Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O94769

- ECM2_HUMAN

UniProt

O94769 - ECM2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Extracellular matrix protein 2

Gene

ECM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Promotes matrix assembly and cell adhesiveness.By similarity

GO - Molecular functioni

  1. heparin binding Source: Ensembl
  2. integrin binding Source: ProtInc

GO - Biological processi

  1. cell-matrix adhesion Source: ProtInc
  2. extracellular matrix organization Source: Ensembl
  3. positive regulation of cell-substrate adhesion Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular matrix protein 2
Alternative name(s):
Matrix glycoprotein SC1/ECM2
Gene namesi
Name:ECM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:3154. ECM2.

Subcellular locationi

GO - Cellular componenti

  1. interstitial matrix Source: Ensembl
  2. proteinaceous extracellular matrix Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27599.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 699679Extracellular matrix protein 2PRO_0000032731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi506 – 5061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO94769.
PRIDEiO94769.

PTM databases

PhosphoSiteiO94769.

Expressioni

Tissue specificityi

Expressed predominantly in adipose tissue as well as female-specific organs such as mammary gland, ovary, and uterus.

Gene expression databases

BgeeiO94769.
CleanExiHS_ECM2.
ExpressionAtlasiO94769. baseline and differential.
GenevestigatoriO94769.

Organism-specific databases

HPAiHPA035347.

Interactioni

Subunit structurei

Interacts with numerous extracellular matrix proteins.By similarity

Protein-protein interaction databases

MINTiMINT-4722311.
STRINGi9606.ENSP00000344758.

Structurei

3D structure databases

ProteinModelPortaliO94769.
SMRiO94769. Positions 99-162, 317-694.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 15858VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini307 – 34438LRRNTAdd
BLAST
Repeati368 – 38821LRR 1Add
BLAST
Repeati394 – 41522LRR 2Add
BLAST
Repeati416 – 43621LRR 3Add
BLAST
Repeati439 – 45921LRR 4Add
BLAST
Repeati465 – 48420LRR 5Add
BLAST
Repeati486 – 50722LRR 6Add
BLAST
Repeati510 – 53021LRR 7Add
BLAST
Repeati536 – 55722LRR 8Add
BLAST
Repeati558 – 57821LRR 9Add
BLAST
Repeati582 – 60221LRR 10Add
BLAST
Repeati609 – 63022LRR 11Add
BLAST
Repeati632 – 65322LRR 12Add
BLAST
Repeati661 – 68424LRR 13Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi294 – 2963Cell attachment siteSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi270 – 28112Poly-GluAdd
BLAST

Sequence similaritiesi

Contains 13 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000112319.
HOVERGENiHBG031529.
InParanoidiO94769.
KOiK08119.
OMAiAVWSPKP.
OrthoDBiEOG773XGV.
PhylomeDBiO94769.
TreeFamiTF330031.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 12 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O94769-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIAVLFCFF LLIIFQTDFG KNEEIPRKQR RKIYHRRLRK SSTSHKHRSN
60 70 80 90 100
RQLGIQQTTV FTPVARLPIV NFDYSMEEKF ESFSSFPGVE SSYNVLPGKK
110 120 130 140 150
GHCLVKGITM YNKAVWSPEP CTTCLCSDGR VLCDETMCHP QRCPQTVIPE
160 170 180 190 200
GECCPVCSAT VSYSLLSGIA LNDRNEFSGD SSEQREPTNL LHKQLPPPQV
210 220 230 240 250
GMDRIVRKEA LQSEEDEEVK EEDTEQKRET PESRNQGQLY SEGDSRGGDR
260 270 280 290 300
KQRPGEERRL AHQQQRQGRE EEEDEEEEGE EGEEDEEDEE DPVRGDMFRM
310 320 330 340 350
PSRSPLPAPP RGTLRLPSGC SLSYRTISCI NAMLTQIPPL TAPQITSLEL
360 370 380 390 400
TGNSIASIPD EAFNGLPNLE RLDLSKNNIT SSGIGPKAFK LLKKLMRLNM
410 420 430 440 450
DGNNLIQIPS QLPSTLEELK VNENNLQAID EESLSDLNQL VTLELEGNNL
460 470 480 490 500
SEANVNPLAF KPLKSLAYLR LGKNKFRIIP QGLPGSIEEL YLENNQIEEI
510 520 530 540 550
TEICFNHTRK INVIVLRYNK IEENRIAPLA WINQENLESI DLSYNKLYHV
560 570 580 590 600
PSYLPKSLLH LVLLGNQIER IPGYVFGHME PGLEYLYLSF NKLADDGMDR
610 620 630 640 650
VSFYGAYHSL RELFLDHNDL KSIPPGIQEM KALHFLRLNN NKIRNILPEE
660 670 680 690
ICNAEEDDDS NLEHLHLENN YIKIREIPSY TFSCIRSYSS IVLKPQNIK
Length:699
Mass (Da):79,789
Last modified:May 1, 1999 - v1
Checksum:iE44E76A40A5C2742
GO
Isoform 2 (identifier: O94769-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-182: Missing.
     645-699: NILPEEICNA...SIVLKPQNIK → CVSDAVLETVTNRSDVAFPLW

