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Protein

GTP-binding protein ypt7

Gene

ypt7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Needed for homotypic vacuole fusion, the last step in the vacuole inheritance process.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTPBy similarity
Nucleotide bindingi63 – 675GTPBy similarity
Nucleotide bindingi125 – 1284GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: PomBase
  • GTP binding Source: PomBase

GO - Biological processi

  • Golgi to vacuole transport Source: PomBase
  • intracellular protein transport Source: PomBase
  • positive regulation of vacuole fusion, non-autophagic Source: PomBase
  • regulation of endocytosis Source: PomBase
  • small GTPase mediated signal transduction Source: InterPro
  • vacuolar acidification Source: PomBase
  • vacuole fusion, non-autophagic Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein ypt7
Gene namesi
Name:ypt7
ORF Names:SPBC405.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC405.04c.
PomBaseiSPBC405.04c. ypt7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • vacuolar membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205GTP-binding protein ypt7PRO_0000121313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi203 – 2031S-geranylgeranyl cysteineBy similarity
Modified residuei205 – 2051Cysteine methyl esterBy similarity
Lipidationi205 – 2051S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiO94655.
PRIDEiO94655.

Interactioni

Protein-protein interaction databases

BioGridi277283. 4 interactions.
MINTiMINT-4685912.

Structurei

3D structure databases

ProteinModelPortaliO94655.
SMRiO94655. Positions 8-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459Effector regionCurated

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

HOGENOMiHOG000233968.
InParanoidiO94655.
KOiK07897.
OMAiQQESFAH.
OrthoDBiEOG7KSXMF.
PhylomeDBiO94655.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKKKHLLK VIILGESGVG KTSIMNQYVN RKFSKDYKAT IGADFLTKEV
60 70 80 90 100
LVDDKVVTLQ LWDTAGQERF QSLGVAFYRG ADCCVLVYDV NNSKSFETLD
110 120 130 140 150
SWRDEFLIQA SPSNPETFPF ILLGNKVDVE EQKRMVSKSK ALAFCQARGE
160 170 180 190 200
IPYFETSAKE AINVQEAFET VAKLALENMD SDDIAADFTD PIHLDMESQK

TSCYC
Length:205
Mass (Da):22,994
Last modified:May 1, 1999 - v1
Checksum:iB63D9B5A019FBA32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB38603.1.
PIRiT40425.
RefSeqiNP_596307.1. NM_001022229.2.

Genome annotation databases

EnsemblFungiiSPBC405.04c.1; SPBC405.04c.1:pep; SPBC405.04c.
GeneIDi2540763.
KEGGispo:SPBC405.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB38603.1.
PIRiT40425.
RefSeqiNP_596307.1. NM_001022229.2.

3D structure databases

ProteinModelPortaliO94655.
SMRiO94655. Positions 8-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277283. 4 interactions.
MINTiMINT-4685912.

Proteomic databases

MaxQBiO94655.
PRIDEiO94655.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC405.04c.1; SPBC405.04c.1:pep; SPBC405.04c.
GeneIDi2540763.
KEGGispo:SPBC405.04c.

Organism-specific databases

EuPathDBiFungiDB:SPBC405.04c.
PomBaseiSPBC405.04c. ypt7.

Phylogenomic databases

HOGENOMiHOG000233968.
InParanoidiO94655.
KOiK07897.
OMAiQQESFAH.
OrthoDBiEOG7KSXMF.
PhylomeDBiO94655.

Miscellaneous databases

NextBioi20801882.
PROiO94655.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Regulated vacuole fusion and fission in Schizosaccharomyces pombe: an osmotic response dependent on MAP kinases."
    Bone N., Millar J.B.A., Toda T., Armstrong J.
    Curr. Biol. 8:135-144(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-190, FUNCTION.

Entry informationi

Entry nameiYPT7_SCHPO
AccessioniPrimary (citable) accession number: O94655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.