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Protein

Metastasis-associated protein MTA2

Gene

MTA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri367 – 394GATA-type; atypicalAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149480-MONOMER.
ReactomeiR-HSA-3214815. HDACs deacetylate histones.
R-HSA-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.
R-HSA-6804758. Regulation of TP53 Activity through Acetylation.
R-HSA-73762. RNA Polymerase I Transcription Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis-associated protein MTA2
Alternative name(s):
Metastasis-associated 1-like 1
Short name:
MTA1-L1 protein
p53 target protein in deacetylase complex
Gene namesi
Name:MTA2
Synonyms:MTA1L1, PID
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:7411. MTA2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • histone deacetylase complex Source: ProtInc
  • membrane Source: UniProtKB
  • nuclear chromatin Source: UniProtKB
  • nucleoplasm Source: HPA
  • NuRD complex Source: UniProtKB
  • protein complex Source: UniProtKB
  • transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9219.
OpenTargetsiENSG00000149480.
PharmGKBiPA31219.

Polymorphism and mutation databases

BioMutaiMTA2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834961 – 668Metastasis-associated protein MTA2Add BLAST668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphoserineCombined sources1
Modified residuei54PhosphoserineCombined sources1
Modified residuei152N6-acetyllysineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei460N6-acetyllysineBy similarity1
Cross-linki492Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3)Curated
Modified residuei522N6-acetyllysineBy similarity1
Modified residuei531N6-acetyllysineBy similarity1
Modified residuei534PhosphothreonineCombined sources1
Modified residuei548PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO94776.
MaxQBiO94776.
PaxDbiO94776.
PeptideAtlasiO94776.
PRIDEiO94776.

PTM databases

iPTMnetiO94776.
PhosphoSitePlusiO94776.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000149480.
CleanExiHS_MTA2.
ExpressionAtlasiO94776. baseline and differential.
GenevisibleiO94776. HS.

Organism-specific databases

HPAiCAB005315.
CAB017522.
HPA006214.

Interactioni

Subunit structurei

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC7, p53/TP53, MINT and MBD3 (By similarity). Interacts with FAM64A. Interacts with NACC2.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EHMT2Q96KQ77EBI-1783035,EBI-744366
ESR1P033723EBI-1783035,EBI-78473
PARK7Q994973EBI-1783035,EBI-1164361
ZEB2O603154EBI-1783035,EBI-717614

GO - Molecular functioni

  • RNA polymerase II repressing transcription factor binding Source: BHF-UCL
  • RNA polymerase II transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi114652. 128 interactors.
DIPiDIP-46519N.
IntActiO94776. 45 interactors.
STRINGi9606.ENSP00000278823.

Structurei

3D structure databases

ProteinModelPortaliO94776.
SMRiO94776.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 144BAHPROSITE-ProRule annotationAdd BLAST144
Domaini145 – 256ELM2PROSITE-ProRule annotationAdd BLAST112
Domaini263 – 315SANTPROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 1 BAH domain.PROSITE-ProRule annotation
Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 1 GATA-type zinc finger.Curated
Contains 1 SANT domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri367 – 394GATA-type; atypicalAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3554. Eukaryota.
ENOG410XSAJ. LUCA.
GeneTreeiENSGT00580000081398.
HOGENOMiHOG000045387.
HOVERGENiHBG002598.
InParanoidiO94776.
KOiK11660.
OMAiGPPTPIN.
OrthoDBiEOG091G04Z4.
PhylomeDBiO94776.
TreeFamiTF106444.

Family and domain databases

InterProiIPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
SMARTiSM00439. BAH. 1 hit.
SM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94776-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANMYRVGD YVYFENSSSN PYLVRRIEEL NKTANGNVEA KVVCLFRRRD
60 70 80 90 100
ISSSLNSLAD SNAREFEEES KQPGVSEQQR HQLKHRELFL SRQFESLPAT
110 120 130 140 150
HIRGKCSVTL LNETDILSQY LEKEDCFFYS LVFDPVQKTL LADQGEIRVG
160 170 180 190 200
CKYQAEIPDR LVEGESDNRN QQKMEMKVWD PDNPLTDRQI DQFLVVARAV
210 220 230 240 250
GTFARALDCS SSIRQPSLHM SAAAASRDIT LFHAMDTLQR NGYDLAKAMS
260 270 280 290 300
TLVPQGGPVL CRDEMEEWSA SEAMLFEEAL EKYGKDFNDI RQDFLPWKSL
310 320 330 340 350
ASIVQFYYMW KTTDRYIQQK RLKAAEADSK LKQVYIPTYT KPNPNQIISV
360 370 380 390 400
GSKPGMNGAG FQKGLTCESC HTTQSAQWYA WGPPNMQCRL CASCWIYWKK
410 420 430 440 450
YGGLKTPTQL EGATRGTTEP HSRGHLSRPE AQSLSPYTTS ANRAKLLAKN
460 470 480 490 500
RQTFLLQTTK LTRLARRMCR DLLQPRRAAR RPYAPINANA IKAECSIRLP
510 520 530 540 550
KAAKTPLKIH PLVRLPLATI VKDLVAQAPL KPKTPRGTKT PINRNQLSQN
560 570 580 590 600
RGLGGIMVKR AYETMAGAGV PFSANGRPLA SGIRSSSQPA AKRQKLNPAD
610 620 630 640 650
APNPVVFVAT KDTRALRKAL THLEMRRAAR RPNLPLKVKP TLIAVRPPVP
660
LPAPSHPAST NEPIVLED
Length:668
Mass (Da):75,023
Last modified:May 1, 1999 - v1
Checksum:i65087AF798BA64EC
GO
Isoform 2 (identifier: O94776-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: Missing.

