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Protein

Extracellular matrix protein 2

Gene

ECM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes matrix assembly and cell adhesiveness.By similarity

GO - Molecular functioni

  • collagen V binding Source: GO_Central
  • heparin binding Source: GO_Central
  • integrin binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106823-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular matrix protein 2
Alternative name(s):
Matrix glycoprotein SC1/ECM2
Gene namesi
Name:ECM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:3154. ECM2.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: GO_Central
  • interstitial matrix Source: Ensembl
  • proteinaceous extracellular matrix Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1842.
OpenTargetsiENSG00000106823.
PharmGKBiPA27599.

Polymorphism and mutation databases

BioMutaiECM2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003273121 – 699Extracellular matrix protein 2Add BLAST679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi378N-linked (GlcNAc...)Sequence analysis1
Glycosylationi449N-linked (GlcNAc...)Sequence analysis1
Glycosylationi506N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO94769.
PeptideAtlasiO94769.
PRIDEiO94769.

PTM databases

iPTMnetiO94769.
PhosphoSitePlusiO94769.

Expressioni

Tissue specificityi

Expressed predominantly in adipose tissue as well as female-specific organs such as mammary gland, ovary, and uterus.

Gene expression databases

BgeeiENSG00000106823.
CleanExiHS_ECM2.
ExpressionAtlasiO94769. baseline and differential.
GenevisibleiO94769. HS.

Organism-specific databases

HPAiHPA035347.

Interactioni

Subunit structurei

Interacts with numerous extracellular matrix proteins.By similarity

GO - Molecular functioni

  • collagen V binding Source: GO_Central
  • integrin binding Source: ProtInc

Protein-protein interaction databases

MINTiMINT-4722311.
STRINGi9606.ENSP00000344758.

Structurei

3D structure databases

ProteinModelPortaliO94769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 158VWFCPROSITE-ProRule annotationAdd BLAST58
Domaini307 – 344LRRNTAdd BLAST38
Repeati368 – 388LRR 1Add BLAST21
Repeati394 – 415LRR 2Add BLAST22
Repeati416 – 436LRR 3Add BLAST21
Repeati439 – 459LRR 4Add BLAST21
Repeati465 – 484LRR 5Add BLAST20
Repeati486 – 507LRR 6Add BLAST22
Repeati510 – 530LRR 7Add BLAST21
Repeati536 – 557LRR 8Add BLAST22
Repeati558 – 578LRR 9Add BLAST21
Repeati582 – 602LRR 10Add BLAST21
Repeati609 – 630LRR 11Add BLAST22
Repeati632 – 653LRR 12Add BLAST22
Repeati661 – 684LRR 13Add BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi294 – 296Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi270 – 281Poly-GluAdd BLAST12

Sequence similaritiesi

Contains 13 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000112319.
HOVERGENiHBG031529.
InParanoidiO94769.
KOiK08119.
OMAiVWSPKPC.
OrthoDBiEOG091G03L1.
PhylomeDBiO94769.
TreeFamiTF330031.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 12 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94769-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIAVLFCFF LLIIFQTDFG KNEEIPRKQR RKIYHRRLRK SSTSHKHRSN
60 70 80 90 100
RQLGIQQTTV FTPVARLPIV NFDYSMEEKF ESFSSFPGVE SSYNVLPGKK
110 120 130 140 150
GHCLVKGITM YNKAVWSPEP CTTCLCSDGR VLCDETMCHP QRCPQTVIPE
160 170 180 190 200
GECCPVCSAT VSYSLLSGIA LNDRNEFSGD SSEQREPTNL LHKQLPPPQV
210 220 230 240 250
GMDRIVRKEA LQSEEDEEVK EEDTEQKRET PESRNQGQLY SEGDSRGGDR
260 270 280 290 300
KQRPGEERRL AHQQQRQGRE EEEDEEEEGE EGEEDEEDEE DPVRGDMFRM
310 320 330 340 350
PSRSPLPAPP RGTLRLPSGC SLSYRTISCI NAMLTQIPPL TAPQITSLEL
360 370 380 390 400
TGNSIASIPD EAFNGLPNLE RLDLSKNNIT SSGIGPKAFK LLKKLMRLNM
410 420 430 440 450
DGNNLIQIPS QLPSTLEELK VNENNLQAID EESLSDLNQL VTLELEGNNL
460 470 480 490 500
SEANVNPLAF KPLKSLAYLR LGKNKFRIIP QGLPGSIEEL YLENNQIEEI
510 520 530 540 550
TEICFNHTRK INVIVLRYNK IEENRIAPLA WINQENLESI DLSYNKLYHV
560 570 580 590 600
PSYLPKSLLH LVLLGNQIER IPGYVFGHME PGLEYLYLSF NKLADDGMDR
610 620 630 640 650
VSFYGAYHSL RELFLDHNDL KSIPPGIQEM KALHFLRLNN NKIRNILPEE
660 670 680 690
ICNAEEDDDS NLEHLHLENN YIKIREIPSY TFSCIRSYSS IVLKPQNIK
Length:699
Mass (Da):79,789
Last modified:May 1, 1999 - v1
Checksum:iE44E76A40A5C2742
GO
Isoform 2 (identifier: O94769-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-182: Missing.
     645-699: NILPEEICNA...SIVLKPQNIK → CVSDAVLETVTNRSDVAFPLW

