Reviewed, UniProtKB/Swiss-Prot O94581 (COX12_SCHPO)

Names and origin

Protein names

Recommended name:
    Cytochrome c oxidase subunit 6B
Alternative name(s):
    Cytochrome c oxidase polypeptide VIb

Gene names

Name:	cox12
ORF Names:	SPCC1442.08c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	83 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. This protein may be one of the heme-binding subunits of the oxidase By similarity.
Subunit structure	Composed of at least 11 subunits By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 6B family.

Ontologies

Keywords
Cellular component	Mitochondrion
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_SPombe mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 83	83	Cytochrome c oxidase subunit 6B		PRO_0000194924
Amino acid modifications
	Disulfide bond	30 ↔ 62		By similarity
	Disulfide bond	40 ↔ 51		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O94581-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 3F7BFD377A35D0D6	FASTA	83	10,014
	10 20 30 40 50 60 MTLVILSLNK LLTISYLLYR FPNTNQTKHC FQSYIDYFRC IKAKGEDFVP CKQFWHAYQS 70 80 LCPMEWVERW DEQRENGTFP API

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329672 Genomic DNA. Translation: CAA21442.1.
PIR	T40973.
RefSeq	NP_588322.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2538835.
KEGG	spo:SPCC1442.08c.
NMPDR	fig|4896.1.peg.660.
Organism-specific databases
GeneDB_Spombe	SPCC1442.08c.
Phylogenomic databases
OMA	O94581. QNFLDYH.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-000245-MON.
BRENDA	1.9.3.1. 653.
Gene expression databases
ArrayExpress	O94581.
Family and domain databases
InterPro	IPR003213. Cyt_c_oxidase_su6B. [Graphical view]
Gene3D	G3DSA:1.10.10.140. Cyt_c_oxidase_6B. 1 hit.
PANTHER	PTHR11387:SF2. Cyt_c_ox6B. 1 hit.
Pfam	PF02297. COX6B. 1 hit. [Graphical view]
PIRSF	PIRSF000278. Cyt_c_oxidase_6B. 1 hit.
ProDom	PD015172. Cyt_c_ox6B. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

COX12_SCHPO

Accession

Primary (citable) accession number: O94581

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2002
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)