O94759 (TRPM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transient receptor potential cation channel subfamily M member 2
EC=3.6.1.13

Alternative name(s):
Estrogen-responsive element-associated gene 1 protein
Long transient receptor potential channel 2
Short name=LTrpC-2
Short name=LTrpC2
Transient receptor potential channel 7
Short name=TrpC7

Gene names

Name:	TRPM2
Synonyms:	EREG1, KNP3, LTRPC2, TRPC7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1503 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD+), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. Ref.12
Catalytic activity	ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate. Ref.10
Subunit structure	Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death.
Subcellular location	Membrane; Multi-pass membrane protein Ref.3 Ref.10.
Tissue specificity	Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. Ref.10 Ref.11
Induction	NAD+. Ref.2 Ref.10 Ref.11
Sequence similarities	Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. [View classification] Contains 1 nudix hydrolase domain.
Biophysicochemical properties	Kinetic parameters: KM=100 µM for ADP-ribose Vmax=0.1 µmol/min/mg enzyme
Sequence caution	The sequence BAB64300.1 differs from that shown. Reason: Frameshift at positions 1227 and 1237.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Sodium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Calcium NAD Sodium
Molecular function	Calcium channel Hydrolase Ion channel Sodium channel
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to hydroperoxide Inferred from electronic annotation. Source: Compara sodium ion transmembrane transport Inferred from electronic annotation. Source: GOC
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	ADP-ribose diphosphatase activity Inferred from electronic annotation. Source: EC calcium channel activity Traceable author statement Ref.1. Source: ProtInc manganese ion transmembrane transporter activity Inferred from electronic annotation. Source: Compara sodium channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O94759-1)

Also known as: TRPM2-L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O94759-2)

The sequence of this isoform differs from the canonical sequence as follows:
     538-557: Missing.
     1291-1325: DTLEPLSTIQYNVVDGLRDRRSFHGPYTVQAGLPL → E

Isoform 3 (identifier: O94759-3)

Also known as: TRPM2-S;

