ID S17B_HUMAN STANDARD; PRT; 372 AA. AC O94768; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-SEP-2003 (Rel. 42, Last annotation update) DE Serine/threonine protein kinase 17B (EC 2.7.1.37) (DAP kinase-related DE apoptosis-inducing protein kinase 2). GN STK17B OR DRAK2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A., AND MUTAGENESIS OF LYS-62. RC TISSUE=Liver, and Placenta; RX MEDLINE=99003259; PubMed=9786912; RA Sanjo H., Kawai T., Akira S.; RT "DRAKs, novel serine/threonine kinases related to death-associated RT protein kinase that trigger apoptosis."; RL J. Biol. Chem. 273:29066-29071(1998). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=B-cell; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: PHOSPHORYLATES THE MYOSIN LIGHT CHAIN (MLC) AS AN CC EXOGENOUS SUBSTRATE AND IS INVOLVED IN APOPTOTIC SIGNALING. THE C- CC TERMINAL REGION PLAYS AN IMPORTANT ROLE IN KINASE ACTIVITY AND FOR CC INITIATION OF APOPTOSIS. CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC -!- SUBCELLULAR LOCATION: Nuclear. CC -!- TISSUE SPECIFICITY: HIGHLY EXPRESSED IN PLACENTA, LUNG, PANCREAS CC AND IN LOWER LEVELS IN HEART, BRAIN, LIVER, SKELETAL MUSCLE AND CC KIDNEY. CC -!- PTM: AUTOPHOSPHORYLATED. CC -!- SIMILARITY: BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB011421; BAA34127.1; -. DR EMBL; BC016040; AAH16040.1; -. DR HSSP; Q63450; 1A06. DR Genew; HGNC:11396; STK17B. DR MIM; 604727; -. DR GO; GO:0005634; C:nucleus; TAS. DR GO; GO:0004674; F:protein serine/threonine kinase activity; TAS. DR GO; GO:0006917; P:induction of apoptosis; TAS. DR GO; GO:0006468; P:protein amino acid phosphorylation; TAS. DR InterPro; IPR000719; Prot_kinase. DR InterPro; IPR002290; Ser_thr_pkinase. DR Pfam; PF00069; pkinase; 1. DR ProDom; PD000001; Prot_kinase; 1. DR SMART; SM00220; S_TKc; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. KW Transferase; Serine/threonine-protein kinase; ATP-binding; KW Phosphorylation; Nuclear protein; Apoptosis. FT DOMAIN 33 293 PROTEIN KINASE. FT DOMAIN 308 311 POLY-SER. FT NP_BIND 39 47 ATP (BY SIMILARITY). FT BINDING 62 62 ATP (BY SIMILARITY). FT MUTAGEN 62 62 K->A: LOSS OF ACTIVITY. SQ SEQUENCE 372 AA; 42344 MW; 7E69FFAED6DC1FF3 CRC64; MSRRRFDCRS ISGLLTTTPQ IPIKMENFNN FYILTSKELG RGKFAVVRQC ISKSTGQEYA AKFLKKRRRG QDCRAEILHE IAVLELAKSC PRVINLHEVY ENTSEIILIL EYAAGGEIFS LCLPELAEMV SENDVIRLIK QILEGVYYLH QNNIVHLDLK PQNILLSSIY PLGDIKIVDF GMSRKIGHAC ELREIMGTPE YLAPEILNYD PITTATDMWN IGIIAYMLLT HTSPFVGEDN QETYLNISQV NVDYSEETFS SVSQLATDFI QSLLVKNPEK RPTAEICLSH SWLQQWDFEN LFHPEETSSS SQTQDHSVRS SEDKTSKSSC NGTCGDREDK ENIPEDSSMV SKRFRFDDSL PNPHELVSDL LC //