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Protein

Serine/threonine-protein kinase 17B

Gene

STK17B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62ATP1
Active sitei158Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 47ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • protein kinase activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • intracellular signal transduction Source: UniProtKB
  • positive regulation of fibroblast apoptotic process Source: UniProtKB
  • protein autophosphorylation Source: UniProtKB
  • protein phosphorylation Source: UniProtKB

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 2681.
SignaLinkiO94768.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 17B (EC:2.7.11.1)
Alternative name(s):
DAP kinase-related apoptosis-inducing protein kinase 2
Gene namesi
Name:STK17B
Synonyms:DRAK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000081320.10.
HGNCiHGNC:11396. STK17B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi62K → A: Loss of activity and of apoptotic function. 1 Publication1

Organism-specific databases

DisGeNETi9262.
OpenTargetsiENSG00000081320.
PharmGKBiPA36204.

Chemistry databases

ChEMBLiCHEMBL3980.
DrugBankiDB04216. Quercetin.
GuidetoPHARMACOLOGYi2215.

Polymorphism and mutation databases

BioMutaiSTK17B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867061 – 372Serine/threonine-protein kinase 17BAdd BLAST372

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO94768.
PaxDbiO94768.
PeptideAtlasiO94768.
PRIDEiO94768.

PTM databases

iPTMnetiO94768.
PhosphoSitePlusiO94768.

Expressioni

Tissue specificityi

Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.1 Publication

Gene expression databases

BgeeiENSG00000081320.
CleanExiHS_STK17B.
ExpressionAtlasiO94768. baseline and differential.
GenevisibleiO94768. HS.

Organism-specific databases

HPAiHPA034858.

Interactioni

Subunit structurei

Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus.By similarity

Protein-protein interaction databases

BioGridi114684. 26 interactors.
IntActiO94768. 14 interactors.
STRINGi9606.ENSP00000263955.

Chemistry databases

BindingDBiO94768.

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 31Combined sources7
Beta strandi32 – 42Combined sources11
Beta strandi45 – 52Combined sources8
Turni53 – 55Combined sources3
Beta strandi58 – 68Combined sources11
Helixi74 – 86Combined sources13
Turni87 – 89Combined sources3
Beta strandi96 – 101Combined sources6
Beta strandi103 – 111Combined sources9
Helixi118 – 122Combined sources5
Helixi124 – 126Combined sources3
Helixi132 – 151Combined sources20
Helixi161 – 163Combined sources3
Beta strandi164 – 167Combined sources4
Turni169 – 172Combined sources4
Beta strandi175 – 177Combined sources3
Helixi180 – 182Combined sources3
Helixi199 – 201Combined sources3
Helixi204 – 207Combined sources4
Helixi215 – 230Combined sources16
Helixi240 – 249Combined sources10
Turni256 – 261Combined sources6
Helixi264 – 273Combined sources10
Helixi278 – 280Combined sources3
Helixi284 – 287Combined sources4
Helixi291 – 293Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LM0X-ray2.35A25-329[»]
3LM5X-ray2.29A25-329[»]
ProteinModelPortaliO94768.
SMRiO94768.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94768.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 293Protein kinasePROSITE-ProRule annotationAdd BLAST261

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi308 – 311Poly-Ser4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118877.
HOGENOMiHOG000233016.
HOVERGENiHBG106718.
InParanoidiO94768.
KOiK08804.
OMAiKIGNACE.
OrthoDBiEOG091G0J2O.
PhylomeDBiO94768.
TreeFamiTF314166.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

O94768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRRFDCRS ISGLLTTTPQ IPIKMENFNN FYILTSKELG RGKFAVVRQC
60 70 80 90 100
ISKSTGQEYA AKFLKKRRRG QDCRAEILHE IAVLELAKSC PRVINLHEVY
110 120 130 140 150
ENTSEIILIL EYAAGGEIFS LCLPELAEMV SENDVIRLIK QILEGVYYLH
160 170 180 190 200
QNNIVHLDLK PQNILLSSIY PLGDIKIVDF GMSRKIGHAC ELREIMGTPE
210 220 230 240 250
YLAPEILNYD PITTATDMWN IGIIAYMLLT HTSPFVGEDN QETYLNISQV
260 270 280 290 300
NVDYSEETFS SVSQLATDFI QSLLVKNPEK RPTAEICLSH SWLQQWDFEN
310 320 330 340 350
LFHPEETSSS SQTQDHSVRS SEDKTSKSSC NGTCGDREDK ENIPEDSSMV
360 370
SKRFRFDDSL PNPHELVSDL LC
Length:372
Mass (Da):42,344
Last modified:May 1, 1999 - v1
Checksum:i7E69FFAED6DC1FF3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041147320S → F1 PublicationCorresponds to variant dbSNP:rs34740616Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011421 mRNA. Translation: BAA34127.1.
BC016040 mRNA. Translation: AAH16040.1.
CCDSiCCDS2315.1.
RefSeqiNP_004217.1. NM_004226.3.
XP_011510470.1. XM_011512168.2.
XP_011510471.1. XM_011512169.1.
XP_011510472.1. XM_011512170.1.
UniGeneiHs.88297.

Genome annotation databases

EnsembliENST00000263955; ENSP00000263955; ENSG00000081320.
ENST00000409228; ENSP00000386853; ENSG00000081320.
GeneIDi9262.
KEGGihsa:9262.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiST17B_HUMAN
AccessioniPrimary (citable) accession number: O94768
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 1999
Last modified: November 22, 2017
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families