The sequence of this isoform differs from the canonical sequence as follows:
     847-1503: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1503	1503	Transient receptor potential cation channel subfamily M member 2		PRO_0000215326
Regions
	Topological domain	1 – 752	752	Cytoplasmic Potential
	Transmembrane	753 – 773	21	Helical; Potential
	Topological domain	774 – 795	22	Extracellular Potential
	Transmembrane	796 – 816	21	Helical; Potential
	Topological domain	817 – 872	56	Cytoplasmic Potential
	Transmembrane	873 – 893	21	Helical; Potential
	Topological domain	894 – 896	3	Extracellular Potential
	Transmembrane	897 – 917	21	Helical; Potential
	Topological domain	918 – 936	19	Cytoplasmic Potential
	Transmembrane	937 – 957	21	Helical; Potential
	Topological domain	958 – 1025	68	Extracellular Potential
	Transmembrane	1026 – 1046	21	Helical; Potential
	Topological domain	1047 – 1503	457	Cytoplasmic Potential
	Domain	1354 – 1498	145	Nudix hydrolase
	Nucleotide binding	1390 – 1412	23	NAD
Amino acid modifications
	Modified residue	405	1	N6-acetyllysine Ref.13
Natural variations
	Alternative sequence	538 – 557	20	Missing in isoform 2.		VSP_006574
	Alternative sequence	847 – 1503	657	Missing in isoform 3.		VSP_013018
	Alternative sequence	1291 – 1325	35	DTLEP…AGLPL → E in isoform 2.		VSP_006575
	Natural variant	52	1	N → K. Ref.6 Corresponds to variant rs45625933 [ dbSNP | Ensembl ].		VAR_025216
	Natural variant	166	1	V → I. Ref.6 Corresponds to variant rs45544142 [ dbSNP | Ensembl ].		VAR_025217
	Natural variant	385	1	V → M. Ref.6 Corresponds to variant rs45485992 [ dbSNP | Ensembl ].		VAR_025218
	Natural variant	543	1	D → E. Ref.6 Corresponds to variant rs1556314 [ dbSNP | Ensembl ].		VAR_020032
	Natural variant	780	1	D → E. Ref.6 Corresponds to variant rs9974927 [ dbSNP | Ensembl ].		VAR_025219
	Natural variant	1189	1	Q → R. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Corresponds to variant rs9978351 [ dbSNP | Ensembl ].		VAR_025220
	Natural variant	1199	1	R → W. Ref.6 Corresponds to variant rs45611537 [ dbSNP | Ensembl ].		VAR_025221
	Natural variant	1201	1	S → G. Ref.6 Corresponds to variant rs45519835 [ dbSNP | Ensembl ].		VAR_025222
	Natural variant	1249	1	N → S. Ref.6 Corresponds to variant rs45513700 [ dbSNP | Ensembl ].		VAR_025223
	Natural variant	1347	1	T → M. Ref.6 Corresponds to variant rs45589233 [ dbSNP | Ensembl ].		VAR_025224
	Natural variant	1359	1	E → K. Ref.6 Corresponds to variant rs45570639 [ dbSNP | Ensembl ].		VAR_025225
	Natural variant	1368	1	I → M. Ref.6 Corresponds to variant rs45613636 [ dbSNP | Ensembl ].		VAR_025226
	Natural variant	1438	1	A → S. Ref.6 Corresponds to variant rs45578242 [ dbSNP | Ensembl ].		VAR_025227
Experimental info
	Mutagenesis	1397	1	M → I: Only slight effect on activity. Ref.12
	Sequence conflict	1088	1	S → N in CAD01139. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (TRPM2-L) [UniParc]. Last modified October 23, 2007. Version 2. Checksum: 02338437501ABFAB	FASTA	1,503	171,198
