Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP-binding protein ypt7

Gene

ypt7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Needed for homotypic vacuole fusion, the last step in the vacuole inheritance process.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: PomBase
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • Golgi to vacuole transport Source: PomBase
  • phagosome-lysosome fusion Source: GO_Central
  • positive regulation of vacuole fusion, non-autophagic Source: PomBase
  • protein transport Source: UniProtKB-KW
  • regulation of endocytosis Source: PomBase
  • small GTPase mediated signal transduction Source: InterPro
  • vacuolar acidification Source: PomBase
  • vacuole fusion, non-autophagic Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein ypt7
Gene namesi
Name:ypt7
ORF Names:SPBC405.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC405.04c.
PomBaseiSPBC405.04c. ypt7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • fungal-type vacuole membrane Source: GO_Central
  • late endosome Source: GO_Central
  • lysosome Source: GO_Central
  • phagocytic vesicle Source: GO_Central
  • vacuolar membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213131 – 205GTP-binding protein ypt7Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi203S-geranylgeranyl cysteineBy similarity1
Modified residuei205Cysteine methyl esterBy similarity1
Lipidationi205S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiO94655.
PRIDEiO94655.

Interactioni

Protein-protein interaction databases

BioGridi277283. 4 interactors.
MINTiMINT-4685912.

Structurei

3D structure databases

ProteinModelPortaliO94655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionCurated9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

HOGENOMiHOG000233968.
InParanoidiO94655.
KOiK07897.
OMAiVGTSNPQ.
OrthoDBiEOG092C5MDH.
PhylomeDBiO94655.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKKKHLLK VIILGESGVG KTSIMNQYVN RKFSKDYKAT IGADFLTKEV
60 70 80 90 100
LVDDKVVTLQ LWDTAGQERF QSLGVAFYRG ADCCVLVYDV NNSKSFETLD
110 120 130 140 150
SWRDEFLIQA SPSNPETFPF ILLGNKVDVE EQKRMVSKSK ALAFCQARGE
160 170 180 190 200
IPYFETSAKE AINVQEAFET VAKLALENMD SDDIAADFTD PIHLDMESQK

TSCYC
Length:205
Mass (Da):22,994
Last modified:May 1, 1999 - v1
Checksum:iB63D9B5A019FBA32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB38603.1.
PIRiT40425.
RefSeqiNP_596307.1. NM_001022229.2.

Genome annotation databases

EnsemblFungiiSPBC405.04c.1; SPBC405.04c.1:pep; SPBC405.04c.
GeneIDi2540763.
KEGGispo:SPBC405.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB38603.1.
PIRiT40425.
RefSeqiNP_596307.1. NM_001022229.2.

3D structure databases

ProteinModelPortaliO94655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277283. 4 interactors.
MINTiMINT-4685912.

Proteomic databases

MaxQBiO94655.
PRIDEiO94655.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC405.04c.1; SPBC405.04c.1:pep; SPBC405.04c.
GeneIDi2540763.
KEGGispo:SPBC405.04c.

Organism-specific databases

EuPathDBiFungiDB:SPBC405.04c.
PomBaseiSPBC405.04c. ypt7.

Phylogenomic databases

HOGENOMiHOG000233968.
InParanoidiO94655.
KOiK07897.
OMAiVGTSNPQ.
OrthoDBiEOG092C5MDH.
PhylomeDBiO94655.

Enzyme and pathway databases

ReactomeiR-SPO-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiO94655.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYPT7_SCHPO
AccessioniPrimary (citable) accession number: O94655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.