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O94769

- ECM2_HUMAN

UniProt

O94769 - ECM2_HUMAN

Protein

Extracellular matrix protein 2

Gene

ECM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Promotes matrix assembly and cell adhesiveness.By similarity

    GO - Molecular functioni

    1. heparin binding Source: Ensembl
    2. integrin binding Source: ProtInc

    GO - Biological processi

    1. cell-matrix adhesion Source: ProtInc
    2. extracellular matrix organization Source: Ensembl
    3. positive regulation of cell-substrate adhesion Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Extracellular matrix protein 2
    Alternative name(s):
    Matrix glycoprotein SC1/ECM2
    Gene namesi
    Name:ECM2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:3154. ECM2.

    Subcellular locationi

    GO - Cellular componenti

    1. interstitial matrix Source: Ensembl
    2. proteinaceous extracellular matrix Source: ProtInc

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27599.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 699679Extracellular matrix protein 2PRO_0000032731Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi506 – 5061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO94769.
    PRIDEiO94769.

    PTM databases

    PhosphoSiteiO94769.

    Expressioni

    Tissue specificityi

    Expressed predominantly in adipose tissue as well as female-specific organs such as mammary gland, ovary, and uterus.

    Gene expression databases

    ArrayExpressiO94769.
    BgeeiO94769.
    CleanExiHS_ECM2.
    GenevestigatoriO94769.

    Organism-specific databases

    HPAiHPA035347.

    Interactioni

    Subunit structurei

    Interacts with numerous extracellular matrix proteins.By similarity

    Protein-protein interaction databases

    MINTiMINT-4722311.
    STRINGi9606.ENSP00000344758.

    Structurei

    3D structure databases

    ProteinModelPortaliO94769.
    SMRiO94769. Positions 99-162, 317-694.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini101 – 15858VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini307 – 34438LRRNTAdd
    BLAST
    Repeati368 – 38821LRR 1Add
    BLAST
    Repeati394 – 41522LRR 2Add
    BLAST
    Repeati416 – 43621LRR 3Add
    BLAST
    Repeati439 – 45921LRR 4Add
    BLAST
    Repeati465 – 48420LRR 5Add
    BLAST
    Repeati486 – 50722LRR 6Add
    BLAST
    Repeati510 – 53021LRR 7Add
    BLAST
    Repeati536 – 55722LRR 8Add
    BLAST
    Repeati558 – 57821LRR 9Add
    BLAST
    Repeati582 – 60221LRR 10Add
    BLAST
    Repeati609 – 63022LRR 11Add
    BLAST
    Repeati632 – 65322LRR 12Add
    BLAST
    Repeati661 – 68424LRR 13Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi294 – 2963Cell attachment siteSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi270 – 28112Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Contains 13 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRNT domain.Curated
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000112319.
    HOVERGENiHBG031529.
    InParanoidiO94769.
    KOiK08119.
    OMAiAVWSPKP.
    OrthoDBiEOG773XGV.
    PhylomeDBiO94769.
    TreeFamiTF330031.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF13855. LRR_8. 4 hits.
    PF00093. VWC. 1 hit.
    [Graphical view]
    SMARTiSM00214. VWC. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 12 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O94769-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKIAVLFCFF LLIIFQTDFG KNEEIPRKQR RKIYHRRLRK SSTSHKHRSN    50
    RQLGIQQTTV FTPVARLPIV NFDYSMEEKF ESFSSFPGVE SSYNVLPGKK 100
    GHCLVKGITM YNKAVWSPEP CTTCLCSDGR VLCDETMCHP QRCPQTVIPE 150
    GECCPVCSAT VSYSLLSGIA LNDRNEFSGD SSEQREPTNL LHKQLPPPQV 200
    GMDRIVRKEA LQSEEDEEVK EEDTEQKRET PESRNQGQLY SEGDSRGGDR 250
    KQRPGEERRL AHQQQRQGRE EEEDEEEEGE EGEEDEEDEE DPVRGDMFRM 300
    PSRSPLPAPP RGTLRLPSGC SLSYRTISCI NAMLTQIPPL TAPQITSLEL 350
    TGNSIASIPD EAFNGLPNLE RLDLSKNNIT SSGIGPKAFK LLKKLMRLNM 400
    DGNNLIQIPS QLPSTLEELK VNENNLQAID EESLSDLNQL VTLELEGNNL 450
    SEANVNPLAF KPLKSLAYLR LGKNKFRIIP QGLPGSIEEL YLENNQIEEI 500
    TEICFNHTRK INVIVLRYNK IEENRIAPLA WINQENLESI DLSYNKLYHV 550
    PSYLPKSLLH LVLLGNQIER IPGYVFGHME PGLEYLYLSF NKLADDGMDR 600
    VSFYGAYHSL RELFLDHNDL KSIPPGIQEM KALHFLRLNN NKIRNILPEE 650
    ICNAEEDDDS NLEHLHLENN YIKIREIPSY TFSCIRSYSS IVLKPQNIK 699
    Length:699
    Mass (Da):79,789
    Last modified:May 1, 1999 - v1
    Checksum:iE44E76A40A5C2742
    GO
    Isoform 2 (identifier: O94769-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         161-182: Missing.
         645-699: NILPEEICNA...SIVLKPQNIK → CVSDAVLETVTNRSDVAFPLW