Note: No experimental confirmation available.
Show »
Length:495
Mass (Da):55,037
Checksum:iF6072C422C0F80C6
GO

Sequence cautioni

The sequence AAH23656 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75V → M in BAA36707 (PubMed:9929979).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0550831 – 173Missing in isoform 2. 2 PublicationsAdd BLAST173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012922 Genomic DNA. Translation: BAA36562.1.
AB016591 mRNA. Translation: BAA36707.1.
AF295807 mRNA. Translation: AAG02241.1.
AK301569 mRNA. Translation: BAG63063.1.
CR749481 mRNA. Translation: CAH18309.1.
AP001458 Genomic DNA. No translation available.
BC023656 mRNA. Translation: AAH23656.1. Sequence problems.
BC053650 mRNA. Translation: AAH53650.1.
CCDSiCCDS8022.1. [O94776-1]
CCDS81576.1. [O94776-2]
RefSeqiNP_001317221.1. NM_001330292.1.
NP_004730.2. NM_004739.3. [O94776-1]
UniGeneiHs.173043.

Genome annotation databases

EnsembliENST00000278823; ENSP00000278823; ENSG00000149480. [O94776-1]
ENST00000524902; ENSP00000431346; ENSG00000149480. [O94776-2]
ENST00000527204; ENSP00000431797; ENSG00000149480. [O94776-2]
GeneIDi9219.
KEGGihsa:9219.
UCSCiuc001ntq.3. human. [O94776-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012922 Genomic DNA. Translation: BAA36562.1.
AB016591 mRNA. Translation: BAA36707.1.
AF295807 mRNA. Translation: AAG02241.1.
AK301569 mRNA. Translation: BAG63063.1.
CR749481 mRNA. Translation: CAH18309.1.
AP001458 Genomic DNA. No translation available.
BC023656 mRNA. Translation: AAH23656.1. Sequence problems.
BC053650 mRNA. Translation: AAH53650.1.
CCDSiCCDS8022.1. [O94776-1]
CCDS81576.1. [O94776-2]
RefSeqiNP_001317221.1. NM_001330292.1.
NP_004730.2. NM_004739.3. [O94776-1]
UniGeneiHs.173043.

3D structure databases

ProteinModelPortaliO94776.
SMRiO94776.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114652. 128 interactors.
DIPiDIP-46519N.
IntActiO94776. 45 interactors.
STRINGi9606.ENSP00000278823.

PTM databases

iPTMnetiO94776.
PhosphoSitePlusiO94776.

Polymorphism and mutation databases

BioMutaiMTA2.

Proteomic databases

EPDiO94776.
MaxQBiO94776.
PaxDbiO94776.
PeptideAtlasiO94776.
PRIDEiO94776.

Protocols and materials databases

DNASUi9219.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278823; ENSP00000278823; ENSG00000149480. [O94776-1]
ENST00000524902; ENSP00000431346; ENSG00000149480. [O94776-2]
ENST00000527204; ENSP00000431797; ENSG00000149480. [O94776-2]
GeneIDi9219.
KEGGihsa:9219.
UCSCiuc001ntq.3. human. [O94776-1]

Organism-specific databases

CTDi9219.
DisGeNETi9219.
GeneCardsiMTA2.
HGNCiHGNC:7411. MTA2.
HPAiCAB005315.
CAB017522.
HPA006214.
MIMi603947. gene.
neXtProtiNX_O94776.
OpenTargetsiENSG00000149480.
PharmGKBiPA31219.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3554. Eukaryota.
ENOG410XSAJ. LUCA.
GeneTreeiENSGT00580000081398.
HOGENOMiHOG000045387.
HOVERGENiHBG002598.
InParanoidiO94776.
KOiK11660.
OMAiGPPTPIN.
OrthoDBiEOG091G04Z4.
PhylomeDBiO94776.
TreeFamiTF106444.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149480-MONOMER.
ReactomeiR-HSA-3214815. HDACs deacetylate histones.
R-HSA-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.
R-HSA-6804758. Regulation of TP53 Activity through Acetylation.
R-HSA-73762. RNA Polymerase I Transcription Initiation.

Miscellaneous databases

ChiTaRSiMTA2. human.
GeneWikiiMTA2.
GenomeRNAii9219.
PROiO94776.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149480.
CleanExiHS_MTA2.
ExpressionAtlasiO94776. baseline and differential.
GenevisibleiO94776. HS.

Family and domain databases

InterProiIPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
SMARTiSM00439. BAH. 1 hit.
SM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTA2_HUMAN
AccessioniPrimary (citable) accession number: O94776
Secondary accession number(s): Q68DB1, Q9UQB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.