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O94567

- SYNC_SCHPO

UniProt

O94567 - SYNC_SCHPO

Protein

Probable asparagine--tRNA ligase, cytoplasmic

Gene

nrs1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Cytosolic asparaginyl-tRNA synthetase which catalyzes the specific attachment of asparagine to its cognate tRNA.By similarity

    Catalytic activityi

    ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

    GO - Molecular functioni

    1. asparagine-tRNA ligase activity Source: PomBase
    2. ATP binding Source: UniProtKB-KW
    3. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. asparaginyl-tRNA aminoacylation Source: InterPro
    2. cytoplasmic translation Source: PomBase

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_207515. Cytosolic tRNA aminoacylation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable asparagine--tRNA ligase, cytoplasmic (EC:6.1.1.22)
    Alternative name(s):
    Asparaginyl-tRNA synthetase
    Short name:
    AsnRS
    Gene namesi
    Name:nrs1
    Synonyms:ded81
    ORF Names:SPBC1773.10c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC1773.10c.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 568568Probable asparagine--tRNA ligase, cytoplasmicPRO_0000176499Add
    BLAST

    Proteomic databases

    MaxQBiO94567.
    PaxDbiO94567.

    Interactioni

    Protein-protein interaction databases

    BioGridi276584. 8 interactions.
    MINTiMINT-4685254.
    STRINGi4896.SPBC1773.10c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO94567.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0017.
    HOGENOMiHOG000226035.
    KOiK01893.
    OMAiFCVQESF.
    OrthoDBiEOG7966R8.
    PhylomeDBiO94567.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    InterProiIPR004364. aa-tRNA-synt_II.
    IPR018150. aa-tRNA-synt_II-like.
    IPR006195. aa-tRNA-synth_II.
    IPR004522. Asn-tRNA-ligase.
    IPR002312. Asp/Asn-tRNA-synth_IIb.
    IPR012340. NA-bd_OB-fold.
    IPR004365. NA-bd_OB_tRNA.
    [Graphical view]
    PANTHERiPTHR22594. PTHR22594. 1 hit.
    PTHR22594:SF16. PTHR22594:SF16. 1 hit.
    PfamiPF00152. tRNA-synt_2. 1 hit.
    PF01336. tRNA_anti-codon. 1 hit.
    [Graphical view]
    PRINTSiPR01042. TRNASYNTHASP.
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00457. asnS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O94567-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLESKVSD MKIKSDVVFY IDEASGNDET GNGSQTSPFK TAIHALETDA    50
    NCTIFVKKNG SEEFEPITTN ALKKAKKGVE QAAKKKAKAA EAEAAAAARA 100
    AAAKEAEAKR LEAAKNIVLK EPKDAPAAKK IAIIDSTNFR DSRVRVNGWV 150
    HRMRTQKGII FIILRDGTGF LQCVLSGKVY DRASYDFINL GPESTVCLYG 200
    VIKELPEGKS APGNHELVVD YYQILHAAPT GEEAFTNRLN AEAEPSYLLD 250
    QRHLVIRGET ASSVLKVRAR ALRAMRDTFE NLKMTEVTPP CMVQTQVEGG 300
    ATLFKFNYYG QDAYLTQSSQ LYLEAALPAL GSVYTIQESF RAEKSLTRRH 350
    LSEFTHVEFE LPFVNFGEFL EIIEEFICQT IDRLLDDPIA TPLIKQLNPD 400
    FVKPSRPFMR LSYEDAIKYL NEHNILTPEG EQHKFGDDIA EAAERKMTDQ 450
    INRPIFLTYF PLEIKSFYMK RVVDRPELTE SVDCLMPNVG EIVGGSMRIS 500
    DIQELLAAYK REGIDPAPYY WFTEQRKYGT TEHGGCGLGL ERFLAWLCDR 550
    YTVRECCLFP RFTERCTP 568
    Length:568
    Mass (Da):63,870
    Last modified:May 1, 1999 - v1
    Checksum:i934483A10962BCAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA21915.1.
    PIRiT39675.
    RefSeqiNP_595125.1. NM_001021032.2.

    Genome annotation databases

    EnsemblFungiiSPBC1773.10c.1; SPBC1773.10c.1:pep; SPBC1773.10c.
    GeneIDi2540046.
    KEGGispo:SPBC1773.10c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA21915.1 .
    PIRi T39675.
    RefSeqi NP_595125.1. NM_001021032.2.

    3D structure databases

    ProteinModelPortali O94567.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276584. 8 interactions.
    MINTi MINT-4685254.
    STRINGi 4896.SPBC1773.10c-1.

    Proteomic databases

    MaxQBi O94567.
    PaxDbi O94567.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC1773.10c.1 ; SPBC1773.10c.1:pep ; SPBC1773.10c .
    GeneIDi 2540046.
    KEGGi spo:SPBC1773.10c.

    Organism-specific databases

    PomBasei SPBC1773.10c.

    Phylogenomic databases

    eggNOGi COG0017.
    HOGENOMi HOG000226035.
    KOi K01893.
    OMAi FCVQESF.
    OrthoDBi EOG7966R8.
    PhylomeDBi O94567.

    Enzyme and pathway databases

    Reactomei REACT_207515. Cytosolic tRNA aminoacylation.

    Miscellaneous databases

    NextBioi 20801183.
    PROi O94567.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    InterProi IPR004364. aa-tRNA-synt_II.
    IPR018150. aa-tRNA-synt_II-like.
    IPR006195. aa-tRNA-synth_II.
    IPR004522. Asn-tRNA-ligase.
    IPR002312. Asp/Asn-tRNA-synth_IIb.
    IPR012340. NA-bd_OB-fold.
    IPR004365. NA-bd_OB_tRNA.
    [Graphical view ]
    PANTHERi PTHR22594. PTHR22594. 1 hit.
    PTHR22594:SF16. PTHR22594:SF16. 1 hit.
    Pfami PF00152. tRNA-synt_2. 1 hit.
    PF01336. tRNA_anti-codon. 1 hit.
    [Graphical view ]
    PRINTSi PR01042. TRNASYNTHASP.
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00457. asnS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSYNC_SCHPO
    AccessioniPrimary (citable) accession number: O94567
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3