ID   S17B_HUMAN     STANDARD;      PRT;   372 AA.
AC   O94768;
DT   20-AUG-2001 (Rel. 40, Created)
DT   20-AUG-2001 (Rel. 40, Last sequence update)
DT   20-AUG-2001 (Rel. 40, Last annotation update)
DE   Serine/threonine kinase 17B (EC 2.7.1.-) (DAP kinase-related
DE   apoptosis-inducing protein kinase 2).
GN   STK17B OR DRAK2.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A., AND MUTAGENESIS OF LYS-62.
RC   TISSUE=Placenta, and Liver;
RX   MEDLINE=99003259; PubMed=9786912;
RA   Sanjo H., Kawai T., Akira S.;
RT   "DRAKs, novel serine/threonine kinases related to death-associated
RT   protein kinase that trigger apoptosis.";
RL   J. Biol. Chem. 273:29066-29071(1998).
CC   -!- FUNCTION: PHOSPHORYLATES THE MYOSIN LIGHT CHAIN (MLC) AS AN
CC       EXOGENOUS SUBSTRATE AND IS INVOLVED IN APOPTOTIC SIGNALING. THE C-
CC       TERMINAL REGION PLAYS AN IMPORTANT ROLE IN KINASE ACTIVITY AND FOR
CC       INITIATION OF APOTOSIS.
CC   -!- SUBCELLULAR LOCATION: NUCLEAR.
CC   -!- TISSUE SPECIFICITY: HIGHLY EXPRESSED IN PLACENTA, LUNG, PANCREAS
CC       AND IN LOWER LEVELS IN HEART, BRAIN, LIVER, SKELETAL MUSCLE AND
CC       KIDNEY.
CC   -!- PTM: AUTOPHOSPHORYLATED.
CC   -!- SIMILARITY: BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.
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DR   EMBL; AB011421; BAA34127.1; -.
DR   HSSP; P00518; 1PHK.
DR   MIM; 604727; -.
DR   InterPro; IPR000719; Euk_pkinase.
DR   InterPro; IPR001245; Tyr_kin.
DR   InterPro; IPR002290; Ser_thr_kin_actsite.
DR   Pfam; PF00069; pkinase; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
KW   Transferase; Serine/threonine-protein kinase; ATP-binding;
KW   Phosphorylation; Nuclear protein; Apoptosis.
FT   DOMAIN       33    293       PROTEIN KINASE.
FT   DOMAIN      308    311       POLY-SER.
FT   NP_BIND      39     47       ATP (BY SIMILARITY).
FT   BINDING      62     62       ATP (BY SIMILARITY).
FT   MUTAGEN      62     62       K->A: LOSS OF ACTIVITY.
SQ   SEQUENCE   372 AA;  42344 MW;  7E69FFAED6DC1FF3 CRC64;
     MSRRRFDCRS ISGLLTTTPQ IPIKMENFNN FYILTSKELG RGKFAVVRQC ISKSTGQEYA
     AKFLKKRRRG QDCRAEILHE IAVLELAKSC PRVINLHEVY ENTSEIILIL EYAAGGEIFS
     LCLPELAEMV SENDVIRLIK QILEGVYYLH QNNIVHLDLK PQNILLSSIY PLGDIKIVDF
     GMSRKIGHAC ELREIMGTPE YLAPEILNYD PITTATDMWN IGIIAYMLLT HTSPFVGEDN
     QETYLNISQV NVDYSEETFS SVSQLATDFI QSLLVKNPEK RPTAEICLSH SWLQQWDFEN
     LFHPEETSSS SQTQDHSVRS SEDKTSKSSC NGTCGDREDK ENIPEDSSMV SKRFRFDDSL
     PNPHELVSDL LC
//