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Protein

Enhancer of mRNA-decapping protein 3

Gene

edc3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates decapping of both stable and unstable mRNA during mRNA decay. Stimulates decapping presumably by preventing the DCP1-DCP2 decapping complex from adopting an inactive conformation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic mRNA processing body assembly Source: GO_Central
  • deadenylation-independent decapping of nuclear-transcribed mRNA Source: PomBase

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of mRNA-decapping protein 3
Gene namesi
Name:edc3
ORF Names:SPBC18E5.11c, SPBC23G7.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC18E5.11c
PomBaseiSPBC18E5.11c edc3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190631 – 454Enhancer of mRNA-decapping protein 3Add BLAST454

Proteomic databases

MaxQBiO94752
PaxDbiO94752
PRIDEiO94752

PTM databases

iPTMnetiO94752

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with dcp2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
dcp2O138285EBI-7556871,EBI-3647323

Protein-protein interaction databases

BioGridi277164, 3 interactors
IntActiO94752, 2 interactors
MINTiO94752
STRINGi4896.SPBC18E5.11c.1

Structurei

Secondary structure

1454
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 6Combined sources4
Beta strandi10 – 15Combined sources6
Beta strandi20 – 29Combined sources10
Turni30 – 33Combined sources4
Beta strandi34 – 39Combined sources6
Turni40 – 42Combined sources3
Beta strandi43 – 48Combined sources6
Helixi49 – 51Combined sources3
Beta strandi52 – 57Combined sources6
Beta strandi63 – 65Combined sources3
Beta strandi68 – 70Combined sources3
Beta strandi88 – 90Combined sources3
Beta strandi93 – 97Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A53NMR-A1-121[»]
4A54NMR-A1-94[»]
ProteinModelPortaliO94752
SMRiO94752
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 123DFDFPROSITE-ProRule annotationAdd BLAST37
Domaini222 – 431YjeF N-terminalPROSITE-ProRule annotationAdd BLAST210

Sequence similaritiesi

Belongs to the EDC3 family.Curated

Phylogenomic databases

InParanoidiO94752
KOiK12615
OMAiTRIEHEY
OrthoDBiEOG092C25XS
PhylomeDBiO94752

Family and domain databases

CDDicd01737 LSm16_N, 1 hit
Gene3Di3.40.50.10260, 1 hit
InterProiView protein in InterPro
IPR025762 DFDF
IPR019050 FDF_dom
IPR034107 Lsm16_N
IPR004443 YjeF_N_dom
IPR036652 YjeF_N_dom_sf
PfamiView protein in Pfam
PF09532 FDF, 1 hit
PF03853 YjeF_N, 1 hit
SMARTiView protein in SMART
SM01199 FDF, 1 hit
SUPFAMiSSF64153 SSF64153, 1 hit
PROSITEiView protein in PROSITE
PS51512 DFDF, 1 hit
PS51385 YJEF_N, 1 hit

Sequencei

Sequence statusi: Complete.

O94752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVADFYGSN VEVLLNNDSK ARGVITNFDS SNSILQLRLA NDSTKSIVTK
60 70 80 90 100
DIKDLRILPK NEIMPKNGTK SPSTNSTKLK SAETYSSKNK WSMDCDEEFD
110 120 130 140 150
FAANLEKFDK KQVFAEFREK DKKDPAKLLV SHNKSPNRNY HHKQNVLGPS
160 170 180 190 200
VKDEFVDLPS AGSQINGIDA VLSSSSNGHV TPGSKKGSRE TLKKKPFVDE
210 220 230 240 250
NIPAELHTTT GDILKPITPE QLSQGIALAI AKTSTDIVVE NAAQLLSQFV
260 270 280 290 300
FSVLGGHKRL SSRNHNSQPL VCILVGSHDH ASAAVAAGRR LCAIGIKVVL
310 320 330 340 350
RLLTPFNVDN RQLLMFQAAG GYIPTENFDQ FLNKLTSPIE LVVDVLTGFH
360 370 380 390 400
PSIDKNSHAL IQWANDLNVL ILSVDIPSGY TVQKKNTAIL PKWTLALGAV
410 420 430 440 450
TTTLAQAALV KQAAGVSVFV GNLGTGSQTW AELGILESQV TGQYLAQISC

TSTN
Length:454
Mass (Da):49,219
Last modified:May 1, 1999 - v1
Checksum:iF488C398D2550275
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA22671.1
PIRiT39762
RefSeqiNP_595858.1, NM_001021762.2

Genome annotation databases

EnsemblFungiiSPBC18E5.11c.1; SPBC18E5.11c.1:pep; SPBC18E5.11c
GeneIDi2540639
KEGGispo:SPBC18E5.11c

Similar proteinsi

Entry informationi

Entry nameiEDC3_SCHPO
AccessioniPrimary (citable) accession number: O94752
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health