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Protein

Alpha-1,3/1,6-mannosyltransferase ALG2

Gene

ALG2

Organism
Rhizomucor pusillus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mannosylates Man2GlcNAc2-dolichol diphosphate and Man1GlcNAc2-dolichol diphosphate to form Man3GlcNAc2-dolichol diphosphate.

Catalytic activityi

GDP-D-mannose + D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-GlcNAc-diphosphodolichol.
GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378

Protein family/group databases

CAZyiGT4 Glycosyltransferase Family 4

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,3/1,6-mannosyltransferase ALG2 (EC:2.4.1.132, EC:2.4.1.257)
Alternative name(s):
GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase
GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
Gene namesi
Name:ALG2
OrganismiRhizomucor pusillus
Taxonomic identifieri4840 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMucoromycotaMucoromycotinaMucoralesLichtheimiaceaeRhizomucor

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei73 – 95HelicalSequence analysisAdd BLAST23
Transmembranei434 – 453HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi368G → R: Temperature-sensitive phenotype. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802681 – 455Alpha-1,3/1,6-mannosyltransferase ALG2Add BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO94738
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd03805 GT1_ALG2_like, 1 hit
InterProiView protein in InterPro
IPR027054 ALG2
IPR001296 Glyco_trans_1
IPR028098 Glyco_trans_4-like_N
PfamiView protein in Pfam
PF13439 Glyco_transf_4, 1 hit
PF00534 Glycos_transf_1, 1 hit

Sequencei

Sequence statusi: Complete.

O94738-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKSLNVAF IHPDLGIGGA ERLVVDAAVG IQKKGHQVIF YTSHHDPNHC
60 70 80 90 100
FEETRDGTLK VQVRGDWLPR TIFGRFYILC AILRQFVLVA SLILWERHSY
110 120 130 140 150
DIFFVDQLSA CVPLLKWFTT AKILFYCHFP DKLLTQRNST IKKLYRAPVD
160 170 180 190 200
KMEELTTGMS DLIAVNSGFT AGMFKKSFPS VHQTPQILYP PINFDAYDRP
210 220 230 240 250
VDRNDPTVKI LETDKRVLLS INRFERKKNV ELALRAFAAL KIKNMVPKDV
260 270 280 290 300
FANYRLVLAG GYDKRVRENV EYLEELDQLA TEEFGLQTFT IHPSSAAADV
310 320 330 340 350
PADAQVVFLC SFNDAQRTFL LDQAKLLLYT PSNEHFGITP VEGMYASVPV
360 370 380 390 400
IAVNTGGPVE TVKNKETGLL LPSDPDVWAE GIRDFIIEKY NGKQMGQHGR
410 420 430 440 450
QHVQSKFSLP AFADRLEAMM IELETSTPDQ SSSGAVYLLG AIGVLFACII

YCIKQ
Length:455
Mass (Da):51,222
Last modified:May 1, 1999 - v1
Checksum:i8128C7C2365E46EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015055 mRNA Translation: BAA34297.1
AB015054 Genomic DNA Translation: BAA34296.1

Similar proteinsi

Entry informationi

Entry nameiALG2_RHIPU
AccessioniPrimary (citable) accession number: O94738
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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