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Protein

GTP-binding protein ypt7

Gene

ypt7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Needed for homotypic vacuole fusion, the last step in the vacuole inheritance process.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • endocytosis Source: PomBase
  • Golgi to vacuole transport Source: PomBase
  • intracellular protein transport Source: PomBase
  • positive regulation of vacuole fusion, non-autophagic Source: PomBase
  • vacuolar acidification Source: PomBase
  • vacuole fusion, non-autophagic Source: PomBase

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-6798695 Neutrophil degranulation
R-SPO-8854214 TBC/RABGAPs
R-SPO-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein ypt7
Gene namesi
Name:ypt7
ORF Names:SPBC405.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC405.04c
PomBaseiSPBC405.04c ypt7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213131 – 205GTP-binding protein ypt7Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi203S-geranylgeranyl cysteineBy similarity1
Modified residuei205Cysteine methyl esterBy similarity1
Lipidationi205S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiO94655
PaxDbiO94655
PRIDEiO94655

PTM databases

iPTMnetiO94655

Interactioni

Protein-protein interaction databases

BioGridi277283, 4 interactors
STRINGi4896.SPBC405.04c.1

Structurei

3D structure databases

ProteinModelPortaliO94655
SMRiO94655
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionCurated9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

HOGENOMiHOG000233968
InParanoidiO94655
KOiK07897
OMAiLMQQFVN
OrthoDBiEOG092C5MDH
PhylomeDBiO94655

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

O94655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKKKHLLK VIILGESGVG KTSIMNQYVN RKFSKDYKAT IGADFLTKEV
60 70 80 90 100
LVDDKVVTLQ LWDTAGQERF QSLGVAFYRG ADCCVLVYDV NNSKSFETLD
110 120 130 140 150
SWRDEFLIQA SPSNPETFPF ILLGNKVDVE EQKRMVSKSK ALAFCQARGE
160 170 180 190 200
IPYFETSAKE AINVQEAFET VAKLALENMD SDDIAADFTD PIHLDMESQK

TSCYC
Length:205
Mass (Da):22,994
Last modified:May 1, 1999 - v1
Checksum:iB63D9B5A019FBA32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB38603.1
PIRiT40425
RefSeqiNP_596307.1, NM_001022229.2

Genome annotation databases

EnsemblFungiiSPBC405.04c.1; SPBC405.04c.1:pep; SPBC405.04c
GeneIDi2540763
KEGGispo:SPBC405.04c

Similar proteinsi

Entry informationi

Entry nameiYPT7_SCHPO
AccessioniPrimary (citable) accession number: O94655
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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