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Protein

Lymphocyte antigen 6H

Gene

LY6H

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • animal organ morphogenesis Source: ProtInc
  • nervous system development Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176956-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 6H
Short name:
Ly-6H
Gene namesi
Name:LY6H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:6728. LY6H.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176956.
ENSG00000274488.
PharmGKBiPA30492.

Polymorphism and mutation databases

BioMutaiLY6H.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003614826 – 115Lymphocyte antigen 6HAdd BLAST90
PropeptideiPRO_0000036149116 – 140Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 52By similarity
Disulfide bondi31 ↔ 40By similarity
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi45 ↔ 73By similarity
Disulfide bondi77 ↔ 104By similarity
Disulfide bondi105 ↔ 110By similarity
Lipidationi115GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO94772.
PeptideAtlasiO94772.
PRIDEiO94772.

PTM databases

iPTMnetiO94772.
PhosphoSitePlusiO94772.

Expressioni

Tissue specificityi

Highly expressed in brain (cerebral cortex, amygdala, hippocampus and subthalamic nucleus) and in acute human leukemic cell line MOLT-3. Also found in lower levels in testis, pancreas, small intestine and colon.

Gene expression databases

BgeeiENSG00000176956.
CleanExiHS_LY6H.
GenevisibleiO94772. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP5-9P263713EBI-724687,EBI-3958099

Protein-protein interaction databases

BioGridi110240. 1 interactor.
IntActiO94772. 3 interactors.
MINTiMINT-1415145.
STRINGi9606.ENSP00000342711.

Structurei

3D structure databases

ProteinModelPortaliO94772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 91UPAR/Ly6Add BLAST66

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4NS. Eukaryota.
ENOG41117ZV. LUCA.
GeneTreeiENSGT00730000111458.
HOGENOMiHOG000059606.
HOVERGENiHBG006295.
InParanoidiO94772.
KOiK06846.
OMAiAWSMLPA.
OrthoDBiEOG091G0VTU.
PhylomeDBiO94772.
TreeFamiTF337757.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
[Graphical view]
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94772-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPAAMKGLG LALLAVLLCS APAHGLWCQD CTLTTNSSHC TPKQCQPSDT
60 70 80 90 100
VCASVRITDP SSSRKDHSVN KMCASSCDFV KRHFFSDYLM GFINSGILKV
110 120 130 140
DVDCCEKDLC NGAAGAGHSP WALAGGLLLS LGPALLWAGP
Length:140
Mass (Da):14,669
Last modified:May 1, 1999 - v1
Checksum:iA9274BFE89B6CBA3
GO
Isoform 2 (identifier: O94772-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLAPQRTRAPSPRAAPRPTRSM

Note: No experimental confirmation available.
Show »
Length:161
Mass (Da):16,969
Checksum:i4936AA12622DAB76
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4A → T in CAG33315 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0534971M → MLAPQRTRAPSPRAAPRPTR SM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012293 mRNA. Translation: BAA34115.1.
BX419752 mRNA. No translation available.
CR457034 mRNA. Translation: CAG33315.1.
AK314139 mRNA. Translation: BAG36829.1.
AC083982 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82277.1.
BC028894 mRNA. Translation: AAH28894.1.
BC030192 mRNA. Translation: AAH30192.1.
CCDSiCCDS47926.1. [O94772-2]
CCDS6396.1. [O94772-1]
RefSeqiNP_001123950.1. NM_001130478.1. [O94772-2]
NP_001129127.1. NM_001135655.1. [O94772-2]
NP_002338.3. NM_002347.4. [O94772-1]
XP_016868903.1. XM_017013414.1. [O94772-1]
UniGeneiHs.159590.

Genome annotation databases

EnsembliENST00000342752; ENSP00000342711; ENSG00000176956. [O94772-2]
ENST00000414417; ENSP00000399485; ENSG00000176956. [O94772-2]
ENST00000430474; ENSP00000409899; ENSG00000176956. [O94772-1]
ENST00000610554; ENSP00000478470; ENSG00000274488. [O94772-1]
ENST00000615409; ENSP00000480084; ENSG00000176956. [O94772-1]
ENST00000615434; ENSP00000482094; ENSG00000274488. [O94772-2]
ENST00000631670; ENSP00000487965; ENSG00000274488. [O94772-2]
GeneIDi4062.
KEGGihsa:4062.
UCSCiuc011lka.2. human. [O94772-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012293 mRNA. Translation: BAA34115.1.
BX419752 mRNA. No translation available.
CR457034 mRNA. Translation: CAG33315.1.
AK314139 mRNA. Translation: BAG36829.1.
AC083982 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82277.1.
BC028894 mRNA. Translation: AAH28894.1.
BC030192 mRNA. Translation: AAH30192.1.
CCDSiCCDS47926.1. [O94772-2]
CCDS6396.1. [O94772-1]
RefSeqiNP_001123950.1. NM_001130478.1. [O94772-2]
NP_001129127.1. NM_001135655.1. [O94772-2]
NP_002338.3. NM_002347.4. [O94772-1]
XP_016868903.1. XM_017013414.1. [O94772-1]
UniGeneiHs.159590.

3D structure databases

ProteinModelPortaliO94772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110240. 1 interactor.
IntActiO94772. 3 interactors.
MINTiMINT-1415145.
STRINGi9606.ENSP00000342711.

PTM databases

iPTMnetiO94772.
PhosphoSitePlusiO94772.

Polymorphism and mutation databases

BioMutaiLY6H.

Proteomic databases

PaxDbiO94772.
PeptideAtlasiO94772.
PRIDEiO94772.

Protocols and materials databases

DNASUi4062.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342752; ENSP00000342711; ENSG00000176956. [O94772-2]
ENST00000414417; ENSP00000399485; ENSG00000176956. [O94772-2]
ENST00000430474; ENSP00000409899; ENSG00000176956. [O94772-1]
ENST00000610554; ENSP00000478470; ENSG00000274488. [O94772-1]
ENST00000615409; ENSP00000480084; ENSG00000176956. [O94772-1]
ENST00000615434; ENSP00000482094; ENSG00000274488. [O94772-2]
ENST00000631670; ENSP00000487965; ENSG00000274488. [O94772-2]
GeneIDi4062.
KEGGihsa:4062.
UCSCiuc011lka.2. human. [O94772-1]

Organism-specific databases

CTDi4062.
GeneCardsiLY6H.
HGNCiHGNC:6728. LY6H.
MIMi603625. gene.
neXtProtiNX_O94772.
OpenTargetsiENSG00000176956.
ENSG00000274488.
PharmGKBiPA30492.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4NS. Eukaryota.
ENOG41117ZV. LUCA.
GeneTreeiENSGT00730000111458.
HOGENOMiHOG000059606.
HOVERGENiHBG006295.
InParanoidiO94772.
KOiK06846.
OMAiAWSMLPA.
OrthoDBiEOG091G0VTU.
PhylomeDBiO94772.
TreeFamiTF337757.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176956-MONOMER.

Miscellaneous databases

GenomeRNAii4062.
PROiO94772.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176956.
CleanExiHS_LY6H.
GenevisibleiO94772. HS.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
[Graphical view]
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLY6H_HUMAN
AccessioniPrimary (citable) accession number: O94772
Secondary accession number(s): B2RAD2, J3KQI0, Q6IAX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.