Serine/threonine-protein kinase 17B

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O94768 (ST17B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 122. History...

Clusters with 100%, 90%, 50% identity |

Documents (7) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase 17B
EC=2.7.11.1

Alternative name(s):
DAP kinase-related apoptosis-inducing protein kinase 2

Gene names

Name:	STK17B
Synonyms:	DRAK2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Phosphorylates myosin light chains By similarity. Acts as a positive regulator of apoptosis. Ref.1
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus By similarity.
Subcellular location	Nucleus. Cell membrane By similarity. Endoplasmic reticulum-Golgi intermediate compartment By similarity. Note: Colocalizes with STK17B at the plasma membrane By similarity. Ref.1
Tissue specificity	Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney. Ref.1
Post-translational modification	Autophosphorylated.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cell membrane Membrane Nucleus
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW induction of apoptosis Inferred from mutant phenotype Ref.1. Source: UniProtKB intracellular protein kinase cascade Inferred from direct assay Ref.1. Source: UniProtKB protein autophosphorylation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	actin cytoskeleton Inferred from electronic annotation. Source: Compara endoplasmic reticulum-Golgi intermediate compartment Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay Ref.1. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from direct assay Ref.1. Source: UniProtKB protein serine/threonine kinase activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 372

372

Serine/threonine-protein kinase 17B

PRO_0000086706

Regions

Domain

33 – 293

261

Protein kinase

Nucleotide binding

39 – 47

ATP By similarity

Compositional bias

308 – 311

Poly-Ser

Sites

Active site

158

Proton acceptor By similarity

Binding site

ATP

Natural variations

Natural variant

320

S → F. Ref.5
Corresponds to variant rs34740616 [ dbSNP | Ensembl ].

VAR_041147

Experimental info

Mutagenesis

K → A: Loss of activity and of apoptotic function. Ref.1

Secondary structure

372

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

O94768 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 7E69FFAED6DC1FF3
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FASTA

372

42,344

        10         20         30         40         50         60 
MSRRRFDCRS ISGLLTTTPQ IPIKMENFNN FYILTSKELG RGKFAVVRQC ISKSTGQEYA 

        70         80         90        100        110        120 
AKFLKKRRRG QDCRAEILHE IAVLELAKSC PRVINLHEVY ENTSEIILIL EYAAGGEIFS 

       130        140        150        160        170        180 
LCLPELAEMV SENDVIRLIK QILEGVYYLH QNNIVHLDLK PQNILLSSIY PLGDIKIVDF 

       190        200        210        220        230        240 
GMSRKIGHAC ELREIMGTPE YLAPEILNYD PITTATDMWN IGIIAYMLLT HTSPFVGEDN 

       250        260        270        280        290        300 
QETYLNISQV NVDYSEETFS SVSQLATDFI QSLLVKNPEK RPTAEICLSH SWLQQWDFEN 

       310        320        330        340        350        360 
LFHPEETSSS SQTQDHSVRS SEDKTSKSSC NGTCGDREDK ENIPEDSSMV SKRFRFDDSL 

       370 
PNPHELVSDL LC

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis." Sanjo H., Kawai T., Akira S. J. Biol. Chem. 273:29066-29071(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-62. Tissue: Liver and Placenta.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell.
[3]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[4]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[5]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-320.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB011421 mRNA. Translation: BAA34127.1.
BC016040 mRNA. Translation: AAH16040.1.

IPI

IPI00014934.

RefSeq

NP_004217.1. NM_004226.3.

UniGene

Hs.88297.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3LM0	X-ray	2.35	A	25-329	[»]
3LM5	X-ray	2.29	A	25-329	[»]

ProteinModelPortal

O94768.

ModBase

Search...

Protein-protein interaction databases

IntAct

O94768. 4 interactions.

STRING

9606.ENSP00000263955.

PTM databases

PhosphoSite

O94768.

Proteomic databases

PaxDb

O94768.

PRIDE

O94768.

Protocols and materials databases

DNASU

9262.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000263955; ENSP00000263955; ENSG00000081320.
ENST00000409228; ENSP00000386853; ENSG00000081320.

GeneID

9262.

KEGG

hsa:9262.

UCSC

uc002utk.3. human.

Organism-specific databases

CTD

9262.

GeneCards

GC02M196964.

HGNC

HGNC:11396. STK17B.

HPA

HPA034858.

MIM

604727. gene.

neXtProt

NX_O94768.

PharmGKB

PA36204.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0515.

HOGENOM

HOG000233016.

HOVERGEN

HBG106718.

InParanoid

O94768.

K08804.

OMA

CKETEAV.

OrthoDB

EOG4GTKD7.

Enzyme and pathway databases

BRENDA

2.7.11.1. 2681.

Gene expression databases

ArrayExpress

O94768.

Bgee

O94768.

CleanEx

HS_STK17B.

Genevestigator

O94768.

GermOnline

ENSG00000081320. Homo sapiens.

Family and domain databases

InterPro

IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]

Pfam

PF00069. Pkinase. 1 hit.
[Graphical view]

SMART

SM00220. S_TKc. 1 hit.
[Graphical view]

SUPFAM

SSF56112. Kinase_like. 1 hit.

PROSITE

PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

O94768.

ChEMBL

CHEMBL3980.

ChiTaRS

STK17B. human.

EvolutionaryTrace

O94768.

GenomeRNAi

9262.

NextBio

34721.

SOURCE

Search...

Entry information

Entry name

ST17B_HUMAN

Accession

Primary (citable) accession number: O94768

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 122 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.