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O94769 (ECM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Extracellular matrix protein 2
Alternative name(s):
Matrix glycoprotein SC1/ECM2
Gene names
Name:ECM2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length699 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Promotes matrix assembly and cell adhesiveness By similarity.

Subunit structure

Interacts with numerous extracellular matrix proteins By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Tissue specificity

Expressed predominantly in adipose tissue as well as female-specific organs such as mammary gland, ovary, and uterus.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.

Contains 13 LRR (leucine-rich) repeats.

Contains 1 LRRNT domain.

Contains 1 VWFC domain.

Sequence caution

The sequence CAD97940.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O94769-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O94769-2)

The sequence of this isoform differs from the canonical sequence as follows:
     161-182: Missing.
     645-699: NILPEEICNA...SIVLKPQNIK → CVSDAVLETVTNRSDVAFPLW

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 699679Extracellular matrix protein 2
PRO_0000032731

Regions

Domain101 – 15858VWFC
Domain307 – 34438LRRNT
Repeat368 – 38821LRR 1
Repeat394 – 41522LRR 2
Repeat416 – 43621LRR 3
Repeat439 – 45921LRR 4
Repeat465 – 48420LRR 5
Repeat486 – 50722LRR 6
Repeat510 – 53021LRR 7
Repeat536 – 55722LRR 8
Repeat558 – 57821LRR 9
Repeat582 – 60221LRR 10
Repeat609 – 63022LRR 11
Repeat632 – 65322LRR 12
Repeat661 – 68424LRR 13
Motif294 – 2963Cell attachment site Potential
Compositional bias270 – 28112Poly-Glu

Amino acid modifications

Glycosylation3781N-linked (GlcNAc...) Potential
Glycosylation4491N-linked (GlcNAc...) Potential
Glycosylation5061N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence161 – 18222Missing in isoform 2.
VSP_039114
Alternative sequence645 – 69955NILPE…PQNIK → CVSDAVLETVTNRSDVAFPL W in isoform 2.
VSP_039115
Natural variant561Q → P. Ref.3
Corresponds to variant rs10120210 [ dbSNP | Ensembl ].
VAR_024646
Natural variant1091T → S.
Corresponds to variant rs35496743 [ dbSNP | Ensembl ].
VAR_052010
Natural variant2041R → Q.
Corresponds to variant rs34758505 [ dbSNP | Ensembl ].
VAR_052011

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: E44E76A40A5C2742

FASTA69979,789
        10         20         30         40         50         60 
MKIAVLFCFF LLIIFQTDFG KNEEIPRKQR RKIYHRRLRK SSTSHKHRSN RQLGIQQTTV 

        70         80         90        100        110        120 
FTPVARLPIV NFDYSMEEKF ESFSSFPGVE SSYNVLPGKK GHCLVKGITM YNKAVWSPEP 

       130        140        150        160        170        180 
CTTCLCSDGR VLCDETMCHP QRCPQTVIPE GECCPVCSAT VSYSLLSGIA LNDRNEFSGD 

       190        200        210        220        230        240 
SSEQREPTNL LHKQLPPPQV GMDRIVRKEA LQSEEDEEVK EEDTEQKRET PESRNQGQLY 

       250        260        270        280        290        300 
SEGDSRGGDR KQRPGEERRL AHQQQRQGRE EEEDEEEEGE EGEEDEEDEE DPVRGDMFRM 

       310        320        330        340        350        360 
PSRSPLPAPP RGTLRLPSGC SLSYRTISCI NAMLTQIPPL TAPQITSLEL TGNSIASIPD 

       370        380        390        400        410        420 
EAFNGLPNLE RLDLSKNNIT SSGIGPKAFK LLKKLMRLNM DGNNLIQIPS QLPSTLEELK 

       430        440        450        460        470        480 
VNENNLQAID EESLSDLNQL VTLELEGNNL SEANVNPLAF KPLKSLAYLR LGKNKFRIIP 

       490        500        510        520        530        540 
QGLPGSIEEL YLENNQIEEI TEICFNHTRK INVIVLRYNK IEENRIAPLA WINQENLESI 

       550        560        570        580        590        600 
DLSYNKLYHV PSYLPKSLLH LVLLGNQIER IPGYVFGHME PGLEYLYLSF NKLADDGMDR 

       610        620        630        640        650        660 
VSFYGAYHSL RELFLDHNDL KSIPPGIQEM KALHFLRLNN NKIRNILPEE ICNAEEDDDS 

       670        680        690 
NLEHLHLENN YIKIREIPSY TFSCIRSYSS IVLKPQNIK 

« Hide

Isoform 2 [UniParc].

Checksum: 7F7C9722614F657A
Show »

FASTA64373,348

References

« Hide 'large scale' references
[1]"Identification of a novel gene (ECM2) encoding a putative extracellular matrix protein expressed predominantly in adipose and female-specific tissues and its chromosomal localization to 9q22.3."
Nishiu J., Tanaka T., Nakamura Y.
Genomics 52:378-381(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-56.
Tissue: Retina.
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB011792 mRNA. Translation: BAA33958.1.
AK312820 mRNA. Translation: BAG35677.1.
BX537976 mRNA. Translation: CAD97940.1. Different initiation.
AL137848, AL157827 Genomic DNA. Translation: CAI16693.1.
AL157827, AL137848 Genomic DNA. Translation: CAI12589.1.
CH471089 Genomic DNA. Translation: EAW62824.1.
BC107493 mRNA. Translation: AAI07494.1.
CCDSCCDS56578.1. [O94769-2]
CCDS6698.1. [O94769-1]
RefSeqNP_001184224.1. NM_001197295.1.
NP_001184225.1. NM_001197296.1. [O94769-2]
NP_001384.1. NM_001393.3. [O94769-1]
UniGeneHs.117060.

3D structure databases

ProteinModelPortalO94769.
SMRO94769. Positions 99-162, 317-694.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4722311.
STRING9606.ENSP00000344758.

PTM databases

PhosphoSiteO94769.

Proteomic databases

PaxDbO94769.
PRIDEO94769.

Protocols and materials databases

DNASU1842.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344604; ENSP00000344758; ENSG00000106823. [O94769-1]
ENST00000444490; ENSP00000393971; ENSG00000106823. [O94769-2]
GeneID1842.
KEGGhsa:1842.
UCSCuc004asf.4. human. [O94769-2]
uc011lty.2. human. [O94769-1]

Organism-specific databases

CTD1842.
GeneCardsGC09M095257.
HGNCHGNC:3154. ECM2.
HPAHPA035347.
MIM603479. gene.
neXtProtNX_O94769.
PharmGKBPA27599.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000112319.
HOVERGENHBG031529.
InParanoidO94769.
KOK08119.
OMAAVWSPKP.
OrthoDBEOG773XGV.
PhylomeDBO94769.
TreeFamTF330031.

Gene expression databases

ArrayExpressO94769.
BgeeO94769.
CleanExHS_ECM2.
GenevestigatorO94769.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF13855. LRR_8. 4 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTSM00214. VWC. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 12 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiECM2.
GenomeRNAi1842.
NextBio7543.
PROO94769.
SOURCESearch...

Entry information

Entry nameECM2_HUMAN
AccessionPrimary (citable) accession number: O94769
Secondary accession number(s): B2R730 expand/collapse secondary AC list , E2PU11, Q5T9F2, Q7Z3D0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM