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Protein

Zinc-regulated transporter 1

Gene

zrt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity zinc transport protein. Regulates intracellular zinc levels.1 Publication

GO - Molecular functioni

GO - Biological processi

  • high-affinity zinc II ion transmembrane import Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Protein family/group databases

TCDBi2.A.5.1.8. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-regulated transporter 1
Alternative name(s):
High-affinity zinc transport protein zrt1
Gene namesi
Name:zrt1
ORF Names:SPBC16D10.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16D10.06.
PomBaseiSPBC16D10.06. zrt1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8421HelicalSequence analysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence analysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Transmembranei254 – 27421HelicalSequence analysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence analysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence analysisAdd
BLAST
Transmembranei351 – 37121HelicalSequence analysisAdd
BLAST
Transmembranei387 – 40721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Zinc-regulated transporter 1PRO_0000316574Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei234 – 2341Phosphothreonine1 Publication
Modified residuei237 – 2371Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO94639.

PTM databases

iPTMnetiO94639.

Interactioni

Protein-protein interaction databases

BioGridi276210. 1 interaction.
MINTiMINT-4685760.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000157076.
InParanoidiO94639.
KOiK14709.
OrthoDBiEOG7M0P3K.
PhylomeDBiO94639.

Family and domain databases

InterProiIPR003689. ZIP.
IPR004698. Zn/Fe_permease_fun/pln.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00820. zip. 1 hit.

Sequencei

Sequence statusi: Complete.

O94639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNNLSNSY NQYLAQESHQ ILRHLFLNKQ YSPLVKRDDD SSATVTCGGD
60 70 80 90 100
ANEFNEYGHL GYRIGAIFVI LATSLIGMNL PLVLSKITKN RPNVYIEYLY
110 120 130 140 150
LFARYFGSGV ILATAFIHLL APACNKLYDP CLDDLFGGYD WAPGICLISC
160 170 180 190 200
WFILLLEVLL NRYVEWRFGM EIGDHHGPTL GAKQHSHSHE DGAHGVHEHP
210 220 230 240 250
VYDIEECADG VEHECVKDDL EEVKLEPYTN TDSTDLTTKE EARSFLLKQQ
260 270 280 290 300
LTAFIILESS IILHSVIIGL TTAVSGEEFK TLFPVIIFHQ AFEGCGLGSR
310 320 330 340 350
LAGMAWGPKT AWVPWVLGVI YSLVTPIGMA AGLGVREHWD PLAHGSYAAQ
360 370 380 390 400
GVLDAISSGI LVYAGLVELL AHDFLFSPER ERNWYKLIYL LACSMAGTGV

MALLGKWA
Length:408
Mass (Da):45,272
Last modified:May 1, 1999 - v1
Checksum:i0EBC0AF53CC3F0CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB38510.1.
PIRiT39570.
RefSeqiNP_596501.1. NM_001022422.2.

Genome annotation databases

EnsemblFungiiSPBC16D10.06.1; SPBC16D10.06.1:pep; SPBC16D10.06.
GeneIDi2539655.
KEGGispo:SPBC16D10.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB38510.1.
PIRiT39570.
RefSeqiNP_596501.1. NM_001022422.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276210. 1 interaction.
MINTiMINT-4685760.

Protein family/group databases

TCDBi2.A.5.1.8. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

iPTMnetiO94639.

Proteomic databases

MaxQBiO94639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC16D10.06.1; SPBC16D10.06.1:pep; SPBC16D10.06.
GeneIDi2539655.
KEGGispo:SPBC16D10.06.

Organism-specific databases

EuPathDBiFungiDB:SPBC16D10.06.
PomBaseiSPBC16D10.06. zrt1.

Phylogenomic databases

HOGENOMiHOG000157076.
InParanoidiO94639.
KOiK14709.
OrthoDBiEOG7M0P3K.
PhylomeDBiO94639.

Miscellaneous databases

NextBioi20800809.
PROiO94639.

Family and domain databases

InterProiIPR003689. ZIP.
IPR004698. Zn/Fe_permease_fun/pln.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00820. zip. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. "Response of Schizosaccharomyces pombe to zinc deficiency."
    Dainty S.J., Kennedy C.A., Watt S., Baehler J., Whitehall S.K.
    Eukaryot. Cell 7:454-464(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-234 AND THR-237, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiZRT1_SCHPO
AccessioniPrimary (citable) accession number: O94639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.