	10 20 30 40 50 60 MEPSALRKAG SEQEEGFEGL PRRVTDLGMV SNLRRSNSSL FKSWRLQCPF GNNDKQESLS 70 80 90 100 110 120 SWIPENIKKK ECVYFVESSK LSDAGKVVCQ CGYTHEQHLE EATKPHTFQG TQWDPKKHVQ 130 140 150 160 170 180 EMPTDAFGDI VFTGLSQKVK KYVRVSQDTP SSVIYHLMTQ HWGLDVPNLL ISVTGGAKNF 190 200 210 220 230 240 NMKPRLKSIF RRGLVKVAQT TGAWIITGGS HTGVMKQVGE AVRDFSLSSS YKEGELITIG 250 260 270 280 290 300 VATWGTVHRR EGLIHPTGSF PAEYILDEDG QGNLTCLDSN HSHFILVDDG THGQYGVEIP 310 320 330 340 350 360 LRTRLEKFIS EQTKERGGVA IKIPIVCVVL EGGPGTLHTI DNATTNGTPC VVVEGSGRVA 370 380 390 400 410 420 DVIAQVANLP VSDITISLIQ QKLSVFFQEM FETFTESRIV EWTKKIQDIV RRRQLLTVFR 430 440 450 460 470 480 EGKDGQQDVD VAILQALLKA SRSQDHFGHE NWDHQLKLAV AWNRVDIARS EIFMDEWQWK 490 500 510 520 530 540 PSDLHPTMTA ALISNKPEFV KLFLENGVQL KEFVTWDTLL YLYENLDPSC LFHSKLQKVL 550 560 570 580 590 600 VEDPERPACA PAAPRLQMHH VAQVLRELLG DFTQPLYPRP RHNDRLRLLL PVPHVKLNVQ 610 620 630 640 650 660 GVSLRSLYKR SSGHVTFTMD PIRDLLIWAI VQNRRELAGI IWAQSQDCIA AALACSKILK 670 680 690 700 710 720 ELSKEEEDTD SSEEMLALAE EYEHRAIGVF TECYRKDEER AQKLLTRVSE AWGKTTCLQL 730 740 750 760 770 780 ALEAKDMKFV SHGGIQAFLT KVWWGQLSVD NGLWRVTLCM LAFPLLLTGL ISFREKRLQD 790 800 810 820 830 840 VGTPAARARA FFTAPVVVFH LNILSYFAFL CLFAYVLMVD FQPVPSWCEC AIYLWLFSLV 850 860 870 880 890 900 CEEMRQLFYD PDECGLMKKA ALYFSDFWNK LDVGAILLFV AGLTCRLIPA TLYPGRVILS 910 920 930 940 950 960 LDFILFCLRL MHIFTISKTL GPKIIIVKRM MKDVFFFLFL LAVWVVSFGV AKQAILIHNE 970 980 990 1000 1010 1020 RRVDWLFRGA VYHSYLTIFG QIPGYIDGVN FNPEHCSPNG TDPYKPKCPE SDATQQRPAF 1030 1040 1050 1060 1070 1080 PEWLTVLLLC LYLLFTNILL LNLLIAMFNY TFQQVQEHTD QIWKFQRHDL IEEYHGRPAA 1090 1100 1110 1120 1130 1140 PPPFILLSHL QLFIKRVVLK TPAKRHKQLK NKLEKNEEAA LLSWEIYLKE NYLQNRQFQQ 1150 1160 1170 1180 1190 1200 KQRPEQKIED ISNKVDAMVD LLDLDPLKRS GSMEQRLASL EEQVAQTAQA LHWIVRTLRA 1210 1220 1230 1240 1250 1260 SGFSSEADVP TLASQKAAEE PDAEPGGRKK TEEPGDSYHV NARHLLYPNC PVTRFPVPNE 1270 1280 1290 1300 1310 1320 KVPWETEFLI YDPPFYTAER KDAAAMDPMG DTLEPLSTIQ YNVVDGLRDR RSFHGPYTVQ 1330 1340 1350 1360 1370 1380 AGLPLNPMGR TGLRGRGSLS CFGPNHTLYP MVTRWRRNED GAICRKSIKK MLEVLVVKLP 1390 1400 1410 1420 1430 1440 LSEHWALPGG SREPGEMLPR KLKRILRQEH WPSFENLLKC GMEVYKGYMD DPRNTDNAWI 1450 1460 1470 1480 1490 1500 ETVAVSVHFQ DQNDVELNRL NSNLHACDSG ASIRWQVVDR RIPLYANHKT LLQKAAAEFG AHY
	Isoform 2 [UniParc]. Checksum: CFFA7E256DABB60B	FASTA	1,449	165,273
	10 20 30 40 50 60 MEPSALRKAG SEQEEGFEGL PRRVTDLGMV SNLRRSNSSL FKSWRLQCPF GNNDKQESLS 70 80 90 100 110 120 SWIPENIKKK ECVYFVESSK LSDAGKVVCQ CGYTHEQHLE EATKPHTFQG TQWDPKKHVQ 130 140 150 160 170 180 EMPTDAFGDI VFTGLSQKVK KYVRVSQDTP SSVIYHLMTQ HWGLDVPNLL ISVTGGAKNF 190 200 210 220 230 240 NMKPRLKSIF RRGLVKVAQT TGAWIITGGS HTGVMKQVGE AVRDFSLSSS YKEGELITIG 250 260 270 280 290 300 VATWGTVHRR EGLIHPTGSF PAEYILDEDG QGNLTCLDSN HSHFILVDDG THGQYGVEIP 310 320 330 340 350 360 LRTRLEKFIS EQTKERGGVA IKIPIVCVVL EGGPGTLHTI DNATTNGTPC VVVEGSGRVA 370 380 390 400 410 420 DVIAQVANLP VSDITISLIQ QKLSVFFQEM FETFTESRIV EWTKKIQDIV RRRQLLTVFR 430 440 450 460 470 480 EGKDGQQDVD VAILQALLKA SRSQDHFGHE NWDHQLKLAV AWNRVDIARS EIFMDEWQWK 490 500 510 520 530 540 PSDLHPTMTA ALISNKPEFV KLFLENGVQL KEFVTWDTLL YLYENLDPSC LFHSKLQMHH 550 560 570 580 590 600 VAQVLRELLG DFTQPLYPRP RHNDRLRLLL PVPHVKLNVQ GVSLRSLYKR SSGHVTFTMD 610 620 630 640 650 660 PIRDLLIWAI VQNRRELAGI IWAQSQDCIA AALACSKILK ELSKEEEDTD SSEEMLALAE 670 680 690 700 710 720 EYEHRAIGVF TECYRKDEER AQKLLTRVSE AWGKTTCLQL ALEAKDMKFV SHGGIQAFLT 730 740 750 760 770 780 KVWWGQLSVD NGLWRVTLCM LAFPLLLTGL ISFREKRLQD VGTPAARARA FFTAPVVVFH 790 800 810 820 830 840 LNILSYFAFL CLFAYVLMVD FQPVPSWCEC AIYLWLFSLV CEEMRQLFYD PDECGLMKKA 850 860 870 880 890 900 ALYFSDFWNK LDVGAILLFV AGLTCRLIPA TLYPGRVILS LDFILFCLRL MHIFTISKTL 910 920 930 940 950 960 GPKIIIVKRM MKDVFFFLFL LAVWVVSFGV AKQAILIHNE RRVDWLFRGA VYHSYLTIFG 970 980 990 1000 1010 1020 QIPGYIDGVN FNPEHCSPNG TDPYKPKCPE SDATQQRPAF PEWLTVLLLC LYLLFTNILL 1030 1040 1050 1060 1070 1080 LNLLIAMFNY TFQQVQEHTD QIWKFQRHDL IEEYHGRPAA PPPFILLSHL