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Protein

Siderophore iron transporter 2

Gene

str2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of siderophore iron and so has a role in iron homeostasis.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Protein family/group databases

TCDBi2.A.1.16.5. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Siderophore iron transporter 2
Gene namesi
Name:str2
ORF Names:SPCC61.01c, SPCC622.20c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC61.01c.
PomBaseiSPCC61.01c. str2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence analysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence analysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence analysisAdd
BLAST
Transmembranei390 – 41021HelicalSequence analysisAdd
BLAST
Transmembranei419 – 43921HelicalSequence analysisAdd
BLAST
Transmembranei448 – 46821HelicalSequence analysisAdd
BLAST
Transmembranei485 – 50521HelicalSequence analysisAdd
BLAST
Transmembranei558 – 57821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • fungal-type vacuole membrane Source: PomBase
  • integral component of membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 597597Siderophore iron transporter 2PRO_0000084880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiO94607.
SwissPalmiO94607.

Structurei

3D structure databases

ProteinModelPortaliO94607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000162750.
InParanoidiO94607.
OrthoDBiEOG7K3TW5.
PhylomeDBiO94607.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENYGSMEH RKKSFRNNEN LEQQFHPLRE ELDNAGPIND RTSELSLEGV
60 70 80 90 100
SKAEAIASTW SKRSIIVAYL GLYLLSFASS LEQQTTYSLQ RYATSNFSAH
110 120 130 140 150
SNLATINLVG NILLAVVRAP MVKAADVFGR SESLSLALGM TVLGYLSLAF
160 170 180 190 200
SRNIQMFTVA YILYICGQTG LGLLSQLIIA DTSSLLNRGI LSAIPELPYL
210 220 230 240 250
ATVWIGPVLA QAFHPEKNYG WRLGYGIWAF ILPTVSLPLL ASLFLNQRKA
260 270 280 290 300
KAAGLYREHH NLINHSTPEK LRLFYLFWQE LDGLGIVLFV SGFTLLLLPF
310 320 330 340 350
SHSSQVVSPD STILTLFTIT LSIALLVTLC FYDVKYARYP VFALKSLKDR
360 370 380 390 400
TILGSCVLIF TYFMSYYIFS NFLTSFLQVS YGLSIDMSSL TLNVFVFSMT
410 420 430 440 450
TTAILSGFLM KRFGRFKMLL MISVPMYVLG ILGIILFGIN DNHYTRPLVL
460 470 480 490 500
VLILAGMGGG LLTLSAQIAV QSVSSHAKLG MNLTLYLTFS SVGGAFGSAI
510 520 530 540 550
AGGVWSKRLS SRLLHDLKDH LPVPEIESIF RDLRTALSYP QGTQIRNIIN
560 570 580 590
VAYTATEKDL FHISLVASLF MFAGLVIIRD VPLSTENHDT AVETPSE
Length:597
Mass (Da):66,122
Last modified:May 1, 1999 - v1
Checksum:i336E91E888ED8BA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21876.1.
PIRiT41501.
RefSeqiNP_588192.1. NM_001023182.2.

Genome annotation databases

EnsemblFungiiSPCC61.01c.1; SPCC61.01c.1:pep; SPCC61.01c.
GeneIDi2539559.
KEGGispo:SPCC61.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21876.1.
PIRiT41501.
RefSeqiNP_588192.1. NM_001023182.2.

3D structure databases

ProteinModelPortaliO94607.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.1.16.5. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiO94607.
SwissPalmiO94607.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC61.01c.1; SPCC61.01c.1:pep; SPCC61.01c.
GeneIDi2539559.
KEGGispo:SPCC61.01c.

Organism-specific databases

EuPathDBiFungiDB:SPCC61.01c.
PomBaseiSPCC61.01c. str2.

Phylogenomic databases

HOGENOMiHOG000162750.
InParanoidiO94607.
OrthoDBiEOG7K3TW5.
PhylomeDBiO94607.

Miscellaneous databases

NextBioi20800719.
PROiO94607.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system."
    Pelletier B., Beaudoin J., Philpott C.C., Labbe S.
    Nucleic Acids Res. 31:4332-4344(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSTR2_SCHPO
AccessioniPrimary (citable) accession number: O94607
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 1, 1999
Last modified: February 17, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.