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Protein

Probable proteasome subunit alpha type-2

Gene

pre8

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-SPO-5689603 UCH proteinases
R-SPO-5689880 Ub-specific processing proteases
R-SPO-6798695 Neutrophil degranulation
R-SPO-68949 Orc1 removal from chromatin
R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.A11

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit alpha type-2 (EC:3.4.25.1)
Gene namesi
Name:pre8
ORF Names:SPCC1442.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1442.06
PomBaseiSPCC1442.06 pre8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001240891 – 245Probable proteasome subunit alpha type-2Add BLAST245

Proteomic databases

MaxQBiO94579
PaxDbiO94579
PRIDEiO94579

PTM databases

iPTMnetiO94579

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi275599, 6 interactors
STRINGi4896.SPCC1442.06.1

Structurei

3D structure databases

ProteinModelPortaliO94579
SMRiO94579
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000091085
InParanoidiO94579
KOiK02726
OMAiFAWKASA
OrthoDBiEOG092C47D8
PhylomeDBiO94579

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
IPR034644 Proteasome_subunit_alpha2
PANTHERiPTHR11599:SF16 PTHR11599:SF16, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

O94579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDKYAFSLT TFSPNGKLVQ IEYALNAVNA GVTSVGIKAT DGVVLATEKK
60 70 80 90 100
PTSELAIGAS LEKVCAITPD IGMVYSGMGP DFRVLVDKSR KVAQTTYKKI
110 120 130 140 150
YNEYPPTKIL VQEIASVMQE STQSGGVRPF GVSLLVAGMD EKGPSLYQVD
160 170 180 190 200
PSGTYFAWKA TAIGKSSTAA KTFLEKRYND ELELDDAVHT AILALKETFE
210 220 230 240
GELTEDNIEI AVVSTKPTDS GIVGVPGGHF CRLSQSEIRD YLDQV
Length:245
Mass (Da):26,404
Last modified:May 1, 1999 - v1
Checksum:iCFCCA93537D2464A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA21440.1
PIRiT40971
RefSeqiNP_588320.1, NM_001023311.2

Genome annotation databases

EnsemblFungiiSPCC1442.06.1; SPCC1442.06.1:pep; SPCC1442.06
GeneIDi2539026
KEGGispo:SPCC1442.06

Similar proteinsi

Entry informationi

Entry nameiPSA2_SCHPO
AccessioniPrimary (citable) accession number: O94579
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health