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Protein

tRNA-specific adenosine deaminase subunit tad2

Gene

tad2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Deaminates adenosine-34 to inosine in many tRNAs.By similarity

Catalytic activityi

Adenine(34) in tRNA + H2O = hypoxanthine(34) in tRNA + NH3.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi266 – 2661Zinc; catalyticBy similarity
Active sitei268 – 2681Proton donorBy similarity
Metal bindingi296 – 2961Zinc; catalyticBy similarity
Metal bindingi299 – 2991Zinc; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

  • adenosine to inosine editing Source: PomBase
  • tRNA modification Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-specific adenosine deaminase subunit tad2 (EC:3.5.4.33)
Alternative name(s):
tRNA-specific adenosine-34 deaminase subunit tad2
Gene namesi
Name:tad2By similarity
ORF Names:SPBC16D10.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16D10.10.
PomBaseiSPBC16D10.10. tad2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • nucleus Source: PomBase
  • tRNA-specific adenosine-34 deaminase complex Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389tRNA-specific adenosine deaminase subunit tad2PRO_0000310823Add
BLAST

Proteomic databases

MaxQBiO94642.

Interactioni

Subunit structurei

Heterodimer with tad3.By similarity

Protein-protein interaction databases

BioGridi276190. 1 interaction.
IntActiO94642. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO94642.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 325114CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO94642.
KOiK15441.
OrthoDBiEOG74FFC7.
PhylomeDBiO94642.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR000764. Uridine_kinase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
PF00485. PRK. 1 hit.
[Graphical view]
PRINTSiPR00988. URIDINKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94642-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGDSVKSAI IGIAGGPFSG KTQLCEQLLE RLKSSAPSTF SKLIHLTSFL
60 70 80 90 100
YPNSVDRYAL SSYDIEAFKK VLSLISQGAE KICLPDGSCI KLPVDQNRII
110 120 130 140 150
LIEGYYLLLP ELLPYYTSKI FVYEDADTRL ERCVLQRVKA EKGDLTKVLN
160 170 180 190 200
DFVTLSKPAY DSSIHPTREN ADIILPQKEN IDTALLFVSQ HLQDILAEMN
210 220 230 240 250
KTSSSNTVKY DTQHETYMKL AHEILNLGPY FVIQPRSPGS CVFVYKGEVI
260 270 280 290 300
GRGFNETNCS LSGIRHAELI AIEKILEHYP ASVFKETTLY VTVEPCLMCA
310 320 330 340 350
AALKQLHIKA VYFGCGNDRF GGCGSVFSIN KDQSIDPSYP VYPGLFYSEA
360 370 380
VMLMREFYVQ ENVKAPVPQS KKQRVLKREV KSLDLSRFK
Length:389
Mass (Da):43,603
Last modified:September 22, 2009 - v2
Checksum:i0182DE8A2DC3606C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB38514.2.
PIRiT39574.
RefSeqiNP_596505.2. NM_001022426.2.

Genome annotation databases

EnsemblFungiiSPBC16D10.10.1; SPBC16D10.10.1:pep; SPBC16D10.10.
GeneIDi2539634.
KEGGispo:SPBC16D10.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB38514.2.
PIRiT39574.
RefSeqiNP_596505.2. NM_001022426.2.

3D structure databases

ProteinModelPortaliO94642.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276190. 1 interaction.
IntActiO94642. 1 interaction.

Proteomic databases

MaxQBiO94642.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC16D10.10.1; SPBC16D10.10.1:pep; SPBC16D10.10.
GeneIDi2539634.
KEGGispo:SPBC16D10.10.

Organism-specific databases

EuPathDBiFungiDB:SPBC16D10.10.
PomBaseiSPBC16D10.10. tad2.

Phylogenomic databases

InParanoidiO94642.
KOiK15441.
OrthoDBiEOG74FFC7.
PhylomeDBiO94642.

Miscellaneous databases

PROiO94642.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR000764. Uridine_kinase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
PF00485. PRK. 1 hit.
[Graphical view]
PRINTSiPR00988. URIDINKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiTAD2_SCHPO
AccessioniPrimary (citable) accession number: O94642
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: September 22, 2009
Last modified: June 8, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.