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Protein

Aromatic amino acid aminotransferase C1773.13

Gene

SPBC1773.13

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has aromatic amino acid transaminase activity.By similarity

Catalytic activityi

An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.

Cofactori

pyridoxal 5'-phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-SPO-71064. Lysine catabolism.
R-SPO-71240. Tryptophan catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatic amino acid aminotransferase C1773.13 (EC:2.6.1.57)
Gene namesi
ORF Names:SPBC1773.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1773.13.
PomBaseiSPBC1773.13.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Aromatic amino acid aminotransferase C1773.13PRO_0000308490Add
BLAST

Interactioni

Protein-protein interaction databases

MINTiMINT-4685274.

Structurei

3D structure databases

ProteinModelPortaliO94570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000223057.
InParanoidiO94570.
KOiK00838.
OMAiTWGHEGF.
OrthoDBiEOG7M6DHB.
PhylomeDBiO94570.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.

Sequencei

Sequence statusi: Complete.

O94570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRNSEDFSH HLSRESKARE KGPFQMLGRI KSSTGIDAIS FSSGLPHPNK
60 70 80 90 100
FAIRELSIKF PQLGCFKEEN GTYAKEVNVT FNIKADPSEG LLNFSQSLQY
110 120 130 140 150
GQCQGISELV GFIKEHIRRI HAPRYENWDI KMSNGNTSGL EYCLRLLVNY
160 170 180 190 200
GDHVLTEKYT YPAAITAMRA LGVQFVSVDM DSEGMLPESL EEIMRDWDIS
210 220 230 240 250
LGPRPHVLYT VPTGQNPTGS TLSLSRRKKL LALARKYDII IVEDEPYYFL
260 270 280 290 300
QMEDYNGSLN PAQQKCDGST FLKSLVPSLL SLDTEGRVLR LDSFSKLIAP
310 320 330 340 350
GTRLGYITGN SMFIDHITRI AEVCTESPSG ICQSVLYAML HNWGQEGFCA
360 370 380 390 400
WLQELQYSYT VRRNAFLNVA NKYLPNSVCI YHVPRAGLFL WVELNLNHYR
410 420 430 440 450
FSDTKKSVSQ IEMEIFLALV EKGVKTVCGQ FFMANPERST KIFFRFAYSI
460 470 480
ADFEDFEEGI KRFTSVINEH FNVESRVRIC P
Length:481
Mass (Da):54,756
Last modified:May 1, 1999 - v1
Checksum:i0476C46731B5E1C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21918.1.
PIRiT39678.
RefSeqiNP_595128.1. NM_001021035.2.

Genome annotation databases

EnsemblFungiiSPBC1773.13.1; SPBC1773.13.1:pep; SPBC1773.13.
GeneIDi2540092.
KEGGispo:SPBC1773.13.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21918.1.
PIRiT39678.
RefSeqiNP_595128.1. NM_001021035.2.

3D structure databases

ProteinModelPortaliO94570.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4685274.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1773.13.1; SPBC1773.13.1:pep; SPBC1773.13.
GeneIDi2540092.
KEGGispo:SPBC1773.13.

Organism-specific databases

EuPathDBiFungiDB:SPBC1773.13.
PomBaseiSPBC1773.13.

Phylogenomic databases

HOGENOMiHOG000223057.
InParanoidiO94570.
KOiK00838.
OMAiTWGHEGF.
OrthoDBiEOG7M6DHB.
PhylomeDBiO94570.

Enzyme and pathway databases

ReactomeiR-SPO-71064. Lysine catabolism.
R-SPO-71240. Tryptophan catabolism.

Miscellaneous databases

NextBioi20801229.
PROiO94570.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAATR2_SCHPO
AccessioniPrimary (citable) accession number: O94570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 1, 1999
Last modified: November 11, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.