST00000219660; ENSP00000219660; ENSG00000103375.
GeneIDi343.
KEGGihsa:343.
UCSCiuc002doc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013456 mRNA. Translation: BAA34223.1.
AF067797 mRNA. Translation: AAF19050.1.
BC040630 mRNA. Translation: AAH40630.1.
CCDSiCCDS10626.1.
RefSeqiNP_001160.2. NM_001169.2.
UniGeneiHs.176658.

3D structure databases

ProteinModelPortaliO94778.
SMRiO94778.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000219660.

Protein family/group databases

TCDBi1.A.8.16.1. the major intrinsic protein (mip) family.

Polymorphism and mutation databases

BioMutaiAQP8.

Proteomic databases

PaxDbiO94778.
PeptideAtlasiO94778.
PRIDEiO94778.

Protocols and materials databases

DNASUi343.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219660; ENSP00000219660; ENSG00000103375.
GeneIDi343.
KEGGihsa:343.
UCSCiuc002doc.4. human.

Organism-specific databases

CTDi343.
DisGeNETi343.
GeneCardsiAQP8.
HGNCiHGNC:642. AQP8.
HPAiHPA046259.
MIMi603750. gene.
neXtProtiNX_O94778.
OpenTargetsiENSG00000103375.
PharmGKBiPA24926.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG100478.
InParanoidiO94778.
KOiK09869.
OMAiWYERLVQ.
OrthoDBiEOG091G166T.
PhylomeDBiO94778.
TreeFamiTF312940.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103375-MONOMER.
ReactomeiR-HSA-3299685. Detoxification of Reactive Oxygen Species.
R-HSA-432047. Passive transport by Aquaporins.

Miscellaneous databases

GeneWikiiAQP8.
GenomeRNAii343.
PROiO94778.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103375.
CleanExiHS_AQP8.
ExpressionAtlasiO94778. baseline and differential.
GenevisibleiO94778. HS.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023277. Aquaporin_8.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02020. AQUAPORIN8.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAQP8_HUMAN
AccessioniPrimary (citable) accession number: O94778
Secondary accession number(s): Q8IUU3, Q9UIA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 10, 2004
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.