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Protein

Probable proteasome subunit alpha type-2

Gene

pre8

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-5689603. UCH proteinases.
R-SPO-5689880. Ub-specific processing proteases.
R-SPO-6798695. Neutrophil degranulation.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.A11.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit alpha type-2 (EC:3.4.25.1)
Gene namesi
Name:pre8
ORF Names:SPCC1442.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1442.06.
PomBaseiSPCC1442.06. pre8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001240891 – 245Probable proteasome subunit alpha type-2Add BLAST245

Proteomic databases

MaxQBiO94579.
PRIDEiO94579.

PTM databases

iPTMnetiO94579.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi275599. 6 interactors.
MINTiMINT-4685310.
STRINGi4896.SPCC1442.06.1.

Structurei

3D structure databases

ProteinModelPortaliO94579.
SMRiO94579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000091085.
InParanoidiO94579.
KOiK02726.
OMAiSGAYFGW.
OrthoDBiEOG092C47D8.
PhylomeDBiO94579.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
IPR034644. Proteasome_subunit_alpha2.
PANTHERiPTHR11599:SF16. PTHR11599:SF16. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O94579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDKYAFSLT TFSPNGKLVQ IEYALNAVNA GVTSVGIKAT DGVVLATEKK
60 70 80 90 100
PTSELAIGAS LEKVCAITPD IGMVYSGMGP DFRVLVDKSR KVAQTTYKKI
110 120 130 140 150
YNEYPPTKIL VQEIASVMQE STQSGGVRPF GVSLLVAGMD EKGPSLYQVD
160 170 180 190 200
PSGTYFAWKA TAIGKSSTAA KTFLEKRYND ELELDDAVHT AILALKETFE
210 220 230 240
GELTEDNIEI AVVSTKPTDS GIVGVPGGHF CRLSQSEIRD YLDQV
Length:245
Mass (Da):26,404
Last modified:May 1, 1999 - v1
Checksum:iCFCCA93537D2464A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21440.1.
PIRiT40971.
RefSeqiNP_588320.1. NM_001023311.2.

Genome annotation databases

EnsemblFungiiSPCC1442.06.1; SPCC1442.06.1:pep; SPCC1442.06.
GeneIDi2539026.
KEGGispo:SPCC1442.06.

Similar proteinsi

Entry informationi

Entry nameiPSA2_SCHPO
AccessioniPrimary (citable) accession number: O94579
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families