QLFIKRVVLK 1090 1100 1110 1120 1130 1140 TPAKRHKQLK NKLEKNEEAA LLSWEIYLKE NYLQNRQFQQ KQRPEQKIED ISNKVDAMVD 1150 1160 1170 1180 1190 1200 LLDLDPLKRS GSMEQRLASL EEQVAQTAQA LHWIVRTLRA SGFSSEADVP TLASQKAAEE 1210 1220 1230 1240 1250 1260 PDAEPGGRKK TEEPGDSYHV NARHLLYPNC PVTRFPVPNE KVPWETEFLI YDPPFYTAER 1270 1280 1290 1300 1310 1320 KDAAAMDPMG ENPMGRTGLR GRGSLSCFGP NHTLYPMVTR WRRNEDGAIC RKSIKKMLEV 1330 1340 1350 1360 1370 1380 LVVKLPLSEH WALPGGSREP GEMLPRKLKR ILRQEHWPSF ENLLKCGMEV YKGYMDDPRN 1390 1400 1410 1420 1430 1440 TDNAWIETVA VSVHFQDQND VELNRLNSNL HACDSGASIR WQVVDRRIPL YANHKTLLQK AAAEFGAHY
	Isoform 3 (TRPM2-S) [UniParc]. Checksum: 70B0B29CADE26939	FASTA	846	95,699
	10 20 30 40 50 60 MEPSALRKAG SEQEEGFEGL PRRVTDLGMV SNLRRSNSSL FKSWRLQCPF GNNDKQESLS 70 80 90 100 110 120 SWIPENIKKK ECVYFVESSK LSDAGKVVCQ CGYTHEQHLE EATKPHTFQG TQWDPKKHVQ 130 140 150 160 170 180 EMPTDAFGDI VFTGLSQKVK KYVRVSQDTP SSVIYHLMTQ HWGLDVPNLL ISVTGGAKNF 190 200 210 220 230 240 NMKPRLKSIF RRGLVKVAQT TGAWIITGGS HTGVMKQVGE AVRDFSLSSS YKEGELITIG 250 260 270 280 290 300 VATWGTVHRR EGLIHPTGSF PAEYILDEDG QGNLTCLDSN HSHFILVDDG THGQYGVEIP 310 320 330 340 350 360 LRTRLEKFIS EQTKERGGVA IKIPIVCVVL EGGPGTLHTI DNATTNGTPC VVVEGSGRVA 370 380 390 400 410 420 DVIAQVANLP VSDITISLIQ QKLSVFFQEM FETFTESRIV EWTKKIQDIV RRRQLLTVFR 430 440 450 460 470 480 EGKDGQQDVD VAILQALLKA SRSQDHFGHE NWDHQLKLAV AWNRVDIARS EIFMDEWQWK 490 500 510 520 530 540 PSDLHPTMTA ALISNKPEFV KLFLENGVQL KEFVTWDTLL YLYENLDPSC LFHSKLQKVL 550 560 570 580 590 600 VEDPERPACA PAAPRLQMHH VAQVLRELLG DFTQPLYPRP RHNDRLRLLL PVPHVKLNVQ 610 620 630 640 650 660 GVSLRSLYKR SSGHVTFTMD PIRDLLIWAI VQNRRELAGI IWAQSQDCIA AALACSKILK 670 680 690 700 710 720 ELSKEEEDTD SSEEMLALAE EYEHRAIGVF TECYRKDEER AQKLLTRVSE AWGKTTCLQL 730 740 750 760 770 780 ALEAKDMKFV SHGGIQAFLT KVWWGQLSVD NGLWRVTLCM LAFPLLLTGL ISFREKRLQD 790 800 810 820 830 840 VGTPAARARA FFTAPVVVFH LNILSYFAFL CLFAYVLMVD FQPVPSWCEC AIYLWLFSLV CEEMRQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain." Nagamine K., Kudoh J., Minoshima S., Kawasaki K., Asakawa S., Ito F., Shimizu N. Genomics 54:124-131(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-1189. Tissue: Brain.
[2]	"Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose." Wehage E., Eisfeld J., Heiner I., Juengling E., Zitt C., Lueckhoff A. J. Biol. Chem. 277:23150-23156(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ARG-1189, REGULATION BY OXIDATIVE STRESS. Tissue: Promyelocytic leukemia.
[3]	"A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death." Zhang W., Chu X., Tong Q., Cheung J.Y., Conrad K., Masker K., Miller B.A. J. Biol. Chem. 278:16222-16229(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT ARG-1189, INTERACTION BETWEEN ISOFORMS 1 AND 3, SUBCELLULAR LOCATION. Tissue: Bone marrow.
[4]	"Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum." Uemura T., Kudoh J., Noda S., Kanba S., Shimizu N. Biochem. Biophys. Res. Commun. 328:1232-1243(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-1189. Tissue: Brain.
[5]	"Cloning of the human TRPM2." Hayes P.D. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-1189.
[6]	NIEHS SNPs program Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-52; ILE-166; MET-385; GLU-543; GLU-780; TRP-1199; GLY-1201; SER-1249; MET-1347; LYS-1359; MET-1368 AND SER-1438.
[7]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"Molecular cloning of a novel estrogen responsive gene, estrogen responsive element associated gene 1 (EREG1), which contains MutT like domain." Hiroi H., Muramatsu M., Inoue S. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1190-1503.
