ID   ST17B_HUMAN             Reviewed;         372 AA.
AC   O94768;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   28-JUL-2009, entry version 86.
DE   RecName: Full=Serine/threonine-protein kinase 17B;
DE            EC=2.7.11.1;
DE   AltName: Full=DAP kinase-related apoptosis-inducing protein kinase 2;
GN   Name=STK17B; Synonyms=DRAK2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND MUTAGENESIS OF LYS-62.
RC   TISSUE=Liver, and Placenta;
RX   MEDLINE=99003259; PubMed=9786912; DOI=10.1074/jbc.273.44.29066;
RA   Sanjo H., Kawai T., Akira S.;
RT   "DRAKs, novel serine/threonine kinases related to death-associated
RT   protein kinase that trigger apoptosis.";
RL   J. Biol. Chem. 273:29066-29071(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=B-cell;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   VARIANT [LARGE SCALE ANALYSIS] PHE-320.
RX   PubMed=17344846; DOI=10.1038/nature05610;
RA   Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C.,
RA   Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S.,
RA   O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S.,
RA   Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E.,
RA   Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J.,
RA   Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K.,
RA   Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T.,
RA   West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P.,
RA   Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E.,
RA   DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E.,
RA   Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T.,
RA   Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.;
RT   "Patterns of somatic mutation in human cancer genomes.";
RL   Nature 446:153-158(2007).
CC   -!- FUNCTION: Acts as a positive regulator of apoptosis.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBUNIT: Interacts with CHP causing CHP to translocate from the
CC       Golgi to the nucleus (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Highly expressed in placenta, lung, pancreas.
CC       Lower levels in heart, brain, liver, skeletal muscle and kidney.
CC   -!- PTM: Autophosphorylated.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK
CC       Ser/Thr protein kinase family. DAP kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; AB011421; BAA34127.1; -; mRNA.
DR   EMBL; BC016040; AAH16040.1; -; mRNA.
DR   IPI; IPI00014934; -.
DR   RefSeq; NP_004217.1; -.
DR   UniGene; Hs.710234; -.
DR   UniGene; Hs.88297; -.
DR   HSSP; P53355; 1JKT.
DR   PhosphoSite; O94768; -.
DR   PRIDE; O94768; -.
DR   Ensembl; ENST00000263955; ENSP00000263955; ENSG00000081320; Homo sapiens.
DR   Ensembl; ENST00000409228; ENSP00000386853; ENSG00000081320; Homo sapiens.
DR   GeneID; 9262; -.
DR   KEGG; hsa:9262; -.
DR   UCSC; uc002utk.1; human.
DR   GeneCards; GC02M196709; -.
DR   H-InvDB; HIX0002694; -.
DR   HGNC; HGNC:11396; STK17B.
DR   MIM; 604727; gene.
DR   PharmGKB; PA36204; -.
DR   HOGENOM; O94768; -.
DR   HOVERGEN; O94768; -.
DR   OMA; O94768; LFHPEET.
DR   BRENDA; 2.7.11.1; 247.
DR   NextBio; 34721; -.
DR   ArrayExpress; O94768; -.
DR   Bgee; O94768; -.
DR   CleanEx; HS_STK17B; -.
DR   GermOnline; ENSG00000081320; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IDA:UniProtKB.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0006917; P:induction of apoptosis; IMP:UniProtKB.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IDA:UniProtKB.
DR   GO; GO:0007243; P:protein kinase cascade; IDA:UniProtKB.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   1: Evidence at protein level;
KW   Apoptosis; ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Nucleus; Phosphoprotein; Polymorphism;
KW   Serine/threonine-protein kinase; Transferase.
FT   CHAIN         1    372       Serine/threonine-protein kinase 17B.
FT                                /FTId=PRO_0000086706.
FT   DOMAIN       33    293       Protein kinase.
FT   NP_BIND      39     47       ATP (By similarity).
FT   COMPBIAS    308    311       Poly-Ser.
FT   ACT_SITE    158    158       Proton acceptor (By similarity).
FT   BINDING      62     62       ATP.
FT   VARIANT     320    320       S -> F.
FT                                /FTId=VAR_041147.
FT   MUTAGEN      62     62       K->A: Loss of activity and of apoptotic
FT                                function.
SQ   SEQUENCE   372 AA;  42344 MW;  7E69FFAED6DC1FF3 CRC64;
     MSRRRFDCRS ISGLLTTTPQ IPIKMENFNN FYILTSKELG RGKFAVVRQC ISKSTGQEYA
     AKFLKKRRRG QDCRAEILHE IAVLELAKSC PRVINLHEVY ENTSEIILIL EYAAGGEIFS
     LCLPELAEMV SENDVIRLIK QILEGVYYLH QNNIVHLDLK PQNILLSSIY PLGDIKIVDF
     GMSRKIGHAC ELREIMGTPE YLAPEILNYD PITTATDMWN IGIIAYMLLT HTSPFVGEDN
     QETYLNISQV NVDYSEETFS SVSQLATDFI QSLLVKNPEK RPTAEICLSH SWLQQWDFEN
     LFHPEETSSS SQTQDHSVRS SEDKTSKSSC NGTCGDREDK ENIPEDSSMV SKRFRFDDSL
     PNPHELVSDL LC
//