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O94769

- ECM2_HUMAN

UniProt

O94769 - ECM2_HUMAN

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Protein
Extracellular matrix protein 2
Gene
ECM2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Promotes matrix assembly and cell adhesiveness By similarity.

GO - Molecular functioni

  1. heparin binding Source: Ensembl
  2. integrin binding Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. cell-matrix adhesion Source: ProtInc
  2. extracellular matrix organization Source: Ensembl
  3. positive regulation of cell-substrate adhesion Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular matrix protein 2
Alternative name(s):
Matrix glycoprotein SC1/ECM2
Gene namesi
Name:ECM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:3154. ECM2.

Subcellular locationi

GO - Cellular componenti

  1. interstitial matrix Source: Ensembl
  2. proteinaceous extracellular matrix Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27599.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 699679Extracellular matrix protein 2
PRO_0000032731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi378 – 3781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi449 – 4491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi506 – 5061N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO94769.
PRIDEiO94769.

PTM databases

PhosphoSiteiO94769.

Expressioni

Tissue specificityi

Expressed predominantly in adipose tissue as well as female-specific organs such as mammary gland, ovary, and uterus.

Gene expression databases

ArrayExpressiO94769.
BgeeiO94769.
CleanExiHS_ECM2.
GenevestigatoriO94769.

Organism-specific databases

HPAiHPA035347.

Interactioni

Subunit structurei

Interacts with numerous extracellular matrix proteins By similarity.

Protein-protein interaction databases

MINTiMINT-4722311.
STRINGi9606.ENSP00000344758.

Structurei

3D structure databases

ProteinModelPortaliO94769.
SMRiO94769. Positions 99-162, 317-694.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 15858VWFC
Add
BLAST
Domaini307 – 34438LRRNT
Add
BLAST
Repeati368 – 38821LRR 1
Add
BLAST
Repeati394 – 41522LRR 2
Add
BLAST
Repeati416 – 43621LRR 3
Add
BLAST
Repeati439 – 45921LRR 4
Add
BLAST
Repeati465 – 48420LRR 5
Add
BLAST
Repeati486 – 50722LRR 6
Add
BLAST
Repeati510 – 53021LRR 7
Add
BLAST
Repeati536 – 55722LRR 8
Add
BLAST
Repeati558 – 57821LRR 9
Add
BLAST
Repeati582 – 60221LRR 10
Add
BLAST
Repeati609 – 63022LRR 11
Add
BLAST
Repeati632 – 65322LRR 12
Add
BLAST
Repeati661 – 68424LRR 13
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi294 – 2963Cell attachment site Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi270 – 28112Poly-Glu
Add
BLAST

Sequence similaritiesi

Contains 1 LRRNT domain.
Contains 1 VWFC domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000112319.
HOVERGENiHBG031529.
InParanoidiO94769.
KOiK08119.
OMAiAVWSPKP.
OrthoDBiEOG773XGV.
PhylomeDBiO94769.
TreeFamiTF330031.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 12 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O94769-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKIAVLFCFF LLIIFQTDFG KNEEIPRKQR RKIYHRRLRK SSTSHKHRSN    50
RQLGIQQTTV FTPVARLPIV NFDYSMEEKF ESFSSFPGVE SSYNVLPGKK 100
GHCLVKGITM YNKAVWSPEP CTTCLCSDGR VLCDETMCHP QRCPQTVIPE 150
GECCPVCSAT VSYSLLSGIA LNDRNEFSGD SSEQREPTNL LHKQLPPPQV 200
GMDRIVRKEA LQSEEDEEVK EEDTEQKRET PESRNQGQLY SEGDSRGGDR 250
KQRPGEERRL AHQQQRQGRE EEEDEEEEGE EGEEDEEDEE DPVRGDMFRM 300
PSRSPLPAPP RGTLRLPSGC SLSYRTISCI NAMLTQIPPL TAPQITSLEL 350
TGNSIASIPD EAFNGLPNLE RLDLSKNNIT SSGIGPKAFK LLKKLMRLNM 400
DGNNLIQIPS QLPSTLEELK VNENNLQAID EESLSDLNQL VTLELEGNNL 450
SEANVNPLAF KPLKSLAYLR LGKNKFRIIP QGLPGSIEEL YLENNQIEEI 500
TEICFNHTRK INVIVLRYNK IEENRIAPLA WINQENLESI DLSYNKLYHV 550
PSYLPKSLLH LVLLGNQIER IPGYVFGHME PGLEYLYLSF NKLADDGMDR 600
VSFYGAYHSL RELFLDHNDL KSIPPGIQEM KALHFLRLNN NKIRNILPEE 650
ICNAEEDDDS NLEHLHLENN YIKIREIPSY TFSCIRSYSS IVLKPQNIK 699
Length:699
Mass (Da):79,789
Last modified:May 1, 1999 - v1
Checksum:iE44E76A40A5C2742
GO
Isoform 2 (identifier: O94769-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-182: Missing.
     645-699: NILPEEICNA...SIVLKPQNIK → CVSDAVLETVTNRSDVAFPLW