    Show »
    Length:643
    Mass (Da):73,348
    Checksum:i7F7C9722614F657A
    GO

    Sequence cautioni

    The sequence CAD97940.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti56 – 561Q → P.1 Publication
    Corresponds to variant rs10120210 [ dbSNP | Ensembl ].
    VAR_024646
    Natural varianti109 – 1091T → S.
    Corresponds to variant rs35496743 [ dbSNP | Ensembl ].
    VAR_052010
    Natural varianti204 – 2041R → Q.
    Corresponds to variant rs34758505 [ dbSNP | Ensembl ].
    VAR_052011

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei161 – 18222Missing in isoform 2. 1 PublicationVSP_039114Add
    BLAST
    Alternative sequencei645 – 69955NILPE…PQNIK → CVSDAVLETVTNRSDVAFPL W in isoform 2. 1 PublicationVSP_039115Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011792 mRNA. Translation: BAA33958.1.
    AK312820 mRNA. Translation: BAG35677.1.
    BX537976 mRNA. Translation: CAD97940.1. Different initiation.
    AL137848, AL157827 Genomic DNA. Translation: CAI16693.1.
    AL157827, AL137848 Genomic DNA. Translation: CAI12589.1.
    CH471089 Genomic DNA. Translation: EAW62824.1.
    BC107493 mRNA. Translation: AAI07494.1.
    CCDSiCCDS56578.1. [O94769-2]
    CCDS6698.1. [O94769-1]
    RefSeqiNP_001184224.1. NM_001197295.1.
    NP_001184225.1. NM_001197296.1. [O94769-2]
    NP_001384.1. NM_001393.3. [O94769-1]
    UniGeneiHs.117060.

    Genome annotation databases

    EnsembliENST00000344604; ENSP00000344758; ENSG00000106823. [O94769-1]
    ENST00000444490; ENSP00000393971; ENSG00000106823. [O94769-2]
    GeneIDi1842.
    KEGGihsa:1842.
    UCSCiuc004asf.4. human. [O94769-2]
    uc011lty.2. human. [O94769-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011792 mRNA. Translation: BAA33958.1 .
    AK312820 mRNA. Translation: BAG35677.1 .
    BX537976 mRNA. Translation: CAD97940.1 . Different initiation.
    AL137848 , AL157827 Genomic DNA. Translation: CAI16693.1 .
    AL157827 , AL137848 Genomic DNA. Translation: CAI12589.1 .
    CH471089 Genomic DNA. Translation: EAW62824.1 .
    BC107493 mRNA. Translation: AAI07494.1 .
    CCDSi CCDS56578.1. [O94769-2 ]
    CCDS6698.1. [O94769-1 ]
    RefSeqi NP_001184224.1. NM_001197295.1.
    NP_001184225.1. NM_001197296.1. [O94769-2 ]
    NP_001384.1. NM_001393.3. [O94769-1 ]
    UniGenei Hs.117060.

    3D structure databases

    ProteinModelPortali O94769.
    SMRi O94769. Positions 99-162, 317-694.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4722311.
    STRINGi 9606.ENSP00000344758.

    PTM databases

    PhosphoSitei O94769.

    Proteomic databases

    PaxDbi O94769.
    PRIDEi O94769.

    Protocols and materials databases

    DNASUi 1842.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344604 ; ENSP00000344758 ; ENSG00000106823 . [O94769-1 ]
    ENST00000444490 ; ENSP00000393971 ; ENSG00000106823 . [O94769-2 ]
    GeneIDi 1842.
    KEGGi hsa:1842.
    UCSCi uc004asf.4. human. [O94769-2 ]
    uc011lty.2. human. [O94769-1 ]

    Organism-specific databases

    CTDi 1842.
    GeneCardsi GC09M095257.
    HGNCi HGNC:3154. ECM2.
    HPAi HPA035347.
    MIMi 603479. gene.
    neXtProti NX_O94769.
    PharmGKBi PA27599.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000112319.
    HOVERGENi HBG031529.
    InParanoidi O94769.
    KOi K08119.
    OMAi AVWSPKP.
    OrthoDBi EOG773XGV.
    PhylomeDBi O94769.
    TreeFami TF330031.

    Miscellaneous databases

    GeneWikii ECM2.
    GenomeRNAii 1842.
    NextBioi 7543.
    PROi O94769.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O94769.
    Bgeei O94769.
    CleanExi HS_ECM2.
    Genevestigatori O94769.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF13855. LRR_8. 4 hits.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    SMARTi SM00214. VWC. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 12 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel gene (ECM2) encoding a putative extracellular matrix protein expressed predominantly in adipose and female-specific tissues and its chromosomal localization to 9q22.3."
      Nishiu J., Tanaka T., Nakamura Y.
      Genomics 52:378-381(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-56.
      Tissue: Retina.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

    Entry informationi

    Entry nameiECM2_HUMAN
    AccessioniPrimary (citable) accession number: O94769
    Secondary accession number(s): B2R730
    , E2PU11, Q5T9F2, Q7Z3D0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3