Show »
Length:643
Mass (Da):73,348
Checksum:i7F7C9722614F657A
GO

Sequence cautioni

The sequence CAD97940 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02464656Q → P.1 PublicationCorresponds to variant rs10120210dbSNPEnsembl.1
Natural variantiVAR_052010109T → S.Corresponds to variant rs35496743dbSNPEnsembl.1
Natural variantiVAR_052011204R → Q.Corresponds to variant rs34758505dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039114161 – 182Missing in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_039115645 – 699NILPE…PQNIK → CVSDAVLETVTNRSDVAFPL W in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011792 mRNA. Translation: BAA33958.1.
AK312820 mRNA. Translation: BAG35677.1.
BX537976 mRNA. Translation: CAD97940.1. Different initiation.
AL137848, AL157827 Genomic DNA. Translation: CAI16693.1.
AL157827, AL137848 Genomic DNA. Translation: CAI12589.1.
CH471089 Genomic DNA. Translation: EAW62824.1.
BC107493 mRNA. Translation: AAI07494.1.
CCDSiCCDS56578.1. [O94769-2]
CCDS6698.1. [O94769-1]
RefSeqiNP_001184224.1. NM_001197295.1.
NP_001184225.1. NM_001197296.1. [O94769-2]
NP_001384.1. NM_001393.3. [O94769-1]
UniGeneiHs.117060.

Genome annotation databases

EnsembliENST00000344604; ENSP00000344758; ENSG00000106823. [O94769-1]
ENST00000444490; ENSP00000393971; ENSG00000106823. [O94769-2]
GeneIDi1842.
KEGGihsa:1842.
UCSCiuc004asf.5. human. [O94769-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011792 mRNA. Translation: BAA33958.1.
AK312820 mRNA. Translation: BAG35677.1.
BX537976 mRNA. Translation: CAD97940.1. Different initiation.
AL137848, AL157827 Genomic DNA. Translation: CAI16693.1.
AL157827, AL137848 Genomic DNA. Translation: CAI12589.1.
CH471089 Genomic DNA. Translation: EAW62824.1.
BC107493 mRNA. Translation: AAI07494.1.
CCDSiCCDS56578.1. [O94769-2]
CCDS6698.1. [O94769-1]
RefSeqiNP_001184224.1. NM_001197295.1.
NP_001184225.1. NM_001197296.1. [O94769-2]
NP_001384.1. NM_001393.3. [O94769-1]
UniGeneiHs.117060.

3D structure databases

ProteinModelPortaliO94769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4722311.
STRINGi9606.ENSP00000344758.

PTM databases

iPTMnetiO94769.
PhosphoSitePlusiO94769.

Polymorphism and mutation databases

BioMutaiECM2.

Proteomic databases

PaxDbiO94769.
PeptideAtlasiO94769.
PRIDEiO94769.

Protocols and materials databases

DNASUi1842.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344604; ENSP00000344758; ENSG00000106823. [O94769-1]
ENST00000444490; ENSP00000393971; ENSG00000106823. [O94769-2]
GeneIDi1842.
KEGGihsa:1842.
UCSCiuc004asf.5. human. [O94769-1]

Organism-specific databases

CTDi1842.
DisGeNETi1842.
GeneCardsiECM2.
HGNCiHGNC:3154. ECM2.
HPAiHPA035347.
MIMi603479. gene.
neXtProtiNX_O94769.
OpenTargetsiENSG00000106823.
PharmGKBiPA27599.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000112319.
HOVERGENiHBG031529.
InParanoidiO94769.
KOiK08119.
OMAiVWSPKPC.
OrthoDBiEOG091G03L1.
PhylomeDBiO94769.
TreeFamiTF330031.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106823-MONOMER.

Miscellaneous databases

GeneWikiiECM2.
GenomeRNAii1842.
PROiO94769.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106823.
CleanExiHS_ECM2.
ExpressionAtlasiO94769. baseline and differential.
GenevisibleiO94769. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 12 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECM2_HUMAN
AccessioniPrimary (citable) accession number: O94769
Secondary accession number(s): B2R730
, E2PU11, Q5T9F2, Q7Z3D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.