Show »
Length:643
Mass (Da):73,348
Checksum:i7F7C9722614F657A
GO

Sequence cautioni

The sequence CAD97940.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561Q → P.1 Publication
Corresponds to variant rs10120210 [ dbSNP | Ensembl ].
VAR_024646
Natural varianti109 – 1091T → S.
Corresponds to variant rs35496743 [ dbSNP | Ensembl ].
VAR_052010
Natural varianti204 – 2041R → Q.
Corresponds to variant rs34758505 [ dbSNP | Ensembl ].
VAR_052011

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei161 – 18222Missing in isoform 2.
VSP_039114Add
BLAST
Alternative sequencei645 – 69955NILPE…PQNIK → CVSDAVLETVTNRSDVAFPL W in isoform 2.
VSP_039115Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011792 mRNA. Translation: BAA33958.1.
AK312820 mRNA. Translation: BAG35677.1.
BX537976 mRNA. Translation: CAD97940.1. Different initiation.
AL137848, AL157827 Genomic DNA. Translation: CAI16693.1.
AL157827, AL137848 Genomic DNA. Translation: CAI12589.1.
CH471089 Genomic DNA. Translation: EAW62824.1.
BC107493 mRNA. Translation: AAI07494.1.
CCDSiCCDS56578.1. [O94769-2]
CCDS6698.1. [O94769-1]
RefSeqiNP_001184224.1. NM_001197295.1.
NP_001184225.1. NM_001197296.1. [O94769-2]
NP_001384.1. NM_001393.3. [O94769-1]
UniGeneiHs.117060.

Genome annotation databases

EnsembliENST00000344604; ENSP00000344758; ENSG00000106823. [O94769-1]
ENST00000444490; ENSP00000393971; ENSG00000106823. [O94769-2]
GeneIDi1842.
KEGGihsa:1842.
UCSCiuc004asf.4. human. [O94769-2]
uc011lty.2. human. [O94769-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011792 mRNA. Translation: BAA33958.1 .
AK312820 mRNA. Translation: BAG35677.1 .
BX537976 mRNA. Translation: CAD97940.1 . Different initiation.
AL137848 , AL157827 Genomic DNA. Translation: CAI16693.1 .
AL157827 , AL137848 Genomic DNA. Translation: CAI12589.1 .
CH471089 Genomic DNA. Translation: EAW62824.1 .
BC107493 mRNA. Translation: AAI07494.1 .
CCDSi CCDS56578.1. [O94769-2 ]
CCDS6698.1. [O94769-1 ]
RefSeqi NP_001184224.1. NM_001197295.1.
NP_001184225.1. NM_001197296.1. [O94769-2 ]
NP_001384.1. NM_001393.3. [O94769-1 ]
UniGenei Hs.117060.

3D structure databases

ProteinModelPortali O94769.
SMRi O94769. Positions 99-162, 317-694.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-4722311.
STRINGi 9606.ENSP00000344758.

PTM databases

PhosphoSitei O94769.

Proteomic databases

PaxDbi O94769.
PRIDEi O94769.

Protocols and materials databases

DNASUi 1842.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344604 ; ENSP00000344758 ; ENSG00000106823 . [O94769-1 ]
ENST00000444490 ; ENSP00000393971 ; ENSG00000106823 . [O94769-2 ]
GeneIDi 1842.
KEGGi hsa:1842.
UCSCi uc004asf.4. human. [O94769-2 ]
uc011lty.2. human. [O94769-1 ]

Organism-specific databases

CTDi 1842.
GeneCardsi GC09M095257.
HGNCi HGNC:3154. ECM2.
HPAi HPA035347.
MIMi 603479. gene.
neXtProti NX_O94769.
PharmGKBi PA27599.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000112319.
HOVERGENi HBG031529.
InParanoidi O94769.
KOi K08119.
OMAi AVWSPKP.
OrthoDBi EOG773XGV.
PhylomeDBi O94769.
TreeFami TF330031.

Miscellaneous databases

GeneWikii ECM2.
GenomeRNAii 1842.
NextBioi 7543.
PROi O94769.
SOURCEi Search...

Gene expression databases

ArrayExpressi O94769.
Bgeei O94769.
CleanExi HS_ECM2.
Genevestigatori O94769.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF13855. LRR_8. 4 hits.
PF00093. VWC. 1 hit.
[Graphical view ]
SMARTi SM00214. VWC. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 12 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel gene (ECM2) encoding a putative extracellular matrix protein expressed predominantly in adipose and female-specific tissues and its chromosomal localization to 9q22.3."
    Nishiu J., Tanaka T., Nakamura Y.
    Genomics 52:378-381(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-56.
    Tissue: Retina.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiECM2_HUMAN
AccessioniPrimary (citable) accession number: O94769
Secondary accession number(s): B2R730
, E2PU11, Q5T9F2, Q7Z3D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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