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Protein

Zinc-regulated transporter 1

Gene

zrt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity zinc transport protein. Regulates intracellular zinc levels.1 Publication

GO - Molecular functioni

  • high-affinity zinc transmembrane transporter activity Source: PomBase
  • zinc ion transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • zinc II ion transmembrane import Source: PomBase

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Protein family/group databases

TCDBi2.A.5.1.8 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-regulated transporter 1
Alternative name(s):
High-affinity zinc transport protein zrt1
Gene namesi
Name:zrt1
ORF Names:SPBC16D10.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16D10.06
PomBaseiSPBC16D10.06 zrt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003165741 – 408Zinc-regulated transporter 1Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234Phosphothreonine1 Publication1
Modified residuei237Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO94639
PaxDbiO94639
PRIDEiO94639

PTM databases

iPTMnetiO94639

Interactioni

Protein-protein interaction databases

BioGridi276210, 1 interactor
STRINGi4896.SPBC16D10.06.1

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000157076
InParanoidiO94639
KOiK14709
OMAiRSIVIMI
OrthoDBiEOG092C357X
PhylomeDBiO94639

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
IPR004698 Zn/Fe_permease_fun/pln
PfamiView protein in Pfam
PF02535 Zip, 1 hit
TIGRFAMsiTIGR00820 zip, 1 hit

Sequencei

Sequence statusi: Complete.

O94639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNNLSNSY NQYLAQESHQ ILRHLFLNKQ YSPLVKRDDD SSATVTCGGD
60 70 80 90 100
ANEFNEYGHL GYRIGAIFVI LATSLIGMNL PLVLSKITKN RPNVYIEYLY
110 120 130 140 150
LFARYFGSGV ILATAFIHLL APACNKLYDP CLDDLFGGYD WAPGICLISC
160 170 180 190 200
WFILLLEVLL NRYVEWRFGM EIGDHHGPTL GAKQHSHSHE DGAHGVHEHP
210 220 230 240 250
VYDIEECADG VEHECVKDDL EEVKLEPYTN TDSTDLTTKE EARSFLLKQQ
260 270 280 290 300
LTAFIILESS IILHSVIIGL TTAVSGEEFK TLFPVIIFHQ AFEGCGLGSR
310 320 330 340 350
LAGMAWGPKT AWVPWVLGVI YSLVTPIGMA AGLGVREHWD PLAHGSYAAQ
360 370 380 390 400
GVLDAISSGI LVYAGLVELL AHDFLFSPER ERNWYKLIYL LACSMAGTGV

MALLGKWA
Length:408
Mass (Da):45,272
Last modified:May 1, 1999 - v1
Checksum:i0EBC0AF53CC3F0CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB38510.1
PIRiT39570
RefSeqiNP_596501.1, NM_001022422.2

Genome annotation databases

EnsemblFungiiSPBC16D10.06.1; SPBC16D10.06.1:pep; SPBC16D10.06
GeneIDi2539655
KEGGispo:SPBC16D10.06

Similar proteinsi

Entry informationi

Entry nameiZRT1_SCHPO
AccessioniPrimary (citable) accession number: O94639
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health