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Protein

Putative 2-hydroxyacid dehydrogenase C1773.17c

Gene

SPBC1773.17c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei251 – 2511By similarity
Binding sitei275 – 2751NADBy similarity
Active sitei280 – 2801By similarity
Active sitei298 – 2981Proton donorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi169 – 1702NADBy similarity
Nucleotide bindingi249 – 2513NADBy similarity
Nucleotide bindingi298 – 3014NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-SPO-977347. Serine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-hydroxyacid dehydrogenase C1773.17c (EC:1.-.-.-)
Gene namesi
ORF Names:SPBC1773.17c, SPBP26C9.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1773.17c.
PomBaseiSPBC1773.17c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Putative 2-hydroxyacid dehydrogenase C1773.17cPRO_0000076039Add
BLAST

Proteomic databases

MaxQBiO94574.

Interactioni

Protein-protein interaction databases

BioGridi276695. 22 interactions.

Structurei

3D structure databases

ProteinModelPortaliO94574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000136700.
InParanoidiO94574.
OMAiVEPCRES.
OrthoDBiEOG092C4Y4L.
PhylomeDBiO94574.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQSRTKRVL AIGELKFATN TLKRLSEKYH FEFIVPDPHD RSKTIEKIHE
60 70 80 90 100
AASKSTFDAC FWLFRNAAIS PFTEEMLGPL LPTCKLFVTG AAGYNNVDVD
110 120 130 140 150
WATRNGVYVA NTPNGPTEGT ANMNLMLFMC TLRGAREAEQ SLRLGKWRQN
160 170 180 190 200
LSLTDDPYGK RVGIIGMGAI GKSFAQKILP LGCEIVYHNR NRLEAEEEKR
210 220 230 240 250
LGASFVSFDE LLSSSDVISI NCPLTPATHD LISTKEFEKM KDGVYIINTA
260 270 280 290 300
RGAIINEDAF IKAIKSGKVA RAGLDVFLNE PTPNKFWLEC DKVTIQPHCG
310 320 330 340
VYTNFTVAKT EECVLASIET FLDTGIPTNP VNGPFGMNGC
Length:340
Mass (Da):37,658
Last modified:April 13, 2004 - v3
Checksum:i44ED8DD371062043
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21922.2.
PIRiT39682.
RefSeqiNP_595132.2. NM_001021039.3.

Genome annotation databases

EnsemblFungiiSPBC1773.17c.1; SPBC1773.17c.1:pep; SPBC1773.17c.
GeneIDi2540160.
KEGGispo:SPBC1773.17c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21922.2.
PIRiT39682.
RefSeqiNP_595132.2. NM_001021039.3.

3D structure databases

ProteinModelPortaliO94574.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276695. 22 interactions.

Proteomic databases

MaxQBiO94574.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1773.17c.1; SPBC1773.17c.1:pep; SPBC1773.17c.
GeneIDi2540160.
KEGGispo:SPBC1773.17c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1773.17c.
PomBaseiSPBC1773.17c.

Phylogenomic databases

HOGENOMiHOG000136700.
InParanoidiO94574.
OMAiVEPCRES.
OrthoDBiEOG092C4Y4L.
PhylomeDBiO94574.

Enzyme and pathway databases

ReactomeiR-SPO-977347. Serine biosynthesis.

Miscellaneous databases

PROiO94574.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYGDH_SCHPO
AccessioniPrimary (citable) accession number: O94574
Secondary accession number(s): Q9HFE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: September 7, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.