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O94567

- SYNC_SCHPO

UniProt

O94567 - SYNC_SCHPO

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Protein

Probable asparagine--tRNA ligase, cytoplasmic

Gene

nrs1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytosolic asparaginyl-tRNA synthetase which catalyzes the specific attachment of asparagine to its cognate tRNA.By similarity

Catalytic activityi

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

GO - Molecular functioni

  1. asparagine-tRNA ligase activity Source: PomBase
  2. ATP binding Source: UniProtKB-KW
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. asparaginyl-tRNA aminoacylation Source: InterPro
  2. cytoplasmic translation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_207515. Cytosolic tRNA aminoacylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable asparagine--tRNA ligase, cytoplasmic (EC:6.1.1.22)
Alternative name(s):
Asparaginyl-tRNA synthetase
Short name:
AsnRS
Gene namesi
Name:nrs1
Synonyms:ded81
ORF Names:SPBC1773.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC1773.10c.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Probable asparagine--tRNA ligase, cytoplasmicPRO_0000176499Add
BLAST

Proteomic databases

MaxQBiO94567.
PaxDbiO94567.

Interactioni

Protein-protein interaction databases

BioGridi276584. 8 interactions.
MINTiMINT-4685254.
STRINGi4896.SPBC1773.10c-1.

Structurei

3D structure databases

ProteinModelPortaliO94567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0017.
HOGENOMiHOG000226035.
InParanoidiO94567.
KOiK01893.
OMAiFCVQESF.
OrthoDBiEOG7966R8.
PhylomeDBiO94567.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-ligase.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PTHR22594:SF16. PTHR22594:SF16. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR01042. TRNASYNTHASP.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00457. asnS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94567-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGLESKVSD MKIKSDVVFY IDEASGNDET GNGSQTSPFK TAIHALETDA
60 70 80 90 100
NCTIFVKKNG SEEFEPITTN ALKKAKKGVE QAAKKKAKAA EAEAAAAARA
110 120 130 140 150
AAAKEAEAKR LEAAKNIVLK EPKDAPAAKK IAIIDSTNFR DSRVRVNGWV
160 170 180 190 200
HRMRTQKGII FIILRDGTGF LQCVLSGKVY DRASYDFINL GPESTVCLYG
210 220 230 240 250
VIKELPEGKS APGNHELVVD YYQILHAAPT GEEAFTNRLN AEAEPSYLLD
260 270 280 290 300
QRHLVIRGET ASSVLKVRAR ALRAMRDTFE NLKMTEVTPP CMVQTQVEGG
310 320 330 340 350
ATLFKFNYYG QDAYLTQSSQ LYLEAALPAL GSVYTIQESF RAEKSLTRRH
360 370 380 390 400
LSEFTHVEFE LPFVNFGEFL EIIEEFICQT IDRLLDDPIA TPLIKQLNPD
410 420 430 440 450
FVKPSRPFMR LSYEDAIKYL NEHNILTPEG EQHKFGDDIA EAAERKMTDQ
460 470 480 490 500
INRPIFLTYF PLEIKSFYMK RVVDRPELTE SVDCLMPNVG EIVGGSMRIS
510 520 530 540 550
DIQELLAAYK REGIDPAPYY WFTEQRKYGT TEHGGCGLGL ERFLAWLCDR
560
YTVRECCLFP RFTERCTP
Length:568
Mass (Da):63,870
Last modified:May 1, 1999 - v1
Checksum:i934483A10962BCAC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA21915.1.
PIRiT39675.
RefSeqiNP_595125.1. NM_001021032.2.

Genome annotation databases

EnsemblFungiiSPBC1773.10c.1; SPBC1773.10c.1:pep; SPBC1773.10c.
GeneIDi2540046.
KEGGispo:SPBC1773.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA21915.1 .
PIRi T39675.
RefSeqi NP_595125.1. NM_001021032.2.

3D structure databases

ProteinModelPortali O94567.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276584. 8 interactions.
MINTi MINT-4685254.
STRINGi 4896.SPBC1773.10c-1.

Proteomic databases

MaxQBi O94567.
PaxDbi O94567.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC1773.10c.1 ; SPBC1773.10c.1:pep ; SPBC1773.10c .
GeneIDi 2540046.
KEGGi spo:SPBC1773.10c.

Organism-specific databases

PomBasei SPBC1773.10c.

Phylogenomic databases

eggNOGi COG0017.
HOGENOMi HOG000226035.
InParanoidi O94567.
KOi K01893.
OMAi FCVQESF.
OrthoDBi EOG7966R8.
PhylomeDBi O94567.

Enzyme and pathway databases

Reactomei REACT_207515. Cytosolic tRNA aminoacylation.

Miscellaneous databases

NextBioi 20801183.
PROi O94567.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
InterProi IPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-ligase.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view ]
PANTHERi PTHR22594. PTHR22594. 1 hit.
PTHR22594:SF16. PTHR22594:SF16. 1 hit.
Pfami PF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view ]
PRINTSi PR01042. TRNASYNTHASP.
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00457. asnS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYNC_SCHPO
AccessioniPrimary (citable) accession number: O94567
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3