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Protein

Enhancer of mRNA-decapping protein 3

Gene

edc3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates decapping of both stable and unstable mRNA during mRNA decay. Stimulates decapping presumably by preventing the DCP1-DCP2 decapping complex from adopting an inactive conformation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic mRNA processing body assembly Source: GO_Central
  • deadenylation-independent decapping of nuclear-transcribed mRNA Source: PomBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of mRNA-decapping protein 3
Gene namesi
Name:edc3
ORF Names:SPBC18E5.11c, SPBC23G7.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC18E5.11c.
PomBaseiSPBC18E5.11c. edc3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytoplasmic mRNA processing body Source: PomBase
  • cytoplasmic stress granule Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Enhancer of mRNA-decapping protein 3PRO_0000119063Add
BLAST

Proteomic databases

MaxQBiO94752.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with dcp2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
dcp2O138285EBI-7556871,EBI-3647323

Protein-protein interaction databases

BioGridi277164. 3 interactions.
IntActiO94752. 2 interactions.
MINTiMINT-4686637.

Structurei

Secondary structure

1
454
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 64Combined sources
Beta strandi10 – 156Combined sources
Beta strandi20 – 2910Combined sources
Turni30 – 334Combined sources
Beta strandi34 – 396Combined sources
Turni40 – 423Combined sources
Beta strandi43 – 486Combined sources
Helixi49 – 513Combined sources
Beta strandi52 – 576Combined sources
Beta strandi63 – 653Combined sources
Beta strandi68 – 703Combined sources
Beta strandi88 – 903Combined sources
Beta strandi93 – 975Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A53NMR-A1-121[»]
4A54NMR-A1-94[»]
ProteinModelPortaliO94752.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini87 – 12337DFDFPROSITE-ProRule annotationAdd
BLAST
Domaini222 – 431210YjeF N-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the EDC3 family.Curated
Contains 1 DFDF domain.PROSITE-ProRule annotation
Contains 1 YjeF N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO94752.
KOiK12615.
OMAiEFDFQKN.
OrthoDBiEOG092C25XS.
PhylomeDBiO94752.

Family and domain databases

Gene3Di3.40.50.10260. 1 hit.
InterProiIPR025762. DFDF.
IPR019050. FDF_dom.
IPR004443. YjeF_N_dom.
[Graphical view]
PfamiPF09532. FDF. 1 hit.
PF03853. YjeF_N. 1 hit.
[Graphical view]
SMARTiSM01199. FDF. 1 hit.
[Graphical view]
SUPFAMiSSF64153. SSF64153. 1 hit.
PROSITEiPS51512. DFDF. 1 hit.
PS51385. YJEF_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVADFYGSN VEVLLNNDSK ARGVITNFDS SNSILQLRLA NDSTKSIVTK
60 70 80 90 100
DIKDLRILPK NEIMPKNGTK SPSTNSTKLK SAETYSSKNK WSMDCDEEFD
110 120 130 140 150
FAANLEKFDK KQVFAEFREK DKKDPAKLLV SHNKSPNRNY HHKQNVLGPS
160 170 180 190 200
VKDEFVDLPS AGSQINGIDA VLSSSSNGHV TPGSKKGSRE TLKKKPFVDE
210 220 230 240 250
NIPAELHTTT GDILKPITPE QLSQGIALAI AKTSTDIVVE NAAQLLSQFV
260 270 280 290 300
FSVLGGHKRL SSRNHNSQPL VCILVGSHDH ASAAVAAGRR LCAIGIKVVL
310 320 330 340 350
RLLTPFNVDN RQLLMFQAAG GYIPTENFDQ FLNKLTSPIE LVVDVLTGFH
360 370 380 390 400
PSIDKNSHAL IQWANDLNVL ILSVDIPSGY TVQKKNTAIL PKWTLALGAV
410 420 430 440 450
TTTLAQAALV KQAAGVSVFV GNLGTGSQTW AELGILESQV TGQYLAQISC

TSTN
Length:454
Mass (Da):49,219
Last modified:May 1, 1999 - v1
Checksum:iF488C398D2550275
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22671.1.
PIRiT39762.
RefSeqiNP_595858.1. NM_001021762.2.

Genome annotation databases

EnsemblFungiiSPBC18E5.11c.1; SPBC18E5.11c.1:pep; SPBC18E5.11c.
GeneIDi2540639.
KEGGispo:SPBC18E5.11c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22671.1.
PIRiT39762.
RefSeqiNP_595858.1. NM_001021762.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A53NMR-A1-121[»]
4A54NMR-A1-94[»]
ProteinModelPortaliO94752.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277164. 3 interactions.
IntActiO94752. 2 interactions.
MINTiMINT-4686637.

Proteomic databases

MaxQBiO94752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC18E5.11c.1; SPBC18E5.11c.1:pep; SPBC18E5.11c.
GeneIDi2540639.
KEGGispo:SPBC18E5.11c.

Organism-specific databases

EuPathDBiFungiDB:SPBC18E5.11c.
PomBaseiSPBC18E5.11c. edc3.

Phylogenomic databases

InParanoidiO94752.
KOiK12615.
OMAiEFDFQKN.
OrthoDBiEOG092C25XS.
PhylomeDBiO94752.

Miscellaneous databases

PROiO94752.

Family and domain databases

Gene3Di3.40.50.10260. 1 hit.
InterProiIPR025762. DFDF.
IPR019050. FDF_dom.
IPR004443. YjeF_N_dom.
[Graphical view]
PfamiPF09532. FDF. 1 hit.
PF03853. YjeF_N. 1 hit.
[Graphical view]
SMARTiSM01199. FDF. 1 hit.
[Graphical view]
SUPFAMiSSF64153. SSF64153. 1 hit.
PROSITEiPS51512. DFDF. 1 hit.
PS51385. YJEF_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDC3_SCHPO
AccessioniPrimary (citable) accession number: O94752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.