[10]	"ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology." Perraud A.-L., Fleig A., Dunn C.A., Bagley L.A., Launay P., Schmitz C., Stokes A.J., Zhu Q., Bessman M.J., Penner R., Kinet J.-P., Scharenberg A.M. Nature 411:595-599(2001) [PubMed] [Europe PMC] [Abstract] Cited for: CATALYTIC ACTIVITY, REGULATION BY ADP-RIBOSE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[11]	"Immunocyte Ca2+ influx system mediated by LTRPC2." Sano Y., Inamura K., Miyake A., Mochizuki S., Yokoi H., Matsushime H., Furuichi K. Science 293:1327-1330(2001) [PubMed] [Europe PMC] [Abstract] Cited for: REGULATION BY PYRIMIDINE NUCLEOTIDES, TISSUE SPECIFICITY.
[12]	"LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death." Hara Y., Wakamori M., Ishii M., Maeno E., Nishida M., Yoshida T., Yamada H., Shimizu S., Mori E., Kudoh J., Shimizu N., Kurose H., Okada Y., Imoto K., Mori Y. Mol. Cell 9:163-173(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF MET-1397.
[13]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-405, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB001535 mRNA. Translation: BAA34700.1. AJ417076 mRNA. Translation: CAD01139.1. AY603182 mRNA. Translation: AAT12288.1. AB166745 mRNA. Translation: BAD83705.1. AJ878416 mRNA. Translation: CAI47593.1. DQ012935 Genomic DNA. Translation: AAY22174.1. AP001754 Genomic DNA. Translation: BAA95563.1. CH471079 Genomic DNA. Translation: EAX09426.1. CH471079 Genomic DNA. Translation: EAX09427.1. AB017549 mRNA. Translation: BAB64300.1. Frameshift.
IPI	IPI00014911. IPI00412399. IPI00480087.
RefSeq	NP_003298.1. NM_003307.3.
UniGene	Hs.369759.
3D structure databases
ProteinModelPortal	O94759.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000300482.
Protein family/group databases
TCDB	1.A.4.5.5. transient receptor potential Ca2+ channel (TRP-CC) family.
PTM databases
PhosphoSite	O94759.
Proteomic databases
PaxDb	O94759.
PRIDE	O94759.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300481; ENSP00000300481; ENSG00000142185. ENST00000300482; ENSP00000300482; ENSG00000142185. ENST00000397928; ENSP00000381023; ENSG00000142185.
GeneID	7226.
KEGG	hsa:7226.
UCSC	uc002zet.1. human. uc002zey.1. human.
Organism-specific databases
CTD	7226.
GeneCards	GC21P045770.
HGNC	HGNC:12339. TRPM2.
HPA	HPA030974.
MIM	603749. gene.
neXtProt	NX_O94759.
PharmGKB	PA37012.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG253824.
HOGENOM	HOG000236350.
HOVERGEN	HBG055825.
KO	K04977.
OrthoDB	EOG4BVRSV.
PhylomeDB	O94759.
Gene expression databases
ArrayExpress	O94759.
Bgee	O94759.
CleanEx	HS_TRPC7. HS_TRPM2.
Genevestigator	O94759.
GermOnline	ENSG00000142185. Homo sapiens.
Family and domain databases
Gene3D	3.90.79.10. 1 hit.
InterPro	IPR005821. Ion_trans_dom. IPR000086. NUDIX_hydrolase_dom. IPR015797. NUDIX_hydrolase_dom-like. [Graphical view]
Pfam	PF00520. Ion_trans. 1 hit. [Graphical view]
SUPFAM	SSF55811. NUDIX_hydrolase. 1 hit.
PROSITE	PS51462. NUDIX. 1 hit. PS00893. NUDIX_BOX. False negative. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1250402.
GenomeRNAi	7226.
NextBio	28299.
SOURCE	Search...

Entry information

Entry name

TRPM2_HUMAN

Accession

Primary (citable) accession number: O94759
Secondary accession number(s): D3DSL6 , Q5KTC2, Q6J3P5, Q96KN6, Q96Q93

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 128 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.