Show »
Length:643
Mass (Da):73,348
Checksum:i7F7C9722614F657A
GO

Sequence cautioni

The sequence CAD97940.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561Q → P.1 Publication
Corresponds to variant rs10120210 [ dbSNP | Ensembl ].
VAR_024646
Natural varianti109 – 1091T → S.
Corresponds to variant rs35496743 [ dbSNP | Ensembl ].
VAR_052010
Natural varianti204 – 2041R → Q.
Corresponds to variant rs34758505 [ dbSNP | Ensembl ].
VAR_052011

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei161 – 18222Missing in isoform 2. 1 PublicationVSP_039114Add
BLAST
Alternative sequencei645 – 69955NILPE…PQNIK → CVSDAVLETVTNRSDVAFPL W in isoform 2. 1 PublicationVSP_039115Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011792 mRNA. Translation: BAA33958.1.
AK312820 mRNA. Translation: BAG35677.1.
BX537976 mRNA. Translation: CAD97940.1. Different initiation.
AL137848, AL157827 Genomic DNA. Translation: CAI16693.1.
AL157827, AL137848 Genomic DNA. Translation: CAI12589.1.
CH471089 Genomic DNA. Translation: EAW62824.1.
BC107493 mRNA. Translation: AAI07494.1.
CCDSiCCDS56578.1. [O94769-2]
CCDS6698.1. [O94769-1]
RefSeqiNP_001184224.1. NM_001197295.1.
NP_001184225.1. NM_001197296.1. [O94769-2]
NP_001384.1. NM_001393.3. [O94769-1]
UniGeneiHs.117060.

Genome annotation databases

EnsembliENST00000344604; ENSP00000344758; ENSG00000106823. [O94769-1]
ENST00000444490; ENSP00000393971; ENSG00000106823. [O94769-2]
GeneIDi1842.
KEGGihsa:1842.
UCSCiuc004asf.4. human. [O94769-2]
uc011lty.2. human. [O94769-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011792 mRNA. Translation: BAA33958.1 .
AK312820 mRNA. Translation: BAG35677.1 .
BX537976 mRNA. Translation: CAD97940.1 . Different initiation.
AL137848 , AL157827 Genomic DNA. Translation: CAI16693.1 .
AL157827 , AL137848 Genomic DNA. Translation: CAI12589.1 .
CH471089 Genomic DNA. Translation: EAW62824.1 .
BC107493 mRNA. Translation: AAI07494.1 .
CCDSi CCDS56578.1. [O94769-2 ]
CCDS6698.1. [O94769-1 ]
RefSeqi NP_001184224.1. NM_001197295.1.
NP_001184225.1. NM_001197296.1. [O94769-2 ]
NP_001384.1. NM_001393.3. [O94769-1 ]
UniGenei Hs.117060.

3D structure databases

ProteinModelPortali O94769.
SMRi O94769. Positions 99-162, 317-694.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4722311.
STRINGi 9606.ENSP00000344758.

PTM databases

PhosphoSitei O94769.

Proteomic databases

PaxDbi O94769.
PRIDEi O94769.

Protocols and materials databases

DNASUi 1842.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344604 ; ENSP00000344758 ; ENSG00000106823 . [O94769-1 ]
ENST00000444490 ; ENSP00000393971 ; ENSG00000106823 . [O94769-2 ]
GeneIDi 1842.
KEGGi hsa:1842.
UCSCi uc004asf.4. human. [O94769-2 ]
uc011lty.2. human. [O94769-1 ]

Organism-specific databases

CTDi 1842.
GeneCardsi GC09M095257.
HGNCi HGNC:3154. ECM2.
HPAi HPA035347.
MIMi 603479. gene.
neXtProti NX_O94769.
PharmGKBi PA27599.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118969.
HOGENOMi HOG000112319.
HOVERGENi HBG031529.
InParanoidi O94769.
KOi K08119.
OMAi AVWSPKP.
OrthoDBi EOG773XGV.
PhylomeDBi O94769.
TreeFami TF330031.

Miscellaneous databases

GeneWikii ECM2.
GenomeRNAii 1842.
NextBioi 7543.
PROi O94769.
SOURCEi Search...

Gene expression databases

Bgeei O94769.
CleanExi HS_ECM2.
ExpressionAtlasi O94769. baseline and differential.
Genevestigatori O94769.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF13855. LRR_8. 4 hits.
PF00093. VWC. 1 hit.
[Graphical view ]
SMARTi SM00214. VWC. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 12 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel gene (ECM2) encoding a putative extracellular matrix protein expressed predominantly in adipose and female-specific tissues and its chromosomal localization to 9q22.3."
    Nishiu J., Tanaka T., Nakamura Y.
    Genomics 52:378-381(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-56.
    Tissue: Retina.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiECM2_HUMAN
AccessioniPrimary (citable) accession number: O94769
Secondary accession number(s): B2R730
, E2PU11, Q5T9F2, Q7Z3D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3